{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:28:49Z","timestamp":1775024929212,"version":"3.50.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Oral microbiome imbalance is involved in the development of head and neck cancers (HNCs). There is a group of oral pathogens, such as\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    ,\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    , and\n                    <jats:italic>Treponema denticola<\/jats:italic>\n                    , that creates red-complex. Currently, the oral pathogens\u2019 role in the pathogenesis of periodontitis is well-described; nevertheless, data regarding the link between HNCs and periopathogens are still limited, especially considering\n                    <jats:italic>T. forsythia<\/jats:italic>\n                    and\n                    <jats:italic>T. denticola<\/jats:italic>\n                    . These microbes utilise various virulence factors to promote the carcinogenesis process, affecting the immunological background. This paper presents modern insights into the role of red-complex bacteria in the development of HNCs, concentrating on the immunological aspects.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1804268","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:27:16Z","timestamp":1775017636000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Red-complex bacteria: immunological background leading to the development of head and neck cancers"],"prefix":"10.3389","volume":"17","author":[{"given":"Karolina","family":"Ka\u017amierczak-Siedlecka","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Diagnostics \u2013 Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk","place":["Gdansk, Poland"]},{"name":"Neodentica Dentistry Center","place":["Gdansk, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kucharski","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostics \u2013 Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk","place":["Gdansk, Poland"]},{"name":"Neodentica Dentistry Center","place":["Gdansk, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kosi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Clinical Anatomy, Medical University of Gdansk","place":["Gdansk, Poland"]},{"name":"Academy of Applied Medical and Social Sciences","place":["Elblag, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Marano","sequence":"additional","affiliation":[{"name":"Academy of Applied Medical and Social Sciences","place":["Elblag, 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