{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:33:13Z","timestamp":1793835193059,"version":"4.6.1"},"reference-count":356,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Chronic oral inflammatory diseases, particularly periodontitis, are increasingly recognized as important contributors to the onset and progression of systemic disorders. Accumulating epidemiological, clinical, and mechanistic evidence indicates that the oral cavity is not an isolated organ, but rather a critical hub and early window for systemic disease development. Through microbial translocation, chronic low-grade inflammation, immune dysregulation, oxidative stress, and epigenetic reprogramming, oral diseases engage in bidirectional communication with distant organs.We conceptualize this integrated network as the \u201coral-X axis, \u201c encompassing the oral-cardiovascular, oral-metabolic, oral\u2013respiratory, oral\u2013gastrointestinal, oral-oncologic, oral-immune, oral\u2013brain, and other systemic axes. At the core of these interactions lies periodontitis-associated microbial dysbiosis dominated by key pathogens such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. The ensuing inflammatory response compromises periodontal barrier integrity, facilitating the dissemination of bacteria, virulence factors, and inflammatory mediators into the systemic circulation. These processes promote endothelial dysfunction, insulin resistance, breakdown of immune tolerance, neuroinflammation, and the formation of pro-tumorigenic microenvironments, thereby mechanistically linking oral inflammation to a broad spectrum of systemic diseases. This review systematically summarizes the current evidence supporting the oral-X axis, with a particular focus on epidemiological associations and underlying molecular and cellular mechanisms. In addition, we discuss periodontal interventions and oral microbiome modulation as potential strategies for the prevention and treatment of systemic diseases. A deeper understanding of the oral-X axis may provide novel insights into integrated oral\u2013systemic healthcare and precision medicine.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1806445","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:39:30Z","timestamp":1777437570000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The oral - X axis: from periodontal dysbiosis to systemic disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenqin","family":"Jin","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Tang","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlong","family":"Hu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangping","family":"Ai","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zuo","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jin","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dental J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S94","DOI":"10.1111\/jcpe.12677","article-title":"Global epidemiology of dental caries and severe periodontitis\u2013a comprehensive review","volume":"44","author":"Frencken","year":"2017","journal-title":"J Clin Periodontology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-020-00392-z","article-title":"Periodontitis and hypertension: is the association causal","volume":"27","author":"Del Pinto","year":"2020","journal-title":"High Blood Pressure Cardiovasc Prev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12089","article-title":"Local inflammatory reactions in patients with diabetes and periodontitis","volume":"69","author":"Sonnenschein","year":"2015","journal-title":"Periodontology 2000"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.24-0148","article-title":"Gingival inflammation and leukocyte\u2013endothelium cell interactions in women with polycystic ovary syndrome","volume":"96","author":"M\u00e1rquez-Arrico","year":"2025","journal-title":"J Periodontology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5736394","article-title":"Transcriptomic analysis reveals genetic cross-talk between periodontitis and hypothyroidism","volume":"2022","author":"Yan","year":"2022","journal-title":"Dis Markers"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518805739","article-title":"The oral microbiota is modified by systemic diseases","volume":"98","author":"Graves","year":"2019","journal-title":"J Dent Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70261-3","article-title":"Relationships between oral and systemic health","volume":"47","author":"Casamassimo","year":"2000","journal-title":"Pediatr Clinics North America"},{"key":"B9","doi-asserted-by":"publisher","first-page":"00220345251385966","DOI":"10.1177\/00220345251385966","article-title":"Oral lichen planus and systemic diseases","author":"Warnakulasuriya","year":"2026","journal-title":"J Dent Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1714\/2729.27821","article-title":"European guidelines on cardiovascular disease prevention in clinical practice: The sixth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur Heart J"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-019-0611-1","article-title":"Review of obesity and periodontitis: an epidemiological view","volume":"227","author":"Arboleda","year":"2019","journal-title":"Br Dent J"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00410.x","article-title":"Periodontal disease in men","volume":"61","author":"Haytac","year":"2013","journal-title":"Periodontology 2000"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1714\/3026.30245","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.85","article-title":"Interactions of lymphotoxin \u03b1 (TNF-\u03b2), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis","volume":"72","author":"Holl\u00e1","year":"2001","journal-title":"J Periodontology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: a systematic review and meta-analysis","volume":"116","author":"Mu\u00f1oz Aguilera","year":"2020","journal-title":"Cardiovasc Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11883-020-00848-6","article-title":"Periodontal inflammation and the risk of cardiovascular disease","volume":"22","author":"Priyamvara","year":"2020","journal-title":"Curr Atheroscl Rep"},{"key":"B17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/prd.12302","article-title":"Periodontal diseases and association with atherosclerotic disease","volume":"83","author":"Herrera","year":"2020","journal-title":"Periodontology 2000"},{"key":"B18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontology 2000"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.097001","article-title":"The American Journal of Cardiology and Journal of Periodontology editors\u2019 consensus: periodontitis and atherosclerotic cardiovascular disease","volume":"80","author":"Friedewald","year":"2009","journal-title":"J Periodontology"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.037","article-title":"Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease","volume":"206","author":"Higashi","year":"2009","journal-title":"Atherosclerosis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/jcpe.12060","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"84","author":"Schenkein","year":"2013","journal-title":"J Periodontol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2016.01.006","article-title":"Links between atherosclerotic and periodontal disease","volume":"100","author":"Chistiakov","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases:consensus report","volume":"15","author":"Sanz","year":"2020","journal-title":"Glob Heart"},{"key":"B24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.atherosclerosis.2020.02.012","article-title":"Risk of peripheral arterial disease in patients with periodontitis:a nationwide, population- based.matched cohort study","volume":"297","author":"Cho","year":"2020","journal-title":"Atherosclerosis"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2020.101498","article-title":"Periodontitis may be associated with respiratory diseases such as asthma, COPD, and pneumonia","volume":"20","author":"Kelly","year":"2020","journal-title":"J Evidence-Based Dental Pract"},{"key":"B26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/jcpe.12828","article-title":"Periodontal disease and pneumonia mortality in haemodialysis patients: a 7\u2010year cohort study","volume":"45","author":"Iwasaki","year":"2018","journal-title":"J Clin Periodontology"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1392473","article-title":"Association between oral microbiome and five types of respiratory infections: a two-sample Mendelian randomization study in east Asian population","volume":"15","author":"He","year":"2024","journal-title":"Front Microbiol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_435_18","article-title":"Prevalence of periodontitis in patients with pulmonary disease: a cross-sectional survey in the industrial district of India","volume":"23","author":"Rastogi","year":"2019","journal-title":"J Indian Soc Periodontology"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1159\/000441724","article-title":"Gingipains: critical factors in the development of aspiration pneumonia caused by Porphyromonas gingivalis","volume":"8","author":"Benedyk","year":"2016","journal-title":"J Innate Immun"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2174\/15701611otc46njamtcvy","article-title":"The growing epidemic of diabetes mellitus","volume":"18","author":"Lovic","year":"2020","journal-title":"Curr Vasc Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: a two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2006.00214.x","article-title":"Diabetes mellitus and periodontal diseases","volume":"77","author":"Mealey","year":"2006","journal-title":"J Periodontology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.5114\/pedm.2020.93249","article-title":"Periodontal status in children and adolescents with type 1 diabetes mellitus","volume":"53","author":"Xavier","year":"2009","journal-title":"Arq Bras Endocrinol Metab"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30038-X","article-title":"Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial","volume":"6","author":"D\u2019Aiuto","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-103","article-title":"Gingival vascular functions are altered in type 2 diabetes mellitus model and\/or periodontitis model","volume":"51","author":"Sugiyama","year":"2012","journal-title":"J Clin Biochem Nutr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"106563","DOI":"10.1016\/j.jdent.2026.106563","article-title":"Association between HbA1c chairside values and periodontitis","volume":"167","author":"Ide","year":"2026","journal-title":"J Dentistry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1177\/10454411940050010201","article-title":"Sex steroid hormones and cell dynamics in the periodontium","volume":"5","author":"Mariotti","year":"1994","journal-title":"Crit Rev Oral Biol Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014903","article-title":"Gestational diabetes mellitus increases the detection rate and the number of oral bacteria in pregnant women","volume":"98","author":"Yao","year":"2019","journal-title":"Medicine"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120344","article-title":"Periodontitis and gestational diabetes mellitus in non\u2010smoking females","volume":"84","author":"Chokwiriyachit","year":"2013","journal-title":"J Periodontology"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12902","article-title":"Association between periodontal disease and gestational diabetes mellitus\u2014a prospective cohort study","volume":"45","author":"Kumar","year":"2018","journal-title":"J Clin Periodontology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2016.06.001","article-title":"Periodontitis may be associated with gestational diabetes mellitus but not affirmatively","volume":"16","author":"Jiang","year":"2016","journal-title":"J Evidence Based Dental Pract"},{"key":"B42","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1902\/jop.2015.150311","article-title":"Association between periodontitis and gestational diabetes mellitus: systematic review and meta\u2010analysis","volume":"87","author":"Esteves Lima","year":"2016","journal-title":"J Periodontology"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2020.12.012","article-title":"Systemic condition, periodontal status, and quality of life in obese women during pregnancy and after delivery","volume":"71","author":"Foratori-Junior","year":"2021","journal-title":"Int Dental J"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1700074","article-title":"American, European, and Chinese practice guidelines or consensuses of polycystic ovary syndrome: a comparative analysis","volume":"19","author":"Wang","year":"2018","journal-title":"J Zhejiang University-Science B"},{"key":"B45","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertility Sterility"},{"key":"B46","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/ijir.2017.7","article-title":"Association between periodontal disease and polycystic ovary syndrome: a systematic review","volume":"29","author":"Kellesarian","year":"2017","journal-title":"Int J Impotence Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.07.1052","article-title":"Periodontal disease in polycystic ovary syndrome","volume":"95","author":"Dursun","year":"2011","journal-title":"Fertility Sterility"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130756","article-title":"Periodontal status and highsensitivity c-reactive protein levels in polycystic ovary syndrome with and without medical treatment","volume":"85","author":"Porwal","year":"2014","journal-title":"J Periodontology"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2018.7648","article-title":"Increased risk of polycystic ovary syndrome in Taiwanese women with chronic periodontitis: a nationwide population-based retrospective cohort study","volume":"28","author":"Tong","year":"2019","journal-title":"J Women\u2019s Health"},{"key":"B50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.22074\/IJFS.2021.522861.1073","article-title":"Evaluation of levels of advanced oxidative protein products in patients with polycystic ovary syndrome with and without chronic periodontitis: A cross-sectional study","volume":"16","author":"Dharuman","year":"2022","journal-title":"Int J Fertility Sterility"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061961","article-title":"Is there a bidirectional association between polycystic ovarian syndrome and periodontitis? A systematic review and meta-analysis","volume":"9","author":"MaChado","year":"2020","journal-title":"J Clin Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism","volume":"390","author":"Chaker","year":"2017","journal-title":"Lancet"},{"key":"B53","doi-asserted-by":"publisher","first-page":"MON","DOI":"10.1210\/js.2019-mon-616","article-title":"MON -616 potential relationship between hypothyroidism and periodontal disease severty","volume":"3","author":"Yerke","year":"2019","journal-title":"J Endocr Soc"},{"key":"B54","volume-title":"Investigation on oral health awareness and periodontal status of patients with hypothyroidism","author":"Wang","year":"2024"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14127","article-title":"Autoimmune disorders in oral lichen planus: A systematic review and meta\u2010analysis","volume":"29","author":"De Porras\u2010Carrique","year":"2023","journal-title":"Oral Dis"},{"key":"B56","article-title":"Obesity: preventing and managing the global epidemic: report of a WHO consultation","volume":"894","year":"2000"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.923","article-title":"Determination of smoking and obesity as periodontitis risks using the classification and regression tree method","volume":"76","author":"Nishida","year":"2005","journal-title":"J Periodontology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4810597","article-title":"Obesity and periodontal disease in young, middle\u2010aged, and older adults","volume":"74","author":"Al\u2010Zahrani","year":"2003","journal-title":"J Periodontology"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100321","article-title":"Association between chronic periodontal disease and obesity: a systematic review and meta\u2010analysis","volume":"81","author":"Chaffee","year":"2010","journal-title":"J Periodontology"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01677.x","article-title":"Association between periodontal infection and obesity: results of the Health 2000 Survey","volume":"38","author":"Saxlin","year":"2011","journal-title":"J Clin Periodontology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/0022034510382548","article-title":"Five-year incidence of periodontal disease is related to body mass index","volume":"90","author":"Morita","year":"2011","journal-title":"J Dent Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01824.x","article-title":"Overweight and obesity predict time to periodontal disease progression in men","volume":"39","author":"Gorman","year":"2012","journal-title":"J Clin Periodontology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30587","article-title":"The fundamental basis of inflammatory bowel disease","volume":"117","author":"Strober","year":"2007","journal-title":"J Clin Invest"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9030077","article-title":"Prevalence of oral lesions and correlation with intestinal symptoms of inflammatory bowel disease: a systematic review","volume":"9","author":"Lauritano","year":"2019","journal-title":"Diagnostics"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0322","article-title":"Periodontitis prevalence and severity in inflammatory bowel disease: A case\u2013control study","volume":"94","author":"Baima","year":"2023","journal-title":"J Periodontology"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001455","article-title":"Extraintestinal manifestations of pediatric inflammatory bowel disease: prevalence, presentation, and anti\u2010TNF treatment","volume":"65","author":"Greuter","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000452","article-title":"Dental caries and periodontal disease in children and adolescents with inflammatory bowel disease: a case\u2013control study","volume":"21","author":"Koutsochristou","year":"2015","journal-title":"Inflammatory Bowel Dis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00004836-199607000-00009","article-title":"Immune-related systemic manifestations of inflammatory bowel disease: a prospective study of 792 patients","volume":"23","author":"Veloso","year":"1996","journal-title":"J Clin Gastroenterol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i46.8571","article-title":"Oral manifestation in inflammatory bowel disease: a review","volume":"19","author":"Lankarani","year":"2013","journal-title":"World J Gastroenterology: WJG"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70167-9","article-title":"Pyodermatitis-pyostomatitis vegetans: a specific marker for inflammatory bowel disease","volume":"31","author":"Storwick","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00424-6","article-title":"A prospective study of the oral manifestations of Crohn\u2019s disease","volume":"3","author":"Harty","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1034\/j.1601-0825.2003.00879.x","article-title":"Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease","volume":"9","author":"Katz","year":"2003","journal-title":"Oral Dis"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.113008","article-title":"The oral cavity in Crohn\u2019s disease","volume":"138","author":"Pittock","year":"2001","journal-title":"J Pediatr"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i25.5655","article-title":"Oral pathology in inflammatory bowel disease","volume":"22","author":"Muhvi\u0107-Urek","year":"2016","journal-title":"World J Gastroenterol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0106","article-title":"Gingival involvement in Crohn disease","volume":"138","author":"Ojha","year":"2007","journal-title":"J Am Dent Assoc"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53914","article-title":"Oral manifestations as the first presenting sign of Crohn\u2019s disease in a pediatric patient","volume":"9","author":"Eckel","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01231.x","article-title":"Prevalence of periodontitis and DMFT index in patients with Crohn\u2019s disease and ulcerative colitis","volume":"35","author":"Brito","year":"2008","journal-title":"J Clin Periodontology"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000438356.84263.3b","article-title":"Periodontitis and gingivitis in inflammatory bowel disease: a case\u2013control study","volume":"19","author":"Vavricka","year":"2013","journal-title":"Inflammatory Bowel Dis"},{"key":"B79","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/apt.13217","article-title":"Non\u2010malignant oral manifestations in inflammatory bowel diseases","volume":"42","author":"Katsanos","year":"2015","journal-title":"Alimentary Pharmacol Ther"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12698","article-title":"Inflammatory bowel disease and oral health: systematic review and a meta\u2010analysis","volume":"44","author":"Papageorgiou","year":"2017","journal-title":"J Clin Periodontology"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01431.x","article-title":"The association between inflammatory bowel disease and periodontitis among Jordanians: a case\u2013control study","volume":"47","author":"Habashneh","year":"2012","journal-title":"J Periodontal Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6692420","article-title":"The association between periodontitis and inflammatory bowel disease: a systematic review and meta\u2010analysis","volume":"2021","author":"Zhang","year":"2021","journal-title":"BioMed Research International"},{"key":"B83","article-title":"Research progress on the correlation between the gut-liver axis and liver cirrhosis","volume":"29","author":"Liu","year":"2021","journal-title":"Chin J Integrated Traditional Western Med Digestion"},{"key":"B84","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/00016350903291913","article-title":"Relationship between periodontitis and hepatic abnormalities in young adults","volume":"68","author":"Furuta","year":"2010","journal-title":"Acta Odontol Scand"},{"key":"B85","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12903-018-0487-5","article-title":"Periodontitis in patients with cirrhosis: a cross-sectional study","volume":"18","author":"Gr\u00f8nkj\u00e6r","year":"2018","journal-title":"BMC Oral Health"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01777.x","article-title":"Stage of hepatocellular carcinoma is associated with periodontitis","volume":"38","author":"Tamaki","year":"2011","journal-title":"J Clin Periodontology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta\u2010analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-16","article-title":"Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease","volume":"12","author":"Yoneda","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000520","article-title":"Periodontal treatment and usual care for nonalcoholic fatty liver disease: a multicenter, randomized controlled trial","volume":"13","author":"Kamata","year":"2022","journal-title":"Clin Trans Gastroenterol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02476.x","article-title":"Prevalence and risk factors for peri\u2010implant disease in Belgian adults","volume":"24","author":"Marrone","year":"2013","journal-title":"Clin Oral Implants Res"},{"key":"B91","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/2050640617715846","article-title":"Severe periodontitis and higher cirrhosis mortality","volume":"6","author":"Ladegaard Gr\u00f8nkj\u00e6r","year":"2018","journal-title":"United Eur Gastroenterol J"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13172","article-title":"Periodontitis in individuals with liver cirrhosis: a case-control study","volume":"46","author":"Costa","year":"2019","journal-title":"J Clin Periodontology"},{"key":"B93","article-title":"Periodontal status in post-liver transplantation patients: 10 years of follow-up","volume":"43","author":"Machtei","year":"2012","journal-title":"Quintessence Int"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-3142","article-title":"Periodontal outcomes in liver transplantation individuals: a systematic review and meta-analysis","volume":"30","author":"Galdino","year":"2021","journal-title":"J Gastrointestinal Liver Diseases: JGLD"},{"key":"B95","volume-title":"GLOBO-CAN 2012:Estimated cancer incidence, mortality and prevalence worldwide in 2012","year":""},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-144","article-title":"Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma","volume":"12","author":"Pushalkar","year":"2012","journal-title":"BMC Microbiol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3322\/ca.2007.0010","article-title":"Cancer statistics, 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.02.0220","article-title":"Association of periodontitis with the risk of oral leukoplakia","volume":"48","author":"Meisel","year":"2012","journal-title":"Oral Oncol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"11773","DOI":"10.1038\/s41598-017-11779-9","article-title":"Variations in oral microbiota associated with oral cancer","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA: A Cancer J For Clin"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70106-2","article-title":"Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study","volume":"9","author":"Michaud","year":"2008","journal-title":"Lancet Oncol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30484","article-title":"Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma\u2010a population\u2010based case\u2010control study in China","volume":"140","author":"Chen","year":"2017","journal-title":"Int J Cancer"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109444","article-title":"Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan","volume":"9","author":"Lee","year":"2014","journal-title":"PloS One"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA: A Cancer J For Clin"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160829","article-title":"Chronic periodontal disease, periodontal pathogen colonization, and increased risk of precancerous gastric lesions","volume":"88","author":"Sun","year":"2017","journal-title":"J Periodontology"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5195","article-title":"Oral microbiota and cancer","volume":"2","author":"Meurman","year":"2010","journal-title":"J Oral Microbiol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"Castellarin","year":"2012","journal-title":"Genome Res"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30486","article-title":"Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses\u2019 Health Study","volume":"140","author":"Momen-Heravi","year":"2017","journal-title":"Int J Cancer"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.24920\/003984","article-title":"Multi-omics technologies and their clinical applications in hepatocellular carcinoma: current advances and future opportunities","volume":"36","author":"Yang","year":"2021","journal-title":"Chin Med Sci J"},{"key":"B110","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s10552-017-0906-y","article-title":"Tooth loss and liver cancer incidence in a Finnish cohort","volume":"28","author":"Yang","year":"2017","journal-title":"Cancer Causes Control"},{"key":"B111","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx019","article-title":"Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis","volume":"28","author":"Maisonneuve","year":"2017","journal-title":"Ann Oncol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000000419","article-title":"Investigating the association between periodontal disease and risk of pancreatic cancer","volume":"45","author":"Chang","year":"2016","journal-title":"Pancreas"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/jc.29710","article-title":"A prospective cohort study on poor oral hygiene and pancreatic cancer risk","volume":"138","author":"Huang","year":"2016","journal-title":"Int Cancer"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.02.001","article-title":"Epidemiology of lung cancer","volume":"25","author":"Mao","year":"2016","journal-title":"Surg Oncol Clin North Am"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150597","article-title":"Periodontal disease and incident lung cancer risk: a meta\u2010analysis of cohort studies","volume":"87","author":"Zeng","year":"2016","journal-title":"J Periodontology"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0699-9","article-title":"Periodontal disease severity and cancer risk in postmenopausal women: the buffalo OsteoPerio study","volume":"27","author":"Mai","year":"2016","journal-title":"Cancer Causes Control"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx278","article-title":"Periodontal disease assessed using clinical dental measurements and cancer risk in the ARIC study","volume":"110","author":"Michaud","year":"2018","journal-title":"JNCI: J Natl Cancer Institute"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcu078","article-title":"Periodontal disease with treatment reduces subsequent cancer risks","volume":"107","author":"Hwang","year":"2014","journal-title":"QJM: Int J Med"},{"key":"B120","doi-asserted-by":"publisher","first-page":"7632","DOI":"10.1038\/s41598-023-34155-2","article-title":"The 15-year national trends of endocrine cancers incidence among Iranian men and women; 2005\u20132020","volume":"13","author":"Balajam","year":"2023","journal-title":"Sci Rep"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.901098","article-title":"Periodontal disease and cancer risk: A nationwide population-based cohort study","volume":"12","author":"Kim","year":"2022","journal-title":"Front Oncol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-5","article-title":"Viruses and thyroiditis: an update","volume":"6","author":"Desailloud","year":"2009","journal-title":"Virol J"},{"key":"B123","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1158\/1055-9965.EPI-15-0750","article-title":"Periodontal disease and breast cancer: prospective cohort study of postmenopausal women","volume":"25","author":"Freudenheim","year":"2016","journal-title":"Cancer Epidemiology Biomarkers Prev"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12318","article-title":"Periodontitis and breast cancer: A case-control study","volume":"45","author":"Sfreddo","year":"2017","journal-title":"Community Dent Oral Epidemiol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8077.2004.00062.x","article-title":"Therapeutic advances in rheumatoid arthritis","volume":"384","author":"Brown","year":"2024","journal-title":"BMJ"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12530","article-title":"Periodontitis and rheumatoid arthritis\u2014Global efforts to untangle two complex diseases","author":"Lopez Oliva","year":"2024","journal-title":"Periodontology 2000"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050630","article-title":"Periodontal health and oral microbiota in patients with rheumatoid arthritis","volume":"8","author":"Eriksson","year":"2019","journal-title":"J Clin Med"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.04.024","article-title":"Rheumatoid arthritis risk in periodontitis patients: a systematic review and meta-analysis","volume":"87","author":"Qiao","year":"2020","journal-title":"Joint Bone Spine"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae358","article-title":"The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial","volume":"64","author":"Silva","year":"2025","journal-title":"Rheumatology"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060194","article-title":"The combined genotypes of stimulatory and inhibitory Fc\u03b3 receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults","volume":"78","author":"Kobayashi","year":"2007","journal-title":"J Periodontology"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2473-2","article-title":"Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy","volume":"33","author":"Fabbri","year":"2014","journal-title":"Clin Rheumatol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40168-017-0252-z","article-title":"Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status","volume":"5","author":"Corr\u00eaa","year":"2017","journal-title":"Microbiome"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.19439\/j.sjos.2018.01.010","article-title":"Detection and significance of IL-6 and TNF-\u03b1 in patients with Graves\u2019 disease and concurrent periodontitis","volume":"27","author":"Wang","year":"2018","journal-title":"Shanghai J Stomatology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1034\/j.1600-051x.2000.027005366.x","article-title":"Cytokine levels in plasma and gingival crevicular fluid in chronic periodontitis","volume":"28","author":"Chen","year":"2015","journal-title":"Am J Dentistry"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb03906.x","article-title":"Graves\u2019 disease following hypothyroidism due to Hashimoto\u2019s disease: studies of eight cases","volume":"33","author":"Takasu","year":"1990","journal-title":"Clin Endocrinol"},{"key":"B136","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/ggi.12425","article-title":"Alzheimer\u2019s disease and chronic periodontitis: is there an association","volume":"15","author":"Gaur","year":"2015","journal-title":"Geriatrics Gerontology Int"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12065","article-title":"Does Helicobacter pylori infection increase incidence of dementia? The Personnes Ag\u00e9es QUID Study","volume":"61","author":"Roubaud Baudron","year":"2013","journal-title":"J Am Geriatrics Soc"},{"key":"B138","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jalz.2011.04.006","article-title":"Serum antibodies to periodontal pathogens are a risk factor for Alzheimer\u2019s disease","volume":"8","author":"Stein","year":"2012","journal-title":"Alzheimer\u2019s Dementia"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15828","article-title":"Association of chronic periodontitis on Alzheimer\u2019s disease or vascular dementia","volume":"67","author":"Choi","year":"2019","journal-title":"J Am Geriatrics Soc"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202459","article-title":"Oral dysbiosis and inflammation in Parkinson\u2019s disease","volume":"11","author":"Fleury","year":"2021","journal-title":"J Parkinson\u2019s Dis"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3647","article-title":"Periodontal inflammatory disease is associated with the risk of Parkinson\u2019s diseasea population-based retrospective matched-cohort study","volume":"5","author":"Chen","year":"2017","journal-title":"Peerl"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2023.105712","article-title":"Parkinson\u2019s disease and oral health: A systematic review","volume":"151","author":"Verhoeff","year":"2023","journal-title":"Arch Oral Biol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4760512","article-title":"Association of tooth loss with new\u2010onset Parkinson\u2019s disease: A nationwide population\u2010based cohort study","volume":"2020","author":"Woo","year":"2020","journal-title":"Parkinson\u2019s Dis"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-clinpsy-050817084811","article-title":"Risk factors for depression: an autobiographical review","volume":"14","author":"Hammen","year":"2018","journal-title":"Annu Rev Clin Psychol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080334","article-title":"Stress, depression, cortisol, and periodontal disease","volume":"80","author":"Rosania","year":"2009","journal-title":"J Periodontology"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12036","article-title":"Role of chronic stress and depression in periodontal diseases","volume":"64","author":"Warren","year":"2014","journal-title":"Periodontology 2000"},{"key":"B147","article-title":"Investigation and analysis of depression occurrence in patients with chronic periodontitis","volume":"20","author":"Tang","year":"2011","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002347","article-title":"Association of periodontitis and subsequent depression: a nationwide population-based study","volume":"94","author":"Hsu","year":"2015","journal-title":"Medicine"},{"key":"B149","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12916-024-03309-y","article-title":"Autoimmune diseases and adverse pregnancy outcomes: an umbrella review","volume":"22","author":"Singh","year":"2024","journal-title":"BMC Med"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12167","article-title":"Oral health promotion interventions during pregnancy: a systematic review","volume":"43","author":"Vamos","year":"2015","journal-title":"Community Dentistry Oral Epidemiol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02624","article-title":"Systemic inflammation in pregnant women with periodontitis and preterm prelabor rupture of membranes: a prospective case-control study","volume":"10","author":"Mohr","year":"2019","journal-title":"Front Immunol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwad142","article-title":"Preconception periodontitis and risk of spontaneous abortion in a prospective cohort study","volume":"192","author":"Bond","year":"2023","journal-title":"Am J Epidemiol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0266","article-title":"Maternal periodontal status, oral inflammatory load, and systemic inflammation are associated with low infant birth weight","volume":"92","author":"Mahapatra","year":"2021","journal-title":"J Periodontology"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0090","article-title":"Choosing the left fork: Steven Offenbacher and understanding maternal periodontal disease and adverse pregnancy outcomes","volume":"91","author":"Boggess","year":"2020","journal-title":"J Periodontology"},{"key":"B155","doi-asserted-by":"publisher","first-page":"14606","DOI":"10.1038\/s41598-020-71762-9","article-title":"Fetal growth restriction is a host specific response to infection with an impaired spiral artery remodeling-inducing strain of Porphyromonas gingivalis","volume":"10","author":"Tavarna","year":"2020","journal-title":"Sci Rep"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13578","article-title":"Development of gestational diabetes mellitus in women with periodontitis in early pregnancy: A population\u2010based clinical study","volume":"49","author":"Liu","year":"2022","journal-title":"J Clin Periodontology"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00375.2015","article-title":"Systemic and renal lipids in kidney disease development and progression","volume":"310","author":"Wahl","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.009","article-title":"Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study","volume":"45","author":"Kshirsagar","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.08.024","article-title":"Periodontal pocket depth, hyperglycemia, and progression of chronic kidney disease: a population-based longitudinal study","volume":"130","author":"Chang","year":"2017","journal-title":"Am J Med"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv312","article-title":"The association of periodontal disease with kidney function declinea longitudinal retrospective analysis of the MrOS dental study","volume":"31","author":"Grubbs","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1086\/652861","article-title":"Treatment of bacterial prostatitis","volume":"50","author":"Lipsky","year":"2010","journal-title":"Clin Infect Dis"},{"key":"B162","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40779-019-0223-8","article-title":"Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study","volume":"6","author":"Wu","year":"2019","journal-title":"Mil Med Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.3390\/coatings12020265","article-title":"A cross-sectional study for association between periodontitis and benign prostatic hyperplasia using the Korean genome and epidemiology study data","volume":"12","author":"Byun","year":"2022","journal-title":"Coatings"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2016.07.002","article-title":"Diagnostic and therapeutic strategies for prostate cancer","volume":"46","author":"Nguyen Nielsen","year":"2016","journal-title":"Semin NucdI Med"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1812-8","article-title":"Evaluation of cancer risk in patients with periodontal diseases","volume":"49","author":"G\u00fcven","year":"2019","journal-title":"Turk J Med Sci"},{"key":"B166","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.7150\/jca.20532","article-title":"Association between periodontal disease and prostate cancer: results of a 12-year longitudinal cohort study in South Korea","volume":"8","author":"Lee","year":"2017","journal-title":"J Cancer"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276375","article-title":"Prevalence of cancer in relation to signs of periodontal inflammation","volume":"17","author":"Meurman","year":"2022","journal-title":"PloS One"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(97)80489-2","article-title":"The epidemiology and pathogenesis of osteoporosis","volume":"11","author":"Center","year":"1997","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12309","article-title":"The association between periodontal disease, tooth loss and bone mineral density in a Korean population","volume":"41","author":"Tak","year":"2014","journal-title":"J Clin Periodontology"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100190","article-title":"Association between periodontal disease and osteoporosis in postmenopausal women in Jordan","volume":"81","author":"Al Habashneh","year":"2010","journal-title":"J Periodontology"},{"key":"B171","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/JPER.20-0029","article-title":"Association between low bone mineral density and periodontitis in generally healthy perimenopausal women","volume":"92","author":"Gil-Montoya","year":"2021","journal-title":"J Periodontology"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002348","article-title":"The impact of oral hygiene maintenance on the association between periodontitis and osteoporosis: a nationwide population-based cross sectional study","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine"},{"key":"B173","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12905-017-0440-9","article-title":"Effect of periodontitis on the development of osteoporosis: results from a nationwide population-based cohort study (2003-2013)","volume":"17","author":"Choi","year":"2017","journal-title":"BMC Womens Health"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300705","article-title":"Streptococcus mutans strains harboring collagen-binding adhesin","volume":"83","author":"Sato","year":"2004","journal-title":"J Dent Res"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12016","article-title":"Potential involvement of collagen-binding proteins of S treptococcus mutans in infective endocarditis","volume":"19","author":"Naka","year":"2013","journal-title":"Oral Dis"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.06.008","article-title":"Potential high virulence for infective endocarditis in Streptococcus mutans strains with collagen-binding proteins but lacking PA expression","volume":"58","author":"Nomura","year":"2013","journal-title":"Arch Oral Biol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-1072-0","article-title":"Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients","volume":"19","author":"Misaki","year":"2015","journal-title":"Clin Exp Nephrol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1038\/srep36455","article-title":"Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions","volume":"6","author":"Misaki","year":"2016","journal-title":"Sci Rep"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1159\/000487103","article-title":"Campylobacter rectus in the oral cavity correlates with proteinuria in immunoglobulin A nephropathy patients","volume":"139","author":"Misaki","year":"2018","journal-title":"Nephron"},{"key":"B180","doi-asserted-by":"publisher","first-page":"20130","DOI":"10.1038\/s41598-019-56679-2","article-title":"Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy","volume":"9","author":"Ito","year":"2019","journal-title":"Sci Rep"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-020-01961-1","article-title":"Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions","volume":"24","author":"Naka","year":"2020","journal-title":"Clin Exp Nephrol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1038\/s41598-021-85196-4","article-title":"Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries","volume":"11","author":"Naka","year":"2021","journal-title":"Sci Rep"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104444","article-title":"F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production","volume":"88","author":"Sun","year":"2023","journal-title":"eBioMedicine"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00862","article-title":"Oral microbiota community dynamics associated with oral squamous cell carcinoma staging","volume":"9","author":"Yang","year":"2018","journal-title":"Front Microbiol"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2001.00966.x","article-title":"Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York","volume":"109","author":"Mitchell Lewis","year":"2001","journal-title":"Eur J Oral Sci"},{"key":"B186","first-page":"89","article-title":"Maternal chronic infection as a risk factor in preterm low birth weight infants: the link with periodontal infection","volume":"6","author":"S\u00e1nchez","year":"2004","journal-title":"J Int Acad Periodontology"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060047","article-title":"Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study","volume":"77","author":"Offenbacher","year":"2006","journal-title":"J Periodontology"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060368","article-title":"Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor","volume":"78","author":"Silva","year":"2007","journal-title":"J Periodontology"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328338cd36","article-title":"Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)","volume":"28","author":"Desvarieux","year":"2010","journal-title":"J Hypertens"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14536","article-title":"Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction","volume":"176","author":"Czesnikiewicz Guzik","year":"2019","journal-title":"Br J Pharmacol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.gpp3-0042-2018","article-title":"Biology of oral streptococci","volume":"6","author":"Abranches","year":"2018","journal-title":"Microbiol Spectr"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0046","article-title":"Definition of hypertension-associated oral pathogens in NHANES","volume":"90","author":"Pietropaoli","year":"2019","journal-title":"J Periodontology"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.70001","article-title":"Oral microbiota linking humoral response, periodontitis and atherosclerosis","volume":"52","author":"Akhi","year":"2025","journal-title":"J Clin Periodontology"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33316","article-title":"Oral infectious bacteria in dental plaque and saliva as risk factors in patients with esophageal cancer","volume":"127","author":"Kawasaki","year":"2021","journal-title":"Cancer"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/370314","article-title":"Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study","volume":"2015","author":"Ismail","year":"2015","journal-title":"BioMed Res Int"},{"key":"B196","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1601-0825.2006.01267.x","article-title":"Periodontal and oral microbiological status of an adult population undergoing haemodialysis: a cross-sectional study","volume":"13","author":"Castillo","year":"2007","journal-title":"Oral Dis"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuae012","article-title":"Ectopic colonization by oral bacteria as an emerging theme in health and disease","volume":"48","author":"Hern\u00e1ndez Cabanyero","year":"2024","journal-title":"FEMS Microbiol Rev"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098271","article-title":"Dissemination of periodontal pathogens in the bloodstream after periodontal procedures: a systematic review","volume":"9","author":"Horliana","year":"2014","journal-title":"PloS One"},{"key":"B199","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41419-018-0389-0","article-title":"Indoleamine 2, 3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages","volume":"9","author":"Xue","year":"2018","journal-title":"Cell Death Dis"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2608","article-title":"Control of pathogens and pathobionts by the gut microbiota","volume":"14","author":"Kamada","year":"2013","journal-title":"Nat Immunol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"20150504","DOI":"10.1098\/rstb.2015.0504","article-title":"When pathogenic bacteria meet the intestinal microbiota","volume":"371","author":"Rolhion","year":"2016","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41385-018-0053-0","article-title":"Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them","volume":"12","author":"Sorbara","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051604","article-title":"Association between selected oral pathogens and gastric precancerous lesions","volume":"8","author":"Salazar","year":"2013","journal-title":"PloS One"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2073785","article-title":"Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils","volume":"14","author":"Tan","year":"2022","journal-title":"Gut Microbes"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314219","article-title":"Tumour-associated and non-tumour-associated microbiota in colorectal cancer","volume":"66","author":"Flemer","year":"2017","journal-title":"Gut"},{"key":"B206","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13073-016-0290-3","article-title":"Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions","volume":"8","author":"Baxter","year":"2016","journal-title":"Genome Med"},{"key":"B207","doi-asserted-by":"publisher","first-page":"766","DOI":"10.15252\/msb.20145645","article-title":"Potential of fecal microbiota for early\u2010stage detection of colorectal cancer","volume":"10","author":"Zeller","year":"2014","journal-title":"Mol Syst Biol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-16","article-title":"Co-occurrence of anaerobic bacteria in colorectal carcinomas","volume":"1","author":"Warren","year":"2013","journal-title":"Microbiome"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B211","doi-asserted-by":"publisher","first-page":"8727","DOI":"10.1038\/ncomms9727","article-title":"Gut mucosal microbiome across stages of colorectal carcinogenesis","volume":"6","author":"Nakatsu","year":"2015","journal-title":"Nat Commun"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1599","article-title":"Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer","volume":"23","author":"Liang","year":"2017","journal-title":"Clin Cancer Res"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.048","article-title":"The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis","volume":"182","author":"Kitamoto","year":"2020","journal-title":"Cell"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/srep04828","article-title":"Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota","volume":"4","author":"Arimatsu","year":"2014","journal-title":"Sci Rep"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2501","article-title":"Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response","volume":"179","author":"Liu","year":"2007","journal-title":"J Immunol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00400","article-title":"Colon cancer-associated Fusobacterium nucleatum may originate from the oral cavity and reach colon tumors via the circulatory system","volume":"10","author":"Abed","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1128\/aac.43.6.1379","article-title":"Emergence of antibiotic-resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents","volume":"43","author":"Carmeli","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2014.06.005","article-title":"Oral health disparities in older adults: oral bacteria, inflammation, and aspiration pneumonia","volume":"58","author":"Scannapieco","year":"2014","journal-title":"Dental Clinics"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13228","article-title":"Periodontitis and respiratory diseases: A systematic review with meta-analysis","volume":"26","author":"Gomes-Filho","year":"2020","journal-title":"Oral Dis"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008367.pub4","article-title":"Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia","volume":"12","author":"Zhang","year":"2020","journal-title":"Cochrane Database Systematic Rev"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519833630","article-title":"Periodontitis is associated with chronic obstructive pulmonary disease","volume":"98","author":"Takeuchi","year":"2019","journal-title":"J Dent Res"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)31374-X","article-title":"Colonization of dental plaques: a reservoir of respiratory pathogens for hospital-acquired pneumonia in institutionalized elders","volume":"126","author":"El-Solh","year":"2004","journal-title":"Chest"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap9298","article-title":"Intestinal inflammation induced by oral bacteria","volume":"358","author":"Cao","year":"2017","journal-title":"Science"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.120","article-title":"Reducing the risk of CVD in patients with periodontitis","volume":"7","author":"Genco","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000167525.69400.9c","article-title":"Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs","volume":"25","author":"Brodala","year":"2005","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"B226","doi-asserted-by":"publisher","first-page":"237ra65","DOI":"10.1126\/scitranslmed.3008599","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci Transl Med"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513487559","article-title":"Mobile microbiome: oral bacteria in extra-oral infections and inflammation","volume":"92","author":"Han","year":"2013","journal-title":"J Dent Res"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12083","article-title":"Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"84","author":"Sanz","year":"2013","journal-title":"J Periodontology"},{"key":"B229","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/jog.13782","article-title":"Periodontal diseases and adverse pregnancy outcomes","volume":"45","author":"Komine-Aizawa","year":"2019","journal-title":"J Obstetrics Gynaecology Res"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140248","article-title":"Effect of intensive oral hygiene regimen during pregnancy on periodontal health, cytokine levels, and pregnancy outcomes: a pilot study","volume":"85","author":"Kaur","year":"2014","journal-title":"J Periodontology"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060201","article-title":"Persistently high levels of periodontal pathogens associated with preterm pregnancy outcome","volume":"78","author":"Lin","year":"2007","journal-title":"J Periodontology"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181cb9955","article-title":"Term stillbirth caused by oral Fusobacterium nucleatum","volume":"115","author":"Han","year":"2010","journal-title":"Obstetrics Gynecology"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.013","article-title":"Fusobacterium nucleatum: a commensal-turned pathogen","volume":"23","author":"Han","year":"2015","journal-title":"Curr Opin Microbiol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.550977","article-title":"The origin of Fusobacterium nucleatum involved in intra-amniotic infection and preterm birth","volume":"24","author":"Gauthier","year":"2011","journal-title":"J Maternal-Fetal Neonatal Med"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509338032","article-title":"Localization of P. gingivalis in preterm delivery placenta","volume":"88","author":"Katz","year":"2009","journal-title":"J Dent Res"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2017.1374153","article-title":"Porphyromonas gingivalis and adverse pregnancy outcome","volume":"9","author":"Reyes","year":"2017","journal-title":"J Oral Microbiol"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.674835","article-title":"Porphyromonas somerae invasion of endometrial cancer cells","volume":"12","author":"Crooks","year":"2021","journal-title":"Front Microbiol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/odi.12177","article-title":"The effect of Porphyromonas gingivalis lipopolysaccharide on pregnancy in the rat","volume":"20","author":"Kunnen","year":"2014","journal-title":"Oral Dis"},{"key":"B239","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41598-020-79496-4","article-title":"Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey","volume":"11","author":"Escalda","year":"2021","journal-title":"Sci Rep"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12424","article-title":"Periodontal connection with intestinal inflammation: Microbiological and immunological mechanisms","volume":"89","author":"Kitamoto","year":"2022","journal-title":"Periodontology 2000"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121918","article-title":"Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer\u2019s disease brain tissue","volume":"36","author":"Poole","year":"2013","journal-title":"J Alzheimer\u2019s Dis"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00108.x","article-title":"Spirochetes at the forefront of periodontal infections","volume":"38","author":"Ellen","year":"2005","journal-title":"Periodontology 2000"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2015.09.008","article-title":"Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues","volume":"106","author":"Roulis","year":"2015","journal-title":"Genomics"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-121","article-title":"Immunohistological detection of Chlamydia pneumoniae in the Alzheimer\u2019s disease brain","volume":"11","author":"Hammond","year":"2010","journal-title":"BMC Neurosci"},{"key":"B245","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3233\/978-1-61499-706-1-119","article-title":"Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-\/-mice brains","volume":"43","author":"Poole","year":"2014","journal-title":"J Alzheimer\u2019s Dis"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160477","article-title":"Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases","volume":"88","author":"Estemalik","year":"2017","journal-title":"J Periodontology"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17742","article-title":"Presence ofspecilic periodontal pathogens in prostate gland diagnosed withchronic inflammation and adenocarcinoma","volume":"13","author":"Alluri","year":"2021","journal-title":"Cureus"},{"key":"B248","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B249","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1902\/annals.1998.3.1.51","article-title":"Periodontal disease and diabetes mellitus: a two\u2010way relationship","volume":"3","author":"Grossi","year":"1998","journal-title":"Ann Periodontology"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x","article-title":"A systematic review and meta\u2010analyses on C\u2010reactive protein in relation to periodontitis","volume":"35","author":"Paraskevas","year":"2008","journal-title":"J Clin Periodontology"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-013-0122-5","article-title":"Effect of topical application of melatonin to the gingiva on salivary osteoprotegerin, RANKL and melatonin levels in patients with diabetes and periodontal disease","volume":"102","author":"Cutando","year":"2014","journal-title":"Odontology"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12634","article-title":"Does obesity influence the subgingival microbiota composition in periodontal health and disease","volume":"43","author":"Maciel","year":"2016","journal-title":"J Clin Periodontology"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12634","article-title":"Association between overweight\/obesity and periodontitis in adults. A systematic review","volume":"12","author":"Suvan","year":"2011","journal-title":"Obes Rev"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12773","article-title":"Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross\u2010sectional study","volume":"44","author":"Martinez\u2010Herrera","year":"2017","journal-title":"J Clin Periodontology"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075","article-title":"A proposed model linking inflammation to obesity, diabetes, and periodontal infections","volume":"76","author":"Genco","year":"2005","journal-title":"J Periodontology"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375830","article-title":"Oxidative stress, systemic inflammation, and severe periodontitis","volume":"89","author":"Daiuto","year":"2010","journal-title":"J Dent Res"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509337479","article-title":"Metabolic syndrome and periodontitis: is oxidative stress a common link","volume":"88","author":"Bullon","year":"2009","journal-title":"J Dent Res"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2022.104065","article-title":"Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndrome","volume":"118","author":"Nibali","year":"2022","journal-title":"J Dentistry"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070140","article-title":"Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta\u2010analysis","volume":"78","author":"Mustapha","year":"2007","journal-title":"J Periodontology"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12335","article-title":"Cardiovascular risks associated with incident and prevalent periodontal disease","volume":"42","author":"Yu","year":"2015","journal-title":"J Clin Periodontology"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i1.26","article-title":"Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions","volume":"7","author":"Saffi","year":"2015","journal-title":"World J Cardiol"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J Periodontology"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2017.10.005","article-title":"Micro-inflammation and digestive bacterial translocation in chronic kidney disease","volume":"14","author":"Olivier","year":"2018","journal-title":"N\u00e9phrologie Th\u00e9rapeutique"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12067","article-title":"Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate","volume":"40","author":"Chambrone","year":"2013","journal-title":"J Clin Periodontology"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13114","article-title":"Periodontitis as the risk factor of chronic kidney disease: Mediation analysis","volume":"46","author":"Lertpimonchai","year":"2019","journal-title":"J Clin Periodontology"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Biopsychosocial Sci Med"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-014-8320-z","article-title":"Phosphoinositide 3-kinase \u03b3 affects LPS-induced disturbance of blood\u2013brain barrier via lipid kinase-independent control of cAMP in microglial cells","volume":"16","author":"Frister","year":"2014","journal-title":"NeuroMol Med"},{"key":"B268","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1186\/s12903-024-05335-x","article-title":"Correlation between systemic immune-inflammatory index and graded diagnosis of periodontitis: a combined cross-sectional and retrospective study","volume":"24","author":"Hu","year":"2024","journal-title":"BMC Oral Health"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-15","article-title":"Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia","volume":"5","author":"Henry","year":"2008","journal-title":"J Neuroinflamm"},{"key":"B270","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12903-023-02908-0","article-title":"Periodontal and peri-implant status and whole salivary interleukin 1-beta levels among individuals using selective serotonin reuptake inhibitors: an observational study","volume":"23","author":"ALHarthi","year":"2023","journal-title":"BMC Oral Health"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.04.029","article-title":"Placental colonization with periodontal pathogens: the potential missing link","volume":"221","author":"Fischer","year":"2019","journal-title":"Am J Obstetrics Gynecology"},{"key":"B272","doi-asserted-by":"publisher","first-page":"16870","DOI":"10.1038\/s41598-021-96495-1","article-title":"Oral microflora and pregnancy: a systematic review and meta-analysis","volume":"11","author":"Jang","year":"2021","journal-title":"Sci Rep"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.873683","article-title":"Subgingival microbiome in pregnancy and a potential relationship to early term birth","volume":"12","author":"Yang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B274","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/prd.12153","article-title":"The periodontal pocket: pathogenesis, histopathology and consequences","volume":"76","author":"Bosshardt","year":"2018","journal-title":"Periodontology 2000"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2205291","article-title":"Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers","volume":"15","author":"de Jongh","year":"2023","journal-title":"J Oral Microbiol"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092358","article-title":"The role of Fusobacterium nucleatum in oral and colorectal carcinogenesis","volume":"11","author":"Pignatelli","year":"2023","journal-title":"Microorganisms"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00270-7","article-title":"Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche","volume":"8","author":"Lithgow","year":"2022","journal-title":"NPJ Biofilms Microbiomes"},{"key":"B278","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.anaerobe.2018.01.008","article-title":"Fusobacterium nucleatum and adverse pregnancy outcomes: epidemiological and mechanistic evidence","volume":"50","author":"Vander Haar","year":"2018","journal-title":"Anaerobe"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.591626","article-title":"Porphyromonas gingivalis placental atopobiosis and inflammatory responses in women with adverse pregnancy outcomes","volume":"11","author":"G\u00f3mez","year":"2020","journal-title":"Front Microbiol"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18137194","article-title":"Periodontal conditions and pathogens associated with pre-eclampsia: a scoping review","volume":"18","author":"Gare","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i16.2745","article-title":"Relationship between ultrasound parameters of the umbilical and middle cerebral arteries and intrauterine fetal distress","volume":"12","author":"Chen","year":"2024","journal-title":"World Journal of Clinical Cases"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170193","article-title":"Porphyromonas gingivalis suppresses trophoblast invasion by soluble factors","volume":"88","author":"Hirohata","year":"2017","journal-title":"J Periodontology"},{"key":"B283","doi-asserted-by":"publisher","first-page":"14799","DOI":"10.1038\/s41598-022-19239-9","article-title":"Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1","volume":"12","author":"Tavarna","year":"2022","journal-title":"Sci Rep"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020733","article-title":"Melatonin alleviates lipopolysaccharide-induced abnormal pregnancy through MTNR1B regulation of m6A","volume":"25","author":"Zhao","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01007-9","article-title":"Cervicovaginal cytokines to predict the onset of normal and preterm labor: a pseudo-longitudinal study","volume":"30","author":"Sandoval-Colin","year":"2023","journal-title":"Reprod Sci"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00558","article-title":"TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation","volume":"11","author":"Presicce","year":"2020","journal-title":"Front Immunol"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118237","article-title":"Upregulation of TNF-\u03b1 and IL-6 induces preterm premature rupture of membranes by activation of ADAMTS-9 in embryonic membrane cells","volume":"260","author":"Li","year":"2020","journal-title":"Life Sci"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.19538\/j.fk2022020102","article-title":"Emphasis on the etiology and pathogenesis of preterm birth syndrome","volume":"38","author":"Qi","year":"2022","journal-title":"Chin J Pract Gynecology Obstetrics"},{"key":"B289","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/j.1600-051X.2011.01764.x","article-title":"Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis","volume":"38","author":"Allen","year":"2011","journal-title":"J Clin Periodontology"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.118342","article-title":"4-Hydroxy-2-nonenal, an oxidative stress marker in crevicular fluid and serum in type 2 diabetes with chronic periodontitis","volume":"4","author":"Pradeep","year":"2013","journal-title":"Contemp Clin Dentistry"},{"key":"B291","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1902\/jop.2017.170129","article-title":"Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: A cross\u2010sectional study","volume":"89","author":"Saglam","year":"2018","journal-title":"J Periodontology"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04144-8","article-title":"Effect of periodontal disease on oxidative stress markers in patients with atherosclerosis","volume":"26","author":"Sari","year":"2022","journal-title":"Clin Oral Investigations"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021024","article-title":"Mitochondrial dysfunction in periodontitis and associated systemic diseases: lmplications for pathomechanisms and therapeutic strategies","volume":"25","author":"Deng","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B294","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/jre.12941","article-title":"Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis","volume":"57","author":"Liu","year":"2022","journal-title":"J Periodontal Res"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.036913","article-title":"The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction","volume":"65","author":"Marotte","year":"2006","journal-title":"Ann Rheumatic Dis"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.139","article-title":"Periodontitis in RA\u2014the citrullinated enolase connection","volume":"6","author":"Lundberg","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510381903","article-title":"Involvement of autoimmunity in the pathogenesis of aggressive periodontitis","volume":"89","author":"Hendler","year":"2010","journal-title":"J Dent Res"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1002\/art.34539","article-title":"Periodontal disease and the oral microbiota in new\u2010onset rheumatoid arthritis","volume":"64","author":"Scher","year":"2012","journal-title":"Arthritis Rheumatism"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0295","article-title":"Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis","volume":"92","author":"Manoil","year":"2021","journal-title":"J Periodontology"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14103","article-title":"Oxidative stress in human gingival fibroblasts from periodontitis versus healthy counterparts","volume":"29","author":"Liu","year":"2023","journal-title":"Oral Dis"},{"key":"B301","doi-asserted-by":"publisher","first-page":"898","DOI":"10.13701\/j.cnki.kqyxyj.2017.08.024","article-title":"Comparison of salivary 8-OHdG levels among patients with different types of periodontitis","volume":"33","author":"Zhang","year":"2017","journal-title":"J Oral Sci Res"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080464","article-title":"Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study","volume":"80","author":"Ebersole","year":"2009","journal-title":"J Periodontology"},{"key":"B303","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1177\/0022034518818445","article-title":"Salivary IgA to MAA-LDL and oral pathogens are linked to coronary disease","volume":"98","author":"Akhi","year":"2019","journal-title":"J Dent Res"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13729","article-title":"Tobacco smoke exacerbates Filifactor alocis pathogenicity","volume":"50","author":"Iskander","year":"2023","journal-title":"J Clin Periodontology"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2020.04.002","article-title":"The implication of the PD-1\/PD-L1 checkpoint in chronic periodontitis suggests novel therapeutic opportunities with natural products","volume":"56","author":"Bailly","year":"2020","journal-title":"Japanese Dental Sci Rev"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231158269","article-title":"Ligature-induced periodontitis drives colorectal cancer: an experimental model in mice","volume":"102","author":"Shi","year":"2023","journal-title":"J Dent Res"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.1377","article-title":"Fusobacterium nucleatum and T cells in colorectal carcinoma","volume":"1","author":"Mima","year":"2015","journal-title":"JAMA Oncol"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.05.012","article-title":"Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis","volume":"15","author":"Maekawa","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.952040","article-title":"Macrophages: a communication network linking Porphyromonas gingivalis infection and associated systemic diseases","volume":"13","author":"Lin","year":"2022","journal-title":"Front Immunol"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb02488.x","article-title":"Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers","volume":"95","author":"Narikiyo","year":"2004","journal-title":"Cancer Sci"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1980347","article-title":"Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322\/CCL20 axis and M2 polarization","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2017.170410","article-title":"Porphyromonas gingivalis infection accelerates atherosclerosis mediated by oxidative stress and inflammatory responses in ApoE-\/- mice","volume":"63","author":"Xuan","year":"2017","journal-title":"Clin Lab"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.09.118","article-title":"High glucose induces inflammatory cytokine through protein kinase C-induced toll-like receptor 2 pathway in gingival fibroblasts","volume":"427","author":"Jiang","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100643","article-title":"Cytokines and bone\u2010related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and chronic periodontitis","volume":"82","author":"Vieira Ribeiro","year":"2011","journal-title":"J Periodontology"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100125","article-title":"Receptor activator of nuclear factor\u2010kappa B ligand\/osteoprotegerin ratio in sites of chronic periodontitis of subjects with poorly and well\u2010controlled type 2 diabetes","volume":"81","author":"Santos","year":"2010","journal-title":"J Periodontology"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100754","article-title":"Matrix metalloproteinase\u20101 of gingival fibroblasts influenced by advanced glycation end products (AGEs) and their association with receptor for AGEs and nuclear factor\u2010\u03baB in gingival connective tissue","volume":"83","author":"Yu","year":"2012","journal-title":"J Periodontology"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.10.021","article-title":"RAGE in tissue homeostasis, repair and regeneration","volume":"1833","author":"Sorci","year":"2013","journal-title":"Biochim Biophys Acta (BBA)-Molecular Cell Res"},{"key":"B318","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1128\/iai.72.7.3743-3751.2004","article-title":"Activation of the phosphatidylinositol 3-kinase\/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis","volume":"72","author":"Yilmaz","year":"2004","journal-title":"Infect Immun"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00082-11","article-title":"Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells","volume":"79","author":"Moffatt","year":"2011","journal-title":"Infect Immun"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00032","article-title":"Porphyromonas gingivalis infection promoted the proliferation of oral squamous cell carcinoma cells through the miR-21\/PDCD4\/AP-1 negative signaling pathway","volume":"5","author":"Chang","year":"2019","journal-title":"ACS Infect Dis"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01450.x","article-title":"Cyclosporine\u2010A inhibits MMP\u20102 and\u20109 activities in the presence of Porphyromonas gingivalis lipopolysaccharide: an experiment in human gingival fibroblast and U937 macrophage co\u2010culture","volume":"47","author":"Kuo","year":"2012","journal-title":"J Periodontal Res"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12211","article-title":"Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of pro MMP 9 and its activation","volume":"16","author":"Inaba","year":"2014","journal-title":"Cell Microbiol"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2019.09.001","article-title":"The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management","volume":"5","author":"Sun","year":"2019","journal-title":"Chronic Dis Trans Med"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"B326","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1158\/2326-6066.CIR-22-0541","article-title":"P. gingivalis infection upregulates PD-L1 expression on dendritic cells, suppresses CD8+ T-cell responses, and aggravates oral cancer","volume":"11","author":"Ren","year":"2023","journal-title":"Cancer Immunol Res"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14413","article-title":"Porphyromonas gingivalis outer membrane vesicles in cerebral ventricles activate microglia in mice","volume":"29","author":"Yoshida","year":"2023","journal-title":"Oral Dis"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.012","article-title":"Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt\/GSK-3\u03b2 signaling pathway","volume":"1832","author":"Ishikawa","year":"2013","journal-title":"Biochim Biophys Acta (BBA)-Molecular Basis Dis"},{"key":"B329","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41368-019-0054-1","article-title":"Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial\u2013mesenchymal transition in mice","volume":"11","author":"Suh","year":"2019","journal-title":"Int J Oral Sci"},{"key":"B330","doi-asserted-by":"crossref","DOI":"10.1002\/2211-5463.12151","article-title":"Porphyromonas gingivalis\u2010derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1\/2\u2010RUNX 2","volume":"6","author":"Yang","year":"2016","journal-title":"FEBS Open Bio"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14193","article-title":"Genetic loci associated with periodontitis: the finngen study based on national health registers","volume":"52","author":"Salminen","year":"2025","journal-title":"J Clin Periodontology"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316649","article-title":"Associations between host genetic variants and subgingival microbiota in patients with the metabolic syndrome","volume":"24","author":"Nibali","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B333","unstructured":"Oral Porphyromonas gingivalis infection induces epigenetic changes that promote persistence of cardiovascular disease risk\n          \n          211 p\n          \n            \n              Lehmann\n              K\n            \n          \n          10.7939\/R3-1YJT-EN58\n          Edmonton (AB)\n          University of Alberta\n          \n          2020"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.043","article-title":"Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-014-4710-6","article-title":"Metabolic memory: mechanisms and implications for diabetic vasculopathies","volume":"57","author":"Zhang","year":"2014","journal-title":"Sci China Life Sci"},{"key":"B336","doi-asserted-by":"publisher","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans\u2013induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci Transl Med"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N Engl J Med"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front Immunol"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511425045","article-title":"MicroRNA modulation in obesity and periodontitis","volume":"91","author":"Perri","year":"2012","journal-title":"J Dent Res"},{"key":"B340","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/jcpe.13040","article-title":"Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects","volume":"46","author":"Naqvi","year":"2019","journal-title":"J Clin Periodontology"},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25041992","article-title":"MicroRNAs: the missing link between hypertension and periodontitis","volume":"25","author":"Rodriguez","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01508.x","article-title":"Significance of periodontal risk assessment in the recurrence of periodontitis and tooth loss","volume":"37","author":"Matuliene","year":"2010","journal-title":"J Clin Periodontology"},{"key":"B343","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/jcpe.13553","article-title":"Recurrence and progression of periodontitis and methods of management in long\u2010term care: a systematic review and meta\u2010analysis","volume":"49","author":"Leow","year":"2022","journal-title":"J Clin Periodontology"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1996.tb02091.x","article-title":"Refractory periodontitis or recurrence of disease","volume":"23","author":"Magnusson","year":"1996","journal-title":"J Clin Periodontology"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00935.x","article-title":"Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti\u2010depressant tianeptine","volume":"33","author":"Breivik","year":"2006","journal-title":"J Clin Periodontology"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0569","article-title":"Protective effects of desipramine on alveolar bone in experimental periodontitis","volume":"91","author":"Brancode Almeida","year":"2020","journal-title":"J Periodontology"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140706","article-title":"Effect of fluoxetine on periodontal status in patients with depression: a cross\u2010sectional observational study","volume":"86","author":"Bhatia","year":"2015","journal-title":"J Periodontology"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104633","article-title":"Inhibition of experimental periodontitis by a monoclonal antibody against porphyromonas gingivalis HA2","volume":"154","author":"An","year":"2021","journal-title":"Microb Pathogen"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14782","article-title":"Microbiome\u2010based therapies for periodontitis and peri\u2010implantitis","volume":"30","author":"Wei","year":"2024","journal-title":"Oral Dis"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1038\/42257","article-title":"Microglial activation by alzheimeramyloid precursor protein and modulation by apolipoproteinE","volume":"388","author":"Barger","year":"1997","journal-title":"Nature"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2021.105058","article-title":"Inhibitory effects of curcumin against cytotoxicity of porphyromonas gingivalis outer membrane vesicles","volume":"124","author":"Izui","year":"2021","journal-title":"Arch Oral Biol"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0603-8","article-title":"Tanshinone I1A attenuates atherosclerosis in apolipoprotein E knockout mice infected with porphyromonas gingivalis","volume":"40","author":"Xuan","year":"2017","journal-title":"Inflammation"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.816047","article-title":"Dual inhibitory activity of petroselinic acid enriched in fennel against porphyromonas gingivalis","volume":"13","author":"Yoshino","year":"2022","journal-title":"Front Microbiol"},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22684","article-title":"Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro","volume":"226","author":"Cantley","year":"2011","journal-title":"J Cell Physiol"},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21410","article-title":"HDAC inhibitor MS\u2010275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis","volume":"72","author":"Zhang","year":"2012","journal-title":"Prostate"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2667-8","article-title":"Left ventricular geometry and periodontitis in patients with the metabolic syndrome","volume":"23","author":"Nibali","year":"2019","journal-title":"Clin Oral Investigations"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806445\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:39:51Z","timestamp":1777437591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806445\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":356,"alternative-id":["10.3389\/fimmu.2026.1806445"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1806445","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"article-number":"1806445"}}