{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:26:08Z","timestamp":1787959568172,"version":"build-2784847793"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) and major depressive disorder (MDD) exhibit significant comorbidity, with shared pathological mechanisms such as inflammation and abnormal lipid metabolism. However, the specific molecular features and functional pathways linking the two diseases remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study integrated public transcriptomic data from five MDD and five RA cohorts. Lipid metabolism-related module genes were screened in MDD cohorts and intersected with RA-upregulated differentially expressed genes to construct a candidate set. LASSO regression and machine learning (XGBoost, Random Forest) were used for feature selection and model construction. Functional exploration included protein-protein interaction network analysis, immune infiltration analysis, and multi-cohort validation. To experimentally test the proposed lipid\u2013immune link and a potential neuron-to-synovium axis, we established an\n                      <jats:italic>in vitro<\/jats:italic>\n                      model. Hippocampal HT-22 neurons were subjected to combined glucocorticoid and saturated fatty acid stimulation to mimic MDD-associated stress\u2013lipotoxicity. The conditioned medium (CM) from these neurons was then applied to human fibroblast-like synoviocytes (FLS). The inflammatory and functional responses of FLS were assessed through qPCR, ELISA, and Western blot.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A nine-gene lipid\u2013immune signature (ANXA3, IL18, CD59, TNFSF13B, BMX, WASF1, SLC8A1, COMMD8, NXT2) was identified. It showed excellent discriminative performance in independent RA cohorts (AUC 0.86\u20131.00) but weaker performance in MDD cohorts (AUC 0.55\u20130.65). TNFSF13B, IL18, and CD59 were consistently identified as core hubs. The signature\u2019s expression correlated significantly with immune cell infiltration in RA. Critically, our\n                      <jats:italic>in vitro<\/jats:italic>\n                      validation demonstrated that CM from lipid-stressed neurons directly activated FLS. This was evidenced by: (i) significant upregulation of CD59 mRNA and protein levels (via qPCR and Western blot); (ii) elevated secretion of key inflammatory mediators IL-6 and MMP3 (via ELISA); and (iii) enhanced migratory capacity of FLS. These data support a putative paracrine communication axis from stressed neurons to synovial cells, suggesting a role for lipid-mediated inflammatory reprogramming.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies a conserved lipid\u2013immune gene signature associated with the risk of MDD-RA comorbidity and provides multi-level validation encompassing bioinformatic prediction, clinical cohort correlation, and direct experimental evidence (qPCR, ELISA, WB). The signature may represent an immune-inflammatory state activated in a subset of MDD individuals that overlaps with RA pathology. Based on the hub genes, a \u201cLipid Metabolism \u2013 Membrane Microenvironment \u2013 Immune Inflammation\u201d axis hypothesis is proposed. The experimentally demonstrated neuron\u2013synovium paracrine axis, characterized by specific molecular changes (CD59, IL-6, MMP3), offers a novel and testable mechanistic conduit for cross-disease pathology, providing new molecular insights and directions for understanding psychiatric\u2013immune comorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1806730","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:03:38Z","timestamp":1779775418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comorbidity risk characteristics of rheumatoid arthritis in the context of depression-associated lipid metabolism"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiaru","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuitian","family":"Xiang","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirui","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhu","family":"Ding","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arong","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Medicine Guangdong Laboratory, Guangdong-Macao In-Depth Cooperation Zone in Hengqin","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: Double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15759","article-title":"Contribution of ceramides metabolism in psychiatric disorders","volume":"164","author":"Bernal-Vega","year":"2023","journal-title":"J Neurochem"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.112","article-title":"Affective disturbance in rheumatoid arthritis: Psychological and disease-related pathways","volume":"12","author":"Sturgeon","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s41927-018-0039-2","article-title":"The extra-articular impacts of rheumatoid arthritis: Moving towards holistic care","volume":"2","author":"Scott","year":"2018","journal-title":"BMC Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-6","article-title":"Depression and anxiety in patients with rheumatoid arthritis: Prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS)","volume":"12","author":"Covic","year":"2012","journal-title":"BMC Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/srep20647","article-title":"Bidirectional associations between rheumatoid arthritis and depression: A nationwide longitudinal study","volume":"6","author":"Lu","year":"2016","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000670","article-title":"Depression as a risk factor for the development of rheumatoid arthritis: A population-based cohort study","volume":"4","author":"Vallerand","year":"2018","journal-title":"RMD Open"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30255-4","article-title":"Rheumatoid arthritis and depression: An inflammatory perspective","volume":"6","author":"Nerurkar","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.3","article-title":"A meta-analysis of blood cytokine network alterations in psychiatric patients: Comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J Affect Disord"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1155\/da\/5564796","article-title":"Association between abnormal plasma lipid metabolism and psychological characteristics in adolescents with major depressive disorder","volume":"2025","author":"Wang","year":"2025","journal-title":"Depression Anxiety"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01948-w","article-title":"Plasma lipidomic profile of depressive symptoms: A longitudinal study in a large sample of community-dwelling American Indians in the strong heart study","volume":"28","author":"Miao","year":"2023","journal-title":"Mol Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105455","article-title":"Screening for depression in the general population through lipid biomarkers","volume":"110","author":"Tkachev","year":"2024","journal-title":"EBioMedicine"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-016-9768-5","article-title":"Plasma lipidomics reveals potential lipid markers of major depressive disorder","volume":"408","author":"Liu","year":"2016","journal-title":"Anal Bioanal Chem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00725-z","article-title":"Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis","volume":"54","author":"Koh","year":"2022","journal-title":"Exp Mol Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1410365","article-title":"Serum and urine lipidomic profiles identify biomarkers diagnostic for seropositive and seronegative rheumatoid arthritis","volume":"15","author":"Li","year":"2024","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1464698","article-title":"Identification of cancer stem cell-related genes through single cells and machine learning for predicting prostate cancer prognosis and immunotherapy","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)80953-8","article-title":"A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion","volume":"19","author":"Li","year":"1997","journal-title":"Neuron"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115994","article-title":"Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF\/TrkB\/PI3K signaling axis","volume":"170","author":"Zeng","year":"2024","journal-title":"Biomed Pharmacother = Biomed Pharmacother"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115846","article-title":"Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms","volume":"217","author":"Gao","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-1","article-title":"Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells","volume":"11","author":"Zhang","year":"2012","journal-title":"Lipids Health Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/s41538-025-00602-9","article-title":"Standardized rice bran supplement ameliorates depressive behaviors via FKBP5 mediated glucocorticoid receptor signaling","volume":"9","author":"Kim","year":"2025","journal-title":"NPJ Sci Food"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222605","article-title":"Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-\u03b1-mediated ERK1\/2 and JAK-STAT1 pathways","volume":"81","author":"Qin","year":"2022","journal-title":"Ann Rheumatic Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58577","article-title":"Hematopoietic AMPK \u03b21 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity","volume":"121","author":"Galic","year":"2011","journal-title":"J Clin Invest"},{"key":"B25","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/cr.2009.73","article-title":"Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells","volume":"19","author":"Wobser","year":"2009","journal-title":"Cell Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00339","article-title":"Cell via cell viability assay changes cellular metabolic characteristics by intervening with glycolysis and pentose phosphate pathway","volume":"37","author":"Fan","year":"2024","journal-title":"Chem Res Toxicol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/ar1462","article-title":"MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin alpha5beta1","volume":"7","author":"Zeisel","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/art.30294","article-title":"RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide","volume":"63","author":"Carrion","year":"2011","journal-title":"Arthritis Rheumatism"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.971745","article-title":"Interleukin-18 in metabolism: From mice physiology to human diseases","volume":"13","author":"Somm","year":"2022","journal-title":"Front Endocrinol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12944-021-01446-4","article-title":"Role of ASM\/Cer\/TXNIP signaling module in the NLRP3 inflammasome activation","volume":"20","author":"Jiang","year":"2021","journal-title":"Lipids Health Dis"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01043.x","article-title":"Sensing damage by the NLRP3 inflammasome","volume":"243","author":"Leemans","year":"2011","journal-title":"Immunol Rev"},{"key":"B33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/03009742.2018.1477989","article-title":"Interleukin-18 is associated with the presence of interstitial lung disease in rheumatoid arthritis: A cross-sectional study","volume":"48","author":"Matsuo","year":"2019","journal-title":"Scand J Rheumatol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s12888-022-04176-8","article-title":"Peripheral interleukin-18 is negatively correlated with abnormal brain activity in patients with depression: A resting-state fMRI study","volume":"22","author":"Du","year":"2022","journal-title":"BMC Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: A tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1038\/s41467-025-61271-6","article-title":"Highly ordered clustering of TNF\u03b1 and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane","volume":"16","author":"Lim","year":"2025","journal-title":"Nat Commun"},{"key":"B37","article-title":"Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis","volume":"35","author":"Bosello","year":"2008","journal-title":"J Rheumatol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15070430","article-title":"Dynamics and molecular interactions of GPI-anchored CD59","volume":"15","author":"Voisin","year":"2023","journal-title":"Toxins"},{"key":"B39","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/s41467-023-36441-z","article-title":"Structural basis for membrane attack complex inhibition by CD59","volume":"14","author":"Couves","year":"2023","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/biom8020028","article-title":"Determination of the membrane environment of CD59 in living cells","volume":"8","author":"F\u00fcl\u00f6p","year":"2018","journal-title":"Biomolecules"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01057","article-title":"Complement in the initiation and evolution of rheumatoid arthritis","volume":"9","author":"Holers","year":"2018","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1186\/s12888-022-04410-3","article-title":"Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma","volume":"22","author":"Luo","year":"2022","journal-title":"BMC Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s41467-024-45954-0","article-title":"Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics","volume":"15","author":"Gerke","year":"2024","journal-title":"Nat Commun"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.716415","article-title":"Annexin A3, a calcium-dependent phospholipid-binding protein: Implication in cancer","volume":"8","author":"Yang","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/imm.13239","article-title":"Annexin A3 in sepsis: Novel perspectives from an exploration of public transcriptome data","volume":"161","author":"Toufiq","year":"2020","journal-title":"Immunology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.04.006","article-title":"Exosome-mediated metastasis: From epithelial-mesenchymal transition to escape from immunosurveillance","volume":"37","author":"Syn","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrm3290","article-title":"PI3K signalling: The path to discovery and understanding","volume":"13","author":"Vanhaesebroeck","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton","volume":"8","author":"Takenawa","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100814-125330","article-title":"Signaling and polarized communication across the T cell immunological synapse","volume":"32","author":"Dustin","year":"2016","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol Rev"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01033.2004","article-title":"Na+\/Ca2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes","volume":"288","author":"Hagihara","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.6.3989","article-title":"COMMD proteins and the control of the NF kappa B pathway","volume":"6","author":"Maine","year":"2007","journal-title":"Cell Cycle (Georgetown Tex)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"B56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O'Neill","year":"2016","journal-title":"J Exp Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adk3506","article-title":"Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis","volume":"16","author":"Bai","year":"2024","journal-title":"Sci Transl Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254753","article-title":"Dyslipidemia in rheumatoid arthritis: the possible mechanisms","volume":"14","author":"Yan","year":"2023","journal-title":"Front Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neubiorev.2021.06.017","article-title":"The lipid paradox in neuroprogressive disorders: Causes and consequences","volume":"128","author":"Morris","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-025-00908-3","article-title":"Lipid metabolism, remodelling and intercellular transfer in the CNS","volume":"26","author":"Vanherle","year":"2025","journal-title":"Nat Rev Neurosci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22635","article-title":"Differential association of psychosocial comorbidities with subclinical atherosclerosis in rheumatoid arthritis","volume":"67","author":"Liu","year":"2015","journal-title":"Arthritis Care Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/hh1901.098735","article-title":"Interleukin-18\/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability","volume":"89","author":"Mallat","year":"2001","journal-title":"Circ Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.191361","article-title":"Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex","volume":"104","author":"Wu","year":"2009","journal-title":"Circ Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.0105-2896.2005.00219.x","article-title":"The role of BAFF in immune function and implications for autoimmunity","volume":"204","author":"Kalled","year":"2005","journal-title":"Immunol Rev"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.suppl_2.ii100","article-title":"Role of interleukin 15 and interleukin 18 in inflammatory response","volume":"61","author":"Liew","year":"2002","journal-title":"Ann Rheumatic Dis"},{"key":"B69","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040564","article-title":"Toxic effects of endocrine disruptor exposure on collagen-induced arthritis","volume":"12","author":"D'Amico","year":"2022","journal-title":"Biomolecules"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.semnephrol.2006.09.013","article-title":"Interleukin-18 and the pathogenesis of inflammatory diseases","volume":"27","author":"Dinarello","year":"2007","journal-title":"Semin Nephrol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806730\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:03:39Z","timestamp":1779775419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806730\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":72,"alternative-id":["10.3389\/fimmu.2026.1806730"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1806730","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"article-number":"1806730"}}