{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:14:41Z","timestamp":1778130881478,"version":"3.51.4"},"reference-count":158,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The gut microbiota has received considerable attention in the field of colorectal cancer (CRC) research in recent years. In this review, we have explored the multifaceted relationship between the gut microbiota and CRC progression and treatment. The composition, distribution, and normal physiological functions of the gut microbiota have been summarized, along with the association between gut dysbiosis and CRC based on the body of evidence from animal experiments and clinical studies. In addition, we have discussed the mechanisms through which specific microbial configurations or microbiota-derived metabolites may contribute to colorectal carcinogenesis, including genotoxic effects, inflammation, and immune dysregulation. The impact of the gut microbiota on the efficacy of chemotherapy, radiotherapy, and immunotherapy, and new treatment strategies based on the gut microbiota, such as probiotic intervention, prebiotic application, and fecal microbiota transplantation have also been explored. Despite some promising outcomes, the specific carcinogenic microorganisms have not been identified, and it is challenging to distinguish association from causation, determine the influence of individual differences, and translate the research to clinical applications. In the future, more rigorous longitudinal studies, gnotobiotic models with defined microbial communities, and mechanistic interventional studies are needed to strengthen causal inference, and provide practical guidance for CRC prevention and treatment. Beyond summarizing reported associations, this review proposes a microbiota-immune-metabolism-therapy axis by integrating tumorigenic mechanisms, immune contexture, and treatment responsiveness into a single translational framework.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1807247","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:47:15Z","timestamp":1778129235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment"],"prefix":"10.3389","volume":"17","author":[{"given":"Haiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Transfusion, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Transfusion, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1560714","article-title":"The Wnt\/\u03b2-catenin signaling pathway in colorectal cancer: mechanism and intervention of traditional Chinese medicine and chemical compound","volume":"16","author":"Zeng","year":"2025","journal-title":"Front Pharmacol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c04690","article-title":"Visualization of mechanical force regulation of exosome secretion using high time-spatial resolution imaging","volume":"97","author":"Ji","year":"2025","journal-title":"Anal Chem"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06796-3","article-title":"Viral infection and glioma: a meta-analysis of prognosis","volume":"20","author":"Cai","year":"2020","journal-title":"BMC Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms241310764","article-title":"Unraveling the roles of miR-204-5p and HMGA2 in papillary thyroid cancer tumorigenesis","volume":"24","author":"Branteghem","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1007\/16833_2024_216","article-title":"Two sides of the same coin: Genes involved in neurodegeneration and cancer","volume-title":"Cancer Immunology and Genetics: An Interdisciplinary Approach","author":"Montanari","year":"2024"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413612","article-title":"Tumorigenesis caused by aberrant expression of GANP, a central component in the mammalian TREX-2 complex-lessons from transcription-coupled DNA damages","volume":"25","author":"Rezano","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03299-8","article-title":"TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42405-0","article-title":"Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer","volume":"15","author":"Lykoskoufis","year":"2024","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.623048","article-title":"TIPE regulates DcR3 expression and function by activating the PI3K\/AKT signaling pathway in CRC","volume":"10","author":"Zhong","year":"2021","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166281","article-title":"Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota","volume":"1868","author":"Pan","year":"2022","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671-6264.2015.06.028","article-title":"Synergy of tumorigenesis between high-Glut1 expression and Kras mutation in pancreatic cancer","volume":"34","author":"Wu","year":"2015","journal-title":"J Southeast Univ(Medical Sci Edition)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.19613\/j.cnki.1671-3141.2019.06.101","article-title":"Study on the value of blood lipids in colorectal cancer","volume":"19","author":"Dong","year":"2019","journal-title":"World Latest Med Inf"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-4992.2016.02.25","article-title":"Study on the relationship between NIBP expression on tumour- infiltrating immune cells in gastric carcinoma and gastric tumorigenesis and progression","volume":"24","author":"Liu","year":"2016","journal-title":"J Modern Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v22.i33.5079","article-title":"Study on the relationship between ING4 and gastric cancer","volume":"26","author":"Li","year":"2015","journal-title":"Hainan Med J"},{"key":"B15","doi-asserted-by":"crossref","DOI":"10.1007\/16833_2024_294","article-title":"Steroids in cancer: Mechanisms, therapies, and challenges in hormone-driven malignancies","volume-title":"Cancer Treatment Modalities: An Interdisciplinary Approach","author":"Li","year":"2024"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26464","article-title":"Stathmin expression in metastatic colorectal cancer","volume":"123","author":"Leiphrakpam","year":"2021","journal-title":"J Surg Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2022.100040","article-title":"Single-cell phenotyping of CD73 expression reveals the diversity of the tumor immune microenvironment and reflects the prognosis of bladder cancer","volume":"103","author":"Izawa","year":"2023","journal-title":"Lab Invest"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01093-z","article-title":"Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors","volume":"14","author":"Wang","year":"2022","journal-title":"Genome Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14002","article-title":"Significance of tumor mutation burden and immune infiltration in thymic epithelial tumors","volume":"12","author":"Wang","year":"2021","journal-title":"Thorac Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13414","article-title":"The significance of microRNA-449a and its potential target HDAC1 in patients with colorectal cancer","volume":"39","author":"Ishikawa","year":"2019","journal-title":"Anticancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28436","article-title":"Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.19613\/j.cnki.1671-3141.2019.99.018","article-title":"The role of ROS-AMPK signaling pathway in tumorigenesis and development","volume":"19","author":"Zhang","year":"2019","journal-title":"World Latest Medicine Information"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115575","article-title":"The role of MALAT-1 gene in digestive system cancer research","volume":"24","author":"Li","year":"2017","journal-title":"Labeled Immunoassays Clin Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.s424245","article-title":"Role of kinetochore scaffold 1 (KNL1) in tumorigenesis and tumor immune microenvironment in pan-cancer: Bioinformatics analyses and validation of expression","volume":"16","author":"Ding","year":"2023","journal-title":"Int J Gen Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.13431\/j.cnki.immunol.j.20150134","article-title":"The role of innate lymphoid cells in tumorigenesis","volume":"31","author":"Yan","year":"2015","journal-title":"Immunol J"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.16571\/j.cnki.1008-8199.2017.09.022","article-title":"The role of IL-17 in tumor angiogenesis and metastasis","volume":"30","author":"Yue","year":"2017","journal-title":"J Med Postgraduates"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-3511.2018.09.001","article-title":"The role of autophagy in cancer biological therapy strategy","volume":"30","author":"Hu","year":"2018","journal-title":"Med J West China"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-545641\/v1","article-title":"Role and mechanism of miR-130a-3p in the chemosensitivity of retinoblastoma cells to vincristine","author":"Lu","year":"2021"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa616","article-title":"RNA sequencing and somatic mutation status of adrenocortical tumors: Novel pathogenetic insights","volume":"105","author":"Guido","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-4992.2015.10.43","article-title":"Research progresses on the relationship between autophagy and apoptosis in tumor","volume":"23","author":"Deng","year":"2015","journal-title":"J Modern Oncol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.13376\/j.cbls\/2015159","article-title":"Research progress on the tumor-inducing activity and mechanism of human microbiome","volume":"27","author":"Wang","year":"2015","journal-title":"Chin Bull Life Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.13376\/j.cbls\/2015021","article-title":"Research progress on the relationship between miR-133 and malignant tumors","volume":"27","author":"Guo","year":"2015","journal-title":"Chin Bull Life Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.26689\/aogr.v2i1.6455","article-title":"Research progress on the relationship between KiSS-1 and MMP-9 and cervical cancer","volume":"26","author":"Chen","year":"2015","journal-title":"Modern Diagnosis Treat"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1515\/ii-2017-0170","article-title":"Research progress on the relationship between high-risk HPV infection and urinary system tumor","volume":"6","author":"Yang","year":"2017","journal-title":"Infect Intl"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.13488\/j.smhx.20160205","article-title":"Research progress on the relationship between BubR1 and cancer","volume":"36","author":"Chen","year":"2016","journal-title":"Chem Life"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009-3419.2020.102.36","article-title":"Research progress on the relationship between blood lipids and lung cancer risk and prognosis","volume":"23","author":"Dong","year":"2020","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.13376\/j.cbls\/2015022","article-title":"Research progress on the relationship between autophagy and tumorigenesis","volume":"27","author":"Yang","year":"2015","journal-title":"Chin Bull Life Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1000-8179.2016.09.083","article-title":"Research progress on STMN1 and gastric cancer","volume":"43","author":"Zhang","year":"2016","journal-title":"Chin J Clin Oncol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.16073\/j.cnki.cjcpt.2015.06.016","article-title":"Research progress of tumor and caveolin-1","volume":"22","author":"Tan","year":"2015","journal-title":"Chin J Cancer Prev Treat"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1361327","article-title":"Research progress of the relationship between ubiquitination enzyme DNA damage specific binding protein 2 and tumor","volume":"30","author":"Ling","year":"2018","journal-title":"Cancer Res Clinic"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-4992.2018.11.035","article-title":"Research progress of the relationship between SIRT1 and NF-\u03baB in non-small cell lung cancer","volume":"26","author":"Niu","year":"2018","journal-title":"J Modern Oncol"},{"key":"B42","article-title":"Research progress of the relationship between integrin \u03b21-FAK-Ras-MAPK signal transduction pathway and tumor","volume":"16","author":"Yang","year":"2019","journal-title":"China Med Herald"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.53388\/fthc202005002","article-title":"Research progress of the relationship between granule head-like 2 gene and tumor in Drosophila melanogaster","volume":"31","author":"Wang","year":"2017","journal-title":"Pract Oncol J"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-5709.2015.10.003","article-title":"Research progress of the relationship between claudins and gastric cancer","volume":"24","author":"Shao","year":"2015","journal-title":"Chin J Gastroenterol Hepatol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1515\/ii-2017-0138","article-title":"Research progress of the relationship between circular RNA and tumorigenesis","volume":"33","author":"Zhang","year":"2018"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47030150","article-title":"Research progress of the relationship between AHR and tumorigenesis","volume":"30","author":"Huang","year":"2017","journal-title":"J Cancer Control Treat"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3724\/sp.j.1008.2015.1233","article-title":"The research progress of relationship between miR-451 and human tumor","author":"Gao","year":"2015","journal-title":"Prog Modern Biomedicine"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095-1264.2016.01.06","article-title":"The research progress of relationship between ECM, MMPs and malignant tumor","volume":"6","author":"Hu","year":"2016","journal-title":"Anti-tumor Pharm"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.08.47","article-title":"Research progress of relationship between CXC chemokine ligand 3 and related diseases","volume":"15","author":"Wang","year":"2019","journal-title":"Chin J Obstetrics Gynecology Pediatrics(Electronic Edition)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.13201\/j.issn.1001-1420.2015.05.026","article-title":"Research progress of relationship between circadian rhythm and prostate cancer","volume":"30","author":"Chen","year":"2015","journal-title":"J Clin Urol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-1492.2018.02.017","article-title":"Research progress of autophagy and relationship of autophagy with tumorigenesis","volume":"34","author":"Du","year":"2018","journal-title":"J Hebei North University (Natural Sci Ed)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.35534\/tppc.0401005","article-title":"Research progress in the relationship between SASH1 and tumors","volume":"31","author":"Bowen","year":"2018","journal-title":"J Cancer Control Treat"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.11904\/j.issn.1002-3070.2018.04.013","article-title":"Research progress in the relationship between neutrophils and malignant tumors","volume":"32","author":"Han","year":"2018","journal-title":"Pract Oncol J"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47030150","article-title":"Research progress in relationship between chronic inflammation and development of esophageal cancer","volume":"4","author":"Wang","year":"2022","journal-title":"Int J Front Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-8883.2016.04.020","article-title":"Research on the relationship between mTOR signaling pathway and mechanism of tumorigenesis","volume":"37","author":"Gao","year":"2016","journal-title":"Foreign Med Sciences (Section Medgeography)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.14188\/j.1671-8852.2017.1003","article-title":"Research advances on the relationship between LGR5 and tumorigenesis","volume":"39","author":"Wei","year":"2018","journal-title":"J Wuhan Univ (Medical Ed)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.13241\/j.cnki.pmb.2016.01.039","article-title":"Research advances of the role of microRNA in tumorigenesis, development and diagnosis","volume":"16","author":"Liu","year":"2016","journal-title":"Prog Modern Biomedicine"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095-1264.2016.04.01","article-title":"Research advances of the relationship between BMI-1 gene and tumorigenesis","volume":"6","author":"Xu","year":"2016","journal-title":"Anti-tumor Pharmacy"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3781\/j.issn.1000-7431.2019.55.025","article-title":"Relationship of heart failure with occurrence and development of tumors","volume":"39","author":"Xia","year":"2019","journal-title":"Tumor"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2023.149907","article-title":"Relationship between tumorigenesis, metastasis, immune evasion, and chemoresistance in osteosarcoma therapy","volume":"14","author":"Lim","year":"2024","journal-title":"J Appl Phram Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04477-1","article-title":"Relationship between obesity-related colorectal tumors and the intestinal microbiome: an animal-based trial","volume":"149","author":"I","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04477-1","article-title":"Relationship between obesity-related colorectal tumors and the intestinal microbiome: an animal-based trial","author":"Iwama","year":"2022"},{"key":"B63","article-title":"Relationship between microsatellite instability, KRAS gene mutations and tumor immune microenvironment of gastric cancer","author":"Fu","year":"2019"},{"key":"B64","first-page":"1645","article-title":"Relationship between iron and the tumorigenesis as well as tumor development","volume":"23","author":"Cheng","year":"2016","journal-title":"Chin J Cancer Prev Treat"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-5709.2018.12.024","article-title":"Relationship between homocysteine and digestive system neoplasms","volume":"27","author":"Chunchun","year":"2018","journal-title":"Chin J Gastroenterol Hepatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095-1264.2015.016","article-title":"The relationship between Fusobacterium nucleatum and the development of colorecal neoplasia","volume":"5","author":"Yan","year":"2015","journal-title":"Anti-tumor Pharm"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671-038X.2019.12.13","article-title":"Relationship between expression of miR-21 and tumorigenesis and progression of colorectal cancer","volume":"27","author":"Z","year":"2019","journal-title":"Chin J Integrated Traditional Western Med Digestion"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/174_2012_706","article-title":"The relationship between claudin-1 and renal cell carcinoma","volume":"38","author":"Xu","year":"2016","journal-title":"J Shandong Med Coll"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2022.23.8.2649","article-title":"The relationship between circulating irisin and oxidative stress in gastric and colorectal cancer patientsphysiological","volume":"23","author":"Temur","year":"2022","journal-title":"Asian Pacific J Cancer Prev"},{"key":"B70","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/ijms25115846","article-title":"The relationship between circadian rhythm and cancer disease","volume":"25","author":"Munteanu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)62129-0","article-title":"The relationship between chemokines, inflammation, and prostate cancer","volume":"42","author":"Lu","year":"2015","journal-title":"Modern Prev Med"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4236\/ijcm.2020.115022","article-title":"The relationship between BRAF V600E mutation and the clinicopathological features of the papillary thyroid carcinoma","volume":"11","author":"Shi","year":"2020","journal-title":"Int J Clin Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671-7562.2018.02.013","article-title":"Relationship between beclin-1, bcl-2 protein and prostate cancer tumorigenesis and development","volume":"46","author":"Tao","year":"2018","journal-title":"Modern Med J"},{"key":"B74","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bioorg.2023.106622","article-title":"Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: Structure, function and design","volume":"138","author":"Peng","year":"2023","journal-title":"Bioorg Chem"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaf057","article-title":"PTTM: dissecting the profile of tumor tissue microbiome to reveal microbiota features and associations with host transcriptome","volume":"26","author":"Yao","year":"2024","journal-title":"Brief Bioinform"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082398","article-title":"Protective effects of influenza vaccine against colorectal cancer in populations with chronic kidney disease: a nationwide population-based cohort study","volume":"15","author":"Chen","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110760","article-title":"Natural killer cells contribute to 'hot' tumor regression in the allergic inflammatory environment","volume":"123","author":"Zhou","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"18","DOI":"10.21037\/tlcr-22-595","article-title":"A narrative review from gut to lungs: non-small cell lung cancer and the gastrointestinal microbiome","volume":"12","author":"Shah","year":"2023","journal-title":"Trans Lung Cancer Res"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v21i3.4","article-title":"MicroRNA-300 inhibits the metastasis of prostate cancer through the regulation of TRIM63","volume":"21","author":"Ma","year":"2022","journal-title":"Trop J Pharm Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5294","article-title":"The metastasis suppressor, NDRG1, inhibits \u201cstemness\u201d of colorectal cancer via down-regulation of nuclear \u03b2-catenin and CD44","volume":"6","author":"Xiongzhi","year":"2015","journal-title":"Oncotarget"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-4130.2018.23.019","article-title":"Meta-analysis of the correlation between PCNA expression and laryngeal squamous cell carcinoma","volume":"39","author":"Pu","year":"2018","journal-title":"Int J Lab Med"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7299.2018.06.022","article-title":"Meta analysis of OPN expression related to the occurrence, invasion and metastasis of laryngeal squamous cellcarcinoma","volume":"26","author":"G","year":"2018","journal-title":"J Audiology Speech Pathol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-897609\/v1","article-title":"m6A-related lncRNAs affect tumor immune microenvironment and prognosis in acute myeloid leukemia","author":"Zhong","year":"2021"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3830","article-title":"Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p\/SENP1","volume":"10","author":"Zhou","year":"2021","journal-title":"Cancer Med"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1514780","article-title":"KLF4: a multifunctional nexus connecting tumor progression and immune regulation","volume":"16","author":"Ju","year":"2025","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.08.007","article-title":"Invasive pathobionts contribute to colon cancer initiation by counterbalancing epithelial antimicrobial responses - ScienceDirect","author":"Yu","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6230","DOI":"10.2217\/fmb-2019-0345","article-title":"Intestinal organoids: a model to study the role of microbiota in the colonic tumor microenvironment","volume":"15","author":"Nalluri","year":"2020","journal-title":"Future Microbiol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1038\/s41598-022-05249-0","article-title":"Intestinal microbiota profiles in a genetic model of colon tumorigenesis correlates with colon cancer biomarkers","volume":"12","author":"Vitali","year":"2022","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5533444","article-title":"Pan-cancer analysis of the cuproptosis-related gene DLD","volume":"2023","author":"Lin","year":"2023","journal-title":"Mediators Inflammation"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-65334\/v1","article-title":"Identification of the prognostic enhancer RNA in bladder cancer bone metastasis","author":"Hao","year":"2020"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3390\/nu15132937","article-title":"IDDF2023-ABS-0111Association between gut microbiota and digestive system cancers: a bidirectional two-sample mendelian randomization study","volume":"72","author":"Xie","year":"2023","journal-title":"Gut;Journal Br Soc Gasteroenterology"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-iddf.49","article-title":"IDDF2021-ABS-0166Transplantation of stool from obese patients promotes intestinal tumorigenesis in mice","volume":"70","author":"Kang","year":"2021","journal-title":"Gut;Journal Br Soc Gasteroenterology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/jgh.15042","article-title":"Intestinal microbiota and its association with colon cancer and red\/processed meat consumption","volume":"36","author":"Abu-Ghazaleh","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113894","article-title":"Interaction of microbiome and immunity in tumorigenesis and clinical treatment","volume":"156","author":"Yu","year":"2022","journal-title":"Biomedicine Pharmacotherapy = Biomedecine Pharmacotherapie"},{"key":"B95","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1073\/pnas.2314337121","article-title":"Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance","volume":"121","author":"Zhang","year":"2024","journal-title":"Proc Natl Acad Sci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041447","article-title":"Influence of diet and nutrition on prostate cancer","volume":"21","author":"Matsushita","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.30.1_supplement.1167.1","article-title":"The influence of commensal microflora on small intestinal inflammation and Wnt pathway in high fat- and genetically-induced obese Apc1638N mice","volume":"30","author":"Liu","year":"2016","journal-title":"FASEB J"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37263","article-title":"Induction, growth, drug resistance, and metastasis: a comprehensive summary of the relationship between STAT3 and gastric cancer","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000439","article-title":"The impact of the genetic background in a patient with papillary thyroid cancer and familial adenomatous polyposis","volume":"66","author":"Domingues","year":"2022"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030539","article-title":"The impact of tertiary lymphoid structures on tumor prognosis and the immune microenvironment in colorectal cancer","volume":"13","author":"Zhao","year":"2025","journal-title":"Biomedicines"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.29322\/ijsrp.11.06.2021.p11448","article-title":"An immunohistochemical study of the relationship between estrogen receptor alpha (ER\u03b1) and estrogen receptor beta (ER\u03b2) in papillary thyroid carcinoma (PTC) in general hospital haji adam Malik medan","volume":"11","author":"Tambunan","year":"2021"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13206","article-title":"The gut microbiota can orchestrate the signaling pathways in colorectal cancer","volume":"130","author":"Bennedsen","year":"2022","journal-title":"APMIS: Acta Pathologica Microbiologica Et Immunologica Scandinavica"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103542","article-title":"Gut microbiota and its influence on ovarian cancer carcinogenesis, anticancer therapy and surgical treatment: a literature review","volume":"168","author":"Giudice","year":"2021","journal-title":"Crit Rev Oncology\/Hematology"},{"key":"B104","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000380892","article-title":"Gut microbiota and colorectal cancer","volume":"2","author":"Ya-Nan","year":"2015","journal-title":"Gastrointestinal Tumors"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15590","article-title":"Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-iR84 and releasing AJUBA and inactivating Hippo\/YAP signalling","volume":"24","author":"Wang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-190108","article-title":"Gut microbiota diversity and composition is associated with high-risk myeloma","volume":"142","author":"Feinman","year":"2023","journal-title":"Blood"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-101160\/v1","article-title":"Characterization of a novel MAP4K4-SASH1 kinase cascade regulatingBreast cancer tumorigenesis and metastasis","author":"Li","year":"2020"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31317","article-title":"Cellular senescence and tumorigenesis","author":"Yuan","year":"2019","journal-title":"J Tongji University(Medical Science)"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-25296\/v1","article-title":"ASXL2 promotes colorectal cancer tumorigenesis by inducing cell proliferation","author":"Cui","year":"2020"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v22.i16.2370","article-title":"Analysis of the expression and clinical significance of microRNA-3960 in colon cancer","author":"Xia","year":"2018","journal-title":"Chin Clin Oncol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s275316","article-title":"Analyses of potential driver and passenger bacteria in human colorectal cancer","volume":"2020","author":"Wang","year":"2020","journal-title":"Cancer Manage Res"},{"key":"B112","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.PANCA20-PO-054","article-title":"Abstract PO-054: A stromal PTEN\/STAT3 signaling axis promotes immune evasion and tumor progression in pancreatic cancer","author":"MarElia-Bennett","year":"2020"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2023-3040","article-title":"Abstract 3040: A modified microbiota-accessible carbohydrates diet could change gut microbiota in patients with colorectal cancer after surgery","volume":"83","author":"Kim","year":"2023","journal-title":"Cancer Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1158\/1538-7445.am2015-2882","article-title":"Abstract 2882: Calorie-induced silencing of the tumor suppressive guanylin-GUCY2C paracrine axis underlies colorectal cancer in obesity","volume":"75","author":"Blomain","year":"2015","journal-title":"Cancer Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2013-4792","article-title":"Analysis of the relationship between experimentally induced rodent forestomach hyperplasia and tumorigenesis","volume":"73","author":"Fritz","year":"2013","journal-title":"Cancer Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1158\/1538-7445.am2014-367","article-title":"Abstract 367: Tumorigenesis: an investigation by network evolution and perturbations of somatic mutations in cancer interactome","volume":"74","author":"Cheng","year":"2014","journal-title":"Cancer Res"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2021-2766","article-title":"Abstract 2766: Hypoxia-induced lactate production by tumor-associated macrophages promote tumorigenesis","volume":"81","author":"Cui","year":"2021","journal-title":"Cancer Res"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2022-1862","article-title":"Abstract 1862: Naphthoquinone analogues inhibit Wnt\/\u03b2-catenin signaling and colorectal cancer tumorigenesis","volume":"82","author":"Hoyle","year":"2022","journal-title":"Cancer Res"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3781\/j.issn.1000-7431.2013.12.014","article-title":"The clinical value of excreta microRNAs used as biomarkers for screening and early diagnosis of neoplasms","volume":"33","author":"Fei","year":"2013","journal-title":"Tumor"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.2007","article-title":"CD59 is overexpressed in human lung cancer and regulates apoptosis of human lung cancer cells","volume":"43","author":"Li","year":"2013","journal-title":"Int J Oncol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-422X.2013.05.002","article-title":"Autophagy and tumors","volume":"40","author":"Jiao","year":"2013","journal-title":"J Int Oncol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15034031","article-title":"IJMS, vol. 15, pages 4031-4048: role of miR-191\/425 cluster in tumorigenesis and diagnosis of gastric cancer","volume":"15","author":"Peng","year":"2014"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068525","article-title":"Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with \u03b2-catenin\/TCF4 interaction in colorectal cancer cells","volume":"8","author":"Xingyao","year":"2013","journal-title":"PloS One"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2014.15.21.9523","article-title":"Expression and clinical significance of microRNA-376a in colorectal cancer","volume":"15","author":"Mo","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303235","article-title":"Exercise-induced SPARC prevents tumorigenesis of colon cancer","volume":"62","author":"Yu-Peng","year":"2013","journal-title":"Gut"},{"key":"B126","doi-asserted-by":"publisher","first-page":"9027","DOI":"10.1007\/s13277-014-2076-9","article-title":"E-cadherin gene methylation in lung cancer","volume":"35","author":"Liu","year":"2014","journal-title":"Tumour Biol J Int Soc For Oncodevelopmental Biol Med"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112443","article-title":"Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy","volume":"145","author":"Chen","year":"2022","journal-title":"Retour au num\u00e9ro"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.17.046391","article-title":"Correlation between cancer stem cells, inflammation and Malignant transformation in a DEN-induced model of hepatic carcinogenesis","author":"Wu","year":"2020"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04164-y","article-title":"Corosolic acid inhibits cancer progression by decreasing the level of CDK19-mediated O-GlcNAcylation in liver cancer cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280971","article-title":"Construction of model animals to explore intestinal microbiome for detection of breast cancer","volume":"18","author":"Ji","year":"2023","journal-title":"PLoS One"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v7i12.654","article-title":"Concise review: The role of cancer-derived exosomes in tumorigenesis and immune cell modulation","volume":"7","author":"Huynh","year":"2020","journal-title":"Biomed Res Ther"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.15324\/kjcls.2017.49.4.455","article-title":"Comparison of the miR-23b and miR-203 Expressions in Endometrial Cancer","volume":"49","author":"Lee","year":"2017"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94737-0","article-title":"Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma","volume":"15","author":"Kim","year":"2025","journal-title":"Sci Rep"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae061","article-title":"Colorectal cancer in inflammatory bowel disease: A review of the role of gut microbiota and bacterial biofilms in disease pathogenesis","volume":"18","author":"Mu\u00f1iz Pedrogo","year":"2024","journal-title":"J Crohn's Colitis"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.13241\/j.cnki.pmb.2016.08.010","article-title":"The clinicopathological significance of cyclin D1, bcl-2, P53 and survivin in hepatitis C virus related hepatocellular carcinoma","volume":"16","author":"Wen-Juan","year":"2016","journal-title":"Prog Modern Biomedicine"},{"key":"B136","article-title":"Clinical significance of quantitative detection of human telomerase reverse transcriptase mRNA in colorectal cancer and its precancerous lesions","volume":"46","author":"Shaoping","year":"2015","journal-title":"Chin J Gastroenterol Hepatol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.595585","article-title":"CircASH2L promotes ovarian cancer tumorigenesis, angiogenesis, and lymphangiogenesis by regulating the miR-665\/VEGFA axis as a competing endogenous RNA","volume":"8","author":"Chen","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23259","article-title":"Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR-942-5p and releasing DLG2 via Hippo-YAP signaling","volume":"59","author":"Li","year":"2020","journal-title":"Mol Carcinog"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-01040-2","article-title":"Circ_0007422 knockdown inhibits tumor property and immune escape of colorectal cancer by decreasing PDL1 expression in a miR-1256-dependent manner","volume":"66","author":"Yin","year":"2024","journal-title":"Mol Biotechnol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-022-00756-6","article-title":"Circ_0004585 facilitates tumorigenesis of colorectal cancer via modulating the miR-338-3p\/ZFX axis and activating the MEK\/ERK pathway","volume":"16","author":"Lin","year":"2023","journal-title":"Cell Mol Bioeng"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3452","article-title":"Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p\/YB-1 axis","volume":"38","author":"Wang","year":"2020","journal-title":"Cell Biochem Funct"},{"key":"B142","first-page":"32","article-title":"Characterization of cuproptosis-related lncRNA landscape for predicting the prognosis and aiding immunotherapy in lung adenocarcinoma patients","volume":"13","author":"Sun","year":"2023","journal-title":"Am J Cancer Res"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i32.11340","article-title":"Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients","volume":"20","author":"Wang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-021-03686-1","article-title":"Screening of Lactobacillus strains that enhance SCFA uptake in intestinal epithelial cells","volume":"247","author":"Chen","year":"2021","journal-title":"Eur Food Res Technol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1208\/s12249-021-02024-8","article-title":"Insights on the Critical Parameters Affecting the Probiotic Viability During Stabilization Process and Formulation Development","volume":"22","author":"Gurram","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2236362","article-title":"Depletion of butyrate-producing microbes of the Firmicutes predicts nonresponse to FMT therapy in patients with recurrent Clostridium difficile infection","volume":"15","author":"Tian","year":"2023","journal-title":"Gut Microbes"},{"key":"B147","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41467-024-55668-y","article-title":"Metagenome-guided culturomics for the targeted enrichment of gut microbes","volume":"16","author":"Armetta","year":"2025","journal-title":"Nat Commun"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70252","article-title":"Evaluation of the Fermentation Characteristics of Prebiotic-Containing Granola and Short-Chain Fatty Acid Production in an In Vitro Gut Microbiota Model","volume":"13","author":"Sasaki","year":"2025","journal-title":"Food Sci Nutr"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.1.5.12924","article-title":"How can probiotics and prebiotics impact mucosal immunity","volume":"1","author":"O\u2019Flaherty","year":"2010","journal-title":"Gut Microbes"},{"key":"B150","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.3390\/jcm14113673","article-title":"A Review of the Influence of Prebiotics, Probiotics, Synbiotics, and Postbiotics on the Human Gut Microbiome and Intestinal Integrity","volume":"14","author":"Smolinska","year":"2025","journal-title":"J Clin Med"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00506-1","article-title":"Diversity and dynamism of IgA\u2212microbiota interactions","volume":"21","author":"Huus","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcdf.2024.100462","article-title":"Synbiotics: Effects of prebiotics on the growth and viability of probiotics in food matrices","volume":"32","author":"Parhi","year":"2024","journal-title":"Bioactive Carbohydrates and Dietary Fibre"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1395966","article-title":"The impact of pre-, pro- and synbiotics supplementation in colorectal cancer treatment: a systematic review","volume":"14","author":"Moreira","year":"2024","journal-title":"Front Oncol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41522-025-00818-3","article-title":"Harnessing gut microbiota for colorectal cancer therapy: from clinical insights to therapeutic innovations","volume":"11","author":"Chen","year":"2025","journal-title":"npj Biofilms Microbiomes"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.10.038","article-title":"Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients","volume":"61","author":"Xie","year":"2019","journal-title":"Nutrition"},{"key":"B156","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.3390\/ijms25094834","article-title":"The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health","volume":"25","author":"Yoo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/nri3312","article-title":"The impact of probiotics and prebiotics on the immune system","volume":"12","author":"Klaenhammer","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12409","article-title":"Impact of prebiotics on immune response: from the bench to the clinic","volume":"99","author":"Pujari","year":"2021","journal-title":"Immunol Cell Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1807247\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:48:27Z","timestamp":1778129307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1807247\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":158,"alternative-id":["10.3389\/fimmu.2026.1807247"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1807247","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"article-number":"1807247"}}