{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:11:34Z","timestamp":1778591494215,"version":"3.51.4"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202500, W2523090"],"award-info":[{"award-number":["82202500, W2523090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2026.1808458","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:29:58Z","timestamp":1777526998000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["AAV2-associated liver injury across infection and gene therapy: converging genomic signals"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuanzhi","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, Huaqiao University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xiamen Chang Gung Hospital, Hua Qiao University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fentian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University","place":["Xiamen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-04073-z","article-title":"Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy","volume":"32","author":"Buddle","year":"2026","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06003-w","article-title":"Genomic investigations of unexplained acute hepatitis in children","volume":"617","author":"Morfopoulou","year":"2023","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05948-2","article-title":"Adeno-associated virus 2 infection in children with non-A-E hepatitis","volume":"617","author":"Ho","year":"2023","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05949-1","article-title":"Adeno-associated virus type 2 in US children with acute severe hepatitis","volume":"617","author":"Servellita","year":"2023","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-00570-8","article-title":"Severe hepatitis outbreak in children linked to AAV2 virus","volume":"617","author":"Tacke","year":"2023","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1001\/jama.2023.5625","article-title":"Multiple studies link unexplained pediatric hepatitis to AAV2","volume":"329","author":"Harris","year":"2023","journal-title":"JAMA"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.10.006","article-title":"Could the paediatric acute hepatitis of unknown origin be related to a new autoimmune disease","volume":"82","author":"Martinez-Laso","year":"2025","journal-title":"J Hepatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S2468-1253(23)00118-8","article-title":"AAV2 and severe acute hepatitis of unknown aetiology","volume":"8","author":"The Lancet Gastroenterology","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2025.30.14.2400536","article-title":"Investigation of an outbreak of novel hepatitis of unknown aetiology in children and adolescents, Ireland, 2021 to 2023","volume":"30","author":"Liddy","year":"2025","journal-title":"Euro Surveill"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004924","article-title":"Association between adeno-associated virus 2 and neurologic complications of pediatric human herpesvirus-6B infection","volume":"44","author":"Kawada","year":"2025","journal-title":"Pediatr Infect Dis J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jinf.2023.11.011","article-title":"Demystifying the global outbreak of severe acute hepatitis of unknown aetiology in children: A systematic review and meta-analysis","volume":"88","author":"Phan","year":"2024","journal-title":"J Infect"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333880","article-title":"Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19","volume":"74","author":"R\u00f6ttele","year":"2025","journal-title":"Gut"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.70160","article-title":"Severe acute hepatitis of unknown origin in children: Exploring the role of adenovirus and potential cofactors","volume":"61","author":"Sahoo","year":"2025","journal-title":"J Paediatr Child Health"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh9917","article-title":"Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology","volume":"15","author":"Mitchell","year":"2023","journal-title":"Sci Transl Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.026","article-title":"An alternate receptor for adeno-associated viruses","volume":"188","author":"Dhungel","year":"2025","journal-title":"Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:26:01Z","timestamp":1778588761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":15,"alternative-id":["10.3389\/fimmu.2026.1808458"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1808458","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"article-number":"1808458"}}