{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:46:26Z","timestamp":1782899186010,"version":"3.54.5"},"reference-count":118,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by persistent epidermal hyperplasia and relapsing inflammation. Although extensive progress has been made in elucidating individual pathogenic pathways, a unifying framework that integrates innate immune activation, adaptive immune maintenance, and keratinocyte-driven amplification remains incomplete. Accumulating evidence indicates that nuclear factor-\u03baB (NF-\u03baB) functions as a central convergence hub that coordinates these diverse inflammatory inputs in psoriasis. In this review, we synthesize recent advances demonstrating how innate immune sensors, including nucleic acid\u2013sensing pathways and Toll-like receptors, converge on NF-\u03baB to initiate inflammatory programs, and how adaptive immune circuits\u2014particularly Th17\/IL-17 signaling\u2014exploit NF-\u03baB to sustain disease chronicity. We further highlight the active role of keratinocytes as intrinsic amplifiers of inflammation through NF-\u03baB\u2013dependent programs governing hyperproliferation, oxidative stress responses, and secondary cytokine production. Beyond canonical signaling, emerging evidence reveals that non-coding RNAs and epigenetic regulators fine-tune NF-\u03baB activity, shaping transcriptional persistence and inflammatory memory in psoriatic skin. Finally, we discuss therapeutic strategies targeting the NF-\u03baB convergence hub, including upstream sensor antagonism, adaptor-level modulation, multi-target small molecules, natural products, and advanced skin-targeted delivery systems. By framing NF-\u03baB as a networked regulatory hub rather than a linear pathway, this review provides an integrated perspective on psoriasis pathogenesis and highlights opportunities for precision immunomodulation with improved efficacy and safety.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1808775","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:50:53Z","timestamp":1782895853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The multifaceted role of NF-\u03baB signaling in psoriasis: from inflammatory amplification to epidermal remodeling"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenqin","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Jiashan First People\u2019s Hospital","place":["Jiashan, Zhejiang, 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