{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:35:44Z","timestamp":1794440144148,"version":"4.9.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abdominal IgA vasculitis (IgAV) often presents with nonspecific symptoms, complicating accurate diagnosis. There is an urgent need for plasma biomarkers that can reliably distinguish affected patients from healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify and validate plasma inflammatory biomarkers for abdominal IgAV using Olink technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fasting plasma samples were collected from 10 IgAV patients with abdominal involvement and 10 healthy controls. The Olink Target 96 Inflammation panel was employed to quantify 92 inflammation-related proteins, followed by enzyme-linked immunosorbent assay (ELISA) validation in an expanded cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two cytokines were significantly upregulated in IgAV patients compared to controls. Among these, IL-8, OSM, TGF-\u03b1, TNFSF-14, and HGF exhibited strong diagnostic potential. In the validation cohort, IL-8, OSM, and TNFSF-14 remained significantly elevated. The combined ROC AUC for these three markers was 0.922 (95% CI: 0.823\u20131.021), with a sensitivity of 83.3% and specificity of 90.0%, notably outperforming any single marker. Decision curve analysis confirmed the clinical utility of this combined panel. Functional enrichment analysis revealed that these proteins are closely linked to inflammatory pathways, including cytokine-cytokine receptor interaction and the NF-\u03baB signaling cascade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL-8, OSM, and TNFSF-14 represent promising plasma biomarkers for abdominal IgAV. Our findings offer novel insights into disease pathogenesis and indicate a more accessible diagnostic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1810681","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:33:29Z","timestamp":1778736809000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic value of inflammatory biomarkers of IgA vasculitis based on Olink technology"],"prefix":"10.3389","volume":"17","author":[{"given":"Jin-Yue","family":"Huang","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital, Tianjin University (Tianjin Children\u2019s Hospital)","place":["Tianjin, China"]},{"name":"Tianjin Institute of Pediatrics","place":["Tianjin, China"]},{"name":"Tianjin Key Laboratory of Birth Defects for Prevention and Treatment of Child Birth Defects","place":["Tianjin, 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