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Although numerous treatments are available for these diseases, therapeutic outcomes remain unsatisfactory because of their poorly understood pathogeneses of these diseases. Vagus nerve stimulation (VNS), a noninvasive or minimally invasive neuromodulation technique, has shown significant potential in mitigating neurodegenerative conditions. This review explores the mechanisms of action and clinical applications of VNS in neurodegenerative diseases, providing novel insights for the development of novel treatments.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1811107","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:40:15Z","timestamp":1774248015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms"],"prefix":"10.3389","volume":"17","author":[{"given":"Qian","family":"Hu","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University","place":["Ganzhou, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical 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