{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:34:08Z","timestamp":1777008848535,"version":"3.51.4"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Relapsing polychondritis (RP) and VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) are two clinically overlapping conditions in which neurological complications remain uncommon. Based on the existing literature, neurological involvement in RP most frequently comprises meningitis, encephalitis, cranial nerve palsies, and stroke, whereas VEXAS is additionally characterized by peripheral nerve and muscle involvement. This scoping review summarizes the neurological manifestations associated with RP and VEXAS and highlights the current gaps in knowledge regarding these complications.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1811453","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:34:05Z","timestamp":1777005245000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["What should neurologists expect to observe in relapsing polychondritis and VEXAS?"],"prefix":"10.3389","volume":"17","author":[{"given":"Mickael","family":"Bonnan","sequence":"first","affiliation":[{"name":"Neurology Department, Henri Mondor Hospital","place":["Cr\u00e9teil, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang Tuan R\u00e9my","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Neurology Department, Henri Mondor Hospital","place":["Cr\u00e9teil, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Crickx","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Henri Mondor Hospital","place":["Cr\u00e9teil, France"]},{"name":"Institut Mondor de Recherche Biom\u00e9dicale (IMRB), INSERM U955, Universit\u00e9 Paris Est- Cr\u00e9teil (UPEC)","place":["Cr\u00e9teil, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"B1","first-page":"96","article-title":"Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients","volume":"24","author":"Zeuner","year":"1997","journal-title":"J Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-60-4-653","article-title":"Relapsing polychondritis. 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