{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:18:56Z","timestamp":1788358736621,"version":"build-2803163510"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as important mediators of tissue regeneration and inflammation modulation in periodontitis, yet their clinical use faces ethical and technical challenges. Non-human-derived exosomes present a viable alternative, leveraging their ability to enhance tissue repair, reduce inflammation, and stimulate regeneration. This review synthesizes recent advances (2020\u20132025) in non-human-derived exosome applications, emphasizing their roles in immunomodulation, angiogenesis, and periodontal regeneration, while evaluating clinical translation prospects.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1814654","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:06:25Z","timestamp":1788357985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongbo","family":"Fei","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Jilin University","place":["Changchun, China"]},{"name":"Jilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Jilin University","place":["Changchun, 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