{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:12:15Z","timestamp":1778562735104,"version":"3.51.4"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Class II histone deacetylases (HDAC) orchestrate T cell-dependent immune responses via the epigenetic control of genes and via the post-translational modification of cytoplasmic and nuclear proteins. However, the contribution of single HDAC family members to the differentiation and function of peripheral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells remains elusive. We here demonstrate that HDAC7-deficiency leads to the upregulation of immune checkpoint molecules, increased apoptosis and disturbed glutamine homeostasis of peripheral murine CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, which we could link to a MEF2D-dependent induction of FasL expression ultimately deterring the survival of HDAC7-deficient CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Likewise, we observed in mouse models of lymphoma, that mice with a T cell-specific deletion of\n                    <jats:italic>Hdac7<\/jats:italic>\n                    harbor impaired anti-tumor immune responses in syngeneic transfer models of lymphoma and we found that HDAC7 is required for CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell-dependent memory recall responses in models of lymphocytic choriomeningitis virus infection. Taken together, we identify HDAC7 as a central regulator of cellular exhaustion and apoptosis of peripheral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, controlling CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell dependent anti-tumor and anti-viral immunity in mice.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1816695","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:29:25Z","timestamp":1778560165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells"],"prefix":"10.3389","volume":"17","author":[{"given":"Cansu","family":"Yerinde","sequence":"first","affiliation":[{"name":"Medical Department, Division of Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie 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