{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:49:51Z","timestamp":1782895791022,"version":"3.54.5"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Invariant natural killer T (iNKT) cells play a role in preventing graft-versus-host disease (GVHD) in bone marrow transplantation (BMT), but it is not known whether and how the NKT10 and NKT17 subsets prevent GVHD. Here, we investigated the anti-GVH effects of iNKT cell subsets in a major-MHC mismatched murine BMT in which BALB\/c recipients (H-2\n                    <jats:sup>d<\/jats:sup>\n                    ) received grafts from C57BL\/6 (H-2\n                    <jats:sup>b<\/jats:sup>\n                    ) donors. The graft consisted of bone marrow and T cells from Traj18\n                    <jats:sup>KO<\/jats:sup>\n                    (iNKT cell deficient) mice supplemented with iNKT cells purified from donors with various genetic alterations of iNKT subsets. First, NKT17-enriched CD4\n                    <jats:sup>-<\/jats:sup>\n                    iNKT cells showed anti-GVH effects similar to those of NKT2-enriched CD4\n                    <jats:sup>+<\/jats:sup>\n                    iNKT cells, while NKT2\/17 deficient iNKT cells failed to prevent GVHD, suggesting that either or both of these subsets have anti-GVH function. Furthermore, IL10\n                    <jats:sup>KO<\/jats:sup>\n                    iNKT cells completely lost their protective effects, whereas IL17AFD\n                    <jats:sup>KO<\/jats:sup>\n                    iNKT cells demonstrated partially abrogated anti-GVH effects, supporting the indispensable role of NKT10 in preventing GVHD after BMT. Using IL-17 fate-mapping mice, we demonstrated that NKT17 can trans-differentiate into NKT10\n                    <jats:italic>in vitro<\/jats:italic>\n                    after antigenic stimulation under T regulatory type 1 (Tr1)-promoting conditions. In conclusion, NKT10 plays a role in preventing GVHD in BMT and NKT17 may contribute to the anti-GVH effects via trans-differentiation into NKT10.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1817755","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:40:27Z","timestamp":1782895227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The IL-10-producing NKT10 subset plays a critical role in preventing graft-versus-host-disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Abel","family":"Trujillo-Ocampo","sequence":"first","affiliation":[{"name":"Department of Hematopoietic Biology & Malignancies, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Boagni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maison","family":"Grefe","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Biology & Malignancies, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelita","family":"Clinton","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Discovery, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Biology & Malignancies, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United 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