{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:56:20Z","timestamp":1794012980392,"version":"4.8.0"},"reference-count":190,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA\/RNA\/protein methylation, histone modifications, and non-coding RNA networks, contributes to NPC invasion and metastasis by reshaping epithelial-mesenchymal transition, tumor microenvironment interactions, immune evasion, and therapy adaptation. This review provides a structured overview of the core mechanisms of epigenetic regulation in NPC, highlighting aberrant methylation (DNA, RNA, protein), histone post-translational modifications (acetylation, phosphorylation, ubiquitination, palmitoylation), and the dysregulation of non-coding RNAs. We also summarize current translational progress, including biomarker development and early NPC-specific epigenetic trials, while highlighting the major barriers to clinical implementation, such as tumor heterogeneity, off-target effects, and insufficient validation. Overall, this review integrates mechanistic and translational evidence to clarify how epigenetic insights may support biomarker-guided and precision-oriented management of NPC.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1820374","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:31:30Z","timestamp":1777872690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongpeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Jieyang People\u2019s Hospital","place":["Jieyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimao","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Guangdong Medical University","place":["Dongguan, 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