{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:46:28Z","timestamp":1782798388617,"version":"3.54.5"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Pagetoid reticulosis (PR), also known as Woringer\u2013Kolopp disease (WKD), is a rare subtype of cutaneous T-cell lymphoma. Due to its low incidence and non-specific clinical presentation, it is frequently prone to misdiagnosis. We report the case of a 53-year-old female with a 5-year history of a recalcitrant, pruritic erythematous plaque on the right ankle, initially mismanaged as chronic eczema. Clinical examination revealed a solitary, well-demarcated, infiltrated scaly plaque at an acral site. Histopathological analysis demonstrated striking epidermotropism of medium-sized atypical lymphocytes with a pagetoid distribution and Pautrier-like microabscesses. Immunohistochemistry (IHC) revealed a T-cell lineage (CD3+\/CD5+) with significant loss of CD4, CD7, and predominantly absent CD2\/CD8 expression. A Ki-67 proliferation index of approximately 40% and focal CD30 positivity were observed, while EBER\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization was negative. Following a definitive diagnosis of localized PR, the patient was treated with topical clobetasol propionate twice daily, resulting in substantial clinical resolution. Literature review highlights the marked immunophenotypic heterogeneity of WKD and its favorable prognosis in localized forms. For treatment-refractory acral plaques, a high index of clinical suspicion is paramount. Early biopsy with appropriate immunophenotypic evaluation is essential to avoid diagnostic delay and guide effective local treatment, including radiotherapy or surgical excision.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1821015","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:37:07Z","timestamp":1782797827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pagetoid reticulosis (Woringer\u2013Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review"],"prefix":"10.3389","volume":"17","author":[{"given":"Yansi","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shenzhen University General Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghua","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen University General Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyuxin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, The First Affiliated Hospital of Shenzhen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqin","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maomao","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shenzhen University General Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16397","article-title":"Pediatric pagetoid reticulosis: a case in a Japanese boy and review of published reports","volume":"62","author":"Ishikawa","year":"2023","journal-title":"Int J Dermatol"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1111\/ijd.16224","article-title":"Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review","volume":"62","author":"Osto","year":"2023","journal-title":"Int J Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12472","article-title":"Dermoscopy of pagetoid reticulosis, with dermoscopic-pathologic correlation","volume":"35","author":"Manoli","year":"2019","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4057661","article-title":"Primary cutaneous lymphomas in Thailand: a 10-year retrospective study","volume":"2021","author":"Pruksaeakanan","year":"2021","journal-title":"BioMed Res Int"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2016.04.004","article-title":"Unusual variants of mycosis fungoides","volume":"22","author":"Virmani","year":"2016","journal-title":"Diagn Histopathol (Oxf)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.018","article-title":"Clinicopathologic features and treatment outcomes in Woringer-Kolopp disease","volume":"59","author":"Lee","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0059","article-title":"A solitary scaly plaque on the lower extremity of a young girl","volume":"156","author":"Margheim","year":"2020","journal-title":"JAMA Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1985.tb05733.x","article-title":"Unusual clinical presentation of epidermotropic cutaneous lymphoma. 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