{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:59:41Z","timestamp":1790683181103,"version":"4.1.0"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Although reperfusion therapy improves the prognosis of acute myocardial infarction, myocardial ischemia\u2013reperfusion injury continues to limit its clinical benefits, with neutrophil-driven inflammatory cascades representing a central mechanism of injury amplification. This article delineates the molecular event chain of neutrophils from recruitment to effector execution: activated neutrophils damage cardiomyocytes through three principal pathways\u2014respiratory burst, degranulation, and neutrophil extracellular traps formation\u2014thereby establishing a positive feedback loop that exacerbates inflammatory amplification. On this basis, we summarize therapeutic strategies targeting neutrophil migration, neutrophil extracellular traps formation, intracellular signaling pathways, mitochondrial homeostasis, immune phenotypes, and targeted drug delivery systems.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1821747","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:24:21Z","timestamp":1790681061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil-mediated myocardial ischemia\u2013reperfusion injury: mechanisms and potential therapeutic targets"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenna","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Yangtze University","place":["Jingzhou, China"]},{"name":"Department of Pharmacology, School of Medicine, Yangtze University","place":["Jingzhou, 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