{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:09:12Z","timestamp":1789711752282,"version":"4.0.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease. Based on the previous research results we conducted on the prevention of RA with\n Bifidobacterium animalis<\/jats:italic>\n BD400, we generated a large longitudinal 16S rRNA sequencing dataset to characterize temporal microbial shifts associated with disease progression and probiotic intervention. This study constructed collagen-induced arthritis (CIA) model rats to assess the changes in the gut microbiota species of the rats during the model development. The experimental results showed that as the CIA model developed, the gut microbiota of the rats underwent dynamic changes involving genera such as\n Akkermansia<\/jats:italic>\n ,\n Romboutsia<\/jats:italic>\n ,\n Christensenellaceae<\/jats:italic>\n _R-7_group,\n Bifidobacterium<\/jats:italic>\n ,\n Turicibacter<\/jats:italic>\n ,\n Candidatus<\/jats:italic>\n _\n Saccharimonas<\/jats:italic>\n , etc.\n Bifidobacterium animalis<\/jats:italic>\n BD400 administration altered the relative abundances of genera such as\n Turicibacter<\/jats:italic>\n ,\n Bifidobacterium<\/jats:italic>\n ,\n Lactobacillus<\/jats:italic>\n ,\n Lacticaseibacillus<\/jats:italic>\n , and\n Ligilactobacillus<\/jats:italic>\n , thereby helping to alleviate RA. This study provides data reference for achieving RA prevention through gut microbiota intervention and lays the foundation for the application of probiotics in RA prevention.\n <\/jats:p>","DOI":"10.3389\/fimmu.2026.1821878","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:38:05Z","timestamp":1789709885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The alterations in the gut microbiota and Bifidobacterium animalis BD400 during the development and progression of collagen-induced arthritis in rats"],"prefix":"10.3389","volume":"17","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Dairy Biotechnology, Engineering Research Center of Dairy Biotechnology","place":["Shanghai, China"]},{"name":"Key Laboratory of Functional Dairy Products Processing, Ministry of Agriculture and Rural Affairs","place":["Shanghai, 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