{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:14:41Z","timestamp":1783336481701,"version":"3.54.6"},"reference-count":210,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The endoplasmic reticulum (ER) is responsible for the synthesis, modification, and folding of various intracellular proteins. Under strong external stimuli, the ER often undergoes significant structural disorganization and functional abnormalities, a process that generally accelerates the onset and progression of inflammatory responses and related diseases, such as infections and sepsis, digestive system diseases, cancer, neurological disorders, circulatory diseases, and musculoskeletal diseases. Therefore, maintaining ER homeostasis is crucial for delaying the inflammatory process. As an important type of selective autophagy, ER-phagy has transcended merely \u201cwaste removal\u201d to become a key cellular hub integrating immune and stress signals. It not only effectively curbs the excessive activation of the NF-\u03baB pathway and the NLRP3 inflammasome by timely clearing inflammatory pathogens and ER fragments damaged by calcium store abnormalities and oxidation but also maintains immune cell homeostasis, thereby inhibiting the initiation and spread of excessive inflammatory responses. This review summarizes the key receptors, regulatory mechanisms, and the latest research on ER-phagy in various inflammation-related diseases, aiming to draw academic attention to the important value of ER-phagy in inflammatory diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1822159","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:16:23Z","timestamp":1783332983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoplasmic reticulum autophagy in inflammatory diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Chunxiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhengzhou Eighth People's Hospital","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Heilongjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrm.2015.8","article-title":"Structure and function of ER membrane contact sites with other organelles","volume":"17","author":"Phillips","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06090-9","article-title":"Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy","volume":"618","author":"Foronda","year":"2023","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.03.005","article-title":"ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD","volume":"56","author":"Molinari","year":"2021","journal-title":"Dev Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00838-0","article-title":"Control of immune cell function by the unfolded protein response","volume":"23","author":"Di Conza","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.semcdb.2020.04.006","article-title":"Endoplasmic reticulum protein quality control in \u03b2 cells","volume":"103","author":"Shrestha","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11380-1","article-title":"Integrated signaling system under endoplasmic reticulum stress in eukaryotic microorganisms","volume":"105","author":"Cao","year":"2021","journal-title":"Appl Microbiol Biotechnol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2026.2641614","article-title":"RETREG1\/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis","volume":"22","author":"Duan","year":"2026","journal-title":"Autophagy"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000004858","article-title":"Astrocyte PERK and IRE1 signaling contributes to morphine tolerance and hyperalgesia through upregulation of Lipocalin-2 and NLRP3 inflammasome in the rodent spinal cord","volume":"140","author":"Wang","year":"2024","journal-title":"Anesthesiology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2238579","article-title":"SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1","volume":"19","author":"Jiao","year":"2023","journal-title":"Autophagy"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156952","article-title":"Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function","volume":"144","author":"Zhou","year":"2025","journal-title":"Phytomedicine"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.07.052","article-title":"Nur77 attenuates Paneth cell necroptosis-induced intestinal inflammation through regulating endoplasmic reticulum homeostasis in sepsis","volume":"83","author":"Cui","year":"2026","journal-title":"J Adv Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2026.157863","article-title":"Dendrobium polysaccharides ameliorate alcohol-induced liver injury by inhibiting the pathogenic ER stress-sphingolipid axis","volume":"152","author":"Ling","year":"2026","journal-title":"Phytomedicine"},{"key":"B14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1158\/1541-7786.mcr-21-0702","article-title":"PERK, beyond an unfolded protein response sensor in estrogen-induced apoptosis in endocrine-resistant breast cancer","volume":"20","author":"Fan","year":"2022","journal-title":"Mol Cancer Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0412-x","article-title":"A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability","volume":"25","author":"Jheng","year":"2018","journal-title":"J BioMed Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12964-019-0353-3","article-title":"ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling","volume":"17","author":"Zheng","year":"2019","journal-title":"Cell Commun Signal"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114349","article-title":"Interleukin-36\u03b2 inhibits CD4+CD25+ regulatory T cells by activating endoplasmic reticulum-phagy in septic mice","volume":"151","author":"Ge","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00018-022-04143-2","article-title":"Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation","volume":"79","author":"Su","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166391","article-title":"The unfolded protein response transducer IRE1\u03b1 promotes reticulophagy in podocytes","volume":"1868","author":"Navarro-Betancourt","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142395","article-title":"FAM134B-mediated ER-phagy alleviates alcohol-related liver fibrosis by reducing endoplasmic reticulum stress","volume":"308","author":"Wang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.01.012","article-title":"GRINA alleviates hepatic ischemia\u2013reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination","volume":"83","author":"Yu","year":"2025","journal-title":"J Hepatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-025-01690-1","article-title":"SEL1L-HRD1-mediated ERAD in mammals","volume":"27","author":"Wang","year":"2025","journal-title":"Nat Cell Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e18-12-0754","article-title":"Degradation of integral membrane proteins modified with the photosensitive degron module requires the cytosolic endoplasmic reticulum-associated degradation pathway","volume":"30","author":"Scheffer","year":"2019","journal-title":"Mol Biol Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/s41467-025-67816-z","article-title":"A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis","volume":"17","author":"Yan","year":"2026","journal-title":"Nat Commun"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129812","article-title":"Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins","volume":"1865","author":"Ninagawa","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-025-01491-y","article-title":"Initiation of ERAD by the bifunctional complex of Mnl1\/Htm1 mannosidase and protein disulfide isomerase","volume":"32","author":"Zhao","year":"2025","journal-title":"Nat Struct Mol Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041247","article-title":"Endoplasmic reticulum-associated protein degradation","volume":"14","author":"Krshnan","year":"2022","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2019.1610351","article-title":"Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation(ERAD) and ER-to-lysosome-associated degradation(ERLAD) pathways","volume":"54","author":"Fregno","year":"2019","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411662","article-title":"Coordinated role of autophagy and ERAD in maintaining neuroendocrine function by preventing prohormone aggregation","volume":"12","author":"Pan","year":"2025","journal-title":"Adv Sci(Weinh)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature14498","article-title":"Regulation of endoplasmic reticulum turnover by selective autophagy","volume":"522","author":"Khaminets","year":"2015","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1038\/s41467-019-10345-3","article-title":"Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy","volume":"10","author":"Bhaskara","year":"2019","journal-title":"Nat Commun"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202201068","article-title":"A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy","volume":"222","author":"Wang","year":"2023","journal-title":"J Cell Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2551672","article-title":"Salmonella Typhimurium exploits the reticulophagy\/ERphagy receptor RETREG1 to promote infection","volume":"21","author":"Gatica","year":"2025","journal-title":"Autophagy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.07.004","article-title":"Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development","volume":"58","author":"L\u00fcningschr\u00f6r","year":"2023","journal-title":"Dev Cell"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-15-73","article-title":"Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39","volume":"15","author":"Melchiotti","year":"2014","journal-title":"BMC Med Genet"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00094.2020","article-title":"Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer","volume":"319","author":"Keles","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900340","article-title":"An N-terminal-truncated isoform of FAM134B(FAM134B-2) regulates starvation-induced hepatic selective ER-phagy","volume":"2","author":"Kohno","year":"2019","journal-title":"Life Sci Alliance"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052289","article-title":"Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control","volume":"22","author":"Reggio","year":"2021","journal-title":"EMBO Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e20-06-0409","article-title":"RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy","volume":"32","author":"Kumar","year":"2021","journal-title":"Mol Biol Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/15548627.2024.2414424","article-title":"Reticulophagy and viral infection","volume":"21","author":"Wilson","year":"2025","journal-title":"Autophagy"},{"key":"B42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.devcel.2020.12.014","article-title":"Reticulon-3 promotes endosome maturation at ER membrane contact sites","volume":"56","author":"Wu","year":"2021","journal-title":"Dev Cell"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.7554\/elife.25555","article-title":"Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy","volume":"6","author":"Grumati","year":"2017","journal-title":"Elife"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110630","article-title":"Disposing of misfolded ER proteins: a troubled substrate's way out of the ER","volume":"500","author":"Oikonomou","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2353502","article-title":"RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum","volume":"20","author":"Kumar","year":"2024","journal-title":"Autophagy"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2025.01.011","article-title":"Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass","volume":"60","author":"Song","year":"2025","journal-title":"Dev Cell"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1609862","article-title":"ATL3, a cargo receptor for reticulophagy","volume":"15","author":"Chen","year":"2019","journal-title":"Autophagy"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643587","article-title":"Structural and functional analysis of the GABARAP interaction motif(GIM)","volume":"18","author":"Rogov","year":"2017","journal-title":"EMBO Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.01.041","article-title":"ATL3 is a tubular ER-phagy receptor for GABARAP-mediated selective autophagy","volume":"29","author":"Chen","year":"2019","journal-title":"Curr Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202012091","article-title":"Atlastin 2\/3 regulate ER targeting of the ULK1 complex to initiate autophagy","volume":"220","author":"Liu","year":"2021","journal-title":"J Cell Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koag014","article-title":"Sec62 restricts ER-replicating positive-strand RNA virus infections via UPR-dependent ER-phagy","volume":"38","author":"Wang","year":"2026","journal-title":"Plant Cell"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312757","article-title":"Emerging view on the molecular functions of Sec62 and Sec63 in protein translocation","volume":"22","author":"Jung","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1159\/000513293","article-title":"SEC62 and SEC63 expression in hepatocellular carcinoma and tumor-surrounding liver tissue","volume":"37","author":"Casper","year":"2021","journal-title":"Visc Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15905","article-title":"Membrane protein biogenesis at the ER: the highways and byways","volume":"289","author":"O'Keefe","year":"2022","journal-title":"FEBS J"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens5040067","article-title":"Varicella-Zoster virus infectious cycle: ER stress, autophagic flux, and amphisome-mediated trafficking","volume":"5","author":"Grose","year":"2016","journal-title":"Pathogens"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165024","article-title":"Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis","volume":"8","author":"Papadopoulou","year":"2023","journal-title":"JCI Insight"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1038\/s41467-023-38377-w","article-title":"Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles","volume":"14","author":"Lan","year":"2023","journal-title":"Nat Commun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3423","article-title":"Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery","volume":"18","author":"Fumagalli","year":"2016","journal-title":"Nat Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1038\/s41467-019-12991-z","article-title":"ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress","volume":"10","author":"Loi","year":"2019","journal-title":"Nat Commun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2018.1441631","article-title":"CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health","volume":"5","author":"Smith","year":"2018","journal-title":"Mol Cell Oncol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2023.2213560","article-title":"Cargo-interacting regions(CIR) of CCPG1 capture ER luminal cargos for reticulophagy","volume":"2","author":"Chino","year":"2023","journal-title":"Autophagy Rep"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1038\/s41467-021-21874-1","article-title":"Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation","volume":"12","author":"Zhou","year":"2021","journal-title":"Nat Commun"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e22-09-0432","article-title":"CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy","volume":"34","author":"Ishii","year":"2023","journal-title":"Mol Biol Cell"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1894059","article-title":"TEX264 at the intersection of autophagy and DNA repair","volume":"18","author":"Fielden","year":"2022","journal-title":"Autophagy"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202254801","article-title":"Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins","volume":"23","author":"Chino","year":"2022","journal-title":"EMBO Rep"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.033","article-title":"Intrinsically disordered protein TEX264 mediates ER-phagy","volume":"74","author":"Chino","year":"2019","journal-title":"Mol Cell"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-024-00232-z","article-title":"ER-phagy restrains inflammatory responses through its receptor UBAC2","volume":"43","author":"He","year":"2024","journal-title":"EMBO J"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2431341","article-title":"UBAC2 serves as a reticulophagy receptor to suppress inflammatory responses","volume":"21","author":"He","year":"2025","journal-title":"Autophagy"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-025-00654-3","article-title":"E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival","volume":"45","author":"Jiang","year":"2026","journal-title":"EMBO J"},{"key":"B70","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41419-021-03401-8","article-title":"Cdk5rap3 is essential for intestinal Paneth cell development and maintenance","volume":"12","author":"Quintero","year":"2021","journal-title":"Cell Death Dis"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022112053","article-title":"Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy","volume":"42","author":"Picchianti","year":"2023","journal-title":"EMBO J"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816202116","article-title":"Ribosomal protein RPL26 is the principal target of UFMylation","volume":"116","author":"Walczak","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202504650rr","article-title":"UFMylation: A key role in maintaining endoplasmic reticulum homeostasis","volume":"40","author":"Zheng","year":"2026","journal-title":"FASEB J"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/biology15050382","article-title":"The UFM1 conjugation system: A master regulator of cellular stress surveillance in human disease","volume":"15","author":"Kuang","year":"2026","journal-title":"Biology(Basel)"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07093-w","article-title":"The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons","volume":"627","author":"Makhlouf","year":"2024","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111015","article-title":"A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation","volume":"41","author":"Peter","year":"2022","journal-title":"EMBO J"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.7554\/elife.58396","article-title":"A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress","volume":"9","author":"Stephani","year":"2020","journal-title":"Elife"},{"key":"B78","doi-asserted-by":"publisher","first-page":"7857","DOI":"10.1038\/s41467-022-35501-0","article-title":"The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3","volume":"13","author":"Ishimura","year":"2022","journal-title":"Nat Commun"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1846304","article-title":"C53 is a cross-kingdom conserved reticulophagy receptor that bridges the gap betweenselective autophagy and ribosome stalling at the endoplasmic reticulum","volume":"17","author":"Stephani","year":"2021","journal-title":"Autophagy"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048587","article-title":"Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking","volume":"7","author":"Zhang","year":"2012","journal-title":"PloS One"},{"key":"B81","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41420-025-02414-y","article-title":"Neuronal CDK5RAP3 deficiency leads to encephalo-dysplasia via upregulation of N-glycosylases and glycogen deposition","volume":"11","author":"Chen","year":"2025","journal-title":"Cell Death Discov"},{"key":"B82","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1080\/15548627.2024.2440846","article-title":"The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy","volume":"21","author":"Liu","year":"2025","journal-title":"Autophagy"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230367","article-title":"ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model","volume":"221","author":"Lim","year":"2024","journal-title":"J Exp Med"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2025.2513466","article-title":"ADP ribosylation factor-like GTPase 6-interacting protein 5(ARL6IP5) : a prenylated Rab acceptor protein 1(PRA1) family protein that shapes the ER membrane and regulates ER-phagy","volume":"4","author":"Yamamoto","year":"2025","journal-title":"Autophagy Rep"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108493","article-title":"ADP ribosylation factor-like GTPase 6-interacting protein 5(Arl6IP5) is an ER membrane-shaping protein that modulates ER-phagy","volume":"301","author":"Yamamoto","year":"2025","journal-title":"J Biol Chem"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26618","article-title":"Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins","volume":"233","author":"Joshi","year":"2018","journal-title":"J Cell Physiol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.176685","article-title":"Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination","volume":"286","author":"Wang","year":"2011","journal-title":"J Biol Chem"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2347103","article-title":"USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1\/FAM134B to drive reticulophagy","volume":"20","author":"Zhang","year":"2024","journal-title":"Autophagy"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07398-4","article-title":"Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells","volume":"207","author":"Bidisha","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504552","article-title":"ER-phagy activation by AMFR attenuates cardiac fibrosis post-myocardial infarction via mTORC1 pathway","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci(Weinh)"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2022.2131212","article-title":"RETREG3\/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation","volume":"1","author":"Di Lorenzo","year":"2022","journal-title":"Autophagy Rep"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1719746","article-title":"Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy","volume":"16","author":"Stefely","year":"2020","journal-title":"Autophagy"},{"key":"B93","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1080\/15548627.2024.2410670","article-title":"A novel ER stress regulator ARL6IP5 induces reticulophagy to ameliorate the prion burden","volume":"21","author":"Kamble","year":"2025","journal-title":"Autophagy"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.017","article-title":"A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-resident UFMylation","volume":"180","author":"Liang","year":"2020","journal-title":"Cell"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10010024","article-title":"ROS-mediated cell cycle arrest and apoptosis induced by zearalenone in mouse Sertoli cells via ER stress and the ATP\/AMPK pathway","volume":"10","author":"Zheng","year":"2018","journal-title":"Toxins(Basel)"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105696","article-title":"MiT\/TFE factors control ER-phagy via transcriptional regulation of FAM134B","volume":"39","author":"Cinque","year":"2020","journal-title":"EMBO J"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1968228","article-title":"MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis","volume":"18","author":"Shiozaki","year":"2022","journal-title":"Autophagy"},{"key":"B98","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.canlet.2021.06.029","article-title":"NCAPD2 inhibits autophagy by regulating Ca2+\/CAMKK2\/AMPK\/mTORC1 pathway and PARP-1\/SIRT1 axis to promote colorectal cancer","volume":"520","author":"Jing","year":"2021","journal-title":"Cancer Lett"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2330037","article-title":"CSNK2\/CK2 regulates selective autophagy of the endoplasmic reticulum","volume":"20","author":"Stolz","year":"2024","journal-title":"Autophagy"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2395725","article-title":"Function of CSNK2\/CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mtor-mediated autophagy induction","volume":"21","author":"Sanz-Martinez","year":"2025","journal-title":"Autophagy"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2119350","article-title":"When acidic residues do not mimic phosphorylation: high-affinity binding of the reticulophagy receptor TEX264 to LC3\/GABARAP","volume":"18","author":"Popelka","year":"2022","journal-title":"Autophagy"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo1215","article-title":"Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy","volume":"8","author":"Di Lorenzo","year":"2022","journal-title":"Sci Adv"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24952","article-title":"Overexpression of \u03b1-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75-IP3R interaction","volume":"99","author":"Erustes","year":"2021","journal-title":"J Neurosci Res"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.910452","article-title":"Compositions and functions of mitochondria-associated endoplasmic reticulum membranes and their contribution to cardioprotection by exercise preconditioning","volume":"13","author":"Lv","year":"2022","journal-title":"Front Physiol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.121759","article-title":"Parkin deficiency impairs ER-mitochondria associations and calcium homeostasis via IP3R-Grp75-VDAC1 complex","volume":"22","author":"Xue","year":"2026","journal-title":"Int J Biol Sci"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2019.1683245","article-title":"Cyclooxygenase-2 modulates ER-mitochondria crosstalk to mediate superparamagnetic iron oxide nanoparticles induced hepatotoxicity: an in vitro and in vivo study","volume":"14","author":"Che","year":"2020","journal-title":"Nanotoxicology"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.01.006","article-title":"Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R\/GRP75\/VDAC1 on MAMs","volume":"228","author":"Liu","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156487","article-title":"Centipeda minima extract exhibits anti-liver cancer effects via the ER stress\/HMOX1\/Fe2+\/ROS pathway","volume":"139","author":"Wei","year":"2025","journal-title":"Phytomedicine"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.71571","article-title":"GRP75-faciliated mitochondria-associated ER membrane(MAM) integrity controls cisplatin-resistance in ovarian cancer patients","volume":"18","author":"Li","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B110","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41589-023-01512-1","article-title":"CGI1746 targets \u03c31R to modulate ferroptosis through mitochondria-associated membranes","volume":"20","author":"Zhang","year":"2024","journal-title":"Nat Chem Biol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126525","article-title":"A-syn(ful) MAM: a fresh perspective on a converging domain in Parkinson's disease","volume":"25","author":"Barbuti","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120958","article-title":"Mechanism of Shenzhu components in alleviating chemotherapy-induced diarrhea via mitochondria-associated endoplasmic reticulum membranes(MAMs) regulation","volume":"358","author":"Cao","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2023.05.021","article-title":"\u03b2-carotene targets IP3R\/GRP75\/VDAC1-MCU axis to renovate LPS-induced mitochondrial oxidative damage by regulating STIM1","volume":"205","author":"Meng","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09623-y","article-title":"Ca2+ transfer via the ER-mitochondria tethering complex in neuronal cells contribute to cadmium-induced autophagy","volume":"38","author":"Wang","year":"2022","journal-title":"Cell Biol Toxicol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051036","article-title":"Complexity and specificity of Sec61-channelopathies: human diseases affecting gating of the Sec61 complex","volume":"10","author":"Sicking","year":"2021","journal-title":"Cells"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.880004","article-title":"Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer","volume":"13","author":"K\u00f6rner","year":"2022","journal-title":"Front Physiol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy352","article-title":"Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution","volume":"28","author":"Krols","year":"2019","journal-title":"Hum Mol Genet"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1182455","article-title":"Editorial: the evolving picture of Ca2+ leak from endoplasmic reticulum in health and diseases","volume":"14","author":"Cavali\u00e9","year":"2023","journal-title":"Front Physiol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1573499","article-title":"Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis","volume":"16","author":"Li","year":"2025","journal-title":"Front Endocrinol(Lausanne)"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.86608","article-title":"Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane(MAM) dysfunction in diabetic kidney disease","volume":"19","author":"Liu","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03389-9","article-title":"FAM134B-mediated ER-phagy in Mg2+-free solution-induced mitochondrial calcium homeostasis and cell death in epileptic hippocampal neurons","volume":"46","author":"Wang","year":"2021","journal-title":"Neurochem Res"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00814-5","article-title":"FAM134B attenuates seizure-induced apoptosis and endoplasmic reticulum stress in hippocampal neurons by promoting autophagy","volume":"40","author":"Xie","year":"2020","journal-title":"Cell Mol Neurobiol"},{"key":"B123","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/s12964-025-02305-w","article-title":"STING-\u0394N, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection","volume":"23","author":"Deng","year":"2025","journal-title":"Cell Commun Signal"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-24-2262","article-title":"Systemic inactivation of TREX1 induces selective inflammation of the tumor microenvironment and invigorated T-cell-mediated tumor control","volume":"85","author":"Marinkovic","year":"2025","journal-title":"Cancer Res"},{"key":"B125","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","article-title":"The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy","volume":"12","author":"Oduro","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.09.021","article-title":"STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation","volume":"478","author":"Takashima","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14266","article-title":"Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer","volume":"111","author":"Loo","year":"2020","journal-title":"Cancer Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-025-01766-y","article-title":"Cholesterol sensing by the SCAP-FAM134B complex regulates ER-phagy and STING innate immunity","volume":"27","author":"Li","year":"2025","journal-title":"Nat Cell Biol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2496786","article-title":"ATP2A2 regulates STING1\/MITA-driven signal transduction including selective autophagy","volume":"21","author":"Yang","year":"2025","journal-title":"Autophagy"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.2131\/jts.50.105","article-title":"Prolyl hydroxylase domain enzymes(isoforms 1-3, PHD1-3), but not factor-inhibiting HIF-1(FIH-1), interact with the IKK complex and attenuate LPS-activated NF-kappa-B","volume":"50","author":"Tamura","year":"2025","journal-title":"J Toxicol Sci"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.06.024","article-title":"Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target I\u03baB\u03b1 and activate NF-\u03baB signaling","volume":"71","author":"Luo","year":"2025","journal-title":"J Adv Res"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0542-2","article-title":"ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection","volume":"4","author":"Lu","year":"2019","journal-title":"Nat Microbiol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"7506","DOI":"10.3390\/ijms26157506","article-title":"Biomarker correlations in PTSD: IL-18, IRE1, pERK, and ATF6 via Courtauld Emotional Control Scale(CECS)","volume":"26","author":"Wo\u017any-Rasa\u0142a","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2023.109806","article-title":"Zinc attenuates arsenic overdose-induced brain damage via PERK\/ATF6 and TLR\/MyD88\/NF-\u03baB pathways","volume":"276","author":"Wang","year":"2024","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.01.031","article-title":"TRAIL receptors serve as stress-associated molecular patterns to promote ER-stress-induced inflammation","volume":"52","author":"Sullivan","year":"2020","journal-title":"Dev Cell"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2025.02.003","article-title":"Structural instability of ryanodine receptor 2 causes endoplasmic reticulum(ER) dysfunction as well as sarcoplasmic reticulum(SR) dysfunction","volume":"85","author":"Uchinoumi","year":"2025","journal-title":"J Cardiol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111753","article-title":"Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer","volume":"131","author":"Miao","year":"2025","journal-title":"Cell Signal"},{"key":"B138","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/1098-1136(20010101)33:1<45::aid-glia1005>3.0.co;2-a","article-title":"NF-kappaB activation by N-CAM and cytokines in astrocytes is regulated by multiple protein kinases and redox modulation","volume":"33","author":"Choi","year":"2001","journal-title":"Glia"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-163","article-title":"Disulfiram targeting lymphoid Malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition","volume":"12","author":"Zha","year":"2014","journal-title":"J Transl Med"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.002","article-title":"LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB","volume":"12","author":"Wang","year":"2007","journal-title":"Cancer Cell"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2025-26472","article-title":"Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells","volume":"108","author":"Yang","year":"2025","journal-title":"J Dairy Sci"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01707-z","article-title":"Angiotensin II triggers NLRP3 inflammasome activation by a Ca2+ signaling-dependent pathway in rat cardiac fibroblast Ang-II by a Ca2+-dependent mechanism triggers NLRP3 inflammasome in CF","volume":"45","author":"Espitia-Corredor","year":"2022","journal-title":"Inflammation"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202502567rr","article-title":"A novel mechanism of chlorogenic acid in cardioprotection: blocking NLRP3 inflammasome via Ca2+\/CaMKII\u03b1 signaling in sepsis-induced cardiomyopathy","volume":"39","author":"Meng","year":"2025","journal-title":"FASEB J"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome throug Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"B146","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3892\/mmr.2021.12168","article-title":"\u03ba-opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+\/CaMKII\/CREB signaling pathway and improves synaptic plasticity in APP\/PS1 mice","volume":"24","author":"Song","year":"2021","journal-title":"Mol Med Rep"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.01.005","article-title":"TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation","volume":"62","author":"Wang","year":"2020","journal-title":"Curr Opin Immunol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1186\/s12951-025-03567-9","article-title":"Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation","volume":"23","author":"Lv","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157145","article-title":"Cis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca2+-phagocytosis-ROS axis","volume":"146","author":"Lei","year":"2025","journal-title":"Phytomedicine"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1246491","DOI":"10.1155\/2021\/1246491","article-title":"Anthocyanins from Hibiscus Syriacus L. inhibit NLRP3 inflammasome in BV2 microglia cells by alleviating NF-\u03baB- and ER stress-induced Ca2+ accumulation and mitochondrial ROS production","volume":"2021","author":"Molagoda","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135876","article-title":"Duck hepatitis A virus 1-encoded 2B protein disturbs ion and organelle homeostasis to promote NF-\u03baB\/NLRP3-mediated inflammatory response","volume":"280","author":"Mao","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa792","article-title":"Genomics links inflammation with neurocognitive impairment in children living with human immunodeficiency virus type-1","volume":"224","author":"Rawat","year":"2021","journal-title":"J Infect Dis"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119730","article-title":"FOXO3 deficiency in neutrophils drives colonic inflammation and tumorigenesis","volume":"24","author":"Ghimire","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2022.04.03","article-title":"CCPG1 involved in corneal Aspergillus fumigatus infection","volume":"15","author":"Wang","year":"2022","journal-title":"Int J Ophthalmol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41417-022-00515-9","article-title":"CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages","volume":"30","author":"Wang","year":"2023","journal-title":"Cancer Gene Ther"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00567-7","article-title":"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2560019","article-title":"Regulatory roles of intestinal CD4+ T cells in inflammation and their modulation by the intestinal microbiota","volume":"17","author":"Ma","year":"2025","journal-title":"Gut Microbes"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.07.010","article-title":"Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264. 7 cells","volume":"28","author":"Park","year":"2014","journal-title":"Toxicol Vitro"},{"key":"B159","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41392-023-01603-4","article-title":"Non-small cell lung cancers(NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors","volume":"8","author":"Cui","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14932","article-title":"ER-phagy: shaping up and destressing the endoplasmic reticulum","volume":"286","author":"Wilkinson","year":"2019","journal-title":"FEBS J"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol Rev"},{"key":"B162","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41564-018-0167-x","article-title":"Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis","volume":"3","author":"Kyrmizi","year":"2018","journal-title":"Nat Microbiol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nature01911","article-title":"ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells","volume":"425","author":"Guermonprez","year":"2003","journal-title":"Nature"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"Sanjuan","year":"2007","journal-title":"Nature"},{"key":"B165","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/imr.12266","article-title":"Macrophage defense mechanisms against intracellular bacteria","volume":"264","author":"Weiss","year":"2015","journal-title":"Immunol Rev"},{"key":"B166","doi-asserted-by":"publisher","first-page":"513","DOI":"10.21037\/atm.2016.12.30","article-title":"Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy","volume":"4","author":"Scambler","year":"2016","journal-title":"Ann Transl Med"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.771353","article-title":"ER-Phagy and microbial infection","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00118-14","article-title":"Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells","volume":"88","author":"Junjhon","year":"2014","journal-title":"J Virol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw270","article-title":"FAM134B, the selective autophagy receptor for endoplasmic reticulum turnover, inhibits replication of Ebola virus strains Makona and Mayinga","volume":"214","author":"Chiramel","year":"2016","journal-title":"J Infect Dis"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1441471","article-title":"Detection of a vita-PAMP STINGs cells into reticulophagy","volume":"14","author":"Moretti","year":"2018","journal-title":"Autophagy"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1265192","article-title":"Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B","volume":"13","author":"Lennemann","year":"2017","journal-title":"Autophagy"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2457112","article-title":"Flavivirus NS2A orchestrates reticulophagy to enhance viral pathogenicity","volume":"21","author":"Zhang","year":"2025","journal-title":"Autophagy"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3390\/proceedings2020050031","article-title":"ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly","volume":"4","author":"Neufeldt","year":"2019","journal-title":"Nat Microbiol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.08.011","article-title":"Sepsis","volume":"407","author":"Singer","year":"2026","journal-title":"Lancet"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3390\/life15060928","article-title":"The anti-inflammatory potential of levosimendan in sepsis: An experimental study using a LPS-induced rat model","volume":"15","author":"Dedeler Ertan\u0131d\u0131r","year":"2025","journal-title":"Life(Basel)"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202786","article-title":"FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice","volume":"13","author":"Li","year":"2021","journal-title":"Aging(Albany NY)"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.639","article-title":"NR4A1 suppresses pyroptosis by transcriptionally inhibiting NLRP3 and IL-1\u03b2 and co-localizing with NLRP3 in trans-Golgi to alleviate pathogenic bacteria-induced colitis","volume":"11","author":"Deng","year":"2021","journal-title":"Clin Transl Med"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00170.2025","article-title":"FAM134B controls collagen I dynamics in hepatic stellate cell-driven fibrosis","volume":"330","author":"Misra","year":"2026","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13082030","article-title":"CDK5RAP3 deficiency is associated with hepatic inflammation and increased expression of NLRP3 inflammasome components","volume":"13","author":"Chen","year":"2025","journal-title":"Biomedicines"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3390\/genes17010073","article-title":"Sex-specific downregulation of CDK5RAP3 exacerbates ER stress-mediated inflammation and apoptosis in CCl4-induced acute liver injury","volume":"17","author":"Ruan","year":"2026","journal-title":"Genes(Basel)"},{"key":"B181","doi-asserted-by":"publisher","first-page":"S1499","DOI":"10.1016\/j.hbpd.2026.02.003","article-title":"Interleukin-22 in acute pancreatitis: Balancing damage and repair","volume":"13","author":"Chooklin","year":"2026","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154361","article-title":"Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy","volume":"105","author":"Huang","year":"2022","journal-title":"Phytomedicine"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01607-8","article-title":"Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease(IBD) : focus on the NF-\u0199B and JAK\/STAT pathways","volume":"33","author":"Ismail","year":"2025","journal-title":"Inflammopharmacology"},{"key":"B184","doi-asserted-by":"publisher","first-page":"113330","DOI":"10.2139\/ssrn.5334650","article-title":"Refined photobiomodulation therapy ameliorates inflammatory bowel disease via modulation of immune pathways and gut microbiota","volume":"274","author":"Maeng","year":"2026","journal-title":"J Photochem Photobiol B"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.110619","article-title":"A novel C53\/LZAP-interacting protein regulates stability of C53\/LZAP and DDRGK domain-containing protein 1(DDRGK1) and modulates NF-kappaB signaling","volume":"285","author":"Wu","year":"2010","journal-title":"J Biol Chem"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.065920","article-title":"A novel LZAP-binding protein, NLBP, inhibits cell invasion","volume":"285","author":"Kwon","year":"2010","journal-title":"J Biol Chem"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23041976","article-title":"ADAM8-dependent extracellular signaling in the tumor microenvironment involves regulated release of lipocalin 2 and MMP-9","volume":"23","author":"Cook","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B188","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s41419-022-04813-w","article-title":"Cancer cells adapt FAM134B\/BiP mediated ER-phagy to survive hypoxic stress","volume":"13","author":"Chipurupalli","year":"2022","journal-title":"Cell Death Dis"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00818","article-title":"Anti-inflammatory anthranilate analogue enhances autophagy through mTOR and promotes ER-turnover through TEX264 during Alzheimer-associated neuroinflammation","volume":"13","author":"Wang","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9091251","article-title":"Ladostigil attenuates induced oxidative stress in human neuroblast-like SH-SY5Y cells","volume":"9","author":"Zohar","year":"2021","journal-title":"Biomedicines"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1097\/wnr.0000000000002152","article-title":"Hydrogen sulfide improves poststroke depression-induced inflammation in microglial cells by enhancing endoplasmic reticulum autophagy and inhibiting the cGAS-STING pathway","volume":"36","author":"Luo","year":"2025","journal-title":"Neuroreport"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137098","article-title":"Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus","volume":"798","author":"Zhang","year":"2023","journal-title":"Neurosci Lett"},{"key":"B193","doi-asserted-by":"publisher","first-page":"194","DOI":"10.4244\/eij-d-17-00180","article-title":"The European collaborative project on inflammation and vascular wall remodeling in atherosclerosis - intravascular ultrasound(ATHEROREMO-IVUS) study","volume":"14","author":"de Boer","year":"2018","journal-title":"EuroIntervention"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12820","article-title":"Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype","volume":"17","author":"Peng","year":"2018","journal-title":"Aging Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jcp.25852","article-title":"Emerging roles of ER stress and unfolded protein response pathways in skeletal muscle health and disease","volume":"233","author":"Bohnert","year":"2018","journal-title":"J Cell Physiol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116799","article-title":"Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy","volume":"234","author":"Ji","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70044","article-title":"Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia","volume":"12","author":"Belcher","year":"2024","journal-title":"Physiol Rep"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/nature10980","article-title":"Hsp72 preserves muscle function and slows progression of severe muscular dystrophy","volume":"484","author":"Gehrig","year":"2012","journal-title":"Nature"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1136\/jmg-2025-111261","article-title":"Targeting autophagy in Duchenne muscular dystrophy: mechanistic insights and emerging therapeutic strategies","volume":"63","author":"Krishna","year":"2026","journal-title":"J Med Genet"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/s41419-018-1080-1","article-title":"Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts","volume":"9","author":"Rizzo","year":"2018","journal-title":"Cell Death Dis"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0515-3","article-title":"Biochemical and ultrastructural evidence of endoplasmic reticulum stress in LGMD2I","volume":"451","author":"Boito","year":"2007","journal-title":"Virchows Arch"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23030","article-title":"Etiopathophysiological role of the renin-angiotensin-aldosterone system in age-related muscular weakening: RAAS-independent beneficial role of ACE2 in muscle weakness","volume":"36","author":"Fuloria","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.3109\/13813455.2011.577435","article-title":"Age-associated development of inflammation in Wistar rats: Effects of caloric restriction","volume":"117","author":"Horrillo","year":"2011","journal-title":"Arch Physiol Biochem"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metab"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060597","article-title":"Inhibition of the fission machinery mitigates OPA1 impairment in adult skeletal muscles","volume":"8","author":"Romanello","year":"2019","journal-title":"Cells"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12982","article-title":"Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control","volume":"13","author":"Dantas","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102874","article-title":"Chinese Tuina ameliorates muscle damage by regulating endoplasmic reticulum stress and autophagy in a rat model of skeletal muscle contusion","volume":"95","author":"Liu","year":"2025","journal-title":"Tissue Cell"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1829","article-title":"Autophagic degradation of Collagen 1A1 by cortisol in human amnion fibroblasts","volume":"158","author":"Mi","year":"2017","journal-title":"Endocrinology"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200518","article-title":"ER-phagy is involved in the degradation of Collagen I by IL-1\u03b2 in human amnion in parturition","volume":"209","author":"Mi","year":"2022","journal-title":"J Immunol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109735","article-title":"An additional NF-\u03baB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins","volume":"36","author":"Bosso","year":"2021","journal-title":"Cell Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1822159\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:16:25Z","timestamp":1783332985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1822159\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":210,"alternative-id":["10.3389\/fimmu.2026.1822159"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1822159","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"article-number":"1822159"}}