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These SCFAs mediate communication along the gut\u2013lung axis through multiple mechanisms, including epigenetic modifications, receptor-mediated signaling, and immunomodulation. Consequently, SCFAs promote regulatory T-cell expansion, restore Th1\/Th2 balance, and alleviate airway inflammation in asthma. While clinical observations suggest that high-fiber intake can improve asthma symptoms and lung function, its long-term efficacy and generalizability across diverse populations require further investigation. Elucidating the mechanisms of microbial metabolites within the gut\u2013lung axis through multi-omics integration represents a promising option for developing targeted nutritional interventions, particularly for pediatric and treatment-resistant asthma.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1825261","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:32:47Z","timestamp":1783920767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of high-fiber diets in modulating the gut\u2013lung axis and asthmatic inflammation"],"prefix":"10.3389","volume":"17","author":[{"given":"Ke","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of 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