{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:45:29Z","timestamp":1785908729171,"version":"3.56.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ureteral wall thickening or a periureteral \u201csleeve\u201d on imaging often raise concern for malignancy, but rare non-carcinomatous disorder can mimic this presentation. We report radiology and pathology findings of four prototypical cases of ureteral obstruction due to rare diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We describe four cases presenting with nonspecific urological symptoms such as flank pain, hydronephrosis, and variable degrees of renal dysfunction, in whom computed tomography revealed segmental or circumferential periureteral thickening suggestive of an infiltrative process. Given the absence of specific clinical or laboratory findings, a biopsy was required to confirm the diagnosis in all cases. Four different and rare diseases were diagnosed, namely light-chain amyloidosis, idiopathic retroperitoneal fibrosis, Erdheim-Chester disease, and Gardner\u2019s syndrome. Key imaging and pathology features are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusions<\/jats:title>\n                    <jats:p>Obstructive nephropathy may reveal rare fibro-inflammatory, infiltrative and proliferative diseases that require a thorough diagnostic work-up. Raising awareness of these rare conditions is crucial to guarantee timely diagnosis and effective treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1825897","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:54:25Z","timestamp":1785905665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Ureteral obstruction reveals rare underlying fibro-inflammatory, infiltrative, and proliferative disorders: report of four cases"],"prefix":"10.3389","volume":"17","author":[{"given":"Luca","family":"Malatesta","sequence":"first","affiliation":[{"name":"Department of Biomedical Experimental and Clinical Sciences \u201cMario Serio\u201d, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Rella","sequence":"additional","affiliation":[{"name":"Department of Biomedical Experimental and Clinical Sciences \u201cMario Serio\u201d, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pegoraro","sequence":"additional","affiliation":[{"name":"Haematology and Oncology Department, Meyer Children\u2019s Hospital Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Allinovi","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Canfora","sequence":"additional","affiliation":[{"name":"Interdisciplinary Internal Medicine, Careggi University Hospital","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Biancalana","sequence":"additional","affiliation":[{"name":"Interdisciplinary Internal Medicine, Careggi University Hospital","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Romagnani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Experimental and Clinical Sciences \u201cMario Serio\u201d, University of Florence","place":["Florence, Italy"]},{"name":"Nephrology and Dialysis Unit, Meyer Children\u2019s Hospital Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria C.","family":"Galli","sequence":"additional","affiliation":[{"name":"Histopathology and Molecular Diagnostics, Careggi University Hospital","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Buccoliero","sequence":"additional","affiliation":[{"name":"Pathology Unit, Meyer Children\u2019s Hospital Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Vaglio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Experimental and Clinical Sciences \u201cMario Serio\u201d, University of Florence","place":["Florence, Italy"]},{"name":"Nephrology and Dialysis Unit, Meyer Children\u2019s Hospital Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-025-04214-9","article-title":"Looks like a neoplasm, belongs to amyloidosis, but is usually benign: localized amyloidosis. 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