{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:46:50Z","timestamp":1776919610707,"version":"3.51.2"},"reference-count":328,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ischemia\u2013reperfusion injury (IRI) induces secondary tissue damage following the restoration of blood flow. Currently, there is a lack of specific therapeutic interventions for IRI. Macrophage M1\/M2 polarization plays a pivotal role in the progression of IRI; however, integrated analyses of its dynamic changes and organ-specific characteristics remain insufficient. This review focuses on the critical role of macrophage M1\/M2 phenotypic balance in IRI, systematically elucidating the mechanisms underlying its dynamic regulation. It highlights, for the first time, the impact of metabolic reprogramming and mechanical signaling on polarization imbalance and provides a comprehensive analysis of the organ-specific features of macrophages in four common target organs of reperfusion injury (heart, brain, liver, and kidney). In terms of interventional strategies, cutting-edge approaches are emphasized, including epigenetic drugs, nanoparticle-based targeted delivery systems, and temporally sequenced combination therapies, to achieve precise temporal regulation from suppression of M1-mediated inflammation to promotion of M2-driven repair. In the future, integration of multi-omics and spatiotemporal dynamic analyses will be essential to construct organ-specific and stage-adaptive immune intervention frameworks, thereby advancing the treatment of IRI toward personalization and precision medicine.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1826087","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:22:00Z","timestamp":1776918120000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrophage polarization in ischemia\u2013reperfusion injury: from molecular mechanisms to therapeutic strategies"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaoyang","family":"Han","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shandong Second Medical University","place":["Weifang, China"]},{"name":"The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aili","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Du","sequence":"additional","affiliation":[{"name":"The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinzhou Medical University","place":["Jinzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Traditional Chinese Medicine University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Jinzhou Medical University","place":["Jinzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmin","family":"Guo","sequence":"additional","affiliation":[{"name":"The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Ma","sequence":"additional","affiliation":[{"name":"The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14191509","article-title":"Myocardial ischemia\/reperfusion injury: Molecular insights, forensic perspectives, and therapeutic horizons","volume":"14","author":"Fede","year":"2025","journal-title":"Cells"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0052-0","article-title":"Global epidemiology and outcomes of acute kidney injury","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.967115","article-title":"Preclinical multi-target strategies for myocardial ischemia-reperfusion injury","volume":"9","author":"Li","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/ccm.0b013e318168c4a4","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.52691","article-title":"Macrophage polarization and liver ischemia-reperfusion injury","volume":"18","author":"Wang","year":"2021","journal-title":"Int J Med Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s436560","article-title":"Macrophage heterogeneity and its impact on myocardial ischemia-reperfusion injury: An integrative review","volume":"16","author":"Xu","year":"2023","journal-title":"J Inflammation Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00380.2019","article-title":"Macrophage polarization in chronic kidney disease: A balancing act between renal recovery and decline","volume":"317","author":"Engel","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1642215","article-title":"Correction: Exosomes secreted by ATF3\/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1\/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfusion injury","volume":"16","author":"Tang","year":"2025","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020597","article-title":"Macrophage heterogeneity in the single-cell era: Facts and artifacts","volume":"142","author":"Hume","year":"2023","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7554\/elife.89377.4","article-title":"Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia","volume":"12","author":"Weinberger","year":"2024","journal-title":"Elife"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2025.02.003","article-title":"Macrophage-driven inflammation in acute kidney injury: Therapeutic opportunities and challenges","volume":"278","author":"Mu","year":"2025","journal-title":"Transl Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1038\/s41467-022-32284-2","article-title":"Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2(hi) macrophages in infarcted hearts","volume":"13","author":"Jung","year":"2022","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf7777","article-title":"Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles","volume":"7","author":"Dick","year":"2022","journal-title":"Sci Immunol"},{"key":"B15","doi-asserted-by":"crossref","DOI":"10.1017\/UPO9781922064004.019","article-title":"Pathophysiology of reperfusion injury","volume-title":"Mechanisms of vascular disease: A reference book for vascular specialists","author":"Cowled","year":"2011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102066","article-title":"Transcriptomics-based exploration of shared M1-type macrophage-related biomarker in acute kidney injury after kidney transplantation and acute rejection after kidney transplantation","volume":"85","author":"Pei","year":"2024","journal-title":"Transpl Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89679","article-title":"Early cytokine signatures of ischemia\/reperfusion injury in human orthotopic liver transplantation","volume":"1","author":"Sosa","year":"2016","journal-title":"JCI Insight"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/txd.0000000000001728","article-title":"Dynamics of ischemia\/reperfusion injury markers during normothermic liver machine perfusion","volume":"10","author":"Caballero-Marcos","year":"2024","journal-title":"Transplant Direct"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143961","article-title":"The role of M2 macrophages in the progression of chronic kidney disease following acute kidney injury","volume":"10","author":"Kim","year":"2015","journal-title":"PloS One"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.05.006","article-title":"Dynamic regulation and targeted interventions of macrophages in ischemia-reperfusion injury","volume":"80","author":"Lu","year":"2025","journal-title":"J Adv Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1161\/circulationaha.123.065506","article-title":"Targeting NPM1 epigenetically promotes postinfarction cardiac repair by reprogramming reparative macrophage metabolism","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020141","article-title":"Epigenetic regulation of macrophage polarization in cardiovascular diseases","volume":"16","author":"Komal","year":"2023","journal-title":"Pharm (Basel)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat Commun"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01252-8","article-title":"TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53","volume":"31","author":"Gong","year":"2024","journal-title":"Cell Death Differ"},{"key":"B26","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1038\/s41467-023-42502-0","article-title":"Organoids transplantation attenuates intestinal ischemia\/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6662156","article-title":"SS-31 protects liver from ischemia-reperfusion injury via modulating macrophage polarization","volume":"2021","author":"Shang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.12703\/p6-13","article-title":"The M1 and M2 paradigm of macrophage activation: Time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.016","article-title":"Tissue-specific signals control reversible program of localization and functional polarization of macrophages","volume":"157","author":"Okabe","year":"2014","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/jci59643","article-title":"Macrophage plasticity and polarization: In vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-023-01347-8","article-title":"ROS inhibition increases KDM6A-mediated NOX2 transcription and promotes macrophages oxidative stress and M1 polarization","volume":"28","author":"Zhao","year":"2023","journal-title":"Cell Stress Chaperones"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139687","article-title":"Cirsii Herba glycoprotein promotes macrophage M1 polarization through MAPK and NF-\u03baB signaling pathways via interaction with TLR4","volume":"296","author":"Zhao","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.brainresbull.2021.12.019","article-title":"M1 macrophages impair tight junctions between endothelial cells after spinal cord injury","volume":"180","author":"Luo","year":"2022","journal-title":"Brain Res Bull"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12162","article-title":"An optimized protocol for human M2 macrophages using M-CSF and IL-4\/IL-10\/TGF-\u03b2 yields a dominant immunosuppressive phenotype","volume":"79","author":"Mia","year":"2014","journal-title":"Scand J Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1269045","article-title":"SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization","volume":"16","author":"Wang","year":"2017","journal-title":"Cell Cycle"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105795","article-title":"Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis","volume":"75","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00615-2024","article-title":"Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarisation","volume":"65","author":"Kim","year":"2025","journal-title":"Eur Respir J"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05998","article-title":"Precisely regulating M2 subtype macrophages for renal fibrosis resolution","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"key":"B42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.3ru1018-378rr","article-title":"M2b macrophage polarization and its roles in diseases","volume":"106","author":"Wang","year":"2019","journal-title":"J Leukoc Biol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.7150\/thno.91180","article-title":"Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia\u2013reperfusion","volume":"14","author":"Shen","year":"2024","journal-title":"Theranostics"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s00395-018-0686-x","article-title":"Mapping macrophage polarization over the myocardial infarction time continuum","volume":"113","author":"Mouton","year":"2018","journal-title":"Basic Res Cardiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12974-020-01921-2","article-title":"FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia\/macrophages","volume":"17","author":"Wang","year":"2020","journal-title":"J Neuroinflamm"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N Engl J Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J Inflammation Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1600596","article-title":"Involvement of role of HMGB1-NLRP3 pathway in systemic disorders","volume":"13","author":"Yang","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9029327","article-title":"HIF1\u03b1-induced glycolysis metabolism is essential to the activation of inflammatory macrophages","volume":"2017","author":"Wang","year":"2017","journal-title":"Mediators Inflammation"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816952","article-title":"Photobiomodulation attenuates neurotoxic polarization of macrophages by inhibiting the Notch1-HIF-1\u03b1\/NF-\u03baB signalling pathway in mice with spinal cord injury","volume":"13","author":"Ma","year":"2022","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.934299","article-title":"Macrophages in renal injury, repair, fibrosis following acute kidney injury and targeted therapy","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000366130","article-title":"IL-10 deficiency increases renal ischemia-reperfusion injury","volume":"128","author":"Wan","year":"2014","journal-title":"Nephron Exp Nephrol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2253","article-title":"Shaping gene expression in activated and resting primary macrophages by IL-10","volume":"169","author":"Lang","year":"2002","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.04.016","article-title":"The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-\u03baB family activation","volume":"106","author":"Wang","year":"2024","journal-title":"Kidney Int"},{"key":"B62","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s516001","article-title":"Macrophage polarization in myocardial ischemia\u2013reperfusion injury: pathophysiology and therapeutic targets","volume":"19","author":"Liu","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2016.09.009","article-title":"CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis","volume":"182","author":"Murakami","year":"2016","journal-title":"Vet Immunol Immunopathol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.046","article-title":"mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation","volume":"12","author":"Moon","year":"2015","journal-title":"Cell Rep"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1172\/jci76468","article-title":"NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation","volume":"125","author":"Xu","year":"2015","journal-title":"J Clin Invest"},{"key":"B67","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.yjmcc.2021.06.004","article-title":"The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia","volume":"159","author":"Chen","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111389","article-title":"The role of inflammasome-dependent and inflammasome-independent NLRP3 in the kidney","volume":"8","author":"Kim","year":"2019","journal-title":"Cells"},{"key":"B69","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.immuni.2018.04.032","article-title":"The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation","volume":"49","author":"Di","year":"2018","journal-title":"Immunity"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1177\/15353702221080130","article-title":"Macrophage polarization in hypoxia and ischemia\/reperfusion: insights into the role of energetic metabolism","volume":"247","author":"Yakupova","year":"2022","journal-title":"Exp Biol Med (Maywood)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"19589","DOI":"10.1038\/s41598-023-46237-2","article-title":"IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages","volume":"13","author":"Scott","year":"2023","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.119.13469","article-title":"Targeted VEGF (vascular endothelial growth factor) therapy induces long-term renal recovery in chronic kidney disease via macrophage polarization","volume":"74","author":"Engel","year":"2019","journal-title":"Hypertension"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155497","article-title":"Targeting of CD163(+) macrophages in inflammatory and Malignant diseases","volume":"21","author":"Skytthe","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113310","article-title":"Nrf2 inhibits M1 macrophage polarization to ameliorate renal ischemia-reperfusion injury through antagonizing NF-\u03baB signaling","volume":"143","author":"Han","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1155\/cdr\/8856808","article-title":"Antagonizing CCR2 with propagermanium leads to altered distribution of macrophage subsets and favorable tissue remodeling after myocardial infarction in mice","volume":"2025","author":"Weipert","year":"2025","journal-title":"Cardiovasc Ther"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031542","article-title":"Molecular mechanisms of kidney injury and repair","volume":"23","author":"Rayego-Mateos","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.09.008","article-title":"CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury","volume":"32","author":"Shen","year":"2024","journal-title":"Mol Ther"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr4894","article-title":"The P2X7R\/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk","volume":"11","author":"Gao","year":"2025","journal-title":"Sci Adv"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0734-5","article-title":"Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis","volume":"38","author":"Torres-Hernandez","year":"2019","journal-title":"Oncogene"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234038","article-title":"Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis","volume":"15","author":"Baeza-Raja","year":"2020","journal-title":"PloS One"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00245.2014","article-title":"P2X7 receptor inhibition protects against ischemic acute kidney injury in mice","volume":"308","author":"Yan","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s12035-020-02187-8","article-title":"Correction to: Suppression of TLR4\/NF-\u03baB signaling pathway improves cerebral ischemia-reperfusion injury in rats","volume":"58","author":"Zhao","year":"2021","journal-title":"Mol Neurobiol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2022.00055","article-title":"VSIG4 regulates macrophages polarization and alleviates inflammation through activating PI3K\/AKT and inhibiting TLR4\/NF-\u03baB pathway in myocardial ischemia-reperfusion injury rats","volume":"109","author":"Wang","year":"2022","journal-title":"Physiol Int"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01467-2","article-title":"New insights and novel therapeutic potentials for macrophages in myocardial infarction","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.34067\/kid.0000000000000376","article-title":"Macrophage ontogeny, phenotype, and function in ischemia reperfusion-induced injury and repair","volume":"5","author":"Maryam","year":"2024","journal-title":"Kidney360"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.314028","article-title":"Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ Res"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00553-6","article-title":"Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury","volume":"3","author":"Kadyrov","year":"2024","journal-title":"Nat Cardiovasc Res"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3390\/life14080981","article-title":"Myeloid cells in myocardial ischemic injury: the role of the macrophage migration inhibitory factor","volume":"14","author":"Wang","year":"2024","journal-title":"Life (Basel)"},{"key":"B92","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrneph.2014.180","article-title":"Immune cells in experimental acute kidney injury","volume":"11","author":"Jang","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1172\/jci31008","article-title":"TLR4 activation mediates kidney ischemia\/reperfusion injury","volume":"117","author":"Wu","year":"2007","journal-title":"J Clin Invest"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763760","article-title":"Nrf2 promotes inflammation in early myocardial ischemia-reperfusion via recruitment and activation of macrophages","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1358\/dnp.2004.17.2.829042","article-title":"NF-kappaB and reperfusion injury","volume":"17","author":"Nichols","year":"2004","journal-title":"Drug News Perspect"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"Glass","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14020213","article-title":"Molecular insights into ischemia-reperfusion injury in coronary artery disease: mechanisms and therapeutic implications: a comprehensive review","volume":"14","author":"Ghanta","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.07.031","article-title":"NF\u03baB promotes oxidative stress-induced necrosis and ischemia\/reperfusion injury by inhibiting Nrf2-ARE pathway","volume":"159","author":"Guo","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2021.1894624","article-title":"Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses","volume":"31","author":"Wang","year":"2021","journal-title":"Toxicol Mech Methods"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2020.1836191","article-title":"Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice","volume":"43","author":"Farooqui","year":"2021","journal-title":"Clin Exp Hypertens"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5666","article-title":"RP105 exerts hepatoprotective effects in sepsis by modulating the SOCS2\/JAK2\/STAT3 signaling pathway","volume":"56","author":"Deng","year":"2025","journal-title":"Int J Mol Med"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.349","article-title":"Signaling pathways in macrophages: molecular mechanisms and therapeutic targets","volume":"4","author":"Li","year":"2023","journal-title":"MedComm (2020)"},{"key":"B106","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13075-022-02960-1","article-title":"Augmented PFKFB3-mediated glycolysis by interferon-\u03b3 promotes inflammatory M1 polarization through the JAK2\/STAT1 pathway in local vascular inflammation in Takayasu arteritis","volume":"24","author":"Chen","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/ni828","article-title":"Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation","volume":"3","author":"Hu","year":"2002","journal-title":"Nat Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.020","article-title":"IL-4\/IL-13-mediated polarization of renal macrophages\/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury","volume":"91","author":"Zhang","year":"2017","journal-title":"Kidney Int"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00004.2018","article-title":"STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury","volume":"316","author":"Kemmner","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez165","article-title":"Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K\/Akt\/STAT6 pathway","volume":"58","author":"Liu","year":"2019","journal-title":"Rheumatol (Oxford)"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114253","article-title":"Protective role for kidney TREM2(high) macrophages in obesity- and diabetes-induced kidney injury","volume":"43","author":"Subramanian","year":"2024","journal-title":"Cell Rep"},{"key":"B112","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41419-024-06756-w","article-title":"TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice","volume":"15","author":"Cui","year":"2024","journal-title":"Cell Death Dis"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136345","article-title":"High-molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury","volume":"5","author":"Wang","year":"2020","journal-title":"JCI Insight"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m116.746339","article-title":"Benzyl isothiocyanate (BITC) induces reactive oxygen species-dependent repression of STAT3 protein by down-regulation of specificity proteins in pancreatic cancer","volume":"291","author":"Kasiappan","year":"2016","journal-title":"J Biol Chem"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq7307","article-title":"Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion","volume":"11","author":"Zotta","year":"2025","journal-title":"Sci Adv"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119038109","article-title":"Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization","volume":"109","author":"Arranz","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt signaling pathway in macrophage activation and M1\/M2 polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J Immunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.08.012","article-title":"The TSC-mTOR signaling pathway regulates the innate inflammatory response","volume":"29","author":"Weichhart","year":"2008","journal-title":"Immunity"},{"key":"B120","doi-asserted-by":"publisher","first-page":"14050","DOI":"10.1038\/s41598-019-50320-y","article-title":"mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis","volume":"9","author":"Haloul","year":"2019","journal-title":"Sci Rep"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14208","article-title":"mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis","volume":"8","author":"Hallowell","year":"2017","journal-title":"Nat Commun"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124164","article-title":"Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis","volume":"4","author":"Katholnig","year":"2019","journal-title":"JCI Insight"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172916","article-title":"Salvianolic acid B regulates macrophage polarization in ischemic\/reperfused hearts by inhibiting mTORC1-induced glycolysis","volume":"871","author":"Zhao","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600495r","article-title":"mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type","volume":"30","author":"Li","year":"2016","journal-title":"FASEB J"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.016","article-title":"Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation","volume":"45","author":"Huang","year":"2016","journal-title":"Immunity"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1662308","article-title":"Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK","volume":"22","author":"Dan","year":"2008","journal-title":"Genes Dev"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302909","article-title":"Retinal microenvironment-protected rhein-GFFYE nanofibers attenuate retinal ischemia-reperfusion injury via inhibiting oxidative stress and regulating microglial\/macrophage M1\/M2 polarization","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2304","article-title":"Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization","volume":"13","author":"Xu","year":"2012","journal-title":"Nat Immunol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3109\/0886022x.2011.553979","article-title":"Notch2\/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the \u03b3-secretase inhibitor DAPT has a nephroprotective effect","volume":"33","author":"Huang","year":"2011","journal-title":"Ren Fail"},{"key":"B130","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12964-022-00901-8","article-title":"Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of \u03b2-catenin signaling in liver ischemia and reperfusion injury","volume":"20","author":"Xu","year":"2022","journal-title":"Cell Commun Signal"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078128","article-title":"M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis","volume":"8","author":"Cos\u00edn-Roger","year":"2013","journal-title":"PloS One"},{"key":"B132","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2667","article-title":"Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease","volume":"18","author":"Boulter","year":"2012","journal-title":"Nat Med"},{"key":"B134","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41467-020-14700-7","article-title":"Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients","volume":"11","author":"Fendler","year":"2020","journal-title":"Nat Commun"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-020-00072-2","article-title":"The interaction of Notch and Wnt signaling pathways in vertebrate regeneration","volume":"10","author":"Gao","year":"2021","journal-title":"Cell Regener"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115784","article-title":"STING deficiency alleviates ischemia-reperfusion injury via JAK2\/STAT3-mediated macrophage polarization and autophagy","volume":"168","author":"Zhang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41420-023-01636-2","article-title":"PGC-1\u03b1 inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.745425","article-title":"Riclinoctaose attenuates renal ischemia-reperfusion injury by the regulation of macrophage polarization","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Pharmacol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-021-01153-4","article-title":"The innate immune system in human kidney inflammaging","volume":"35","author":"Sepe","year":"2022","journal-title":"J Nephrol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000225404.51320.82","article-title":"HMGB1 signals through toll-like receptor (TLR) 4 and TLR2","volume":"26","author":"Yu","year":"2006","journal-title":"Shock"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt091","article-title":"The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury","volume":"99","author":"Sandanger","year":"2013","journal-title":"Cardiovasc Res"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.009","article-title":"The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice","volume":"92","author":"Franke","year":"2021","journal-title":"Brain Behav Immun"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7115","article-title":"Cutting edge: TLR4 activation mediates liver ischemia\/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway","volume":"173","author":"Zhai","year":"2004","journal-title":"J Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.1","article-title":"Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination","volume":"24","author":"Liu","year":"2017","journal-title":"Cell Death Differ"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030447","article-title":"Inhibition of STAT6 activation by AS1517499 inhibits expression and activity of PPAR\u03b3 in macrophages to resolve acute inflammation in mice","volume":"12","author":"Lee","year":"2022","journal-title":"Biomolecules"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u03b2 secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat Commun"},{"key":"B148","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41419-020-03384-y","article-title":"P2X7 receptor signaling promotes inflammation in renal parenchymal cells suffering from ischemia-reperfusion injury","volume":"12","author":"Qian","year":"2021","journal-title":"Cell Death Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.04.013","article-title":"Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle\/Syk\/NF-\u03baB signaling","volume":"104","author":"Li","year":"2023","journal-title":"Kidney Int"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2749","article-title":"Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain","volume":"18","author":"Shichita","year":"2012","journal-title":"Nat Med"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010402","article-title":"COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK\/NF-\u03baB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis","volume":"16","author":"Zhao","year":"2022","journal-title":"PloS NeglTrop Dis"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11991","article-title":"HIF-1\u03b1 in myocardial ischemia-reperfusion injury (Review)","volume":"23","author":"Zheng","year":"2021","journal-title":"Mol Med Rep"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1097\/hc9.0000000000000399","article-title":"ER stress promotes mitochondrial calcium overload and activates the ROS\/NLRP3 axis to mediate fatty liver ischemic injury","volume":"8","author":"Li","year":"2024","journal-title":"Hepatol Commun"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030306","article-title":"Deciphering the role of heme oxygenase-1 (HO-1) expressing macrophages in renal ischemia-reperfusion injury","volume":"9","author":"Rossi","year":"2021","journal-title":"Biomedicines"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.500","article-title":"The chemokine receptors CCR2 and CX3CR1 mediate monocyte\/macrophage trafficking in kidney ischemia-reperfusion injury","volume":"74","author":"Li","year":"2008","journal-title":"Kidney Int"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073485","article-title":"The role of CCL2\/CCR2 axis in cerebral ischemia-reperfusion injury and treatment: From animal experiments to clinical trials","volume":"23","author":"Geng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B159","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/jir.2023.0132","article-title":"C-C motif chemokine 2 regulates macrophage polarization and contributes to myocardial infarction healing","volume":"44","author":"Chen","year":"2024","journal-title":"J Interferon Cytokine Res"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000089563.63641.a8","article-title":"CCR2 signaling contributes to ischemia-reperfusion injury in kidney","volume":"14","author":"Furuichi","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1159\/000514913","article-title":"The role of CXCL12 in kidney diseases: A friend or foe","volume":"7","author":"Song","year":"2021","journal-title":"Kidney Dis (Basel)"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2753-2","article-title":"Partners in crime: neutrophils and monocytes\/macrophages in inflammation and disease","volume":"371","author":"Prame Kumar","year":"2018","journal-title":"Cell Tissue Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22471","article-title":"Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia\/reperfusion in mice","volume":"48","author":"Kuboki","year":"2008","journal-title":"Hepatology"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1082078","article-title":"Cx3cr1 controls kidney resident macrophage heterogeneity","volume":"14","author":"Yashchenko","year":"2023","journal-title":"Front Immunol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front Immunol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.936167","article-title":"Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages","volume":"13","author":"Marrocco","year":"2022","journal-title":"Front Immunol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1042\/bj20111275","article-title":"The mitochondrial citrate carrier: a new player in inflammation","volume":"438","author":"Infantino","year":"2011","journal-title":"Biochem J"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00800-3","article-title":"Mitochondrial pyruvate carrier-mediated metabolism is dispensable for the classical activation of macrophages","volume":"5","author":"Ran","year":"2023","journal-title":"Nat Metab"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00141","article-title":"A role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation","volume":"9","author":"Williams","year":"2018","journal-title":"Front Immunol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2015.01.017","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1657","article-title":"Triggering the succinate receptor GPR91 on dendritic cells enhances immunity","volume":"9","author":"Rubic","year":"2008","journal-title":"Nat Immunol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109246","article-title":"Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1\/GPR91-mediated Gq signaling","volume":"35","author":"Trauelsen","year":"2021","journal-title":"Cell Rep"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0372-7","article-title":"SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity","volume":"20","author":"Keiran","year":"2019","journal-title":"Nat Immunol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1630310","article-title":"Succinate metabolism: underlying biological mechanisms and emerging therapeutic targets in inflammatory bowel disease","volume":"16","author":"Dai","year":"2025","journal-title":"Front Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4261-z","article-title":"SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes","volume":"60","author":"van Diepen","year":"2017","journal-title":"Diabetologia"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.01927-06","article-title":"Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells","volume":"27","author":"MacKenzie","year":"2007","journal-title":"Mol Cell Biol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-025-02290-9","article-title":"SUCNR1 deficiency alleviates liver ischemia-reperfusion injury by regulating Kupffer cell activation and polarization through the ERK\/NF-\u03baB pathway in mice","volume":"48","author":"Yang","year":"2025","journal-title":"Inflammation"},{"key":"B180","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.molcel.2019.10.023","article-title":"Cancer-derived succinate promotes macrophage polarization and cancer metastasis via succinate receptor","volume":"77","author":"Wu","year":"2020","journal-title":"Mol Cell"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231214255","article-title":"4-Octyl itaconate alleviates renal ischemia reperfusion injury by ameliorating endoplasmic reticulum stress via Nrf2 pathway","volume":"248","author":"Li","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31147","article-title":"Immune-responsive gene 1\/itaconate activates nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury","volume":"72","author":"Yi","year":"2020","journal-title":"Hepatology"},{"key":"B186","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411554","article-title":"4-Octyl itaconate alleviates myocardial ischemia-reperfusion injury through promoting angiogenesis via ERK signaling activation","volume":"12","author":"Yang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav7759","article-title":"A sweet alternative: maintaining M2 macrophage polarization","volume":"3","author":"Hamers","year":"2018","journal-title":"Sci Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052715","article-title":"Macrophage polarization in cardiac tissue repair following myocardial infarction","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00270","article-title":"Metabolic modulation in macrophage effector function","volume":"9","author":"Diskin","year":"2018","journal-title":"Front Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.840246","article-title":"Dihydronicotinamide riboside is a potent NAD(+) precursor promoting a pro-inflammatory phenotype in macrophages","volume":"13","author":"Chini","year":"2022","journal-title":"Front Immunol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00417.2009","article-title":"SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity","volume":"298","author":"Yoshizaki","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110654","article-title":"Vinpocetine alleviates intestinal ischemia\/reperfusion injury and enhances M2 macrophage polarization in rats: Role of SIRT1\/SOCS3\/STAT3 signaling pathway","volume":"122","author":"Elwany","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B194","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s40820-024-01455-9","article-title":"Nanomaterial-based repurposing of macrophage metabolism and its applications","volume":"16","author":"Meng","year":"2024","journal-title":"Nano Micro Lett"},{"key":"B195","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s13340-015-0213-3","article-title":"Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia","volume":"7","author":"Takikawa","year":"2016","journal-title":"Diabetol Int"},{"key":"B196","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s10020-025-01150-4","article-title":"Metrnl ameliorates myocardial ischemia-reperfusion injury by activating AMPK-mediated M2 macrophage polarization","volume":"31","author":"Chen","year":"2025","journal-title":"Mol Med"},{"key":"B197","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1186\/s12967-023-04772-6","article-title":"The role of AMPK in macrophage metabolism, function and polarisation","volume":"21","author":"Cui","year":"2023","journal-title":"J Transl Med"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.895028","article-title":"Nicotinamide mononucleotide administration triggers macrophages reprogramming and alleviates inflammation during sepsis induced by experimental peritonitis","volume":"9","author":"Cros","year":"2022","journal-title":"Front Mol Biosci"},{"key":"B199","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bbrc.2022.12.076","article-title":"USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization","volume":"646","author":"He","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.01.004","article-title":"Gut microbiota-derived glutamine attenuates liver ischemia\/reperfusion injury via macrophage metabolic reprogramming","volume":"15","author":"Lu","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3796","article-title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat Immunol"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.09.002","article-title":"Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation","volume":"1861","author":"Namgaladze","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109352","article-title":"The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages","volume":"113","author":"Zhu","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1159\/000517073","article-title":"Epigenetic modification drives acute kidney injury-to-chronic kidney disease progression","volume":"145","author":"Li","year":"2021","journal-title":"Nephron"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.08.060","article-title":"miR-155 aggravates liver ischemia\/reperfusion injury by suppressing SOCS1 in mice","volume":"50","author":"Tan","year":"2018","journal-title":"Transplant Proc"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000000061","article-title":"Knockdown of microRNA-155 in Kupffer cells results in immunosuppressive effects and prolongs survival of mouse liver allografts","volume":"97","author":"Li","year":"2014","journal-title":"Transplantation"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001765","article-title":"MicroRNA-155 deficiency in Kupffer cells ameliorates liver ischemia-reperfusion injury in mice","volume":"101","author":"Li","year":"2017","journal-title":"Transplantation"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.587693","article-title":"Exosomal microRNA-374b-5p from tubular epithelial cells promoted M1 macrophages activation and worsened renal ischemia\/reperfusion injury","volume":"8","author":"Ding","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13287-017-0599-x","article-title":"Bone mesenchymal stem cells ameliorate ischemia\/reperfusion-induced damage in renal epithelial cells via microRNA-223","volume":"8","author":"Yuan","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042971","article-title":"Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1\u03b2 production in macrophages by targeting STAT3","volume":"7","author":"Chen","year":"2012","journal-title":"PloS One"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161024965","article-title":"miR-223 inhibits lipid deposition and inflammation by suppressing Toll-like receptor 4 signaling in macrophages","volume":"16","author":"Wang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.246124","article-title":"Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4","volume":"286","author":"Li","year":"2011","journal-title":"J Biol Chem"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01222-3","article-title":"Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF\/CCL2\/CCR2 and phenotype switching","volume":"45","author":"Shen","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B214","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol Dis"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.897022","article-title":"The translational potential of microglia and monocyte-derived macrophages in ischemic stroke","volume":"13","author":"Wicks","year":"2022","journal-title":"Front Immunol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1002\/med.21952","article-title":"Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications","volume":"43","author":"Yin","year":"2023","journal-title":"Med Res Rev"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22851","article-title":"Hypoxia-inducible factor-1\u03b1 regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice","volume":"8","author":"Bok","year":"2017","journal-title":"Oncotarget"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1172\/jci189607","article-title":"Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice","volume":"135","author":"Pan","year":"2025","journal-title":"J Clin Invest"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.010","article-title":"Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation","volume":"182","author":"Corbitt","year":"2013","journal-title":"Am J Pathol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5767","article-title":"Intestinal ischemia and the gut-liver axis: an in vitro model","volume":"88","author":"Towfigh","year":"2000","journal-title":"J Surg Res"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.443","article-title":"Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress","volume":"7","author":"Vairappan","year":"2015","journal-title":"World J Hepatol"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.016","article-title":"A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis","volume":"79","author":"Chen","year":"2023","journal-title":"J Hepatol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16327","article-title":"TGR5\/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury","volume":"21","author":"Zhou","year":"2021","journal-title":"Am J Transplant"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13152","article-title":"Macrophages polarization in renal inflammation and fibrosis animal models (Review)","volume":"29","author":"Zeng","year":"2024","journal-title":"Mol Med Rep"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.05.028","article-title":"The novel potential therapeutic target PSMP\/MSMP promotes acute kidney injury via CCR2","volume":"32","author":"Song","year":"2024","journal-title":"Mol Ther"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00794","article-title":"The link between the mitochondrial fatty acid oxidation derangement and kidney injury","volume":"11","author":"Console","year":"2020","journal-title":"Front Physiol"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202510991","article-title":"Piezo1 upregulation in monocyte-derived macrophages impairs post-myocardial infarction cardiac repair via defective efferocytosis and enhanced ferroptosis","volume":"13","author":"Peng","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1149336","article-title":"Mechanosensitive Piezo1 protein as a novel regulator in macrophages and macrophage-mediated inflammatory diseases","volume":"14","author":"Tang","year":"2023","journal-title":"Front Immunol"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122832","article-title":"Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage","volume":"314","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.10.034","article-title":"Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques","volume":"89","author":"Seneviratne","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114566","article-title":"Shear stress induces monocyte\/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteins","volume":"161","author":"Son","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17314","article-title":"Plexin D1 mediates disturbed flow-induced M1 macrophage polarization in atherosclerosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Heliyon"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00383","article-title":"Shear and dynamic compression modulates the inflammatory phenotype of human monocytes in vitro","volume":"10","author":"Fahy","year":"2019","journal-title":"Front Immunol"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-024-03546-5","article-title":"Shear stress induces a time-dependent inflammatory response in human monocyte-derived macrophages","volume":"52","author":"Jui","year":"2024","journal-title":"Ann BioMed Eng"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13440","article-title":"Piezo1-mediated M2 macrophage mechanotransduction enhances bone formation through secretion and activation of transforming growth factor-\u03b21","volume":"56","author":"Cai","year":"2023","journal-title":"Cell Prolif"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200314r","article-title":"Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis","volume":"36","author":"Xu","year":"2022","journal-title":"FASEB J"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570195","article-title":"TRPV4 plays a role in matrix stiffness-induced macrophage polarization","volume":"11","author":"Dutta","year":"2020","journal-title":"Front Immunol"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13640","article-title":"Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis","volume":"57","author":"Mei","year":"2024","journal-title":"Cell Prolif"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg8138","article-title":"Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process","volume":"9","author":"Yan","year":"2023","journal-title":"Sci Adv"},{"key":"B241","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00018-022-04622-6","article-title":"Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation","volume":"79","author":"Foote","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.689397","article-title":"Crosstalk between CD11b and Piezo1 mediates macrophage responses to mechanical cues","volume":"12","author":"Atcha","year":"2021","journal-title":"Front Immunol"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp4726","article-title":"Acute contact with profibrotic macrophages mechanically activates fibroblasts via \u03b1v\u03b23 integrin-mediated engagement of Piezo1","volume":"10","author":"Ezzo","year":"2024","journal-title":"Sci Adv"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk6906","article-title":"Mechanosensing regulates tissue repair program in macrophages","volume":"10","author":"Meizlish","year":"2024","journal-title":"Sci Adv"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6871269","article-title":"Mechanical stretch promotes macrophage polarization and inflammation via the RhoA-ROCK\/NF-\u03baB pathway","volume":"2022","author":"Tu","year":"2022","journal-title":"BioMed Res Int"},{"key":"B246","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s11658-025-00764-0","article-title":"Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing","volume":"30","author":"Wei","year":"2025","journal-title":"Cell Mol Biol Lett"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01544-2023","article-title":"YAP\/TAZ are crucial regulators of macrophage-mediated pulmonary inflammation and fibrosis after bleomycin-induced injury","volume":"65","author":"Mia","year":"2025","journal-title":"Eur Respir J"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2313680","article-title":"M2 macrophages promote subconjunctival fibrosis through YAP\/TAZ signalling","volume":"56","author":"Wang","year":"2024","journal-title":"Ann Med"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613121113","article-title":"Flow-dependent YAP\/TAZ activities regulate endothelial phenotypes and atherosclerosis","volume":"113","author":"Wang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B250","doi-asserted-by":"publisher","first-page":"8582","DOI":"10.1038\/s41467-025-63581-1","article-title":"Mechano-crosstalk between living and artificial cells","volume":"16","author":"Yu","year":"2025","journal-title":"Nat Commun"},{"key":"B251","doi-asserted-by":"publisher","first-page":"114884","DOI":"10.1016\/j.celrep.2024.114180","article-title":"Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep"},{"key":"B252","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab"},{"key":"B253","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.115.305551","article-title":"HIF-1\u03b1 and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages","volume":"35","author":"Tawakol","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4307638","article-title":"Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP\/TEAD4\/ACADL axis in hepatocellular carcinoma","volume":"19","author":"Cai","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B256","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1038\/s41467-021-23240-7","article-title":"Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease","volume":"12","author":"Watt","year":"2021","journal-title":"Nat Commun"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304617","article-title":"Targeting YAP1-regulated glycolysis in fibroblast-like synoviocytes impairs macrophage infiltration to ameliorate diabetic osteoarthritis progression","volume":"11","author":"Yang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400283R","article-title":"Hypoxia activates macrophage-NLRP3 inflammasome promoting atherosclerosis via PFKFB3-driven glycolysis","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24044022","article-title":"Gsmtx4 alleviated osteoarthritis through Piezo1\/Calcineurin\/NFAT1 signaling axis under excessive mechanical strain","volume":"24","author":"Ren","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.121.17177","article-title":"Piezo1-mediated mechanotransduction promotes cardiac hypertrophy by impairing calcium homeostasis to activate calpain\/calcineurin signaling","volume":"78","author":"Zhang","year":"2021","journal-title":"Hypertension"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.188669","article-title":"Rapid cyclic stretching of cultured human visceral smooth muscle cells promotes a synthetic, proinflammatory phenotype","volume":"10","author":"Wolfson","year":"2025","journal-title":"JCI Insight"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.08.041","article-title":"Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transport","volume":"103","author":"Iyer","year":"2012","journal-title":"Biophys J"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00279.2018","article-title":"Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction","volume":"315","author":"Torres","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.08.050","article-title":"Effect of substrate stiffness on mechanical coupling and force propagation at the infarct boundary","volume":"115","author":"Nguyen","year":"2018","journal-title":"Biophys J"},{"key":"B265","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1096\/fj.04-2066fje","article-title":"Transmural stretch-dependent regulation of contractile properties in rat heart and its alteration after myocardial infarction","volume":"19","author":"Cazorla","year":"2005","journal-title":"FASEB J"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.002","article-title":"The effect of substrate stiffness on adult neural stem cell behavior","volume":"30","author":"Leipzig","year":"2009","journal-title":"Biomaterials"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100869","article-title":"Mechanobiology of portal hypertension","volume":"5","author":"Felli","year":"2023","journal-title":"JHEP Rep"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050118","article-title":"Immediate increase of portal pressure, reflecting sinusoidal shear stress, induced liver regeneration after partial hepatectomy","volume":"6","author":"Niiya","year":"1999","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.256.2.r501","article-title":"Structure and concentrating ability in the avian kidney","volume":"256","author":"Goldstein","year":"1989","journal-title":"Am J Physiol"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2024.2390455","article-title":"Sunitinib alleviates hepatic ischemia reperfusion injury by inhibiting the JAK2\/STAT pathway and promoting the M2 polarization of macrophages","volume":"46","author":"Li","year":"2024","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.52691","article-title":"Scutellarin alleviates renal ischemia-reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization","volume":"38","author":"Deng","year":"2024","journal-title":"FASEB J"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1463140","article-title":"Pharmacological effects and the related mechanism of scutellarin on inflammation-related diseases: a review","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Pharmacol"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202143","article-title":"Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK\/NLRP3 inflammasome pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182777","article-title":"Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes","volume":"12","author":"Wang","year":"2017","journal-title":"PloS One"},{"key":"B276","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2020.05.016","article-title":"Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages","volume":"145","author":"Fei","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.010","article-title":"PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties","volume":"6","author":"Bouhlel","year":"2007","journal-title":"Cell Metab"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.07.013","article-title":"Activation of PPAR\u03b3 by curcumin protects mice from ischemia\/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells","volume":"62","author":"Liu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i13.1953","article-title":"Protective effect of curcumin against liver warm ischemia\/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes","volume":"13","author":"Shen","year":"2007","journal-title":"World J Gastroenterol"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110294","article-title":"NAMPT inhibition reduces macrophage inflammation through the NAD+\/PARP1 pathway to attenuate liver ischemia-reperfusion injury","volume":"369","author":"Lu","year":"2023","journal-title":"Chem Biol Interact"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097378","article-title":"NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages","volume":"9","author":"Venter","year":"2014","journal-title":"PloS One"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900394rrr","article-title":"The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome","volume":"34","author":"Zhang","year":"2020","journal-title":"FASEB J"},{"key":"B284","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action","volume":"321","author":"Kim","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.5607\/en.2018.27.5.437","article-title":"HDAC3 inhibition promotes alternative activation of macrophages but does not affect functional recovery after spinal cord injury","volume":"27","author":"Sanchez","year":"2018","journal-title":"Exp Neurobiol"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30707","article-title":"p300\/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization","volume":"9","author":"Peng","year":"2019","journal-title":"Theranostics"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116231","article-title":"The effect of interleukin-10 immunotherapy on renal ischemia-reperfusion injury: a systematic review and meta-analysis of preclinical studies","volume":"25","author":"Prionas","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.898","article-title":"IL-38 attenuates myocardial ischemia-reperfusion injury by inhibiting macrophage inflammation","volume":"11","author":"Wei","year":"2023","journal-title":"Immun Inflammation Dis"},{"key":"B289","doi-asserted-by":"publisher","first-page":"39","DOI":"10.14715\/cmb\/2025.70.1.4","article-title":"IL-38 attenuates renal ischemia\/reperfusion injury through suppressing inflammation in mice","volume":"71","author":"Liang","year":"2025","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121534109","article-title":"IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist","volume":"109","author":"van de Veerdonk","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.11.006","article-title":"METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages","volume":"156","author":"Ushach","year":"2015","journal-title":"Clin Immunol"},{"key":"B292","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/s42255-020-0257-y","article-title":"Author correction: Meteorin-like facilitates skeletal muscle repair through a Stat3\/IGF-1 mechanism","volume":"2","author":"Baht","year":"2020","journal-title":"Nat Metab"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1906-16.2016","article-title":"Monocyte-derived macrophages modulate inflammation and promote long-term functional recovery in a mouse model of ischemia","volume":"36","author":"Kovacs-Litman","year":"2016","journal-title":"J Neurosci"},{"key":"B294","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1124\/mol.110.068064","article-title":"TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules","volume":"79","author":"Matsunaga","year":"2011","journal-title":"Mol Pharmacol"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26178643","article-title":"Anti-HMGB1 antibody therapy ameliorates spinal cord ischemia-reperfusion injury in rabbits","volume":"26","author":"Muraoka","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6389-x","article-title":"Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse","volume":"26","author":"Toldo","year":"2012","journal-title":"Cardiovasc Drugs Ther"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00651.x","article-title":"Administration of interleukin-1 receptor antagonist ameliorates renal ischemia-reperfusion injury","volume":"21","author":"Rusai","year":"2008","journal-title":"Transpl Int"},{"key":"B298","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/00005392-199907000-00068","article-title":"Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury","volume":"162","author":"Donnahoo","year":"1999","journal-title":"J Urol"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108024","article-title":"Etanercept attenuates myocardial ischemia\/reperfusion injury by decreasing inflammation and oxidative stress","volume":"9","author":"Yang","year":"2014","journal-title":"PloS One"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2025.06.066","article-title":"CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion","volume":"121","author":"Noonan","year":"2025","journal-title":"Cardiovasc Res"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.637335","article-title":"TSC1 affects the process of renal ischemia-reperfusion injury by controlling macrophage polarization","volume":"12","author":"Hu","year":"2021","journal-title":"Front Immunol"},{"key":"B302","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.21037\/atm-21-3557","article-title":"Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after myocardial reperfusion injury","volume":"9","author":"Shen","year":"2021","journal-title":"Ann Transl Med"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1456855","article-title":"Canine mesenchymal stem cell-derived exosomes attenuate renal ischemia-reperfusion injury through miR-146a-regulated macrophage polarization","volume":"11","author":"Liu","year":"2024","journal-title":"Front Vet Sci"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1038\/srep38308","article-title":"Human mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE(2)-dependent mechanism","volume":"6","author":"Vasandan","year":"2016","journal-title":"Sci Rep"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5181241","article-title":"Peripheral blood-derived mesenchymal stem cells modulate macrophage plasticity through the IL-10\/STAT3 pathway","volume":"2022","author":"Pang","year":"2022","journal-title":"Stem Cells Int"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.189","article-title":"Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation","volume":"20","author":"Fran\u00e7ois","year":"2012","journal-title":"Mol Ther"},{"key":"B307","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s13287-022-03075-9","article-title":"Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia\/reperfusion-induced acute kidney injury by regulating macrophages polarization","volume":"13","author":"Xie","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2022.2090261","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate diffuse alveolar hemorrhage associated with systemic lupus erythematosus in mice by promoting M2 macrophage polarization via the microRNA-146a-5p\/NOTCH1 axis","volume":"51","author":"Chen","year":"2022","journal-title":"Immunol Invest"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz040","article-title":"Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization","volume":"115","author":"Zhao","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1563427","article-title":"Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases","volume":"13","author":"Zubair","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2008111160","article-title":"Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury","volume":"20","author":"Kinsey","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15005","article-title":"Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury","volume":"24","author":"Mao","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.10.029","article-title":"Imaging-based analysis of liposome internalization to macrophage cells: Effects of liposome size and surface modification with PEG moiety","volume":"136","author":"Lee","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2002.tb00121.x","article-title":"ROCK inhibitor Y-27632 prevents primary graft non-function caused by warm ischemia\/reperfusion in rat liver transplantation","volume":"15","author":"Mizunuma","year":"2002","journal-title":"Transpl Int"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124960","article-title":"Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury","volume":"668","author":"Cao","year":"2025","journal-title":"Int J Pharm"},{"key":"B316","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12951-025-03172-w","article-title":"Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury","volume":"23","author":"Jiang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"B317","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12951-018-0382-x","article-title":"Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis","volume":"16","author":"Duan","year":"2018","journal-title":"J Nanobiotechnology"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1039\/d5nr00808e","article-title":"Upholding hyaluronic acid\u2019s multi-functionality for nucleic acid drug delivery to target EMT in breast cancer","volume":"17","author":"Isert","year":"2025","journal-title":"Nanoscale"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.05.017","article-title":"An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury","volume":"28","author":"Zhang","year":"2023","journal-title":"Bioact Mater"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6108","article-title":"Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles","volume":"6","author":"Zhuang","year":"2020","journal-title":"Sci Adv"},{"key":"B321","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.actbio.2025.02.061","article-title":"Neutrophil-like cell membrane-coated metal-organic frameworks for siRNA delivery targeting NOX4 to alleviate oxidative stress in acute ischemic injury","volume":"196","author":"Wang","year":"2025","journal-title":"Acta Biomater"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s253125","article-title":"Macrophage membrane-coated nanoparticles alleviate hepatic ischemia-reperfusion injury caused by orthotopic liver transplantation by neutralizing endotoxin","volume":"15","author":"Ou","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114159","article-title":"Biomimetic nanoplatform treats myocardial ischemia\/reperfusion injury by synergistically promoting angiogenesis and inhibiting inflammation","volume":"243","author":"Lei","year":"2024","journal-title":"Colloids Surf B Biointerfaces"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.11.041","article-title":"Black phosphorus nanoplatform coated with platelet membrane improves inhibition of atherosclerosis progression through macrophage targeting and efferocytosis","volume":"192","author":"Zhang","year":"2025","journal-title":"Acta Biomater"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.03.005","article-title":"Macrophages, dendritic cells, and kidney ischemia-reperfusion injury","volume":"30","author":"Li","year":"2010","journal-title":"Semin Nephrol"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228549","article-title":"Review: Ischemia reperfusion injury-a translational perspective in organ transplantation","volume":"21","author":"Fern\u00e1ndez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111370","article-title":"Advances in macrophage metabolic reprogramming in myocardial ischemia-reperfusion","volume":"123","author":"Ao-Di","year":"2024","journal-title":"Cell Signal"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.155940","article-title":"Toll-like receptors in kidney ischemia-reperfusion injury: Modulating macrophage responses for therapeutic insights","volume":"269","author":"Malathi","year":"2025","journal-title":"Pathol Res Pract"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1826087\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:22:04Z","timestamp":1776918124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1826087\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":328,"alternative-id":["10.3389\/fimmu.2026.1826087"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1826087","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"article-number":"1826087"}}