{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:57:21Z","timestamp":1781672241512,"version":"3.54.5"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032554","name":"Peking University Shenzhen Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with systemic lupus erythematosus (SLE) often develop age-related adverse outcomes at a young age, raising the possibility that immune-aging processes may interact with chronic immune activation, treatment exposure, and accumulated damage in shaping long-term disease burden. Although immune-age acceleration has also been reported in rheumatoid arthritis and chronic viral infections (e.g., HIV\/CMV), SLE is particularly well suited as a human model of inflammation-driven immune aging because of its typical onset in young women and the convergence of aging signatures across clinical, cellular, and molecular levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>This review synthesizes evidence for accelerated immunosenescence in SLE across systemic manifestations, immune cell remodeling, and molecular senescence markers. Clinically, SLE is linked to premature cardiovascular disease, frailty, cognitive impairment, severe infections, and reduced vaccine responsiveness. Immunologically, senescent-like immune subsets (including terminally differentiated T cells, age-associated\/double-negative B cells, dysfunctional NK cells, and senescence-like myeloid cells) expand prematurely. Molecular features include inflammaging-like cytokine patterns, telomere attrition, and epigenetic age acceleration. We also discuss a translational framework for quantifying immunosenescence using immunophenotyping, telomere\/epigenetic clocks, and composite immune clocks, with potential applications in risk stratification, treatment decisions, and monitoring immune-reprogramming strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Accelerated immunosenescence provides a biologically plausible and clinically relevant framework for understanding SLE heterogeneity across systemic, cellular, and molecular levels. However, immune-aging measures should currently be regarded as candidate research biomarkers rather than validated clinical decision tools. Prospective SLE-specific studies are needed to establish their predictive value, disease specificity, and clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1830804","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:44:01Z","timestamp":1781671441000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerated immunosenescence in SLE: current evidence and clinical translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Qingshuang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking University Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]},{"name":"Department of Experimental Research, South China Hospital, Medical School, Shenzhen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41392-025-02168-0","article-title":"Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics","volume":"10","author":"Dai","year":"2025","journal-title":"Signal Transduction Targeted Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223035","article-title":"Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study","volume":"82","author":"Tian","year":"2023","journal-title":"Ann Rheumatic Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101893","article-title":"Systemic lupus erythematosus and damage: what has changed over the past 20 years","volume":"37","author":"Mu\u00f1oz-Grajales","year":"2023","journal-title":"Best 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