{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:06:58Z","timestamp":1789020418482,"version":"build-2803163510"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A 28-year-old Chinese woman with human leukocyte antigen (HLA)-B27-positive ankylosing spondylitis (AS) for 5 years experienced recurrent left-eye blurred vision and redness for 4 years (2\u20133 episodes\/year). This was previously attributed to AS without etiologic testing. Her father and brother had AS but without ocular involvement. The patient received no systemic disease-modifying therapy for AS throughout her clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ophthalmic examinations [visual acuity, intraocular pressure (IOP), slit-lamp, and dilated fundus] and 100-\u00b5L left-eye aqueous humor testing [via paracentesis: varicella-zoster virus (VZV) immunoglobulin G (IgG), Goldmann\u2013Witmer coefficient (GWC), and herpes simplex virus (HSV)-1\/2\/cytomegalovirus (CMV) antibodies\/DNA] were performed. Targeted stepwise topical anti-inflammatory and IOP-lowering regimens were administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the left eye, the following were observed: 20\/30 visual acuity, 36-mmHg IOP, mutton fat keratic precipitates (KP), and iris atrophy. Findings for the right eye: were normal. Aqueous testing revealed elevated VZV IgG (1,227.02 U\/mL) and a positive GWC (114.03), whereas HSV\/CMV markers were negative. After treatment, visual acuity in the left eye improved to 20\/20, IOP normalized, and symptoms resolved. No corneal sensation assessment was performed at any visit, and the patient denied any subjective corneal sensory discomfort during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Defaulting to AS-related uveitis in HLA-B27-positive patients should be avoided, and aqueous testing is recommended because it enables targeted management. Clinicians should adopt rational, stepped topical hypotensive combination therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1831499","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:31:52Z","timestamp":1789018312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent unilateral anterior uveitis in an HLA-B27-positive ankylosing spondylitis patient: varicella-zoster virus etiology case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Xuan","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, Sichuan, China"]},{"name":"Medical School of Ophthalmology and Optometry, North Sichuan Medical College","place":["Nanchong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, Sichuan, China"]},{"name":"Medical School of Ophthalmology and Optometry, North Sichuan Medical College","place":["Nanchong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Fan","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen Eye Center, Xiamen Research Center for Eye Diseases and Key Laboratory of Ophthalmology, Xiamen University","place":["Xiamen, Fujian, China"]},{"name":"Department of Ophthalmology, Shenzhen People\u2019s Hospital (The First Affiliated Hospital, Southern University of Science and Technology)","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075754","article-title":"Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review","volume":"67","author":"Zeboulon","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.003","article-title":"Acute anterior uveitis and HLA-B27","volume":"50","author":"Chang","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2023.2165113","article-title":"Diagnosis, treatment, and prevention of noninfectious acute anterior uveitis with or without human leukocyte antigen B27 in adults - 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