{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:05:15Z","timestamp":1779433515317,"version":"3.53.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    <jats:italic>Gata2<\/jats:italic>\n                    is indispensable for hematopoiesis, with knockout mice typically exhibiting embryonic lethality attributed to severe anemia and defective hematopoietic stem cell (HSC) development. Intriguingly, we obtained viable adult\n                    <jats:italic>\n                      Gata2\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    mice harboring a 17-nucleotide deletion in exon 2, which displayed intact T-cell development despite a significantly reduced bone marrow HSC pool. While mutant HSCs exhibited attenuated lymphoid potential, they retained partial myeloid reconstitution capacity. Single-cell transcriptomic analysis revealed compensatory upregulation of key hematopoietic regulators, including\n                    <jats:italic>Fos<\/jats:italic>\n                    and\n                    <jats:italic>Klf6<\/jats:italic>\n                    , in\n                    <jats:italic>Gata2<\/jats:italic>\n                    -deficient HSCs. Comprehensive profiling further demonstrated preservation of the complete T-cell hierarchy, including all major subsets, in\n                    <jats:italic>Gata2<\/jats:italic>\n                    mutant mice. These findings provide evidence that\n                    <jats:italic>Gata2<\/jats:italic>\n                    knockout mice may be viable, and T-cell development may proceed independently of definitive hematopoiesis.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1832484","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:10:23Z","timestamp":1779430223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Viable Gata2 deficient mice exhibit T cell development independent of adult definitive hematopoiesis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuhang","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Second Provincial General Hospital, Jinan University","place":["Guangzhou, Guangdong, 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