{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:10:14Z","timestamp":1779253814102,"version":"3.51.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trained immunity provides a framework for understanding persistent innate immune reprogramming in chronic inflammatory and immune-mediated disorders. Its relationship with osteoimmunology and inflammatory bone disease, however, remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a bibliometric and literature-level text-mining analysis using WoSCC as the primary source for formal bibliometric analyses. A two-corpus design was used, with a core corpus for disease-focused bibliometric analysis and an extended corpus for semantic screening and sensitivity analyses. Scopus and PubMed were queried independently for cross-database comparison. Topic modeling, TF-IDF-based semantic screening, disease-context analysis, and bridge-network mapping were used to summarize literature-level patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The core corpus included 83 records, and the extended corpus included 301 records. Within the full-year 2013\u20132025 comparison window, publication output increased over time and reached its highest level in 2025. Cross-database comparison showed broadly concordant publication trends and substantial DOI-level overlap across WoSCC, Scopus, and PubMed. Periodontitis was the most prominent disease context, whereas osteoarthritis, ankylosing spondylitis, osteoporosis, and inflammatory arthritis also appeared in the disease-context mapping. Across bibliometric, semantic, and mapping analyses, recurrent literature-level patterns involved myeloid-cell reprogramming, epigenetic and metabolic remodeling, macrophage- and monocyte-associated terms, myelopoiesis, innate immune signaling, and osteoclast-related pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Research on trained immunity in inflammatory bone disease remains relatively small but is expanding. Current literature most consistently connects trained-immunity-related concepts with myeloid reprogramming, immunometabolic and epigenetic processes, periodontitis, and inflammatory bone remodeling. These findings provide a structured literature-level overview of an emerging field and may help guide future mechanistic, experimental, and translational studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1832996","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:47:49Z","timestamp":1779252469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Trained immunity in inflammatory bone disease: a bibliometric and literature-level text-mining analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Zihang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University","place":["Shijiazhuang, China"]},{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.09.005","article-title":"Trained innate immunity: concept, nomenclature, and future 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