{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:36Z","timestamp":1783660416498,"version":"3.55.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>A 37-year-old non-Caucasian woman presented with a 2-year history of pruritic, concentric erythematous plaques refractory to multiple topical and systemic therapies. The clinical findings were highly suggestive of erythema gyratum repens (EGR), a rare figurate dermatosis classically associated with paraneoplastic syndromes. Routine laboratory investigations and an autoantibody panel were unremarkable, except for a significantly elevated CA-125 level. A targeted gynecological assessment, prompted by a chronic history of pelvic pain and menorrhagia, identified severe adenomyosis with concomitant endometriosis. Given the severity of her symptoms, the patient underwent a total hysterectomy. Following surgery, the cutaneous eruption resolved completely within 2 months without additional dermatologic intervention. This case broadens the spectrum of non-paraneoplastic conditions associated with EGR and suggests that such eruptions may arise within the context of chronic inflammatory gynecological disease. Clinicians should remain aware of both paraneoplastic and non-paraneoplastic etiologies in patients presenting with EGR to ensure accurate diagnosis, appropriate malignancy screening, and tailored management.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1835278","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:24:08Z","timestamp":1783657448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Erythema gyratum repens associated with adenomyosis and endometriosis: an immunological twist?"],"prefix":"10.3389","volume":"17","author":[{"given":"Emanuele","family":"Scala","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Sordi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlind","family":"Kalaja","sequence":"additional","affiliation":[{"name":"Dermatological Department, Ospedale Guglielmo da Saliceto","place":["Piacenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Francesconi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14450","article-title":"Figurate erythemas - update and diagnostic approach","volume":"19","author":"Boehner","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1590\/s0365-05962013000100001","article-title":"Paraneoplastic cutaneous manifestations: concepts and updates","volume":"88","author":"Silva","year":"2013","journal-title":"Bras Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04663.x","article-title":"Erythema gyratum repens is not an obligate paraneoplastic disease: a systematic review of the literature and personal experience","volume":"28","author":"Rongioletti","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1001\/archderm.1952.01530290070010","article-title":"Erythema gyratum repens; skin manifestations in patient with carcinoma of breast","volume":"66","author":"Gammel","year":"1952","journal-title":"AMA Arch Derm Syphilol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02433.x","article-title":"A curious eruption: erythema gyratum repens in resolving pustular psoriasis","volume":"22","author":"Verma","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03457.x","article-title":"Erythema gyratum repens, not always a bad omen for patients","volume":"24","author":"Demonchy","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03861.x","article-title":"Erythema gyratum repens associated with pityriasis rubra pilaris","volume":"36","author":"Almaani","year":"2011","journal-title":"Clin Exp Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.03.012","article-title":"Response to \u201cTransformationfrom pityriasis rubra pilaris to erythema gyratum repens-likeeruption without associated Malignancy: A report of 2 cases","volume":"5","author":"Ridge","year":"2019","journal-title":"JAAD Case Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4103\/0378-6323.90974","article-title":"Erythema gyratum repens and rheumatoid arthritis: an unrecognized association","volume":"78","author":"Lo Schiavo","year":"2012","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb06543.x","article-title":"Erythema gyratum repens with pulmonary tuberculosis","volume":"98","author":"Barber","year":"1978","journal-title":"Br J Dermatol"},{"key":"B11","first-page":"759","article-title":"Erythema gyratum repens. 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