{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:06:13Z","timestamp":1777633573523,"version":"3.51.4"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic inflammation plays a central role in the development of multi-organ diseases. Post-cardiac arrest syndrome (PCAS) is increasingly recognized as a systemic inflammatory condition characterized by myocardial dysfunction, brain injury, and multi-organ dysfunction following resuscitation. Interleukin-17 signaling is an important proinflammatory pathway, but its specific role in the pathogenesis of PCAS remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Using transcriptomic profiling of both cardiac and cerebral tissues after cardiac arrest\/cardiopulmonary resuscitation (CA\/CPR), we found that myocardial dysfunction and brain injury were associated with early activation of the IL-17 signaling pathway during the post-resuscitation period. Further analysis of differentially expressed genes identified interleukin-17A (IL-17A) as a critical cytokine driving systemic inflammation and subsequent cardiac and cerebral dysfunction following CA\/CPR. Consistently, plasma IL-17A levels were significantly elevated in patients who experienced CA after myocardial infarction compared with non-CA controls. Early inhibition of IL-17A with secukinumab in both murine and porcine models of CA\/CPR significantly attenuated PCAS, including improved left ventricular ejection fraction, reduced neuronal apoptosis, and improved 72-hour survival (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05), demonstrating multi-organ protective effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that CA induces a systemic inflammatory response that drives heart\u2013brain injury and multi-organ dysfunction, and IL-17A acts as an inflammatory mediator in this process. Targeting of IL-17A may represent a potential therapeutic strategy for inflammation-driven multi-organ injury after CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1837813","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:43:03Z","timestamp":1777437783000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic inflammatory response drives post-cardiac arrest multi-organ injury via IL-17 signaling in murine and porcine models"],"prefix":"10.3389","volume":"17","author":[{"given":"Yang","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ancai","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiliang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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