{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:55:18Z","timestamp":1781502918880,"version":"3.54.1"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Cytoskeletal remodelling is central to naive T cell fitness, organizing receptor-proximal signaling and mechanotransduction during TCR engagement. However, how cytoskeletal dynamics are coordinated with TCR signaling to preserve naive T cell fitness remains incompletely defined. Here, we identify the\n                    <jats:italic>Sterile 20<\/jats:italic>\n                    -family member\n                    <jats:italic>Thousand and One Kinase 3<\/jats:italic>\n                    (TAOK3) as a kinase-dependent regulator of naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell maintenance that couples TCR signal integration to cytoskeletal control. Genetic deletion or kinase inactivation of TAOK3 resulted in a profound, cell-intrinsic loss of naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Despite enhanced sensitivity to TCR ligation and enhanced downstream signaling, proliferating CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells did not survive\n                    <jats:italic>in vitro<\/jats:italic>\n                    and anti-viral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell immunity was compromised\n                    <jats:italic>in vivo<\/jats:italic>\n                    in the absence of TAOK3. Unbiased phospho-proteomic analysis of\n                    <jats:italic>Taok3<\/jats:italic>\n                    -deficient mice revealed altered phosphorylation of the Rac regulators\n                    <jats:italic>Dedicator of Cytokinesis<\/jats:italic>\n                    DOCK8 and DOCK10, alongside actin-membrane scaffolding proteins. Consistent with this,\n                    <jats:italic>Taok3<\/jats:italic>\n                    -deficient naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells exhibited elevated basal actin polymerisation, excessive reactive oxygen species accumulation, mitochondrial hyperpolarisation, and reduced spare respiratory capacity. Pharmacologic Rac inhibition normalised cytoskeletal dynamics, corrected the heightened TCR sensitivity, and preferentially restored mitochondrial membrane potential. Collectively, these findings identify TAOK3 as a coordinator of membrane-proximal organisation and cytoskeletal regulation that calibrates Rac-dependent signaling, thereby linking TCR signal integration to mitochondrial fitness and long-term maintenance of the naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell pool.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1838764","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:36:19Z","timestamp":1781501779000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8+ T cell homeostasis and activation"],"prefix":"10.3389","volume":"17","author":[{"given":"Sahine","family":"Lameire","sequence":"first","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Vandersarren","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Brown","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pouliot","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]},{"name":"Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Vanhee","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]},{"name":"Department of Head and Skin, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research","place":["Ghent, Belgium"]},{"name":"Department of Internal Medicine and Pediatrics, Ghent University","place":["Ghent, Belgium"]},{"name":"Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam","place":["Rotterdam, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01516-y","article-title":"Guardians of silence: transcriptional networks in T cell quiescence","volume":"57","author":"Choi","year":"2025","journal-title":"Exp Mol Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037879","article-title":"Homeostasis of naive and memory T lymphocytes","volume":"13","author":"Kawabe","year":"2021","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/NI.2018","article-title":"Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells","volume":"12","author":"Sprent","year":"2011","journal-title":"Nat Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature22352","article-title":"Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells","volume":"546","author":"Mendoza","year":"2017","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400858","article-title":"Zap70 is essential for long-term survival of naive CD8 T cells","volume":"193","author":"Schim van der Loeff","year":"2014","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature01146","article-title":"Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes","volume":"420","author":"\u0160tefanov\u00ed","year":"2002","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.161126098","article-title":"IL-7 is critical for homeostatic proliferation and survival of na\u00efve T cells","volume":"98","author":"Tan","year":"2001","journal-title":"PNAS"},{"key":"B8","doi-asserted-by":"publisher","first-page":"10.1111\/imr.12120","DOI":"10.1111\/IMR.12120","article-title":"Regulation of T cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm","volume":"256","author":"Beemiller","year":"2013","journal-title":"Immunol Rev"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201911058","article-title":"Multiple actin networks coordinate mechanotransduction at the immunological synapse","volume":"219","author":"Blumenthal","year":"2020","journal-title":"J Cell Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/SCISIGNAL.AAH3737","article-title":"Cytoskeletal adaptivity regulates T cell receptor signaling","volume":"10","author":"Thauland","year":"2017","journal-title":"Sci Signaling"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10071831","article-title":"The RHO family GTPases: mechanisms of regulation and signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4161\/SGTP.28208","article-title":"Rho-GTPases as key regulators of T lymphocyte biology","volume":"5","author":"Saoudi","year":"2014","journal-title":"Small GTPases"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS25116114","article-title":"Unraveling the role of reactive oxygen species in T lymphocyte signaling","volume":"25","author":"G\u00fclow","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000204727.46710.5E","article-title":"Regulation of NADPH oxidases: the role of Rac proteins","volume":"98","author":"Hordijk","year":"2006","journal-title":"Circ Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0674-y","article-title":"The mammalian family of sterile 20p-like protein kinases","volume":"458","author":"Delpire","year":"2009","journal-title":"Pfl\u00fcgers Archiv - Eur J Physiol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21207463","article-title":"The diverse roles of TAO kinases in health and diseases","volume":"21","author":"Fang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3657","article-title":"Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10","volume":"18","author":"Hammad","year":"2017","journal-title":"Nat Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.jaci.2021.08.020","article-title":"The STE20 kinase TAOK3 controls the development of house dust mite\u2013induced asthma in mice","volume":"149","author":"Maes","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009847117","article-title":"TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells","volume":"117","author":"Vanderkerken","year":"2020","journal-title":"PNAS"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800284","article-title":"TAOK3 regulates canonical TCR signaling by preventing early SHP-1\u2013mediated inactivation of LCK","volume":"201","author":"Ormonde","year":"2018","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adg4422","article-title":"The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation","volume":"17","author":"Poirier","year":"2024","journal-title":"Sci Signaling"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M010677200","article-title":"Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress","volume":"276","author":"Yoneda","year":"2001","journal-title":"J Biol Chem"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210788","article-title":"STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity","volume":"220","author":"Maes","year":"2023","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.005","article-title":"Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection","volume":"52","author":"Bosteels","year":"2020","journal-title":"Immunity"},{"key":"B25","doi-asserted-by":"publisher","first-page":"353709","DOI":"10.3389\/fimmu.2018.00547","article-title":"Spontaneous T cell proliferation: a physiologic process to create and maintain homeostatic balance and diversity of the immune system","volume":"9","author":"Min","year":"2018","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.192.4.557","article-title":"Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation","volume":"192","author":"Goldrath","year":"2000","journal-title":"J Exp Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110308","article-title":"T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse","volume":"208","author":"Moran","year":"2011","journal-title":"J Exp Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature11311","article-title":"Endogenous antigen tunes the responsiveness of naive B cells but not T cells","volume":"489","author":"Zikherman","year":"2012","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ni895","article-title":"TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways","volume":"4","author":"\u0160tefanov\u00e1","year":"2003","journal-title":"Nat Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5126","article-title":"Protein kinase C-\u03b8 is an early survival factor required for differentiation of effector CD8+ T cells","volume":"175","author":"Barouch-Bentov","year":"2005","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.011","article-title":"T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens","volume":"38","author":"Mandl","year":"2013","journal-title":"Immunity"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00065.2011","article-title":"Animal models of human respiratory syncytial virus disease","volume":"301","author":"Bem","year":"2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00375-08","article-title":"Role of T cells in virus control and disease after infection with pneumonia virus of mice","volume":"82","author":"Frey","year":"2008","journal-title":"J Virol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41598-017-03042-y","article-title":"Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL\/6 strain","volume":"7","author":"Vandersarren","year":"2017","journal-title":"Sci Rep"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00339-13","article-title":"CD8 + T-cell epitope mapping for pneumonia virus of mice in H-2 b mice","volume":"87","author":"Walsh","year":"2013","journal-title":"J Virol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/852430","article-title":"Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization","volume":"2012","author":"Grieve","year":"2012","journal-title":"Int J Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083582","article-title":"Insight into the regulation of NDRG1 expression","volume":"26","author":"Saponaro","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0438-7","article-title":"Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms","volume":"22","author":"Bagci","year":"2019","journal-title":"Nat Cell Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.192.supp.47.3","article-title":"Regulation of integrin LFA-1 (CD11a\/CD18) during T cell migration and activation (CAM1P.227)","volume":"192","author":"Capece","year":"2014","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.137.2.493","article-title":"ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes","volume":"137","author":"Del Pozo","year":"1997","journal-title":"J Cell Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122510","article-title":"Implication of Rac1 GTPase in molecular and cellular mitochondrial functions","volume":"342","author":"Bailly","year":"2024","journal-title":"Life Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/365769","article-title":"The interplay between ROS and Ras GTPases: physiological and pathological implications","volume":"2012","author":"Ferro","year":"2012","journal-title":"J Signal Transduction"},{"key":"B43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem J"},{"key":"B44","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-065X.2012.01150.x","article-title":"Metabolic switching and fuel choice during T-cell differentiation and memory development","volume":"249","author":"van der Windt","year":"2012","journal-title":"Immunol Rev"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.0706881104","article-title":"Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development","volume":"104","author":"Cotta-de-Almeida","year":"2007","journal-title":"PNAS"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20030874","article-title":"Vav1\/2\/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells","volume":"198","author":"Fujikawa","year":"2003","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1084\/JEM.20110345","article-title":"DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice","volume":"208","author":"Randall","year":"2011","journal-title":"J Exp Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009743107","article-title":"Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire","volume":"107","author":"Roy","year":"2010","journal-title":"PNAS"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85774","article-title":"A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton","volume":"126","author":"Janssen","year":"2016","journal-title":"J Clin Invest"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1526813","article-title":"Targeted inhibitors of S100A9 alleviate chronic pancreatitis by inhibiting M2 macrophage polarization via the TAOK3-JNK signaling pathway","volume":"16","author":"Tao","year":"2025","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adt9239","article-title":"A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration","volume":"10","author":"Shen","year":"2025","journal-title":"Sci Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam9169","article-title":"Migratory CD11b+ conventional dendritic cells induce T follicular helper cell\u2013dependent antibody responses","volume":"2","author":"Krishnaswamy","year":"2017","journal-title":"Sci Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/J.IMMUNI.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt","year":"2012","journal-title":"Immunity"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.06.010","article-title":"Tonic signals: why do lymphocytes bother","volume":"38","author":"Myers","year":"2017","journal-title":"Trends Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2057","article-title":"Differential requirements for survival and proliferation of CD8 na\u00efve or memory T cells","volume":"276","author":"Tanchot","year":"1997","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.235895","article-title":"Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning","volume":"133","author":"Garg","year":"2020","journal-title":"J Cell Sci"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E07-07-0730","article-title":"Spred1 and TESK1\u2014two new interaction partners of the kinase MARKK\/TAO1 that link the microtubule and actin cytoskeleton","volume":"19","author":"Johne","year":"2008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213064200","article-title":"The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability","volume":"278","author":"Mitsopoulos","year":"2003","journal-title":"J Biol Chem"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1016\/J.DEVCEL.2021.11.015","article-title":"TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules","volume":"56","author":"Nourbakhsh","year":"2021","journal-title":"Dev Cell"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0025-5","article-title":"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling","volume":"24","author":"Richter","year":"2018","journal-title":"Mol Psychiatry"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/EMBOJ\/CDG447","article-title":"MARKK, a Ste20\u2010like kinase, activates the polarity\u2010inducing kinase MARK\/PAR\u20101","volume":"22","author":"Timm","year":"2003","journal-title":"EMBO J"},{"key":"B64","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/S12964-020-00600-2","article-title":"Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-\u03baB signaling pathway","volume":"18","author":"Lai","year":"2020","journal-title":"Cell Commun Signaling"},{"key":"B65","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13059-017-1220-4","article-title":"Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins","volume":"18","author":"Quadros","year":"2017","journal-title":"Genome Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-10-2411","article-title":"Pathogenesis of pneumovirus infections in mice: Detection of pneumonia virus of mice and human respiratory syncytial virus mRNA in lungs of infected mice by in situ hybridization","volume":"79","author":"Cook","year":"1998","journal-title":"J Gen Virol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12434","article-title":"Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria","volume":"15","author":"Xiong","year":"2016","journal-title":"Aging Cell"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2019","journal-title":"Nat Methods"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001624","article-title":"Robust summarization and inference in proteome-wide label-free quantification","volume":"19","author":"Sticker","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1838764\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:36:21Z","timestamp":1781501781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1838764\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2026.1838764"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1838764","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"article-number":"1838764"}}