{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:46Z","timestamp":1783487806130,"version":"3.55.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Group VIA calcium-independent phospholipaseA2 (iPLA2\u03b2 or PLA2G6) is a homeostatic enzyme involved in basal glycerophospholipid metabolism. The mutations in the\n                    <jats:italic>PLA2G6<\/jats:italic>\n                    gene lead to heterogenous neurodegenerative disorders. Global\n                    <jats:italic>PLA2G6<\/jats:italic>\n                    inactivation in iPLA2\u03b2-null mice exhibited liver fibrosis and intestinal atrophy when they reached an advanced age at 20\u201322 months old. Here, we analyzed the phenotypes of iPLA2\u03b2-null mice which happened to be exposed to natural pathogens in our animal facility. Compared with wild-type, male iPLA2\u03b2-null mice at 9\u201314 months of age exhibited reduced body, liver, and subcutaneous fat weights concomitant with decreased hepatic triacylglycerol and decreased expression of\n                    <jats:italic>de novo<\/jats:italic>\n                    lipogenesis genes. Hepatocytes from male mutants were sensitive to apoptosis induced by palmitic acid. Male but not female mutants displayed attenuation of hepatic lipid synthesis; however hepatic fibrosis was increased in mutants of both sexes. Hepatic apoptosis was also increased in mutants of both sexes, and they were susceptible to endotoxin-induced liver injury. Hence, global\n                    <jats:italic>PLA2G6<\/jats:italic>\n                    inactivation combined with natural infection accelerates progression of chronic liver disease in both male and female mice with male-biased alteration of hepatocellular glycerolipid metabolism.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1839554","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:49:14Z","timestamp":1783486154000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["iPLA2\u03b2-null mice exposed to natural pathogens exhibit hepatocellular fibrotic injury with male-biased alteration of glycerolipid metabolism"],"prefix":"10.3389","volume":"17","author":[{"given":"Weihong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Rheumatology, the Second Affiliated Hospital of Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Liebisch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walee","family":"Chamulitrat","sequence":"additional","affiliation":[{"name":"Department of 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