{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:01:31Z","timestamp":1780038091210,"version":"3.53.1"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aberrant metabolic reprogramming-characterized by enhanced glycolysis and lactate accumulation-contributes to the pathogenesis of psoriasis (PsO). However, lactate metabolism-related genes that causally link mitochondrial dysfunction, immune dysregulation, and keratinocyte (KC) abnormalities in PsO remain insufficiently defined. This study aimed to identify robust lactate metabolism\u2013associated biomarkers and new therapeutic targets in PsO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bulk RNA-seq datasets were integrated with a curated lactate-related gene set to identify differentially expressed lactate-related genes (DE-LRGs) in PsO. Weighted Gene Co-expression Network Analysis (WGCNA), differential expression analysis, and two-sample Mendelian randomization (MR) were applied to prioritize candidate genes with causal associations. Machine learning algorithms were employed to identify robust diagnostic biomarkers and construct an artificial neural network (ANN) model. Functional enrichment, immune infiltration analysis, and immune mediator correlation analyzes were performed. Single-cell RNA sequencing (scRNA-seq) data were analyzed to determine cell-type specificity and KC subtype remodeling. Immunohistochemistry and\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments were conducted to validate the biomarker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 23 DE-LRGs were identified in PsO. Integrated network analysis and MR prioritized seven DE-LRGs with potential causal relevance. Machine learning approaches identified three robust biomarkers\u2014GOT2, PYGL, and SLC25A4. The ANN model demonstrated excellent diagnostic performance across independent cohorts (AUC &amp;gt; 0.90). Functional enrichment indicated significant involvement in the JAK\u2013STAT signaling pathway and aminoacyl-tRNA biosynthesis. Expression levels of the biomarkers were significantly correlated with immune-cell infiltration, particularly dendritic cells and resting mast cells, as well as key immune mediators. scRNA-seq analysis revealed substantial remodeling of KC subtypes in PsO, with altered differentiation trajectories and disrupted lactate-associated signaling and intercellular communication networks. SLC25A4 exhibited consistent downregulation in PsO at both bulk and single-cell levels, which was confirmed by immunohistochemistry.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , SLC25A4 knockdown in HaCaT cells reduced cell viability, while promoting apoptosis. However, this study has certain limitations, as it is primarily based on public databases and\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments, without animal model validation. Further validation through multicenter, prospective cohorts and\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiments is required.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study systematically characterized the landscape of lactate metabolism-related genes in PsO and identified SLC25A4 as robust diagnostic biomarker, highlighting the translational potential of targeting lactate metabolism, particularly SLC25A4, as a diagnostic and therapeutic strategy in PsO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1842933","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:02:33Z","timestamp":1780034553000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating bulk RNA-seq, Mendelian randomization and single-cell RNA-seq to elucidate the roles of lactate metabolism related markers-SLC25A4 and keratinocyte in the pathogenesis of psoriasis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yakun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Cosmetology, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Medicine Laboratory, Capital Center for Children\u2019s Health, Capital Medical University, Capital Institute of Pediatrics","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122991","article-title":"Advances in psoriasis research: from pathogenesis to therapeutics","volume":"355","author":"Sugumaran","year":"2024","journal-title":"Life Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220868","article-title":"Assessing the relative efficacy of interleukin-17 and interleukin-23 targeted treatments for moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis of PASI response","volume":"14","author":"Sawyer","year":"2019","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14660","article-title":"New generation biologics for the treatment of psoriasis and psoriatic arthritis. State of the art and considerations about the risk of infection","volume":"34","author":"Ceccarelli","year":"2021","journal-title":"Dermatol Ther"},{"key":"B4","article-title":"Psoriasis: recognition and management strategies","volume":"108","author":"Garner","year":"2023","journal-title":"Am Fam Physician"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15931","article-title":"Tapinarof for the treatment of psoriasis","volume":"35","author":"Nogueira","year":"2022","journal-title":"Dermatol Ther"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.209622","article-title":"Topical therapies in psoriasis","volume":"8","author":"Torsekar","year":"2017","journal-title":"Indian Dermatol Online J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s403854","article-title":"Literature overview of the relation between psoriasis and Alzheimer","volume":"19","author":"Yang","year":"2023","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101454","article-title":"Lactate as a fulcrum of metabolism","volume":"35","author":"Brooks","year":"2020","journal-title":"Redox Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/bst030a010","article-title":"Lactate shuttles in nature","volume":"30","author":"Brooks","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J Physiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12964-024-01624-8","article-title":"Emerging roles of lactate in acute and chronic inflammation","volume":"22","author":"Fang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.07.007","article-title":"Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis","volume":"103","author":"Koguchi-Yoshioka","year":"2021","journal-title":"J Dermatol Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.immuni.2024.04.022","article-title":"Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation","volume":"57","author":"Subudhi","year":"2024","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6872","DOI":"10.1038\/s41598-025-91237-z","article-title":"Immunological profile of lactate metabolism-related genes in psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data","volume":"15","author":"Liu","year":"2025","journal-title":"Sci Rep"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S484034","article-title":"Single-cell sequencing combined with transcriptome sequencing to explore the molecular mechanisms related to psoriasis","volume":"17","author":"E","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/ije\/dyh132","article-title":"Mendelian randomization: prospects, potentials, and limitations","volume":"33","author":"Smith","year":"2004","journal-title":"Int J Epidemiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1544371","article-title":"Corrigendum: the causal relationship between serum metabolites and the risk of psoriasis: a Mendelian randomization and meta-analysis study","volume":"15","author":"Yang","year":"2024","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918224","article-title":"The association between psoriasis and risk of cardiovascular disease: a Mendelian randomization analysis","volume":"13","author":"Gao","year":"2022","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1326717","article-title":"Causal role of immune cells in psoriasis: a Mendelian randomization analysis","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3542","article-title":"Single-cell sequencing-based technologies will revolutionize whole-organism science","volume":"14","author":"Shapiro","year":"2013","journal-title":"Nat Rev Genet"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1038744","article-title":"Applications of single-cell RNA sequencing in atopic dermatitis and psoriasis","volume":"13","author":"Xia","year":"2022","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41419-024-06583-z","article-title":"Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis","volume":"15","author":"Guo","year":"2024","journal-title":"Cell Death Dis"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.028","article-title":"Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8(+) T cells in autoimmunity and cancer","volume":"147","author":"Liu","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13851","article-title":"Identification of psoriasis-associated immune marker G3BP2 through single-cell RNA sequencing and meta analysis","volume":"173","author":"Gao","year":"2024","journal-title":"Immunology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9084","DOI":"10.1038\/s41467-025-64106-6","article-title":"Single cell transcriptomics of human psoriasis and epidermal specific Ube2l3 deficient mice highlight CXCL16\/CXCR6 involvement in psoriasis development","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111993","article-title":"The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes","volume":"132","author":"Yuan","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"23848","DOI":"10.1038\/s41598-024-75069-x","article-title":"Identification of neutrophil extracellular traps genes as potential biomarkers in psoriasis based on bioinformatics analysis","volume":"14","author":"Zhao","year":"2024","journal-title":"Sci Rep"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2024.10327","article-title":"Identifying key inflammatory genes in psoriasis via weighted gene co-expression network analysis: potential targets for therapy","volume":"24","author":"Li","year":"2024","journal-title":"Biomol BioMed"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1388690","article-title":"Discovery of biomarkers in the psoriasis through machine learning and dynamic immune infiltration in three types of skin lesions","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.7554\/elife.97654.3","article-title":"Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis","volume":"13","author":"Kume","year":"2024","journal-title":"Elife"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v046.i11","article-title":"Fast R functions for robust correlations and hierarchical clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J Stat Softw"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.989286","article-title":"Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.7554\/elife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"B40","doi-asserted-by":"publisher","first-page":"14","DOI":"10.7570\/jomes24031","article-title":"A review of Mendelian randomization: assumptions, methods, and application to obesity-related diseases","volume":"34","author":"Lee","year":"2025","journal-title":"J Obes Metab Syndr"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0011-z","article-title":"Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3493","article-title":"Depression and prostate cancer risk: a Mendelian randomization study","volume":"9","author":"Chen","year":"2020","journal-title":"Cancer Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1057602","article-title":"Reverse causal relationship between periodontitis and shortened telomere length: bidirectional two-sample Mendelian random analysis","volume":"13","author":"Hu","year":"2022","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v039.i05","article-title":"Regularization paths for Cox's proportional hazards model via coordinate descent","volume":"39","author":"Simon","year":"2011","journal-title":"J Stat Softw"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab501","article-title":"Stable iterative variable selection","volume":"37","author":"Mahmoudian","year":"2021","journal-title":"Bioinformatics"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1372303","article-title":"Exploration of ferroptosis and necroptosis-related genes and potential molecular mechanisms in psoriasis and atherosclerosis","volume":"15","author":"Fan","year":"2024","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.841813","article-title":"Exploring the immune infiltration landscape and M2 macrophage-related biomarkers of proliferative diabetic retinopathy","volume":"13","author":"Meng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku631","article-title":"The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations","volume":"42","author":"Ru","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.05.012","article-title":"Single-cell transcriptomics suggest distinct upstream drivers of IL-17A\/F in hidradenitis versus psoriasis","volume":"152","author":"Kim","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.021","article-title":"Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets","volume":"148","author":"Kim","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.tir120.002155","article-title":"ReactomeGSA - efficient multi-omics comparative pathway analysis","volume":"19","author":"Griss","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-026-01446-6","article-title":"A macrophage MHC-I axis links intratumoral heterogeneity to terminal CD8(+) T cell exhaustion in lung adenocarcinoma","author":"Yin","year":"2026","journal-title":"NPJ Precis Oncol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02267-8","article-title":"A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues","volume":"26","author":"Steele","year":"2025","journal-title":"Nat Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1101\/gr.278001.123","article-title":"ESICCC as a systematic computational framework for evaluation, selection, and integration of cell-cell communication inference methods","volume":"33","author":"Luo","year":"2023","journal-title":"Genome Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202357127","article-title":"Human mitochondrial ADP\/ATP carrier SLC25A4 operates with a ping-pong kinetic mechanism","volume":"24","author":"Cimadamore-Werthein","year":"2023","journal-title":"EMBO Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1101\/2022.09.09.507271","article-title":"Loss of ANT1 increases fibrosis and epithelial cell senescence in idiopathic pulmonary fibrosis","volume":"69","author":"Sui","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010558","article-title":"HIF-1\u03b1-dependent metabolic reprogramming, oxidative stress, and bioenergetic dysfunction in SARS-CoV-2-infected hamsters","volume":"24","author":"Jana","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1038\/s41467-017-02351-0","article-title":"Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis","volume":"8","author":"Guo","year":"2017","journal-title":"Nat Commun"},{"key":"B64","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/ptt.s327310","article-title":"Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders","volume":"12","author":"Ortiz-Lopez","year":"2022","journal-title":"Psoriasis (Auckl)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279908","article-title":"The study of GSDMB in pathogenesis of psoriasis vulgaris","volume":"18","author":"Ji","year":"2023","journal-title":"PloS One"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.168861","article-title":"Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis","volume":"58","author":"Moorchung","year":"2015","journal-title":"Indian J Pathol Microbiol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12938-021-00943-y","article-title":"Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes","volume":"20","author":"Sun","year":"2021","journal-title":"BioMed Eng Online"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116764","article-title":"Downregulation of RSAD2 ameliorates keratinocyte hyperproliferation and skin inflammation in psoriasis via the TAK1\/NF-\u03baB axis","volume":"233","author":"Li","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1042\/bst20231058","article-title":"The importance of muscle glycogen phosphorylase in glial cells function","volume":"52","author":"Llavero","year":"2024","journal-title":"Biochem Soc Trans"},{"key":"B71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cmet.2011.12.005","article-title":"Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1","volume":"15","author":"Zhang","year":"2012","journal-title":"Cell Metab"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2020.103666","article-title":"The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation","volume":"108","author":"Mart\u00ednez-Navarro","year":"2020","journal-title":"Dev Comp Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2024.101370","article-title":"GOT2: New therapeutic target in pancreatic cancer","volume":"12","author":"Bu","year":"2025","journal-title":"Genes Dis"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.017","article-title":"Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells","volume":"162","author":"Sullivan","year":"2015","journal-title":"Cell"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: impact on human disease and therapeutic intervention","volume":"66","author":"O'Shea","year":"2015","journal-title":"Annu Rev Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.22756","article-title":"Evolution of the JAK-STAT pathway","volume":"2","author":"Liongue","year":"2013","journal-title":"Jakstat"},{"key":"B78","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jdermsci.2018.11.007","article-title":"Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production","volume":"93","author":"Nakajima","year":"2019","journal-title":"J Dermatol Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2147\/ptt.s294173","article-title":"Key signaling pathways in psoriasis: recent insights from antipsoriatic therapeutics","volume":"11","author":"Ben Abdallah","year":"2021","journal-title":"Psoriasis (Auckl)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.adengl.2021.05.008","article-title":"Janus kinase inhibitors in dermatology: part 2: applications in psoriasis, atopic dermatitis, and other dermatoses","volume":"112","author":"Garcia-Melendo","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s380686","article-title":"TYK2 in immune responses and treatment of psoriasis","volume":"15","author":"Shang","year":"2022","journal-title":"J Inflammation Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.12.008","article-title":"IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2\/Stat6 signal transduction pathway: Implication for atopic dermatitis","volume":"50","author":"Bao","year":"2012","journal-title":"Mol Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12929-025-01143-9","article-title":"Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes","volume":"32","author":"Chen","year":"2025","journal-title":"J BioMed Sci"},{"key":"B84","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.immuni.2020.06.004","article-title":"Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis","volume":"53","author":"Lou","year":"2020","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01160-y","article-title":"Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production","volume":"21","author":"Sun","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166988","article-title":"Fucosylation deficiency enhances imiquimod-induced psoriasis-like skin inflammation by promoting CXCL1 expression","volume":"1870","author":"Li","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B87","doi-asserted-by":"publisher","first-page":"100116","DOI":"10.1016\/j.bbih.2020.100116","article-title":"Deletion of indoleamine 2,3 dioxygenase (ido)1 but not ido2 exacerbates disease symptoms of mog(35-55)-induced experimental autoimmune encephalomyelitis","volume":"7","author":"Wetzel","year":"2020","journal-title":"Brain Behav Immun Health"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1097\/cad.0000000000001225","article-title":"Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1\/miR-3194-5p\/Galectin-7 axis","volume":"33","author":"Wang","year":"2022","journal-title":"Anticancer Drugs"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14117","article-title":"The miR-155\/GATA3\/IL37 axis modulates the production of proinflammatory cytokines upon TNF-\u03b1 stimulation to affect psoriasis development","volume":"29","author":"Wang","year":"2020","journal-title":"Exp Dermatol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107334","article-title":"DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters","volume":"91","author":"Chen","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29413","article-title":"Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation","volume":"235","author":"Thatikonda","year":"2020","journal-title":"J Cell Physiol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00159.x","article-title":"Occurrence of hepoxilins and trioxilins in psoriatic lesions","volume":"110","author":"Ant\u00f3n","year":"1998","journal-title":"J Invest Dermatol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102558","article-title":"Apoptotic or antiproliferative activity of natural products against keratinocytes for the treatment of psoriasis","volume":"20","author":"Huang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02262","article-title":"Macrophage migration inhibitory factor (MIF) drives murine psoriasiform dermatitis","volume":"9","author":"Bezdek","year":"2018","journal-title":"Front Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.02.016","article-title":"IL-17A promotes psoriasis-associated keratinocyte proliferation through ACT1-dependent activation of YAP-AREG axis","volume":"142","author":"Yu","year":"2022","journal-title":"J Invest Dermatol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699900","article-title":"RPL22 overexpression promotes psoriasis-like lesion by inducing keratinocytes abnormal biological behavior","volume":"12","author":"Zeng","year":"2021","journal-title":"Front Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1585378","article-title":"Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired","volume":"16","author":"Chen","year":"2025","journal-title":"Front Immunol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1137659","article-title":"Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing","volume":"14","author":"Gauthier","year":"2023","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1038\/s41467-023-37798-x","article-title":"Tenascin C(+) papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis","volume":"14","author":"Cai","year":"2023","journal-title":"Nat Commun"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s574980","article-title":"Immunological antagonism between psoriasis and atopic dermatitis: pathways, clinical implications, and therapeutic perspectives","volume":"18","author":"Qin","year":"2025","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1842933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:02:35Z","timestamp":1780034555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1842933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":100,"alternative-id":["10.3389\/fimmu.2026.1842933"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1842933","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"1842933"}}