{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:08:53Z","timestamp":1780376933985,"version":"3.54.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cytokeratin\u2212positive interstitial reticulum cell (CIRC) tumor, a subtype of fibroblastic reticular cell tumor (FRCT), is an extremely rare primary neoplasm of lymph nodes and soft tissue, with limited understanding of its clinicopathological and molecular features. This case is the first identification of human leukocyte antigen loss of heterozygosity (HLA LOH) in CIRC tumor, which provides novel insights into immune evasion mechanisms and potential therapeutic implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 67\u2212year\u2212old female presented with a local recurrence seven years after initial resection of a CIRC tumor on her right shoulder. Physical examination revealed a firm, poorly mobile subcutaneous mass (12cm\u00d78cm). Imaging confirmed a right parascapular mass with bone destruction. Histologically, the recurrent tumor consisted of spindle and epithelioid cells arranged in storiform and sheet\u2212like patterns, with extensive necrosis and a mitotic count of 3 per 10 high\u2212power fields. Immunohistochemically, tumor cells diffusely expressed cytokeratins, vimentin, CD68, CD163, and EMA, with focal expression of SMA, S\u2212100, calponin, and CD3, but were negative for CD21, CD35, CD1a, ALK, and HHV8. The Ki\u221267 index was 25%. Whole\u2212exome sequencing identified 30 single\u2212nucleotide variants and 7 indels (variant allele frequencies 2.17%\u201312.6%), copy number gains on chromosomes 7, 11, and 14, and microsatellite stability. Notably, two HLA LOH events affecting HLA\u2212B39:01:01:01 and HLA\u2212C07:02:01:01 were detected. No disease progression was observed during follow\u2212up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first report of HLA LOH in FRCT\/CIRC tumor. The key take\u2212away lesson is that HLA LOH represents a potential immune evasion mechanism, which may render single\u2212agent immune checkpoint inhibitors ineffective and thus guide alternative immunotherapeutic strategies. Chromosomal instability appears to be a prominent genomic feature of FRCT. These findings expand the molecular landscape of this rare tumor and underscore the value of comprehensive genomic profiling in guiding individualized treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1844173","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:28:00Z","timestamp":1780374480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Cytokeratin-positive interstitial reticulum cell tumor with HLA loss of heterozygosity"],"prefix":"10.3389","volume":"17","author":[{"given":"Wen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The 960th Hospital of the People\u2019s Liberation Army (PLA) Joint Logistic Support Force","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: Lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2297939","article-title":"The 5th edition of the World Health Organization classification of mature lymphoid and stromal tumors - 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