{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:55:27Z","timestamp":1781502927869,"version":"3.54.1"},"reference-count":6,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of a 52-year-old female with stage IVB cervical squamous cell carcinoma (SCC) and cardiac metastasis presented with exertional dyspnea and chest pain concerning pulmonary embolism (PE) post COVID-19 infection. After empirical anticoagulation and anti-infective therapy, the intracardiac mass and pulmonary embolism persisted. Subsequent PET-CT and histopathological examination revealed advanced cervical squamous cell carcinoma with suspected tumor thrombus involving the right heart and pulmonary artery. Given extensive metastatic disease and high bleeding risk, the multidisciplinary team discussed individualized systemic therapy and suggested conservative management. The patient survived 14 months after diagnosis.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1845280","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:37:20Z","timestamp":1781501840000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Metastatic right ventricular tumor and pulmonary embolism from cervical cancer post COVID-19 infection"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuemei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Beijing Chao-yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13174","article-title":"Cervical cancer screening: a review","volume":"330","author":"Perkins","year":"2023","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.37390","article-title":"Patterns of metastases in cervical cancer: a population-based study","volume":"13","author":"Zhou","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200303060-00004","article-title":"Cancer of the heart: epidemiology and management of primary tumors and metastases","volume":"3","author":"Sarjeant","year":"2003","journal-title":"Am J Cardiovasc Drugs"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/life15020291","article-title":"Cardiac metastasis: epidemiology, pathophysiology, and clinical management","volume":"15","author":"Luc\u00e0","year":"2025","journal-title":"Life (Basel)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.06.001","article-title":"Unraveling the enigmatic world of cardiac tumor imaging","volume":"37","author":"Zubair","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1259\/bjrcr.20150300","article-title":"Cardiac metastasis in cervical cancer","volume":"2","author":"Sasidharan","year":"2016","journal-title":"BJR Case Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1845280\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:37:37Z","timestamp":1781501857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1845280\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":6,"alternative-id":["10.3389\/fimmu.2026.1845280"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1845280","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"article-number":"1845280"}}