{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:35:08Z","timestamp":1790699708744,"version":"4.1.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent inflammatory episodes in the gastrointestinal tract. Conventional therapies, including biologics, corticosteroids, and immunosuppressive drugs, can effectively alleviate disease activity. However, their utility is often limited by adverse effects. Vitamin D plays a role in modulating immune function, intestinal barrier integrity, and the gut microbiota. It has emerged as a promising adjunctive therapy for IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map the research landscape of vitamin D in IBD using bibliometric analysis, focusing on knowledge evolution, core themes, and emerging trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publications from 2006 to 2025 were collected by searching the Web of Science Core Collection (WoSCC) and Scopus databases. After removing duplicates, 2,659 articles and reviews were obtained for analysis. Networks were constructed using CiteSpace, VOSviewer, R, and Python. PubMed clinical trials were included for complementary analysis, and BERTopic was applied to identify latent topics and their temporal dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,659 publications spanning 970 journals were identified, with a steady increase in output. The USA was the leading contributor and also demonstrated strong international collaboration. Ananthakrishnan Ashwin N. was the most influential author, and Inflammatory Bowel Diseases was the journal with the leading journal. Core themes included vitamin D deficiency, gut microbiota, inflammatory response, diet and nutrition. The focus has shifted toward gut microbiota, immune regulation, micronutrients, and evidence-based approaches. Furthermore, BERTopic modeling identified 12 latent topics, with increasing emphasis on gut microbiota, fecal microbiota transplant, and nutritional deficiencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric analysis provides a concise, data-driven overview of research on vitamin D in IBD. The results highlighting its structure, evolution, and emerging trends, and informing future mechanistic and translational research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1845767","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:48:23Z","timestamp":1780030103000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["From nutritional intervention to immune modulation: a multi-database bibliometric and topic modeling study of vitamin D in inflammatory bowel disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Kun","family":"Wang","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Meridian Viscera Correlation ship, Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12319","article-title":"Environmental risk factors for inflammatory bowel disease","volume":"10","author":"Singh","year":"2022","journal-title":"United Eur Gastroenterol J"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137062","article-title":"Inflammatory bowel disease: a comprehensive analysis of molecular bases, predictive biomarkers, diagnostic methods, and therapeutic options","volume":"25","author":"Diez-Martin","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054642","article-title":"Vitamin D and vitamin D-binding protein in health and disease","volume":"24","author":"Delrue","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy025","article-title":"Role of vitamin D in the natural history of inflammatory bowel disease","volume":"12","author":"Nielsen","year":"2018","journal-title":"J Crohn's Colitis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12553","article-title":"Review article: vitamin D and inflammatory bowel diseases","volume":"39","author":"Mouli","year":"2014","journal-title":"Alimentary Pharmacol Ther"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104798","article-title":"Molecular insight into the role of vitamin D in immune-mediated inflammatory diseases","volume":"26","author":"Argano","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102350","article-title":"Emerging role of vitamin D in autoimmune diseases: an update on evidence and therapeutic implications","volume":"18","author":"Murdaca","year":"2019","journal-title":"Autoimmun Rev"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020269","article-title":"Vitamin D in inflammatory bowel diseases. 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