{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:38Z","timestamp":1783487798661,"version":"3.55.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical features of acute Q fever and their link to transient autoantibodies remain poorly defined. We characterized 44 plasma mNGS-confirmed cases and identified predictors of prolonged fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study (2021\u20132026) of 44 patients with confirmed Q fever (mNGS + clinical + exposure criteria). Patients were grouped by post-treatment fever duration (&amp;gt;7 days vs. \u22647 days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cohort was predominantly middle-aged (median 52.5 years) and male (95.5%). Common presentations: fever (95.5%), headache (45.5%), pulmonary involvement (51.2%). Elevated CRP (97.7%) and ESR (90.9%) were universal. Transient antiphospholipid antibodies (78.9%, all negative at 12 weeks) and ANA (23.5%) were frequent. Prolonged fever (&amp;gt;7 days) was associated with higher WBC, CRP, ESR, lower CD8+ and B cells, and aPL positivity (all p&amp;lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute Q fever frequently induces transient autoantibodies. Prolonged fever correlates with an inflammatory and lymphopenic phenotype, underscoring immune dysregulation in recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1847365","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:44:58Z","timestamp":1783485898000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical features of Q fever confirmed by plasma metagenomic next-generation sequencing"],"prefix":"10.3389","volume":"17","author":[{"given":"Man","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]},{"name":"FuRong Laboratory, Central South University","place":["Changsha, Hunan, China"]},{"name":"Clinical Medical Research Center for Viral Hepatitis in Hunan Province","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2025.102401","article-title":"Global epidemiology and molecular typing of Coxiella burnetii: A systematic review of Q fever in humans and animals","volume":"123","author":"Rahal","year":"2025","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2025.107213","article-title":"Coxiella burnetii: Emerging threats, molecular insights, and advances in diagnosis and control measures","volume":"237","author":"Mohammadi","year":"2025","journal-title":"J Microbiol Methods"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11102485","article-title":"Clinical and epidemiological aspects of acute Q fever in Reunion Island over fourteen years: A retrospective cohort 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