{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:50:45Z","timestamp":1794293445380,"version":"4.9.0"},"reference-count":313,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) is the primary source of reactive oxygen species (ROS) in leukocytes for host defense and immune signaling. Loss-of-function mutations in NOX2 leads to chronic granulomatous disease, a life-threatening immunodeficient disorder with defective phagocyte function to produce ROS for killing bacteria and fungi. NOX2, however, is not restricted to phagocytic leukocytes; it is also present in various immune cell types, with expression levels varying among them. Disrupted redox balance in CGD patients predisposes them to develop Th1\/Th17-type (type 1 and type 3) inflammation leading to severe tissue inflammation in organs including joints, lungs, heart and kidneys. The high Th1 cytokines in tissues induce macrophage and T cell activation, which makes a positive feedback loop to recruit more immune cells to facilitate the granuloma formation in CGD patients. Moreover, IFN-\u03b3 has been shown to play a critical role in age-associated B cells (ABC) differentiation by inducing T-bet expression through STAT1 activation in B cells and elevated autoantibody production. The data suggested that the IFN-\u03b3-rich Th1 environment resulting from NOX2 deficiency may promote ABC differentiation via the IFN-STAT axis. Previous studies showed that CGD patients and NOX2 deficient mice have stronger Th17 type inflammation and higher type 3 effector cytokine production. Overexpression of IL-1\u03b2 following NLRP3 inflammasome-dependent or -independent activation aggravates Th17 hyperinflammation in CGD patients, who are prone to develop comorbidities including pulmonary fibrosis, arthritis, lupus-like nephritis and increased risk of cardiovascular diseases. In this review, we summarize the pivotal role of NOX2 in the balance of redox homeostasis and its relationship with type 1\/type 3 inflammation. The key issues to be explored on NOX2-deficiency-associated tissue inflammation include: (i) to elucidate the cellular and molecular bases for the Th1 and Th17 hyperinflammation in CGD-related comorbidities and how the inflammation evolves to autoimmunity (ii) how subjects with low ROS production (e.g. gene carriers of CGD mutations) are affected by these pathogenic tissue inflammation, and (iii) developing therapies that restore NOX2 function in targeted immune cells, enhancing ROS-driven microbial killing while preventing oxidant stress-induced tissue damage, and addressing autoinflammation and autoimmune issues in CGD patients.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1848916","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:20:54Z","timestamp":1784175654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The type 1 and type 3 immune responses underlying the tissue inflammation associated with NOX2 deficiency"],"prefix":"10.3389","volume":"17","author":[{"given":"Wan-Ting","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Yi","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsin","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, Division of Allergy, Immunology and Rheumatology, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chang","family":"Shieh","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Department of Pediatrics, National Cheng Kung University Hospital","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2023","article-title":"Nadph oxidases: Redox regulation of cell homeostasis and disease","volume":"105","author":"Kra\u010dun","year":"2025","journal-title":"Physiol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (Ros) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.07.012","article-title":"Mitochondria reactive oxygen species signaling in immune responses","volume":"58","author":"Weinberg","year":"2025","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00730-2","article-title":"Fundamentals of redox regulation in biology","volume":"25","author":"Sies","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00770","article-title":"Nadph oxidases: From molecular mechanisms to current inhibitors","volume":"66","author":"Cipriano","year":"2023","journal-title":"J Med Chem"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00858-1","article-title":"Nadph oxidase family proteins: Signaling dynamics to disease management","volume":"19","author":"Begum","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102795","article-title":"Unlocking the power of Nox2: A comprehensive review on its role in immune regulation","volume":"64","author":"Bode","year":"2023","journal-title":"Redox Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635021","article-title":"Reactive oxygen species in autoimmune cells: Function, differentiation, and metabolism","volume":"12","author":"Lin","year":"2021","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-9424-3_34","article-title":"Gastrointestinal Complications in Chronic Granulomatous Disease","volume":"1254","author":"Falcone","year":"2019","journal-title":"Methods Mol. Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvz085","article-title":"Redox regulation of tyrosine kinase signalling: More than meets the eye","volume":"167","author":"Dustin","year":"2020","journal-title":"J Biochem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1822","article-title":"Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway","volume":"104","author":"Chuang","year":"2004","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737556","article-title":"Ligand binding of leukocyte integrin very late antigen\u20104 involves exposure of sulfhydryl groups and is subject to redox modulation","volume":"38","author":"Liu","year":"2008","journal-title":"Eur J Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.06.001","article-title":"Low production of reactive oxygen species drives systemic lupus erythematosus","volume":"25","author":"Urbonaviciute","year":"2019","journal-title":"Trends Mol Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13041092","article-title":"Inflammatory complications in chronic granulomatous disease","volume":"13","author":"Grammatikos","year":"2024","journal-title":"J Clin Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.035","article-title":"X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability","volume":"141","author":"Marciano","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.014","article-title":"Inflammatory manifestations in a single-center cohort of patients with chronic granulomatous disease","volume":"134","author":"Magnani","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.freeradbiomed.2018.03.016","article-title":"The dual role of reactive oxygen species in autoimmune and inflammatory diseases: Evidence from preclinical models","volume":"125","author":"Hoffmann","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8027","article-title":"Spatial properties of reactive oxygen species govern pathogen-specific immune system responses","volume":"32","author":"To","year":"2020","journal-title":"Antioxid Redox Signal"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00760-x","article-title":"Mitochondrial control of inflammation","volume":"23","author":"Marchi","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.70962\/jhi.20250003","article-title":"Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"1","author":"Poli","year":"2025","journal-title":"J Hum Immun"},{"key":"B22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/imr.13308","article-title":"Functional neutrophil disorders: Chronic granulomatous disease and beyond","volume":"322","author":"Zerbe","year":"2024","journal-title":"Immunol Rev"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14030309","article-title":"The role of Nadph oxidase 2 in leukocytes","volume":"14","author":"Leiding","year":"2025","journal-title":"Antioxidants"},{"key":"B24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2019.06.004","article-title":"Reactive oxygen species: The signal regulator of B cell","volume":"142","author":"Zhang","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.12.003","article-title":"Human B cells have an active phagocytic capability and undergo immune activation upon phagocytosis of Mycobacterium tuberculosis","volume":"221","author":"Zhu","year":"2016","journal-title":"Immunobiology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4AB1113-607RR","article-title":"Reactive oxygen species-mediated bacterial killing by B lymphocytes","volume":"97","author":"Kov\u00e1cs","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.freeradbiomed.2018.03.040","article-title":"The phagosome and redox control of antigen processing","volume":"125","author":"Ewanchuk","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4073","article-title":"Redox regulation of T-cell function: From molecular mechanisms to significance in human health and disease","volume":"18","author":"Kesarwani","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (Ros) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101966","article-title":"Role of Nadph oxidases in blood-brain barrier disruption and ischemic stroke","volume":"11","author":"Hernandes","year":"2022","journal-title":"Antioxidants"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05664.x","article-title":"Normobaric hyperoxia inhibits Nadph oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke","volume":"107","author":"Liu","year":"2008","journal-title":"J Neurochem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-1-22","article-title":"Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing Nadph oxidase in ischemic stroke","volume":"1","author":"Liu","year":"2011","journal-title":"Med Gas Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060663","article-title":"Short-term inhibition of Nox2 prevents the development of Abeta-induced pathology in mice","volume":"14","author":"Mukhina","year":"2025","journal-title":"Antioxidants"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1038\/s41598-025-86064-1","article-title":"B cells enhance Il-1 beta driven invasiveness in triple negative breast cancer","volume":"15","author":"Toney","year":"2025","journal-title":"Sci Rep"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105754","article-title":"Nadph oxidase 2 activity in Parkinson's disease","volume":"170","author":"Keeney","year":"2022","journal-title":"Neurobiol Dis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24281","article-title":"The nicotinamide adenine dinucleotide phosphate oxidase (Nox) homologues Nox1 and Nox2\/Gp91(Phox) mediate hepatic fibrosis in mice","volume":"53","author":"Paik","year":"2011","journal-title":"Hepatology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/path.4423","article-title":"Macrophage-specific Nox2 contributes to the development of lung emphysema through modulation of Sirt1\/Mmp-9 pathways","volume":"235","author":"Trocme","year":"2015","journal-title":"J Pathol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-025-02389-z","article-title":"Nox2-dependent phagocyte signaling mediates silica-induced murine lung injury via macrophage-neutrophil interactions","volume":"49","author":"Kusaka","year":"2025","journal-title":"Inflammation"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6136","article-title":"Redox regulation of pro-Il-1\u03b2 processing may contribute to the increased severity of serum-induced arthritis in Nox2-deficient mice","volume":"23","author":"Huang","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948141","article-title":"Increased Ilc3s associated with higher levels of Il-1\u03b2 aggravates inflammatory arthritis in mice lacking phagocytic Nadph oxidase","volume":"49","author":"Chan","year":"2019","journal-title":"Eur J Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6639","article-title":"Nox2-mediated Pi3k and cofilin activation confers alternate redox control of macrophage pinocytosis","volume":"26","author":"Ghoshal","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00537","article-title":"Pkc\u03b4-mediated Nox2 activation promotes fluid-phase pinocytosis of antigens by immature dendritic cells","volume":"9","author":"Singla","year":"2018","journal-title":"Front Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-160564","article-title":"Impaired apoptotic cell clearance in Cgd due to altered macrophage programming is reversed by phosphatidylserine-dependent production of Il-4","volume":"113","author":"Fernandez-Boyanapalli","year":"2009","journal-title":"Blood"},{"key":"B45","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1182\/blood.2019003525","article-title":"Nadph oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting Ltb4","volume":"135","author":"Song","year":"2020","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the Nalp3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230774","article-title":"Nadph oxidase exerts a B cell\u2013intrinsic contribution to lupus risk by modulating endosomal Tlr signals","volume":"221","author":"Liu","year":"2024","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.4049\/jimmunol.1302896","article-title":"Nadph oxidase modifies patterns of Mhc class Ii\u2013restricted epitopic repertoires through redox control of antigen processing","volume":"192","author":"Allan","year":"2014","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700774","article-title":"Cutting edge: Processing of oxidized peptides in macrophages regulates T cell activation and development of autoimmune arthritis","volume":"199","author":"Yang","year":"2017","journal-title":"J Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545518","article-title":"B\u2010cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production","volume":"45","author":"Khmaladze","year":"2015","journal-title":"Eur J Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.633629","article-title":"Nox2 deficiency permits sustained survival of S. aureus in macrophages and contributes to severity of infection","volume":"12","author":"Tosetti","year":"2021","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101118","article-title":"Spontaneous netosis and type I IFN signaling activation in resting neutrophils of chronic granulomatous disease patients with Cybb mutations","volume":"11","author":"Lu","year":"2024","journal-title":"Genes Dis"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01828","article-title":"Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes","volume":"8","author":"Sundqvist","year":"2017","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.08.003","article-title":"Neutrophil and eosinophil etosis-mediated extracellular trap formation in a patient with chronic granulomatous disease","volume":"72","author":"Miyabe","year":"2023","journal-title":"Allergol Int"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006824","article-title":"Assessment of atherosclerosis in chronic granulomatous disease","volume":"130","author":"Sibley","year":"2014","journal-title":"Circulation"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.09.030","article-title":"Nox2 deficiency enhances priming and activation of the NLRP3 inflammasome","volume":"157","author":"Monjarret","year":"2026","journal-title":"J Allergy Clin Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111177","article-title":"Phagocyte NADPH oxidase restrains the inflammasome in ANCA-induced GN","volume":"26","author":"Schreiber","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1633","article-title":"Superoxide dismutase 1 regulates caspase-1 and endotoxic shock","volume":"9","author":"Meissner","year":"2008","journal-title":"Nat Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.16.7676","article-title":"Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes","volume":"90","author":"Kapur","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aah3539","article-title":"IL-1beta is an innate immune sensor of microbial proteolysis","volume":"1","author":"LaRock","year":"2016","journal-title":"Sci Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102984","article-title":"The Pseudomonas aeruginosa protease LasB directly activates IL-1beta","volume":"60","author":"Sun","year":"2020","journal-title":"EBioMedicine"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00092","article-title":"Type 3 ILCs in lung disease","volume":"10","author":"Ardain","year":"2019","journal-title":"Front Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.743030","article-title":"Nox2-deficient neutrophils facilitate joint inflammation through higher pro-inflammatory and weakened immune checkpoint activities","volume":"12","author":"Liao","year":"2021","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672523","article-title":"Regulation and function of ILC3s in pulmonary infections","volume":"12","author":"Hoffmann","year":"2021","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119823","article-title":"Regulation of NLRPs by reactive oxygen species: A story of crosstalk","volume":"1871","author":"Ziehr","year":"2024","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-021-00040-5","article-title":"Bridging autoinflammatory and autoimmune diseases","volume":"33","author":"El-Shebiny","year":"2021","journal-title":"Egypt J Intern Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.732933","article-title":"NLRP3 inflammasome: Checkpoint connecting innate and adaptive immunity in autoimmune diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1128581","article-title":"The paradox of autoimmunity and autoinflammation in inherited neutrophil disorders\u2013in search of common patterns","volume":"14","author":"Krzyzanowski","year":"2023","journal-title":"Front Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.188724","article-title":"IL-1\u03b2 signaling modulates T follicular helper and regulatory cells in human lymphoid tissues","volume":"10","author":"Vaineau","year":"2025","journal-title":"JCI Insight"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013404","article-title":"Germinal center B cells provide essential IL-1\u03b2 signals to Tfh cells via canonical NLRP3 inflammasome activity post influenza infection","volume":"21","author":"Restrepo Munera","year":"2025","journal-title":"PloS Pathog"},{"key":"B71","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1016\/j.celrep.2019.11.086","article-title":"Dectin-1 binding to annexins on apoptotic cells induces peripheral immune tolerance via NADPH oxidase-2","volume":"29","author":"Bode","year":"2019","journal-title":"Cell Rep"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162","article-title":"Molecular mechanisms and therapeutic target of netosis in diseases","volume":"3","author":"Huang","year":"2022","journal-title":"MedComm"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.10.002","article-title":"Neutrophil intrinsic and extrinsic regulation of netosis in health and disease","volume":"31","author":"Poli","year":"2023","journal-title":"Trends Microbiol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221606","article-title":"Restoration of NET formation by gene therapy in CGD controls aspergillosis","volume":"114","author":"Bianchi","year":"2009","journal-title":"Blood"},{"key":"B75","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jaci.2019.04.014","article-title":"Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species\u2013independent manner","volume":"144","author":"Sharma","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165664","article-title":"Mitochondrial permeability transition pore is involved in oxidative burst and netosis of human neutrophils","volume":"1866","author":"Vorobjeva","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92920","article-title":"Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps","volume":"2","author":"Kienh\u00f6fer","year":"2017","journal-title":"JCI Insight"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000694","article-title":"Cutting edge: Nox2 NADPH oxidase controls infection by an intracellular bacterial pathogen through limiting the type 1 IFN response","volume":"206","author":"Rojas M\u00e1rquez","year":"2021","journal-title":"J Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxaf031","article-title":"Chronic granulomatous disease: Lessons in cell biology from monogenic immunodeficiency","volume":"219","author":"Mortimer","year":"2025","journal-title":"Clin Exp Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00035","article-title":"Clearance deficiency and cell death pathways: A model for the pathogenesis of SLE","volume":"7","author":"Mahajan","year":"2016","journal-title":"Front Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101279","article-title":"Nox2 mediates quiescent handling of dead cell remnants in phagocytes","volume":"26","author":"Hahn","year":"2019","journal-title":"Redox Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01298","article-title":"LC3-associated phagocytosis (LAP): A potentially influential mediator of efferocytosis-related tumor progression and aggressiveness","volume":"10","author":"Asare","year":"2020","journal-title":"Front Oncol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322831111","article-title":"IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans","volume":"111","author":"de Luca","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-264218","article-title":"Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease","volume":"116","author":"Meissner","year":"2010","journal-title":"Blood"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134791","article-title":"NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells","volume":"112","author":"Mantegazza","year":"2008","journal-title":"Blood"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4557","article-title":"Reactive oxygen species production in the phagosome: Impact on antigen presentation in dendritic cells","volume":"18","author":"Kotsias","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.035","article-title":"Nox2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells","volume":"126","author":"Savina","year":"2006","journal-title":"Cell"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914867107","article-title":"NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes","volume":"107","author":"Rybicka","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.440","article-title":"Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH\u2010independent manner","volume":"31","author":"Rybicka","year":"2012","journal-title":"EMBO J"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103080","article-title":"Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells","volume":"189","author":"Crotzer","year":"2012","journal-title":"J Immunol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091056","article-title":"Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes","volume":"18","author":"Zou","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00310.x","article-title":"The lysosomal cysteine proteases in MHC class II antigen presentation","volume":"207","author":"Hsing","year":"2005","journal-title":"Immunol Rev"},{"key":"B93","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.imlet.2014.11.001","article-title":"B cell epitope spreading: Mechanisms and contribution to autoimmune diseases","volume":"163","author":"Cornaby","year":"2015","journal-title":"Immunol Lett"},{"key":"B94","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/B978-0-323-99130-8.00038-6","article-title":"Epitope spreading in autoimmune diseases","volume-title":"Infection and Autoimmunity","author":"Venkatesha","year":"2024"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1384550","article-title":"Clinical presentation, diagnosis, and treatment of chronic granulomatous disease","volume":"12","author":"Staudacher","year":"2024","journal-title":"Front Pediatr"},{"key":"B96","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1399-3038.2005.00225.x","article-title":"Clinical and laboratory aspects of chronic granulomatous disease in description of eighteen patients","volume":"16","author":"Carnide","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy014","article-title":"Noninfectious manifestations and complications of chronic granulomatous disease","volume":"7","author":"Henrickson","year":"2018","journal-title":"J Pediatr Infect Dis Soc"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.06.005","article-title":"Clinical features and outcomes of patients with chronic granulomatous disease in Taiwan","volume":"56","author":"Lin","year":"2023","journal-title":"J Microbiol Immunol Infect"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.050","article-title":"Chronic granulomatous disease as a risk factor for autoimmune disease","volume":"122","author":"De Ravin","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.081","article-title":"Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease","volume":"134","author":"Feld","year":"2008","journal-title":"Gastroenterology"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138107","article-title":"Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease","volume":"33","author":"Khaldi","year":"2009","journal-title":"Eur Respir J"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12826","article-title":"Association between discoid lupus erythematosus and chronic granulomatous disease\u2014report of two cases and review of the literature","volume":"33","author":"Xie","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v18i4.1426","article-title":"Lupus erythematosus and chronic granulomatous disease: report of four Iranian patients with Ar-Cgd and one Xl-Cgd","volume":"18","author":"Maddah","year":"2019","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.gendis.2019.07.010","article-title":"Recent advances in chronic granulomatous disease","volume":"7","author":"Anjani","year":"2020","journal-title":"Gene Dis"},{"key":"B105","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s10875-021-01002-w","article-title":"Clinical and immunological characteristics of 63 patients with chronic granulomatous disease: Hacettepe experience","volume":"41","author":"Akar","year":"2021","journal-title":"J ClinImmunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-023-01541-4","article-title":"Chronic granulomatous disease: a cohort of 173 patients\u201410-years single center experience from Egypt","volume":"43","author":"Abd Elaziz","year":"2023","journal-title":"J ClinImmunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577229","article-title":"Systemic lupus erythematosus with autoimmune neurological manifestations in a carrier of chronic granulomatous disease-a rare presentation","volume":"343","author":"Prabhat","year":"2020","journal-title":"J Neuroimmunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00118414","article-title":"Pulmonary manifestations in adult patients with chronic granulomatous disease","volume":"45","author":"Salvator","year":"2015","journal-title":"Eur Respir J"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.6.834","article-title":"Chronic granulomatous disease of childhood: an unusual cause of honeycomb lung","volume":"68","author":"Fleming","year":"1975","journal-title":"Chest"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4590127","article-title":"Nadph oxidase deficiency: a multisystem approach","volume":"2017","author":"Giardino","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.2.207","article-title":"Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus","volume":"185","author":"Morgenstern","year":"1997","journal-title":"J Exp Med"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.5.684","article-title":"Surgical pathology of the lung in chronic granulomatous disease","volume":"102","author":"Moskaluk","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28996","article-title":"Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection","volume":"116","author":"Popov","year":"2006","journal-title":"J Clin Invest"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4906(03)00072-3","article-title":"Tolerance, Dcs and tryptophan: much ado about Ido","volume":"24","author":"Grohmann","year":"2003","journal-title":"Trends Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.04.007","article-title":"Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase","volume":"6","author":"Adams","year":"2004","journal-title":"Microbes Infect"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1002\/art.39629","article-title":"Association of increased Treg cell levels with elevated indoleamine 2,3-dioxygenase activity and an imbalanced kynurenine pathway in interferon-positive primary Sjogren's syndrome","volume":"68","author":"Maria","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007955","article-title":"Host cell depletion of tryptophan by Ifn\u03b3-induced indoleamine 2, 3-dioxygenase 1 (Ido1) inhibits lysosomal replication of Coxiella burnetii","volume":"15","author":"Ganesan","year":"2019","journal-title":"PloS Pathog"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.2723-2730.2004","article-title":"Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine 2, 3-dioxygenase","volume":"72","author":"Hucke","year":"2004","journal-title":"Infect Immun"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/nature06471","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease","volume":"451","author":"Romani","year":"2008","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.04.006","article-title":"Modulation of T cells by tryptophan metabolites in the kynurenine pathway","volume":"44","author":"Stone","year":"2023","journal-title":"Trends Pharmacol Sci"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900986","article-title":"Ido activates regulatory T cells and blocks their conversion into Th17-like T cells","volume":"183","author":"Baban","year":"2009","journal-title":"J Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00054.2014","article-title":"Nox2 protects against progressive lung injury and multiple organ dysfunction syndrome","volume":"307","author":"Whitmore","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007652","article-title":"Nadph oxidase 2 limits amplification of Il-1beta-G-Csf axis and an immature neutrophil subset in murine lung inflammation","volume":"7","author":"Song","year":"2023","journal-title":"Blood Adv"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0386-6","article-title":"Severe aspergillus pneumonia and pulmonary artery hypertension in a child with autosomal recessive chronic granulomatous disease and selective Iga deficiency","volume":"37","author":"Jindal","year":"2017","journal-title":"J ClinImmunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"19349","DOI":"10.1038\/s41598-020-76408-4","article-title":"Imaging findings of pulmonary manifestations of chronic granulomatous disease in a large single center from Shanghai, China (1999-2018)","volume":"10","author":"Yao","year":"2020","journal-title":"Sci Rep"},{"key":"B126","article-title":"Increased risk of ischemic coronary and cerebrovascular events in patients with chronic granulomatous disease","volume":"128","author":"Drummond","year":"2013","journal-title":"Circulation"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1530\/VB-23-0018","article-title":"Whole-body insulin resistance leads to accelerated atherosclerosis: role for Nox2 Nadph oxidase","volume":"6","author":"Maqbool","year":"2024","journal-title":"Vasc Biol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr348","article-title":"Nox2-derived reactive oxygen species are crucial for Cd29-induced pro-survival signalling in cardiomyocytes","volume":"93","author":"Rosc-Schluter","year":"2012","journal-title":"Cardiovasc Res"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00086","article-title":"Mechanisms and consequences of defective efferocytosis in atherosclerosis","volume":"4","author":"Yurdagul","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123204","article-title":"Defective macrophage efferocytosis in advanced atherosclerotic plaque and mitochondrial therapy","volume":"359","author":"Li","year":"2024","journal-title":"Life Sci"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.08.012","article-title":"Lc3-associated phagocytosis and inflammation","volume":"429","author":"Heckmann","year":"2017","journal-title":"J Mol Biol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.104","article-title":"Detection of LC3-associated phagocytosis (Lap)","volume":"87","author":"Martinez","year":"2020","journal-title":"Curr Protoc Cell Biol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.034","article-title":"Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment","volume":"136","author":"Fernandez-Boyanapalli","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-272005","article-title":"Ppargamma activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease","volume":"116","author":"Fernandez-Boyanapalli","year":"2010","journal-title":"Blood"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01310-9","article-title":"Hematopoietic stem cell transplantation in late-onset X-linked chronic granulomatous disease in a female carrier","volume":"42","author":"Trevisan","year":"2022","journal-title":"J ClinImmunol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005234","article-title":"Chronic granulomatous disease: the European experience","volume":"4","author":"van den Berg","year":"2009","journal-title":"PloS One"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63509-2","article-title":"Deficiency of Nadph oxidase components P47phox and Gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models","volume":"163","author":"van de Loo","year":"2003","journal-title":"Am J Pathol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403831101","article-title":"Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene","volume":"101","author":"Hultqvist","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012645108","article-title":"Spontaneous and aging-dependent development of arthritis in Nadph oxidase 2 deficiency through altered differentiation of Cd11b+ and Th\/Treg cells","volume":"108","author":"Lee","year":"2011","journal-title":"PNAS"},{"key":"B140","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s43556-022-00076-1","article-title":"Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst","volume":"3","author":"Liang","year":"2022","journal-title":"Mol BioMed"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445020","article-title":"Germ\u2010free mice deficient of reactive oxygen species have increased arthritis susceptibility","volume":"45","author":"Wing","year":"2015","journal-title":"Eur J Immunol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00213","article-title":"K\/Bxn serum-transfer arthritis as a model for human inflammatory arthritis","volume":"7","author":"Christensen","year":"2016","journal-title":"Front Immunol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.5070\/d3233034298","article-title":"Chronic granulomatous disease as a risk factor for cutaneous lupus in childhood","volume":"23","author":"Carvalho","year":"2017","journal-title":"Dermatol Online J"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usab073","article-title":"Adult-diagnosed chronic granulomatous disease: the need to increase awareness","volume":"188","author":"Baxter","year":"2023","journal-title":"Mil Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109451","article-title":"Lupus nephritis with clinical and laboratory features of humoral immune deficiency in a 29-year-old female with a novel Ncf1 variant consistent with autosomal recessive chronic granulomatous disease","volume":"250","author":"Siwakoti","year":"2023","journal-title":"Clin Immunol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-2249.2007.03321.x","article-title":"Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology","volume":"148","author":"Cale","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2018.03.005","article-title":"Association of Nox2 subunits genetic variants with autoimmune diseases","volume":"125","author":"Zhong","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220793","article-title":"Human Sle variant Ncf1-R90h promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages","volume":"81","author":"Geng","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211287","article-title":"A single nucleotide polymorphism in the Ncf1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus","volume":"76","author":"Olsson","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3782","article-title":"A missense variant in Ncf1 is associated with susceptibility to multiple autoimmune diseases","volume":"49","author":"Zhao","year":"2017","journal-title":"Nat Genet"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215820","article-title":"Ncf1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus","volume":"79","author":"Linge","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1172\/JCI153619","article-title":"The Ncf1 variant p. R90h aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells","volume":"132","author":"Meng","year":"2022","journal-title":"J Clin Invest"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1186\/ar4575","article-title":"Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus","volume":"16","author":"Bengtsson","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04547-9","article-title":"The behavior of neutrophil extracellular traps and NADPH oxidative activity in pediatric systemic lupus erythematosus: relation to disease activity and lupus nephritis","volume":"38","author":"El-Ghoneimy","year":"2019","journal-title":"Clin Rheumatol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004801","article-title":"NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus","volume":"4","author":"Campbell","year":"2012","journal-title":"Sci Transl Med"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.164875","article-title":"Ncf1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions","volume":"8","author":"Luo","year":"2023","journal-title":"JCI Insight"},{"key":"B157","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41584-020-00544-4","article-title":"Toll-like receptor signalling in B cells during systemic lupus erythematosus","volume":"17","author":"Fillatreau","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1093208","article-title":"Toll-like receptors 7 and 9 regulate the proliferation and differentiation of B cells in systemic lupus erythematosus","volume":"14","author":"Wen","year":"2023","journal-title":"Front Immunol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-042422","article-title":"Systemic lupus erythematosus pathogenesis: interferon and beyond","volume":"41","author":"Caielli","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0010-6","article-title":"Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients","volume":"16","author":"Liu","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320935976","article-title":"Characterization of type-I IFN subtype autoantibodies and activity in SLE serum and urine","volume":"29","author":"Harris","year":"2020","journal-title":"Lupus"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231882","article-title":"IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints","volume":"222","author":"Fike","year":"2025","journal-title":"J Exp Med"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5828","article-title":"Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature","volume":"21","author":"Kelkka","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/s41467-025-56857-z","article-title":"The systemic lupus erythematosus-associated Ncf190h allele synergizes with viral infection to cause mouse lupus but also limits virus spread","volume":"16","author":"Li","year":"2025","journal-title":"Nat Commun"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02236","article-title":"High levels of IL-18 and IFN-\u0393 in chronically inflamed tissue in chronic granulomatous disease","volume":"10","author":"Meda Spaccamela","year":"2019","journal-title":"Front Immunol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01555","article-title":"Altered humoral immune responses and IgG subtypes in Nox2-deficient mice and patients: a key role for Nox2 in antigen-presenting cells","volume":"9","author":"Cachat","year":"2018","journal-title":"Front Immunol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01391-6","article-title":"Efficacy and safety of interferon-gamma in chronic granulomatous disease: a systematic review and meta-analysis","volume":"43","author":"Lugo Reyes","year":"2023","journal-title":"J ClinImmunol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41392-023-01471-y","article-title":"T cells in health and disease","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1079668","article-title":"The emerging role of Th1 cells in atherosclerosis and its implications for therapy","volume":"13","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1305590","article-title":"Th1-related transcription factors and cytokines in systemic lupus erythematosus","volume":"14","author":"Tang","year":"2023","journal-title":"Front Immunol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac199","article-title":"The pathogenicity and synergistic action of Th1 and Th17 cells in inflammatory bowel diseases","volume":"29","author":"Cao","year":"2023","journal-title":"Inflammation Bowel Dis"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0546","article-title":"Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in type 1 diabetes","volume":"64","author":"Padgett","year":"2015","journal-title":"Diabetes"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242659","article-title":"Decreased STAT5 phosphorylation and GATA\u20103 expression in NOX 2\u2010deficient T cells: role in T helper development","volume":"42","author":"Shatynski","year":"2012","journal-title":"Eur J Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/ni1096","article-title":"T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation","volume":"5","author":"Jackson","year":"2004","journal-title":"Nat Immunol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.8.3759","article-title":"Differential capacities of CD4+, CD8+, and CD4- CD8- T cell subsets to express IL-18 receptor and produce IFN-\u0393 in response to IL-18","volume":"160","author":"Tomura","year":"1998","journal-title":"J Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200107)31:7<2236::aid-immu2236>3.0.co;2-g","article-title":"IFN\u2010A and IL\u201018 synergistically enhance IFN\u2010\u0393 production in human NK cells: differential regulation of STAT4 activation and IFN\u2010\u0393 gene expression by IFN\u2010A and IL\u201012","volume":"31","author":"Matikainen","year":"2001","journal-title":"Eur J Immunol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.423","article-title":"Interleukin-18 regulates both Th1 and Th2 responses","volume":"19","author":"Nakanishi","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919973","article-title":"Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: biological role in induction, regulation, and treatment","volume":"13","author":"Ihim","year":"2022","journal-title":"Front Immunol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028198","article-title":"NADPH oxidase-2 derived ROS dictates murine DC cytokine-mediated cell fate decisions during CD4 T helper-cell commitment","volume":"6","author":"Jendrysik","year":"2011","journal-title":"PloS One"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13300","article-title":"Regulatory T cell features in chronic granulomatous disease","volume":"197","author":"van de Geer","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2018.03.004","article-title":"Redox-sensitive signaling in inflammatory T cells and in autoimmune disease","volume":"125","author":"Weyand","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.09.020","article-title":"JAK-STAT signaling pathway, immunodeficiency, inflammation, immune dysregulation, and inborn errors of immunity","volume":"155","author":"Samra","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914795107","article-title":"Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease","volume":"107","author":"van de Veerdonk","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1210","article-title":"T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells","volume":"352","author":"Arbore","year":"2016","journal-title":"Science"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1393096","article-title":"Interleukin-1 regulates follicular T cells during the germinal center reaction","volume":"15","author":"Belbezier","year":"2024","journal-title":"Front Immunol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-024-09490-9","article-title":"Inflammasome functional activities in B lymphocytes","volume":"72","author":"Hsu","year":"2024","journal-title":"Immunol Res"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.174005","article-title":"Loss of T follicular regulatory cell\u2013derived IL-1R2 augments germinal center reactions via increased IL-1","volume":"9","author":"Pyrillou","year":"2024","journal-title":"JCI Insight"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.731216","article-title":"NADPH oxidases are essential for macrophage differentiation","volume":"291","author":"Xu","year":"2016","journal-title":"J Biol Chem"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000371","article-title":"The metabolic prospective and redox regulation of macrophage polarization","volume":"6","author":"He","year":"2015","journal-title":"J Clin Cell Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021015365","article-title":"Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice","volume":"139","author":"Bhattacharya","year":"2022","journal-title":"Blood"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1999.0837","article-title":"Interleukin-18","volume":"19","author":"Dinarello","year":"1999","journal-title":"Methods"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-461913","article-title":"An efferocytosis-induced, IL-4-dependent macrophage-INKT cell circuit suppresses sterile inflammation and is defective in murine CGD","volume":"121","author":"Zeng","year":"2013","journal-title":"Blood"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1038\/22572","article-title":"Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12\/15-lipoxygenase","volume":"400","author":"Huang","year":"1999","journal-title":"Nature"},{"key":"B195","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/imm.12530","article-title":"Hyper-responsive toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts","volume":"146","author":"McLetchie","year":"2015","journal-title":"Immunology"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.178563","article-title":"NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7","volume":"9","author":"Gordon","year":"2024","journal-title":"JCI Insight"},{"key":"B197","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12016-025-09021-w","article-title":"Age-associated B cells in autoimmune diseases: pathogenesis and clinical implications","volume":"68","author":"Xie","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2025.103433","article-title":"The role of age-associated B cells in systemic lupus erythematosus","volume":"154","author":"Su","year":"2025","journal-title":"J Autoimmun"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1111\/cen3.70011","article-title":"Pathogenic role of age\u2010associated B cells in autoimmune disorders and myasthenia gravis","volume":"16","author":"Akamine","year":"2025","journal-title":"Clin Exp Neuroimmunol"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ads8226","article-title":"CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model","volume":"10","author":"Zhu","year":"2025","journal-title":"Sci Immunol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41641","article-title":"Ifn\u03b3 induces epigenetic programming of human T-Bethi B cells and promotes Tlr7\/8 and Il-21 induced differentiation","volume":"8","author":"Zumaquero","year":"2019","journal-title":"Elife"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt8199","article-title":"Critical roles of chronic Bcr signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity","volume":"11","author":"Imabayashi","year":"2025","journal-title":"Sci Adv"},{"key":"B203","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11926-021-01047-1","article-title":"Tlr7 signaling in lupus B cells: New insights into synergizing factors and downstream signals","volume":"23","author":"Satterthwaite","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13440","article-title":"Know your Abc s: Discovery, differentiation, and targeting of T\u2010Bet+ B cells","volume":"330","author":"Winslow","year":"2025","journal-title":"Immunol Rev"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.110325","article-title":"T peripheral helper (Tph) cells, a marker of immune activation in cancer and autoimmune disorders","volume":"266","author":"Oliva","year":"2024","journal-title":"Clin Immunol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00529-z","article-title":"Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases","volume":"18","author":"Yoshitomi","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B207","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41541-023-00781-0","article-title":"Co-adjuvanting Dda\/Tdb liposomes with a Tlr7 agonist allows for Igg2a\/C class-switching in the absence of Th1 cells","volume":"8","author":"Zimmermann","year":"2023","journal-title":"NPJ Vaccines"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082114899","article-title":"T-Bet regulates Igg class switching and pathogenic autoantibody production","volume":"99","author":"Peng","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B209","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0008-8749(91)90257-c","article-title":"Ifn-\u0393 enhances secretion of Igg2a from Igg2a-committed Lps-stimulated murine B cells: Implications for the role of Ifn-\u0393 in class switching","volume":"135","author":"Bossie","year":"1991","journal-title":"Cell Immunol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.060","article-title":"C-Myb regulates the T-Bet-dependent differentiation program in B cells to coordinate antibody responses","volume":"19","author":"Piovesan","year":"2017","journal-title":"Cell Rep"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201848084","article-title":"B cell\u2010intrinsic Myd88 signaling controls Ifn\u2010\u0393\u2010mediated early Igg2c class switching in mice in response to a particulate adjuvant","volume":"49","author":"Lee","year":"2019","journal-title":"Eur J Immunol"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2406192121","article-title":"Complement activation by Igg subclasses is governed by their ability to oligomerize upon antigen binding","volume":"121","author":"Frischauf","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116775","article-title":"Igg2c subclass dominance drives fatal lupus-like nephritis via Fc\u03b3r and complement activation","volume":"45","author":"Luan","year":"2026","journal-title":"Cell Rep"},{"key":"B214","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1371\/journal.pone.0263370","article-title":"Interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype","volume":"132","author":"Ellison","year":"2018","journal-title":"Blood"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025016213","article-title":"Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring","volume":"9","author":"Bruno","year":"2025","journal-title":"Blood Adv"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0331657","article-title":"Interferon-gamma 1b-induced gene expression alters neutrophil function in patients with chronic granulomatous disease","volume":"20","author":"Ambruso","year":"2025","journal-title":"PloS One"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg193","article-title":"Development of systemic lupus erythematosus in a young child affected with chronic granulomatous disease following withdrawal of treatment with interferon\u2010\u0393","volume":"42","author":"Badolato","year":"2003","journal-title":"Rheumatology"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200005000-00003","article-title":"Chronic granulomatous disease. Report on a national registry of 368 patients","volume":"79","author":"Winkelstein","year":"2000","journal-title":"Med (Baltimore)"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/252460","article-title":"Current concepts of hyperinflammation in chronic granulomatous disease","volume":"2012","author":"Rieber","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1365-2249.2011.04449.x","article-title":"Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease","volume":"166","author":"Horvath","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014417","article-title":"Environment tames Cgd macrophages","volume":"139","author":"Bagaitkar","year":"2022","journal-title":"Blood"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011798","article-title":"Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease","volume":"139","author":"Gibbings","year":"2022","journal-title":"Blood"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1508787","article-title":"Mechanisms of Keap1\/Nrf2 modulation in bacterial infections: Implications in persistence and clearance","volume":"15","author":"Romero-Duran","year":"2024","journal-title":"Front Immunol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009631","article-title":"Nadph oxidase limits innate immune responses in the lungs in mice","volume":"5","author":"Segal","year":"2010","journal-title":"PloS One"},{"key":"B225","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4049\/jimmunol.1801485","article-title":"Attracting attention: Discovery of Il-8\/Cxcl8 and the birth of the chemokine field","volume":"202","author":"Moore","year":"2019","journal-title":"J Immunol"},{"key":"B226","article-title":"Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor","volume":"68","author":"Larsen","year":"1989","journal-title":"Immunology"},{"key":"B227","article-title":"Il-1 transcriptionally activates the neutrophil chemotactic factor\/Il-8 gene in endothelial cells","volume":"69","author":"Sica","year":"1990","journal-title":"Immunology"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804080","article-title":"Il-17a controls Il-17f production and maintains blood neutrophil counts in mice","volume":"183","author":"von Vietinghoff","year":"2009","journal-title":"J Immunol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1159\/000350378","article-title":"Regulation of neutrophil apoptosis differs after in vivo transmigration to skin chambers and synovial fluid: A role for inflammasome-dependent interleukin-1beta release","volume":"5","author":"Christenson","year":"2013","journal-title":"J Innate Immun"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13327","article-title":"Group 1 Ilcs: Heterogeneity, plasticity, and transcriptional regulation","volume":"323","author":"Sudan","year":"2024","journal-title":"Immunol Rev"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1146077","article-title":"Transcriptional control of Ilc identity","volume":"14","author":"Korchagina","year":"2023","journal-title":"Front Immunol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0512265","article-title":"Redox control of Nlrp3 inflammasome activation in health and disease","volume":"92","author":"Rubartelli","year":"2012","journal-title":"J Leukoc Biol"},{"key":"B235","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.clim.2008.12.008","article-title":"Il-1beta and Il-2 convert human Treg into T(H)17 cells","volume":"131","author":"Deknuydt","year":"2009","journal-title":"Clin Immunol"},{"key":"B236","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41598-017-00508-x","article-title":"Il-1beta induced Hif-1alpha inhibits the differentiation of human Foxp3(+) T cells","volume":"7","author":"Feldhoff","year":"2017","journal-title":"Sci Rep"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001536","article-title":"Il-1beta-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into Il-17-producing cells","volume":"185","author":"Li","year":"2010","journal-title":"J Immunol"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15960","article-title":"B cell-derived Il-1beta and Il-6 drive T cell reconstitution following lymphoablation","volume":"20","author":"Hasgur","year":"2020","journal-title":"Am J Transplant"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1038\/ni1488","article-title":"Il-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the Il-21 and Il-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143394","article-title":"Th17 cells and the Il-23\/Il-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases","volume":"20","author":"Bunte","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1038\/nri2295","article-title":"Th17 cells in development: An updated view of their molecular identity and genetic programming","volume":"8","author":"Dong","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.705","article-title":"Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their Cd40 antigen","volume":"173","author":"Rousset","year":"1991","journal-title":"J Exp Med"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9939-5","article-title":"Clinical manifestations of disease in X-linked carriers of chronic granulomatous disease","volume":"33","author":"Battersby","year":"2013","journal-title":"J ClinImmunol"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01055-x","article-title":"Clinical features of female Taiwanese carriers with X-linked chronic granulomatous disease from 2004 to 2019","volume":"41","author":"Wu","year":"2021","journal-title":"J ClinImmunol"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.110364","article-title":"High symptom burden in female X-linked chronic granulomatous disease carriers","volume":"268","author":"Miranda","year":"2024","journal-title":"Clin Immunol"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2025.07.012","article-title":"Rheumatologic manifestations in an X-linked chronic granulomatous disease carrier","volume":"370","author":"Hudson","year":"2025","journal-title":"Am J Med Sci"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v18i4.1425","article-title":"Skewed X-inactivation in a female carrier with X-linked chronic granulomatous disease","volume":"18","author":"L\u00f3pez-Hern\u00e1ndez","year":"2019","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01619.x","article-title":"Skewing of X\u2010chromosome inactivation in three generations of carriers with X\u2010linked chronic granulomatous disease within one family","volume":"36","author":"K\u00f6ker","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.3389\/flupu.2023.1186641","article-title":"Lupus-associated Ncf2 variant P. R395w in the Nadph oxidase 2 complex results in a reduced production of reactive oxygen species by myeloid cells","volume":"1","author":"Song","year":"2023","journal-title":"Front Lupus"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025240","article-title":"Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface","volume":"145","author":"Mansoori Moghadam","year":"2025","journal-title":"Blood"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00438-7","article-title":"Gene regulation in time and space during X-chromosome inactivation","volume":"23","author":"Loda","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1038\/nature24265","article-title":"Landscape of X chromosome inactivation across human tissues","volume":"550","author":"Tukiainen","year":"2017","journal-title":"Nature"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2023.102063","article-title":"Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation","volume":"81","author":"Schw\u00e4mmle","year":"2023","journal-title":"Curr Opin Genet Dev"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.07.022","article-title":"X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel Cybb mutation and late presentation","volume":"129","author":"Lewis","year":"2008","journal-title":"Clin Immunol"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxad129","article-title":"X-linked chronic granulomatous disease secondary to skewed X-chromosome inactivation in female patients","volume":"215","author":"Zhang","year":"2024","journal-title":"Clin Exp Immunol"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0919","article-title":"Adult onset X-linked chronic granulomatous disease in a woman patient caused by a de novo mutation in paternal-origin Cybb gene and skewed inactivation of normal maternal X chromosome","volume":"47","author":"Gono","year":"2008","journal-title":"Internal Med"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000230","article-title":"Increased susceptibility of a carrier of X-linked chronic granulomatous disease (CGD) to Aspergillus fumigatus infection associated with age-related skewing of lyonization","volume":"80","author":"R\u00f6sen-Wolff","year":"2001","journal-title":"Ann Hematol"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.08.002","article-title":"Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in GP91-phox and a non familial, extremely skewed X chromosome inactivation","volume":"109","author":"Anderson-Cohen","year":"2003","journal-title":"Clin Immunol"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv186","article-title":"Diagnostic and treatment options for severe IBD in female X-CGD carriers with non-random X-inactivation","volume":"10","author":"Hauck","year":"2016","journal-title":"J Crohns Colitis"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn6537","article-title":"Altered X-chromosome inactivation predisposes to autoimmunity","volume":"10","author":"Huret","year":"2024","journal-title":"Sci Adv"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0291-3","article-title":"Skewed X-inactivation is common in the general female population","volume":"27","author":"Shvetsova","year":"2019","journal-title":"Eur J Hum Genet"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380611","article-title":"X inactivation in females with X-linked disease","volume":"338","author":"Puck","year":"1998","journal-title":"N Engl J Med"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1391807","article-title":"X\u2010chromosome inactivation and related diseases","volume":"2022","author":"Sun","year":"2022","journal-title":"Genet Res"},{"key":"B265","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13293-023-00527-6","article-title":"X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events","volume":"14","author":"Buono","year":"2023","journal-title":"Biol Sex Differ"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-018-0712-y","article-title":"Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation","volume":"41","author":"Souyris","year":"2019","journal-title":"Semin Immunopathol"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aap8855","article-title":"TLR7 escapes X chromosome inactivation in immune cells","volume":"3","author":"Souyris","year":"2018","journal-title":"Sci Immunol"},{"key":"B268","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41467-024-55690-0","article-title":"An essential role for TASL in mouse autoimmune pathogenesis and toll-like receptor signaling","volume":"16","author":"Lau","year":"2025","journal-title":"Nat Commun"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24395","article-title":"CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation","volume":"82","author":"Hua","year":"2022","journal-title":"Prostate"},{"key":"B270","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.molimm.2023.02.009","article-title":"CXCR3 deficiency decreases autoantibody production by inhibiting aberrant activated T follicular helper cells and B cells in lupus mice","volume":"156","author":"Wang","year":"2023","journal-title":"Mol Immunol"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01140-1","article-title":"Late onset of chronic granulomatous disease revealed by Paecilomyces lilacinus cutaneous infection","volume":"42","author":"Lemaigre","year":"2022","journal-title":"J ClinImmunol"},{"key":"B272","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.stem.2022.05.006","article-title":"Clonal hematopoiesis: mutation-specific adaptation to environmental change","volume":"29","author":"Florez","year":"2022","journal-title":"Cell Stem Cell"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78263","article-title":"Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans","volume":"11","author":"Roberts","year":"2022","journal-title":"Elife"},{"key":"B274","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2018.10.009","article-title":"The epigenetics of inflammaging: the contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli","volume-title":"Semin Immunol","author":"Nardini","year":"2018"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150660","article-title":"Nox2-dependent regulation of inflammation","volume":"130","author":"Singel","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"B276","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.07.030","article-title":"Diagnostic modalities based on flow cytometry for chronic granulomatous disease: a multicenter study in a well-defined cohort","volume":"8","author":"Baris","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9243-y","article-title":"First report of clinical, functional, and molecular investigation of chronic granulomatous disease in nine Jordanian families","volume":"29","author":"Bakri","year":"2009","journal-title":"J ClinImmunol"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12767","article-title":"Genetic and molecular findings of 38 Iranian patients with chronic granulomatous disease caused by P47\u2010phox defect","volume":"90","author":"Tajik","year":"2019","journal-title":"Scand J Immunol"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022590","article-title":"Genotype-phenotype correlations in chronic granulomatous disease: insights from a large national cohort","volume":"144","author":"Wolach","year":"2024","journal-title":"Blood"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018023184","article-title":"NCF1 (P47phox)\u2013deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis","volume":"3","author":"Kuhns","year":"2019","journal-title":"Blood Adv"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02195.x","article-title":"Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations","volume":"39","author":"K\u00f6ker","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00607-6","article-title":"Health-related quality of life and emotional health in X-linked carriers of chronic granulomatous disease in the United Kingdom","volume":"39","author":"Battersby","year":"2019","journal-title":"J ClinImmunol"},{"key":"B284","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1016\/j.jaip.2024.09.018","article-title":"Severe clinical phenotypes of heterozygous females with X-linked chronic granulomatous disease","volume":"12","author":"Patel","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060891","article-title":"Immunological aspects of X-linked chronic granulomatous disease female carriers","volume":"10","author":"Chiriaco","year":"2021","journal-title":"Antioxidants"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch Toxicol"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.519","article-title":"Roles of reactive oxygen species in inflammation and cancer","volume":"5","author":"Yu","year":"2024","journal-title":"MedComm"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14259","article-title":"Novel hypomorphic Cybb variant causing chronic granulomatous disease with incomplete penetrance","volume":"35","author":"Cuesta\u2010Mart\u00edn de la C\u00e1mara","year":"2024","journal-title":"Pediatr Allergy Immunol"},{"key":"B289","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12969-021-00536-y","article-title":"Homozygous variant p. Arg90His in NCF1 is associated with early-onset interferonopathy: a case report","volume":"19","author":"Schnappauf","year":"2021","journal-title":"Pediatr Rheumatol"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1002\/art.40141","article-title":"Haploinsufficiency of NADPH oxidase subunit neutrophil cytosolic factor 2 is sufficient to accelerate full\u2010blown lupus in NZM 2328 mice","volume":"69","author":"Jacob","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21431","article-title":"Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics","volume":"9","author":"Zhao","year":"2023","journal-title":"Heliyon"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1387903","article-title":"Gut redox and microbiome: charting the roadmap to T-cell regulation","volume":"15","author":"Prasad","year":"2024","journal-title":"Front Immunol"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.10.495","article-title":"Redox signaling mediated by the gut microbiota","volume":"105","author":"Jones","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0021-8","article-title":"NADPH oxidases and ROS signaling in the gastrointestinal tract","volume":"11","author":"Aviello","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0205-x","article-title":"Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects","volume":"12","author":"Aviello","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9424-3_34","article-title":"Gastrointestinal complications in chronic granulomatous disease","volume":"1982","author":"Falcone","year":"2019","journal-title":"Methods Mol Biol"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.12.039","article-title":"Gastrointestinal and hepatic manifestations of chronic granulomatous disease","volume":"11","author":"Yang","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B298","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.jaip.2021.12.035","article-title":"Chronic granulomatous disease with inflammatory bowel disease: clinical presentation, treatment, and outcomes from the USIDNET registry","volume":"10","author":"LaBere","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B299","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.jaci.2023.07.022","article-title":"Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease","volume":"152","author":"Chandrasekaran","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01165-6","article-title":"The relationship between mucosal microbiota, colitis, and systemic inflammation in chronic granulomatous disorder","volume":"42","author":"Davrandi","year":"2022","journal-title":"J ClinImmunol"},{"key":"B301","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12017-025-08883-9","article-title":"The role of gut microbiota in modulating immune signaling pathways in autoimmune diseases","volume":"27","author":"Younis","year":"2025","journal-title":"Neuromolecular Med"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.34133\/research.1097","article-title":"The gut microbiota: emerging evidence in autoimmune and inflammatory diseases","volume":"9","author":"Zeng","year":"2026","journal-title":"Research"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj6294","article-title":"Translocating gut pathobiont Enterococcus gallinarum induces Th17 and Igg3 anti-Rna\u2013directed autoimmunity in mouse and human","volume":"17","author":"Gronke","year":"2025","journal-title":"Sci Transl Med"},{"key":"B304","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12016-025-09051-4","article-title":"Exploring gut microbiota in systemic lupus erythematosus: insights and biomarker discovery potential","volume":"68","author":"Jin","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024026332","article-title":"Genotype-specific immune responses at the intestinal barrier predispose to colitis in chronic granulomatous disease","volume":"145","author":"Darbinian","year":"2025","journal-title":"Blood"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091660","article-title":"Novel Nadph oxidase-2 inhibitors as potential anti-inflammatory and neuroprotective agents","volume":"12","author":"Juric","year":"2023","journal-title":"Antioxidants"},{"key":"B307","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1089\/ars.2014.5862","article-title":"Nox2 as a target for drug development: indications, possible complications, and progress","volume":"23","author":"Diebold","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0150-7","article-title":"Nadph oxidase in brain injury and neurodegenerative disorders","volume":"12","author":"Ma","year":"2017","journal-title":"Mol Neurodegener"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8018","article-title":"The dual role of reactive oxygen species-generating nicotinamide adenine dinucleotide phosphate oxidases in gastrointestinal inflammation and therapeutic perspectives","volume":"33","author":"Dang","year":"2020","journal-title":"Antioxid Redox Signal"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5788","article-title":"Pharmacological potential of Nox2 agonists in inflammatory conditions","volume":"23","author":"Hultqvist","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2HI0520-317R","article-title":"Functional selective Fpr1 signaling in favor of an activation of the neutrophil superoxide generating Nox2 complex","volume":"109","author":"Lind","year":"2021","journal-title":"J Leukoc Biol"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01827","article-title":"Chemical tools for targeted amplification of reactive oxygen species in neutrophils","volume":"9","author":"Reshetnikov","year":"2018","journal-title":"Front Immunol"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801599","article-title":"Targeted delivery of curcumin rescues endoplasmic reticulum-retained mutant Nox2 protein and avoids leukocyte apoptosis","volume":"202","author":"Yen ChiaLiang","year":"2019","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1848916\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:20:58Z","timestamp":1784175658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1848916\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":313,"alternative-id":["10.3389\/fimmu.2026.1848916"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1848916","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"article-number":"1848916"}}