{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:44:52Z","timestamp":1785908692739,"version":"3.56.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    GFI1 is a DNA-binding transcription factor that regulates the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in \u03b3\u03b4 T cells and restricts the cellularity of ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    V\u03b36\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells that produce high levels of IL-17A while promoting the expansion of V\u03b31\n                    <jats:sup>+<\/jats:sup>\n                    and V\u03b34\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells. GFI1 deficiency results in an expansion of V\u03b36\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4T17 cells that starts post-birth and is strongly exacerbated upon challenge with an inflammatory allergen. Additionally, we observe an expansion of ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    \/MAF\n                    <jats:sup>+<\/jats:sup>\n                    cells within the thymic DN1e population of GFI1-deficient mice. The DN1e population, along with other DN subsets in GFI1-deficient mice, exhibits a distinctive \u03b3\u03b4T17 cell-specific transcriptomic profile. Specifically, DN1, DN3, and \u03b3\u03b4 T cells lacking GFI1 show upregulation of the B-ZIP transcription factor MAF, which regulates genes critical for \u03b3\u03b4 T cells, such as\n                    <jats:italic>IL-17a<\/jats:italic>\n                    ,\n                    <jats:italic>IL-22<\/jats:italic>\n                    , and\n                    <jats:italic>Blk<\/jats:italic>\n                    . The\n                    <jats:italic>Maf<\/jats:italic>\n                    gene is occupied by GFI1 in DN pre-T cells at cognate binding sites in its promoter region, suggesting that GFI1 acts as a direct repressor of\n                    <jats:italic>Maf<\/jats:italic>\n                    . We conclude that GFI1 functions as a novel regulator of V\u03b36\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4T17 precursor cells restricting their peripheral expansion by acting upstream of a MAF-dependent regulatory network.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1849622","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:52:07Z","timestamp":1785905527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["GFI1 as a novel regulator of \u03b3\u03b4 T cell development and the IL-17\/IFN-\u03b3 lineage commitment"],"prefix":"10.3389","volume":"17","author":[{"given":"Jennifer","family":"Fraszczak","sequence":"first","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM)","place":["Montr\u00e9al, QC, 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Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bavanitha","family":"Thurairajah","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre","place":["Montreal, QC, Canada"]},{"name":"Department of Microbiology and Immunology, McGill University","place":["Montreal, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c8ve","family":"Mallet Gauthier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, McGill University","place":["Montreal, QC, Canada"]},{"name":"Rosalind and Morris Goodman Cancer Institute of the McGill University","place":["Montreal, QC, Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montr\u00e9al, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irah L.","family":"King","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre","place":["Montreal, QC, Canada"]},{"name":"Department of Microbiology and Immunology, McGill University","place":["Montreal, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Melichar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, McGill University","place":["Montreal, QC, Canada"]},{"name":"Rosalind and Morris Goodman Cancer Institute of the McGill University","place":["Montreal, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg","place":["Freiburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"M\u00f6r\u00f6y","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM)","place":["Montr\u00e9al, QC, Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montr\u00e9al, QC, Canada"]},{"name":"Department of Medicine, Division of Clinical and Translational Research, McGill University","place":["Montreal, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.08.006","article-title":"Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation","volume":"23","author":"Moroy","year":"2011","journal-title":"Semin 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