{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:57:11Z","timestamp":1794013031138,"version":"4.8.0"},"reference-count":156,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Lactylation represents a novel post-translational modification originating from lactate, a by-product of glycolysis. It has emerged as a pivotal mechanism linking cellular metabolism to epigenetic regulation. By transferring the lactyl group to lysine residues on both histone and non-histone proteins, this modification regulates gene transcription and protein function, thereby coordinating critical biological processes, including metabolic reprogramming and immune-inflammatory responses. Recent studies have highlighted the pivotal role of lactate and lactylation in the pathogenesis of diverse skin diseases, including immune-inflammatory skin diseases (e.g., psoriasis and atopic dermatitis), pathologic scars, skin malignancies (e.g., melanoma), and skin ageing. In certain diseases, such as psoriasis and melanoma, lactylation has been established as a core molecular mechanism, establishing a pathological link between systemic metabolic disorders, the local skin microenvironment, immune inflammatory processes, and skin diseases. In other conditions, lactate-mediated effects have been well documented, while the specific contribution of lactylation remains an active area of investigation. Currently, lactylation-related inhibitors have demonstrated therapeutic potential in cancer, metabolic, and immunological fields. Consequently, lactate-mediated lactylation may emerge as a novel therapeutic intervention target for skin disorders. In this review, we summarize recent advances in lactylation research in skin diseases and elucidate its potential as a therapeutic target for future clinical applications.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1853603","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:18:03Z","timestamp":1782919083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics"],"prefix":"10.3389","volume":"17","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ren Ji Hospital, Shanghai 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