{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:06:24Z","timestamp":1784700384046,"version":"3.55.0"},"reference-count":161,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Protein O-GlcNAcylation has evolved from a metabolic curiosity into a master post-translational modification that enables cancer cells to translate nutrient availability into coordinated programs of proliferation, therapy resistance, and immune evasion. In this review, we argue that hyper-O-GlcNAcylation is not merely a passive consequence of the Warburg effect but an actively maintained stress-adaptive state that drives malignancy through parallel substrate-selective circuits rather than a single unified axis. We synthesize recent advances in four interconnected dimensions. Metabolically, OGT integrates glucose, lipid, and nucleotide metabolism by modifying key rate-limiting enzymes and is regulated by lineage-specific mechanisms. O-GlcNAcylation modulates responses to chemotherapy and radiotherapy, reinforces DNA damage repair, and controls senescence. Immunologically, it promotes tumor immune evasion by stabilizing PD-L1, reprogramming macrophages, suppressing NK and T cell function, and modulating cGAS\u2013STING signaling, thereby influencing checkpoint blockade efficacy. In the tumor microenvironment, O-GlcNAc signaling remodels the extracellular matrix, drives angiogenesis, and maintains cancer stemness and mechanoadaptation. Collectively, we propose that substrate-selective O-GlcNAc circuits, rather than global OGT activity, are the key drivers of context-dependent malignancy. This framework highlights opportunities for developing next-generation low-toxicity therapeutics, including substrate-selective inhibitors and PROTAC degraders, in rational combinations with chemotherapy, radiotherapy, and immunotherapy.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1854952","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:52:26Z","timestamp":1784699546000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["O-GlcNAcylation at the tumor\u2013immune interface: a metabolic post-translational code driving immune evasion and therapy resistance in cancer"],"prefix":"10.3389","volume":"17","author":[{"given":"Shanshan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Medicine, the Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Urology, the Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJie","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Urology, the Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinning","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of General Medicine, the Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-025-10600-7","article-title":"New types of post-translational modification of proteins in cardiovascular diseases","volume":"18","author":"Fang","year":"2025","journal-title":"J Cardiovasc Transl Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501023","article-title":"Protein posttranslational modifications: the chemistry of proteome diversifications","volume":"44","author":"Walsh","year":"2005","journal-title":"Angew Chem Int Ed Engl"},{"key":"B3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/gm424","article-title":"Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics","volume":"5","author":"Liddy","year":"2013","journal-title":"Genome Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41392-024-01886-1","article-title":"Glycosylation: mechanisms, biological functions and clinical implications","volume":"9","author":"He","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00294-x","article-title":"Global view of human protein glycosylation pathways and functions","volume":"21","author":"Schjoldager","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02120","article-title":"Altered cell adhesion and glycosylation promote cancer immune suppression and metastasis","volume":"10","author":"L\u00e4ubli","year":"2019","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"100031","DOI":"10.1074\/mcp.R120.002206","article-title":"Methods for enrichment and assignment of N-acetylglucosamine modification sites","volume":"20","author":"Maynard","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12672-021-00450-5","article-title":"O-GlcNAcylation links oncogenic signals and cancer epigenetics","volume":"12","author":"Sun","year":"2021","journal-title":"Discov Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.577718","article-title":"Cancer metabolism and elevated O-GlcNAc in oncogenic signaling","volume":"289","author":"Ma","year":"2014","journal-title":"J Biol Chem"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.22","article-title":"Protein O-GlcNAcylation: emerging mechanisms and functions","volume":"18","author":"Yang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2019","article-title":"Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology","volume":"101","author":"Chatham","year":"2021","journal-title":"Physiol Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.AW119.003226","article-title":"Nutrient regulation of signaling and transcription","volume":"294","author":"Hart","year":"2019","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3114","article-title":"O-GlcNAc signalling: implications for cancer cell biology","volume":"11","author":"Slawson","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.228","article-title":"O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway","volume":"36","author":"Ferrer","year":"2017","journal-title":"Oncogene"},{"key":"B16","doi-asserted-by":"publisher","first-page":"10607","DOI":"10.1038\/s41598-017-10886-x","article-title":"Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma","volume":"7","author":"Luanpitpong","year":"2017","journal-title":"Sci Rep"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.41","article-title":"Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1","volume":"29","author":"Caldwell","year":"2010","journal-title":"Oncogene"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.302547","article-title":"Critical role of O-linked \u03b2-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis","volume":"287","author":"Lynch","year":"2012","journal-title":"J Biol Chem"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215365","article-title":"Role and function of O-GlcNAcylation in cancer","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.04.026","article-title":"O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway","volume":"54","author":"Ferrer","year":"2014","journal-title":"Mol Cell"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107709","article-title":"O-GlcNAcylation in tumorigenesis and its implications for cancer therapy","volume":"300","author":"Zhang","year":"2024","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.585288","article-title":"Functional analysis of O-GlcNAcylation in cancer metastasis","volume":"10","author":"Wu","year":"2020","journal-title":"Front Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-018-9742-3","article-title":"O-GlcNAcylation: key regulator of glycolytic pathways","volume":"50","author":"Bacigalupa","year":"2018","journal-title":"J Bioenerg Biomembr"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222278","article-title":"Phosphofructokinase 1 glycosylation regulates cell growth and metabolism","volume":"337","author":"Yi","year":"2012","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01085-5","article-title":"O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1","volume":"18","author":"Zhu","year":"2022","journal-title":"Nat Chem Biol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.4","article-title":"O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent Malignancies","volume":"31","author":"Freund","year":"2017","journal-title":"Leukemia"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216796120","article-title":"O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation","volume":"120","author":"Zhu","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116249","article-title":"The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level","volume":"44","author":"Liu","year":"2025","journal-title":"Cell Rep"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-19-0904","article-title":"Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation","volume":"8","author":"Rodrigues Mantuano","year":"2020","journal-title":"Cancer Immunol Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018959","article-title":"O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation","volume":"6","author":"Isono","year":"2011","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.492512","article-title":"Antibodies that detect O-linked \u03b2-D-N-acetylglucosamine on the extracellular domain of cell surface glycoproteins","volume":"289","author":"Tashima","year":"2014","journal-title":"J Biol Chem"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.861559","article-title":"O-GlcNAcylation and its role in cancer-associated inflammation","volume":"13","author":"Ouyang","year":"2022","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216258","article-title":"O-GlcNAcylation in cancer development and immunotherapy","volume":"566","author":"He","year":"2023","journal-title":"Cancer Lett"},{"key":"B34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s10020-022-00544-y","article-title":"O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy","volume":"28","author":"Lu","year":"2022","journal-title":"Mol Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41419-024-07313-1","article-title":"CARM1-mediated OGT arginine methylation promotes non-small cell lung cancer glycolysis by stabilizing OGT","volume":"15","author":"Lin","year":"2024","journal-title":"Cell Death Dis"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13601-8","article-title":"O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth","volume":"11","author":"Nie","year":"2020","journal-title":"Nat Commun"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05146-2","article-title":"O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer","volume":"480","author":"Panpan","year":"2025","journal-title":"Mol Cell Biochem"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2402674121","article-title":"O-GlcNAcylation of ATP-citrate lyase couples glucose supply to lipogenesis for rapid tumor cell proliferation","volume":"121","author":"Liu","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41589-023-01354-x","article-title":"Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation","volume":"20","author":"Chen","year":"2024","journal-title":"Nat Chem Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/j.cmet.2023.09.009","article-title":"High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate","volume":"35","author":"Zhou","year":"2023","journal-title":"Cell Metab"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1016\/j.molcel.2023.06.010","article-title":"Glucose-induced CRL4(COP1)-p53 axis amplifies glycometabolism to drive tumorigenesis","volume":"83","author":"Su","year":"2023","journal-title":"Mol Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.molcel.2025.02.024","article-title":"PI3K\u03b2 functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth","volume":"85","author":"He","year":"2025","journal-title":"Mol Cell"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0975-3","article-title":"O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth","volume":"39","author":"Singh","year":"2020","journal-title":"Oncogene"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-03035-y","article-title":"ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer","volume":"43","author":"Zhou","year":"2024","journal-title":"Oncogene"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1186\/s12885-024-12811-8","article-title":"GFPT1 accelerates immune escape in breast cancer by modifying PD-L1 via O-glycosylation","volume":"24","author":"Tang","year":"2024","journal-title":"BMC Cancer"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgab063","article-title":"Inhibition of GFAT1 in lung cancer cells destabilizes PD-L1 protein","volume":"42","author":"Chen","year":"2021","journal-title":"Carcinogenesis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1038\/s41467-021-22173-5","article-title":"The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation","volume":"12","author":"Shang","year":"2021","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.canlet.2020.12.012","article-title":"Exosomal O-GlcNAc transferase from esophageal carcinoma stem cell promotes cancer immunosuppression through up-regulation of PD-1 in CD8(+) T cells","volume":"500","author":"Yuan","year":"2021","journal-title":"Cancer Lett"},{"key":"B49","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.chembiol.2025.05.007","article-title":"EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8(+) T cell antitumor responses","volume":"32","author":"Zhang","year":"2025","journal-title":"Cell Chem Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.ccell.2022.08.012","article-title":"Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance","volume":"40","author":"Shi","year":"2022","journal-title":"Cancer Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08820139.2026.2645964","article-title":"Astragalus polysaccharide promotes NLRP3(+) macrophages polarization via suppression of OGT in hepatocellular carcinoma","volume":"55","author":"Lv","year":"2026","journal-title":"Immunol Invest"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.08.062","article-title":"Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity","volume":"84","author":"Oh","year":"2025","journal-title":"J Adv Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.841299","article-title":"Inhibition of O-GlcNAcylation decreases the cytotoxic function of natural killer cells","volume":"13","author":"Feinberg","year":"2022","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290215","article-title":"Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1a chain","volume":"14","author":"Yao","year":"2004","journal-title":"Cell Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01229-8","article-title":"Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells","volume":"21","author":"Sharma","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ccell.2024.11.003","article-title":"Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity","volume":"43","author":"Qiu","year":"2025","journal-title":"Cancer Cell"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2025-011479","article-title":"O-GlcNAc transferase promotes immune evasion and immunotherapy resistance in uterine corpus endometrial cancer by targeting the glucocorticoid receptor","volume":"13","author":"Wang","year":"2025","journal-title":"J Immunother Cancer"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.94849","article-title":"Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway","volume":"13","author":"Chen","year":"2024","journal-title":"Elife"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1016\/j.immuni.2025.07.013","article-title":"Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance","volume":"58","author":"Wang","year":"2025","journal-title":"Immunity"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2025.2593829","article-title":"GFPT1 facilitates immune escape in breast cancer by promoting the OGT-mediate O-GlcNAcylation of CD39","volume":"58","author":"Zhen","year":"2025","journal-title":"Autoimmunity"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2408354121","article-title":"O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer","volume":"121","author":"Zhu","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.04.008","article-title":"Macrophage diversity in cancer revisited in the era of single-cell omics","volume":"43","author":"Ma","year":"2022","journal-title":"Trends Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3439","article-title":"Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and Malignancy","volume":"17","author":"Swamy","year":"2016","journal-title":"Nat Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12964-024-01543-8","article-title":"O-GlcNAc of STING mediates antiviral innate immunity","volume":"22","author":"Li","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50230","article-title":"Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation","volume":"11","author":"Hu","year":"2021","journal-title":"Theranostics"},{"key":"B66","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41419-024-06589-7","article-title":"The GFPT2-O-GlcNAcylation-YBX1 axis promotes IL-18 secretion to regulate the tumor immune microenvironment in pancreatic cancer","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123312","article-title":"Inhibition of O-GlcNAc transferase alters the differentiation and maturation process of human monocyte derived dendritic cells","volume":"10","author":"Weiss","year":"2021","journal-title":"Cells"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107349","article-title":"O-GlcNAcylation and immune cell signaling: A review of known and a preview of unknown","volume":"300","author":"Ramakrishnan","year":"2024","journal-title":"J Biol Chem"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-025-01591-8","article-title":"O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth","volume":"33","author":"Lin","year":"2026","journal-title":"Cell Death Differ"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.116513","article-title":"O-GlcNAcylated Hsp47 as a predictive biomarker in colorectal cancer: Kaempferol targets OGT-collagen axis for therapeutic intervention","volume":"21","author":"Zhou","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B71","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01393-8","article-title":"FOXM1 upregulates O-GlcNAcylation level via the hexosamine biosynthesis pathway to promote angiogenesis in hepatocellular carcinoma","volume":"82","author":"Zhang","year":"2024","journal-title":"Cell Biochem Biophys"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202993","article-title":"Bladder cancer-derived small extracellular vesicles promote tumor angiogenesis by inducing HBP-related metabolic reprogramming and SerRS O-GlcNAcylation in endothelial cells","volume":"9","author":"Li","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40170-025-00393-3","article-title":"Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells","volume":"13","author":"Yin","year":"2025","journal-title":"Cancer Metab"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2025.103897","article-title":"High-glucose microenvironment accelerates Malignant progression via O-GlcNAcylation in oral squamous cell carcinoma","volume":"75","author":"Zhu","year":"2025","journal-title":"Int Dent J"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1172\/jci194378","article-title":"Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence","volume":"136","author":"Lian","year":"2026","journal-title":"J Clin Invest"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-16-0499","article-title":"Augmented TME O-GlcNAcylation promotes tumor proliferation through the inhibition of p38 MAPK","volume":"15","author":"Moriwaki","year":"2017","journal-title":"Mol Cancer Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3724\/abbs.2024222","article-title":"O-GlcNAcylation-related genes mediate tumor microenvironment characteristics and prediction of immunotherapy response in gastric cancer","volume":"57","author":"Wang","year":"2024","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70037","article-title":"O-GlcNAcylation promotes Malignancy and cisplatin resistance of lung cancer by stabilising NRF2","volume":"14","author":"Zhang","year":"2024","journal-title":"Clin Transl Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0341971","article-title":"Reducing OGT and O-GlcNAcylation enhance the anticancer effects of oxaliplatin in SW620 metastatic colorectal cancer cells","volume":"21","author":"Bunsuk","year":"2026","journal-title":"PLoS One"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2021.5207","article-title":"Cisplatin enhances protein O-GlcNAcylation by altering the activity of OGT, OGA and AMPK in human non-small cell lung cancer cells","volume":"58","author":"Wang","year":"2021","journal-title":"Int J Oncol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117400","article-title":"Erbin destabilization by O-GlcNAcylation promotes 5-FU resistance via homologous recombination activation in colorectal cancer","volume":"243","author":"Zhang","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2025.167986","article-title":"Interplay between O-GlcNAcylation and 5-FU response in colorectal cancer: Novel insights from an examination of primary and metastatic cell lines","volume":"1871","author":"Very","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41419-026-08715-z","article-title":"Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil","volume":"17","author":"Jiang","year":"2026","journal-title":"Cell Death Dis"},{"key":"B86","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s10020-025-01285-4","article-title":"O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer","volume":"31","author":"Wang","year":"2025","journal-title":"Mol Med"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-025-00895-8","article-title":"RRM1 O-GlcNAcylation inhibition suppresses pancreatic cancer via TK1-mediated replication stress","volume":"32","author":"Tien","year":"2025","journal-title":"Cancer Gene Ther"},{"key":"B88","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1186\/s13018-022-03449-y","article-title":"LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p\/O-GlcNAc transferase pathway","volume":"17","author":"Sun","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1155\/tbj\/2120017","article-title":"OGT-mediated O-GlcNAcylation stabilizes c-Myc activity and promotes chemoresistance in triple-negative breast cancer","volume":"2026","author":"Li","year":"2026","journal-title":"Breast J"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-025-11129-9","article-title":"OGT enhances adriamycin resistance of breast cancer by promoting glycolysis through MDM4 upregulation in an O-GlcNAcylation-dependent manner","volume":"64","author":"Liu","year":"2025","journal-title":"Biochem Genet"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256458","article-title":"O-GlcNAcylation promotes topoisomerase II\u03b1 catalytic activity in breast cancer chemoresistance","volume":"24","author":"Liu","year":"2023","journal-title":"EMBO Rep"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113154","article-title":"O-GlcNAc transferase inhibitor synergistically enhances doxorubicin-induced apoptosis in HepG2 cells","volume":"12","author":"Lee","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101617","article-title":"KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation","volume":"28","author":"Hua","year":"2023","journal-title":"Transl Oncol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41420-021-00489-x","article-title":"Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer","volume":"7","author":"Qian","year":"2021","journal-title":"Cell Death Discov"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/cells14060398","article-title":"GATAD2B O-GlcNAcylation regulates breast cancer stem-like potential and drug resistance","volume":"14","author":"Le Minh","year":"2025","journal-title":"Cells"},{"key":"B96","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41419-018-0522-0","article-title":"O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death Dis"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00252-18","article-title":"O-GlcNAcylation signal mediates proteasome inhibitor resistance in cancer cells by stabilizing NRF1","volume":"38","author":"Sekine","year":"2018","journal-title":"Mol Cell Biol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27806","article-title":"Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.34133\/research.0809","article-title":"Combinational analysis of metabolomic and O-GlcNAcylation omics reveals the HBP metabolic regulation of chemoresistance via GFPT1\/NR3C1 O-GlcNAcylation\/GPX4 axis","volume":"8","author":"Zhou","year":"2025","journal-title":"Res (Wash D C)"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1177\/1091581820948433","article-title":"Investigating the impact of OGT inhibition on doxorubicin- and docetaxel-induced cytotoxicity in PC-3 and WPMY-1 cells","volume":"39","author":"Makwana","year":"2020","journal-title":"Int J Toxicol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13046-026-03674-x","article-title":"GFAT2-mediated HSPD1 O-GlcNAcylation drives chemotherapy resistance in non-small cell lung cancer","volume":"45","author":"Zhu","year":"2026","journal-title":"J Exp Clin Cancer Res"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1038\/s41467-017-02164-1","article-title":"Pol\u03b7 O-GlcNAcylation governs genome integrity during translesion DNA synthesis","volume":"8","author":"Ma","year":"2017","journal-title":"Nat Commun"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.Mct-18-0426","article-title":"Hexosamine biosynthetic pathway inhibition leads to AML cell differentiation and cell death","volume":"17","author":"Asthana","year":"2018","journal-title":"Mol Cancer Ther"},{"key":"B104","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00438-024-02197-4","article-title":"High expression of ADAR mediated by OGT promotes chemoresistance in colorectal cancer through the A-to-I editing pathway","volume":"299","author":"Liu","year":"2024","journal-title":"Mol Genet Genomics"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28376","article-title":"Resistance to bortezomib in breast cancer cells that downregulate Bim through FOXA1 O-GlcNAcylation","volume":"234","author":"Liu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.254","article-title":"Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition","volume":"29","author":"Park","year":"2010","journal-title":"EMBO J"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1002\/stem.154","article-title":"Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells","volume":"27","author":"Kurrey","year":"2009","journal-title":"Stem Cells"},{"key":"B108","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/acschembio.8b01052","article-title":"An isotope-coded photocleavable probe for quantitative profiling of protein O-GlcNAcylation","volume":"14","author":"Li","year":"2019","journal-title":"ACS Chem Biol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-025-01722-w","article-title":"A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis","volume":"27","author":"Zhang","year":"2025","journal-title":"Nat Cell Biol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41419-025-08209-4","article-title":"O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break damage in cancer cells","volume":"17","author":"Ko","year":"2026","journal-title":"Cell Death Dis"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.785","article-title":"And-1 O-GlcNAcylation regulates homologous recombination repair and radioresistance in colorectal cancer","volume":"12","author":"Zhou","year":"2022","journal-title":"Clin Transl Med"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-026-02233-8","article-title":"O-GlcNAcylation regulates the DNA damage repair function of MND1 in breast cancer","volume":"28","author":"Zhai","year":"2026","journal-title":"Breast Cancer Res"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw663","article-title":"OGT restrains the expansion of DNA damage signaling","volume":"44","author":"Chen","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2015.07.002","article-title":"OGT mediated histone H2B S112 GlcNAcylation regulates DNA damage response","volume":"42","author":"Wang","year":"2015","journal-title":"J Genet Genomics"},{"key":"B115","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41388-023-02881-6","article-title":"O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination","volume":"43","author":"Xu","year":"2024","journal-title":"Oncogene"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.128078","article-title":"O-GlcNAcylation stabilizes RSK4 by antagonizing GSK3\u03b2-mediated phosphorylation to enhance radioresistance in esophageal squamous cell carcinoma","volume":"22","author":"Liu","year":"2026","journal-title":"Int J Biol Sci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-2025-998","article-title":"O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer","volume":"14","author":"Wang","year":"2025","journal-title":"Transl Lung Cancer Res"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-18-1025","article-title":"O-GlcNAcylation enhances double-strand break repair, promotes cancer cell proliferation, and prevents therapy-induced senescence in irradiated tumors","volume":"17","author":"Efimova","year":"2019","journal-title":"Mol Cancer Res"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-15-0263","article-title":"Linking cancer metabolism to DNA repair and accelerated senescence","volume":"14","author":"Efimova","year":"2016","journal-title":"Mol Cancer Res"},{"key":"B120","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41419-024-07131-5","article-title":"O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis","volume":"15","author":"Loison","year":"2024","journal-title":"Cell Death Dis"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2025.120080","article-title":"O-GlcNAcylation of DDX46 promotes hepatocellular carcinoma progression by activating the PI3K\/Akt signaling pathway","volume":"1873","author":"Wang","year":"2026","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400896","article-title":"Silencing of O-GlcNAc transferase attenuated O-GlcNAcylation and metastatic potentials of melanoma cells through suppression of Akt-NF\u03baB signaling pathway","volume":"26","author":"Kanchanangkul","year":"2025","journal-title":"ChemBioChem"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-02121-9","article-title":"Thymidylate synthase O-GlcNAcylation: a molecular mechanism of 5-FU sensitization in colorectal cancer","volume":"41","author":"Very","year":"2022","journal-title":"Oncogene"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1531","article-title":"Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor","volume":"14","author":"Cai","year":"2024","journal-title":"Clin Transl Med"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606899113","article-title":"Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration","volume":"113","author":"Wang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-0589-9","article-title":"An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase","volume":"28","author":"Pravata","year":"2020","journal-title":"Eur J Hum Genet"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.797","article-title":"Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation","volume":"8","author":"Yuzwa","year":"2012","journal-title":"Nat Chem Biol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100309","article-title":"Targeting tau for Alzheimers disease through OGA inhibition","volume":"12","author":"Rafii","year":"2025","journal-title":"J Prev Alzheimers Dis"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100302","article-title":"Results of the first-in-human, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose study of BIIB113 in healthy volunteers","volume":"12","author":"Nery","year":"2025","journal-title":"J Prev Alzheimers Dis"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70020","article-title":"Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease","volume":"10","author":"Kielbasa","year":"2024","journal-title":"Alzheimers Dement (N Y)"},{"key":"B131","unstructured":"2024"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5494","article-title":"The nutrient sensor OGT in PVN neurons regulates feeding","volume":"351","author":"Lagerl\u00f6f","year":"2016","journal-title":"Science"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00451","article-title":"Sialic acid-modified O-GlcNAc transferase inhibitor liposome presents antitumor effect in hepatocellular carcinoma","volume":"21","author":"Lin","year":"2024","journal-title":"Mol Pharm"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.70057","article-title":"Sinomenine suppresses hepatocellular carcinoma cell migration and invasion by inhibiting O-GlcNAcylation of SP1","volume":"52","author":"Liu","year":"2025","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.32604\/or.2026.073156","article-title":"ONX-0914 suppresses hormone-sensitive prostate cancer by promoting O-GlcNAcylation-mediated stabilization of TCF7L1","volume":"34","author":"Xian","year":"2026","journal-title":"Oncol Res"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14380","article-title":"Targeted protein O-GlcNAcylation using bifunctional small molecules","volume":"146","author":"Ma","year":"2024","journal-title":"J Am Chem Soc"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.Mct-17-0390","article-title":"Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid","volume":"17","author":"Luanpitpong","year":"2018","journal-title":"Mol Cancer Ther"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1038\/s41467-025-68271-6","article-title":"Small molecule splicing modulators that disrupt O-GlcNAc homeostasis","volume":"17","author":"Cheng","year":"2026","journal-title":"Nat Commun"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106726","article-title":"Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)","volume":"139","author":"Wu","year":"2023","journal-title":"Bioorg Chem"},{"key":"B140","doi-asserted-by":"publisher","first-page":"12334","DOI":"10.1038\/s41598-017-12522-0","article-title":"Discovery of a low toxicity O-GlcNAc transferase (OGT) inhibitor by structure-based virtual screening of natural products","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00004","article-title":"A small molecule that inhibits OGT activity in cells","volume":"10","author":"Ortiz-Meoz","year":"2015","journal-title":"ACS Chem Biol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121523","article-title":"OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance","volume":"284","author":"Hou","year":"2022","journal-title":"Biomaterials"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.107256","article-title":"Mannose inhibits NSCLC growth and inflammatory microenvironment by regulating gut microbiota and targeting OGT\/hnRNP R\/JUN\/IL-8 axis","volume":"21","author":"Jin","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004709","article-title":"Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer","volume":"293","author":"Qian","year":"2018","journal-title":"J Biol Chem"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0366-1","article-title":"O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1","volume":"37","author":"Phoomak","year":"2018","journal-title":"Oncogene"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/srep27853","article-title":"Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-\u03baB","volume":"6","author":"Phoomak","year":"2016","journal-title":"Sci Rep"},{"key":"B147","article-title":"Overexpression of O-GlcNAc-transferase associates with aggressiveness of mass-forming cholangiocarcinoma","volume":"13","author":"Phoomak","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"B148","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40348-026-00218-3","article-title":"O-GlcNAcylation expression predicts a favorable prognosis and mitigates Malignant phenotypes via MYCN suppression in neuroblastoma","volume":"13","author":"Lin","year":"2026","journal-title":"Mol Cell Pediatr"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3996-4","article-title":"High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome","volume":"160","author":"Tiainen","year":"2016","journal-title":"Breast Cancer Res Treat"},{"key":"B150","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/pai.0000000000000970","article-title":"Relationship between O-GlcNAcase expression and prognosis of patients with osteosarcoma","volume":"30","author":"Sombutthaweesri","year":"2022","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11081460","article-title":"Prognostic significance of O-GlcNAc and PKM2 in hormone receptor-positive and HER2-nonenriched breast cancer","volume":"11","author":"Kuo","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9912-1","article-title":"O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation","volume":"29","author":"Zhu","year":"2012","journal-title":"Med Oncol"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/s41467-025-56633-z","article-title":"FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial Malignancy","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-336277","article-title":"KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy","volume":"75","author":"Liu","year":"2026","journal-title":"Gut"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2026.120117","article-title":"Destabilization of lipoma-preferred partner by TGF-\u03b2-induced O-GlcNAcylation promotes hepatocellular carcinoma metastasis","volume":"1873","author":"Gong","year":"2026","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B156","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41419-025-07844-1","article-title":"O-GlcNAcylation of METTL3 drives hepatocellular carcinoma progression by upregulating MCM10 expression in an m6A-IGF2BP3-dependent manner","volume":"16","author":"Chen","year":"2025","journal-title":"Cell Death Dis"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-24-2492","article-title":"Stabilization of RUNX1 induced by O-GlcNAcylation promotes PDGF-BB-mediated resistance to CDK4\/6 inhibitors in breast cancer","volume":"85","author":"Zhou","year":"2025","journal-title":"Cancer Res"},{"key":"B158","doi-asserted-by":"publisher","first-page":"5597","DOI":"10.1038\/s41467-024-49875-w","article-title":"O-GlcNAcylation of MITF regulates its activity and CDK4\/6 inhibitor resistance in breast cancer","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07328","article-title":"Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors","volume":"140","author":"Martin","year":"2018","journal-title":"J Am Chem Soc"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00388","article-title":"Systematic evaluation of affinity enrichment methods for O-GlcNAc proteomics","volume":"23","author":"Hou","year":"2024","journal-title":"J Proteome Res"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01006","article-title":"Demystifying the O-GlcNAc code: A systems view","volume":"122","author":"Ma","year":"2022","journal-title":"Chem Rev"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1854952\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:52:27Z","timestamp":1784699547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1854952\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":161,"alternative-id":["10.3389\/fimmu.2026.1854952"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1854952","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1854952"}}