{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:04:50Z","timestamp":1784009090013,"version":"3.55.0"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The survival of ectopic endometrial lesions in endometriosis critically depends on their ability to evade immune recognition and clearance by the host, a process known as immune evasion. Recent studies suggest that this process is not driven by a single factor but rather results from a multidimensional, interactive regulatory network involving immune dysregulation, epigenetic remodeling, and metabolic reprogramming. The pathophysiology of endometriosis is characterized by reduced cytotoxic activity and functional exhaustion of effector immune cells, along with excessive activation and expansion of immunosuppressive cells, affecting both innate and adaptive immunity. The overexpression of immune checkpoint molecules further impairs immunological clearance. DNA methylation, histone modifications, and non-coding RNAs contribute to immune cell tolerance by stabilizing repressive transcription programs and silencing pro-inflammatory genes. These epigenetic mechanisms maintain a sustained immunosuppressive state through direct regulation of immune-related genes and hormone-metabolizing enzymes. Additionally, the hypoxic environment of ectopic lesions stimulates glycolysis, leading to the accumulation of metabolites such as lactate. Beyond directly impairing immune cell function, these metabolites act as signaling molecules or cofactors for epigenetic enzymes, thereby influencing chromatin states and gene expression, thus mechanistically and functionally linking metabolism to epigenetics. This review aims to systematically unravel this multidimensional mechanism, elucidate its synergistic role in disease progression, and potentially pave the way for future combined therapeutic strategies targeting this complex pathway. Such approaches offer a novel and promising means to overcome immune evasion and clinical resistance in endometriosis.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1855106","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:38:04Z","timestamp":1784007484000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune-epigenetic-metabolic crosstalk: attempting to unravel the multidimensional mechanisms of immune evasion in endometriosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenyu","family":"Xu","sequence":"first","affiliation":[{"name":"School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1055\/s-0036-1597128","article-title":"Clinical management of endometriosis","volume":"118","author":"Falcone","year":"2011","journal-title":"Obstet Gynecol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0002-9378(86)90389-3","article-title":"Endometriosis in association with uterine anomaly","volume":"154","author":"Sanfilippo","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil Steril"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0828","article-title":"Contribution of bone marrow-derived stem cells to endometrium and endometriosis","volume":"25","author":"Du","year":"2007","journal-title":"Stem Cells"},{"key":"B7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000052855","article-title":"Coelomic metaplasia theory of endometriosis: evidence from in vivo studies and an in vitro experimental model","volume":"47","author":"Matsuura","year":"1999","journal-title":"Gynecol Obstet Invest"},{"key":"B8","article-title":"Pleural and parenchymal pulmonary endometriosis","volume":"58","author":"Foster","year":"1981","journal-title":"Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum Reprod Open"},{"key":"B10","first-page":"93","article-title":"Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation","volume":"3","author":"Sampson","year":"1927","journal-title":"Am J Pathol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.020","article-title":"Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis","volume":"91","author":"Greene","year":"2009","journal-title":"Fertil Steril"},{"key":"B12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13578-021-00613-5","article-title":"Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing","volume":"11","author":"Zou","year":"2021","journal-title":"Cell Biosci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.013","article-title":"Pathogenesis of endometriosis: the genetic\/epigenetic theory","volume":"111","author":"Koninckx","year":"2019","journal-title":"Fertil Steril"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119381","article-title":"Emerging hallmarks of endometriosis metabolism: a promising target for the treatment of endometriosis","volume":"1870","author":"Lu","year":"2023","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","article-title":"Metabolic reprogramming and epigenetic modifications on the path to cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Protein Cell"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.12.006","article-title":"Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments","volume":"46","author":"Gupta","year":"2025","journal-title":"Trends Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1101\/2024.02.27.580606","article-title":"Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level","volume":"7","author":"Sarsenova","year":"2024","journal-title":"Commun Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020908","article-title":"Endometriosis as a systemic and complex disease: toward phenotype-based classification and personalized therapy","volume":"27","author":"Simancas-Racines","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The immunopathophysiology of endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-026-02965-8","article-title":"Endometriosis immune microenvironment timing shifts: from immune escape to immune exhaustion","volume":"12","author":"Fan","year":"2026","journal-title":"Cell Death Discov"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1727183","article-title":"Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies","volume":"16","author":"Shifon","year":"2025","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den393","article-title":"Macrophage expression in endometrium of women with and without endometriosis","volume":"24","author":"Berbic","year":"2009","journal-title":"Hum Reprod"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00009","article-title":"Endometriosis, a disease of the macrophage","volume":"4","author":"Capobianco","year":"2013","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1042\/cs20220531","article-title":"M1\/M2 macrophages and their overlaps - myth or reality","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin Sci (Lond)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/s0021-5198(19)46230-6","article-title":"CD206+\u2009macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model","volume":"11","author":"Ono","year":"2021","journal-title":"Sci Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775758","article-title":"Tumor-associated macrophages in tumor immunity","volume":"11","author":"Pan","year":"2020","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-023-01725-x","article-title":"Roles of tumor-associated macrophages in anti-PD-1\/PD-L1 immunotherapy for solid cancers","volume":"22","author":"Zhang","year":"2023","journal-title":"Mol Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12967-020-02471-0","article-title":"Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology","volume":"18","author":"Malvezzi","year":"2020","journal-title":"J Transl Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/jci181839","article-title":"TET3-overexpressing macrophages promote endometriosis","volume":"134","author":"Lv","year":"2024","journal-title":"J Clin Invest"},{"key":"B30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/ijms251810141","article-title":"The role of NK and T cells in endometriosis","volume":"25","author":"Reis","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(00)01592-2","article-title":"Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis","volume":"74","author":"Wu","year":"2000","journal-title":"Fertil Steril"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(01)03249-6","article-title":"Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis","volume":"77","author":"Maeda","year":"2002","journal-title":"Fertil Steril"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119961","article-title":"Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity","volume":"10","author":"Gonz\u00e1lez-Foruria","year":"2015","journal-title":"PloS One"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.02.008","article-title":"Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients","volume":"67","author":"Salih","year":"2006","journal-title":"Hum Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4098","article-title":"Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding","volume":"169","author":"Salih","year":"2002","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.018","article-title":"Increased frequency of human leukocyte antigen-E inhibitory receptor CD94\/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis","volume":"89","author":"Galandrini","year":"2008","journal-title":"Fertil Steril"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-017-1404-3","article-title":"The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis","volume":"293","author":"Byli\u0144ska","year":"2018","journal-title":"Mol Genet Genomics"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1159\/000292056","article-title":"Effect of culture supernatants of endometriotic lesions, uterine endometrium and peritoneum from rats with experimental endometriosis on the natural killer activity of spleen cells","volume":"41","author":"Mizumoto","year":"1996","journal-title":"Gynecol Obstet Invest"},{"key":"B39","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/humrep\/dex014","article-title":"Platelets impair natural killer cell reactivity and function in endometriosis through multiple mechanisms","volume":"32","author":"Du","year":"2017","journal-title":"Hum Reprod"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0325-2","article-title":"Suppressive regulatory T cells and latent transforming growth factor-\u03b2-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis","volume":"16","author":"Hanada","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.414","article-title":"CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173789","article-title":"Endometriotic peritoneal fluid stimulates recruitment of CD4(+)CD25(high)FOXP3(+) Treg cells","volume":"10","author":"Olkowska-Truchanowicz","year":"2021","journal-title":"J Clin Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190711","article-title":"BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression","volume":"217","author":"Grant","year":"2020","journal-title":"J Exp Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae103","article-title":"The role of regulatory T-cells in the development of endometriosis","volume":"39","author":"Knez","year":"2024","journal-title":"Hum Reprod"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00438","article-title":"Immature, semi-mature, and fully mature dendritic cells: toward a DC-cancer cells interface that augments anticancer immunity","volume":"4","author":"Dudek","year":"2013","journal-title":"Front Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12958-023-01058-w","article-title":"Features of peritoneal dendritic cells in the development of endometriosis","volume":"21","author":"Qiaomei","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065948","article-title":"Expression of Gal-9 on dendritic cells and soluble forms of TIM-3\/Gal-9 in patients suffering from endometriosis","volume":"24","author":"Suszczyk","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2024.2411607","article-title":"HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation","volume":"40","author":"Yang","year":"2024","journal-title":"Gynecol Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.186133","article-title":"Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development","volume":"10","author":"Wilson","year":"2025","journal-title":"JCI Insight"},{"key":"B52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00281-025-01058-5","article-title":"Immunopathological insights into endometriosis: from research advances to future treatments","volume":"47","author":"Dai","year":"2025","journal-title":"Semin Immunopathol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.03.026","article-title":"Expansion of monocytic myeloid-derived suppressor cells in endometriosis patients: A pilot study","volume":"47","author":"Chen","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.940554","article-title":"Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study","volume":"9","author":"Xu","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1397670","article-title":"Causal association of immune cells and endometriosis: a Mendelian randomization study","volume":"15","author":"Fang","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116266","article-title":"Immune checkpoints in endometriosis-a new insight in the pathogenesis","volume":"25","author":"Suszczyk","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12484","article-title":"OX40L-OX40 signaling in atopic dermatitis","volume":"10","author":"Furue","year":"2021","journal-title":"J Clin Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000672","article-title":"Immune checkpoint inhibitors and vasculitis","volume":"32","author":"Boland","year":"2020","journal-title":"Curr Opin Rheumatol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102614","article-title":"Novel targets for immune-checkpoint inhibition in cancer","volume":"120","author":"Borgeaud","year":"2023","journal-title":"Cancer Treat Rev"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126775","article-title":"The PD-1\/PD-L1 gateway: Peripheral immune regulation in the pathogenesis of endometriosis","volume":"25","author":"Sobstyl","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7041342","article-title":"The increase of circulating PD-1- and PD-L1-expressing lymphocytes in endometriosis: Correlation with clinical and laboratory parameters","volume":"2018","author":"Walankiewicz","year":"2018","journal-title":"Mediators Inflammation"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1519787","article-title":"Expression of programmed death-1 (PD-1) and its ligand PD-L1 is upregulated in endometriosis and promoted by 17beta-estradiol","volume":"35","author":"Wu","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911607","article-title":"Clinical value of the PD-1\/PD-L1\/PD-L2 pathway in patients suffering from endometriosis","volume":"23","author":"Suszczyk","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23294","article-title":"A higher number of exhausted local PD1+, but not TIM3+, NK cells in advanced endometriosis","volume":"10","author":"Hosseinzadeh","year":"2024","journal-title":"Heliyon"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/jci123391","article-title":"Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity","volume":"129","author":"Pai","year":"2019","journal-title":"J Clin Invest"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13296","article-title":"Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility","volume":"84","author":"Santoso","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02048","article-title":"Clinical implications of aberrant PD-1 and CTLA4 expression for cancer immunity and prognosis: A pan-cancer study","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"20763","DOI":"10.1038\/s41598-021-00325-3","article-title":"Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients","volume":"11","author":"Marable","year":"2021","journal-title":"Sci Rep"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910341107","article-title":"Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity","volume":"107","author":"Jain","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.11.028","article-title":"Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity","volume":"32","author":"Kennedy","year":"2024","journal-title":"Mol Ther"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030487","article-title":"CLTA-4 expression is associated with the maintenance of chronic inflammation in endometriosis and infertility","volume":"10","author":"Abramiuk","year":"2021","journal-title":"Cells"},{"key":"B73","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s43032-019-00060-1","article-title":"Deep infiltrating endometriosis and activation and memory surface markers and cytokine expression in isolated Treg cells","volume":"27","author":"Gueuvoghlanian-Silva","year":"2020","journal-title":"Reprod Sci"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah225","article-title":"Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis","volume":"11","author":"Vigan\u00f3","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313x.2011.01000.x","article-title":"Analysis of CTLA4 gene variant in infertile Brazilian women with and without endometriosis","volume":"38","author":"Lerner","year":"2011","journal-title":"Int J Immunogenet"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"415","author":"Monney","year":"2002","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.canlet.2021.04.011","article-title":"The TIM3\/Gal9 signaling pathway: An emerging target for cancer immunotherapy","volume":"510","author":"Kandel","year":"2021","journal-title":"Cancer Lett"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02465-y","article-title":"Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes","volume":"69","author":"Zahran","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.09.008","article-title":"Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders","volume":"108","author":"Brubel","year":"2017","journal-title":"Fertil Steril"},{"key":"B81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/ijms21072343","article-title":"Different expression pattern of TIM-3 and galectin-9 molecules by peripheral and peritoneal lymphocytes in women with and without endometriosis","volume":"21","author":"Meggyes","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00768-6","article-title":"TIM-3 regulates the proliferation by BDNF-mediated PI3K\/AKT axis in the process of endometriosis","volume":"29","author":"Tian","year":"2023","journal-title":"Mol Med"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13887","article-title":"TIM-3 expression in endometriosis","volume":"91","author":"Reis","year":"2024","journal-title":"Am J Reprod Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.intimp.2021.107933","article-title":"TIM-3: An update on immunotherapy","volume":"99","author":"Zhao","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.04.004","article-title":"Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response","volume":"233","author":"Garc\u00eda-Gim\u00e9nez","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B86","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"B87","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/biom15010069","article-title":"Quantification of free circulating DNA and differential methylation profiling of selected genes as novel non-invasive biomarkers for endometriosis diagnosis","volume":"15","author":"Benkhalifa","year":"2025","journal-title":"Biomolecules"},{"key":"B88","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.fertnstert.2006.05.077","article-title":"Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis","volume":"87","author":"Wu","year":"2007","journal-title":"Fertil Steril"},{"key":"B89","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/s12276-022-00793-1","article-title":"Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16(-) NK-cell differentiation","volume":"54","author":"Peng","year":"2022","journal-title":"Exp Mol Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004158","article-title":"Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis","volume":"10","author":"Dyson","year":"2014","journal-title":"PloS Genet"},{"key":"B91","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13148-025-01828-w","article-title":"Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives","volume":"17","author":"Ducreux","year":"2025","journal-title":"Clin Epigenet"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.08.288","article-title":"A systematic review of epigenetics of endometriosis","volume":"5","author":"Bedrick","year":"2024","journal-title":"F S Rev"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications - cause and consequence of genome function","volume":"23","author":"Mill\u00e1n-Zambrano","year":"2022","journal-title":"Nat Rev Genet"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(sici)1097-4652(200007)184:1<1::aid-jcp1>3.0.co;2-7","article-title":"Histone deacetylases, transcriptional control, and cancer","volume":"184","author":"Cress","year":"2000","journal-title":"J Cell Physiol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2591-0","article-title":"Aberrant histone acetylation and methylation levels in woman with endometriosis","volume":"287","author":"Xia","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111432870","article-title":"HDAC1 and HDAC2 are differentially expressed in endometriosis","volume":"19","author":"Col\u00f3n-D\u00edaz","year":"2012","journal-title":"Reprod Sci"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113497267","article-title":"Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications","volume":"21","author":"Monteiro","year":"2014","journal-title":"Reprod Sci"},{"key":"B98","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1210\/clinem\/dgab753","article-title":"Role of SIRT1 and progesterone resistance in normal and abnormal endometrium","volume":"107","author":"Kim","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16835","article-title":"Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A\/ARID1A axis","volume":"25","author":"Mai","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101224","article-title":"Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis","volume":"4","author":"Chadchan","year":"2021","journal-title":"Life Sci Alliance"},{"key":"B101","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbadis.2021.166293","article-title":"Non-coding RNAs as new autophagy regulators in cancer progression","volume":"1868","author":"Lin","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp034","article-title":"The role of microRNAs in endometriosis and associated reproductive conditions","volume":"16","author":"Teague","year":"2010","journal-title":"Hum Reprod Update"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gar066","article-title":"MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK\u03b2\/NF-\u03baB pathway and reduced interleukin-8 expression","volume":"18","author":"Dai","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4620","article-title":"MicroRNA-16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor-\u03baB kinase subunit \u03b2\/nuclear factor-\u03baB pathway","volume":"46","author":"Wang","year":"2020","journal-title":"Int J Mol Med"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.993788","article-title":"Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10","volume":"13","author":"Huang","year":"2022","journal-title":"Front Immunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111728","article-title":"Effects of selective inhibition of prostaglandin E2 receptors EP2 and EP4 on the miRNA profile in endometriosis","volume":"558","author":"Arosh","year":"2022","journal-title":"Mol Cell Endocrinol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1002\/ccs3.70020","article-title":"Endometriosis-derived exosomes encapsulated miR-196a-5p mediate macrophage polarization through regulation of the Hippo pathway","volume":"19","author":"Lu","year":"2025","journal-title":"J Cell Commun Signal"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.04.020","article-title":"Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma","volume":"77","author":"Abdelrahman","year":"2016","journal-title":"Hum Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1476809","article-title":"Suppression of autophagy and HCK signaling promotes PTGS2(high) FCGR3(-) NK cell differentiation triggered by ectopic endometrial stromal cells","volume":"14","author":"Mei","year":"2018","journal-title":"Autophagy"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248168","article-title":"Genetic impacts on thermostability of onco-lncRNA HOTAIR during the development and progression of endometriosis","volume":"16","author":"Chang","year":"2021","journal-title":"PloS One"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s354314","article-title":"Exosomal lncRNA HOTAIR promotes the progression and angiogenesis of endometriosis via the miR-761\/HDAC1 axis and activation of STAT3-mediated inflammation","volume":"17","author":"Zhang","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.06.046","article-title":"Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis","volume":"673","author":"Cui","year":"2018","journal-title":"Gene"},{"key":"B113","doi-asserted-by":"publisher","first-page":"996","DOI":"10.15252\/emmm.201505245","article-title":"H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis","volume":"7","author":"Ghazal","year":"2015","journal-title":"EMBO Mol Med"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.05.010","article-title":"LncRNA-H19 regulates cell proliferation and invasion of ectopic endometrium by targeting ITGB3 via modulating miR-124-3p","volume":"381","author":"Liu","year":"2019","journal-title":"Exp Cell Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.02.004","article-title":"Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis","volume":"42","author":"Wang","year":"2021","journal-title":"Reprod BioMed Online"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16039","article-title":"LINC01116 promotes proliferation and migration of endometrial stromal cells by targeting FOXP1 via sponging miR-9-5p in endometriosis","volume":"25","author":"Cui","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B117","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/humupd\/dmy014","article-title":"Non-coding RNAs in endometriosis: a narrative review","volume":"24","author":"Panir","year":"2018","journal-title":"Hum Reprod Update"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad020","article-title":"Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics","volume":"44","author":"Marquardt","year":"2023","journal-title":"Endocr Rev"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943839","article-title":"Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity","volume":"13","author":"Szukiewicz","year":"2022","journal-title":"Front Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.09.004","article-title":"Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis","volume":"29","author":"Qi","year":"2014","journal-title":"Reprod BioMed Online"},{"key":"B121","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/ijms25084238","article-title":"Altered glycolysis, mitochondrial biogenesis, autophagy and apoptosis in peritoneal endometriosis in adolescents","volume":"25","author":"Khashchenko","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2022.856316","article-title":"Endometriosis-associated angiogenesis and anti-angiogenic therapy for endometriosis","volume":"3","author":"Chung","year":"2022","journal-title":"Front Glob Womens Health"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1026","article-title":"Transforming growth factor-\u03b2 induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis","volume":"99","author":"Young","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B124","doi-asserted-by":"publisher","first-page":"86","DOI":"10.21203\/rs.3.rs-134073\/v2","article-title":"HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression","volume":"19","author":"Wang","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew081","article-title":"Hypoxia-inducible factor 1\u03b1-induced epithelial-mesenchymal transition of endometrial epithelial cells may contribute to the development of endometriosis","volume":"31","author":"Xiong","year":"2016","journal-title":"Hum Reprod"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2021.103292","article-title":"Inflammation related to high-mobility group box-1 in endometrial ovarian cyst","volume":"145","author":"Ikeda","year":"2021","journal-title":"J Reprod Immunol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00018-022-04637-z","article-title":"CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis","volume":"80","author":"Sun","year":"2023","journal-title":"Cell Mol Life Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073322","article-title":"Endometrial cancer is associated with altered metabolism and composition of fatty acids","volume":"26","author":"Razghonova","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1002\/path.6079","article-title":"Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients","volume":"260","author":"Dai","year":"2023","journal-title":"J Pathol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1529074","article-title":"Identification of fatty acid metabolism hub genes in endometriosis using integrative bioinformatics analysis","volume":"12","author":"Tu","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02096-y","article-title":"Blood lipids mediate the effects of gut microbiome on endometriosis: a mendelian randomization study","volume":"23","author":"Su","year":"2024","journal-title":"Lipids Health Dis"},{"key":"B132","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/09513590.2025.2500459","article-title":"Correlation between lipid metabolism and endometriosis: a meta-analysis","volume":"41","author":"Yang","year":"2025","journal-title":"Gynecol Endocrinol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rbmo.2024.103856","article-title":"Gene associations of lipid traits, lipid-lowering drug-target genes and endometriosis","volume":"49","author":"Zhou","year":"2024","journal-title":"Reprod BioMed Online"},{"key":"B134","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/ijms26062458","article-title":"The molecular and cellular mechanisms of endometriosis: from basic pathophysiology to clinical implications","volume":"26","author":"Mariadas","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13702","article-title":"Abnormal HCK\/glutamine\/autophagy axis promotes endometriosis development by impairing macrophage phagocytosis","volume":"57","author":"Lei","year":"2024","journal-title":"Cell Prolif"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00332","article-title":"Elevated circulatory proline to glutamine ratio (PQR) in endometriosis and its potential as a diagnostic biomarker","volume":"7","author":"Kusum","year":"2022","journal-title":"ACS Omega"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00834-7","article-title":"IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1","volume":"30","author":"Wang","year":"2024","journal-title":"Mol Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad033","article-title":"The role of iron in the pathogenesis of endometriosis: a systematic review","volume":"2023","author":"Wyatt","year":"2023","journal-title":"Hum Reprod Open"},{"key":"B139","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/ijms24021619","article-title":"The influence of lactoferrin in plasma and peritoneal fluid on iron metabolism in women with endometriosis","volume":"24","author":"Skarzynska","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B140","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/advs.202408220","article-title":"Elevated histone lactylation mediates ferroptosis resistance in endometriosis through the METTL3-regulated HIF1A\/HMOX1 signaling pathway","volume":"12","author":"Liang","year":"2025","journal-title":"Adv Sci"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.02.006","article-title":"Complement membrane attack complex: new roles, mechanisms of action, and therapeutic targets","volume":"190","author":"Xie","year":"2020","journal-title":"Am J Pathol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918551","article-title":"Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages","volume":"13","author":"Jimenez-Duran","year":"2022","journal-title":"Front Immunol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ph18060813","article-title":"Warburg-like metabolic reprogramming in endometriosis: from molecular mechanisms to therapeutic approaches","volume":"18","author":"Kim","year":"2025","journal-title":"Pharmaceuticals"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17142325","article-title":"Divergent immune-metabolic profiles in endometriosis and ovarian cancer: a cross-sectional analysis","volume":"17","author":"Neri","year":"2025","journal-title":"Cancers"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8901326","article-title":"Understanding of immune escape mechanisms and advances in cancer immunotherapy","volume":"2022","author":"Aktar","year":"2022","journal-title":"J Oncol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.011","article-title":"LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300781","article-title":"Endometriotic tissue-derived exosomes downregulate NKG2D-mediated cytotoxicity and promote apoptosis: mechanisms for survival of ectopic endometrial tissue in endometriosis","volume":"213","author":"Bj\u00f6rk","year":"2024","journal-title":"J Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1573686","article-title":"Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.05.306","article-title":"Genetically predicted plasma levels of amino acids and endometriosis: a mendelian randomization study","volume":"37","author":"Li","year":"2024","journal-title":"BioMed Environ Sci"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010029","article-title":"Chronic stress blocks the endometriosis immune response by metabolic reprogramming","volume":"25","author":"Lu","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B151","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41420-023-01606-8","article-title":"Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032901","article-title":"The role of NF-\u03baB in endometrial diseases in humans and animals: a review","volume":"24","author":"Zdrojkowski","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701461","article-title":"Canonical TGF-\u03b2 signaling pathway represses human NK cell metabolism","volume":"200","author":"Zaiatz-Bittencourt","year":"2018","journal-title":"J Immunol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402898","article-title":"IL-10 potentiates differentiation of human induced regulatory T cells via STAT3 and Foxo1","volume":"195","author":"Hsu","year":"2015","journal-title":"J Immunol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073492","article-title":"Peritoneal modulators of EZH2-miR-155 cross-talk in endometriosis","volume":"22","author":"Brunty","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.02.003","article-title":"Cancer epigenetics, tumor immunity, and immunotherapy","volume":"6","author":"Cao","year":"2020","journal-title":"Trends Cancer"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2025.106814","article-title":"Epigenetics' responsibility in endometriosis: a comprehensive assessment","volume":"253","author":"Akano","year":"2025","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188837","article-title":"Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer","volume":"1878","author":"He","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.010","article-title":"AMPK\/\u03b1-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis","volume":"24","author":"Yang","year":"2016","journal-title":"Cell Metab"},{"key":"B160","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.cmet.2020.01.006","article-title":"Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming","volume":"31","author":"Roy","year":"2020","journal-title":"Cell Metab"},{"key":"B161","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-025-02255-4","article-title":"The epigenetic hallmarks of immune cells in cancer","volume":"24","author":"Ji","year":"2025","journal-title":"Mol Cancer"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.016","article-title":"Metabolic and epigenetic coordination of T cell and macrophage immunity","volume":"46","author":"Phan","year":"2017","journal-title":"Immunity"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m115.708560","article-title":"Regulatory T cell modulation by CBP\/EP300 bromodomain inhibition","volume":"291","author":"Ghosh","year":"2016","journal-title":"J Biol Chem"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310444","article-title":"\u03b1-Aminobutyric acid constrains macrophage-associated inflammatory diseases through metabolic reprogramming and epigenetic modification","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00780-y","article-title":"Impact of intracellular innate immune receptors on immunometabolism","volume":"19","author":"Chou","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119291","article-title":"Imperatorin alleviated endometriosis by inhibiting the activation of PI3K\/Akt\/NF-\u03baB pathway in rats","volume":"274","author":"Ma","year":"2021","journal-title":"Life Sci"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051620","article-title":"ImmunoMet oncogenesis: a new concept to understand the molecular drivers of cancer","volume":"14","author":"Sirajee","year":"2025","journal-title":"J Clin Med"},{"key":"B168","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41422-025-01171-y","article-title":"Trained immunity: induction of an inflammatory memory in disease","volume":"35","author":"Schl\u00fcter","year":"2025","journal-title":"Cell Res"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1449912","article-title":"Microbiota-metabolism-epigenetics-immunity axis in cancer","volume":"15","author":"Ren","year":"2024","journal-title":"Front Immunol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-024-01972-6","article-title":"CTLs heterogeneity and plasticity: implications for cancer immunotherapy","volume":"23","author":"Peng","year":"2024","journal-title":"Mol Cancer"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1530\/jme-13-0194","article-title":"Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions","volume":"52","author":"McKinnon","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu332","article-title":"Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3","volume":"30","author":"Okamoto","year":"2015","journal-title":"Hum Reprod"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1530\/rep-24-0018","article-title":"Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation","volume":"168","author":"Wen","year":"2024","journal-title":"Reproduction"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi8602","article-title":"Lactate supports a metabolic-epigenetic link in macrophage polarization","volume":"7","author":"Noe","year":"2021","journal-title":"Sci Adv"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.4161\/onci.26383","article-title":"Tumor-derived lactate and myeloid-derived suppressor cells: linking metabolism to cancer immunology","volume":"2","author":"Husain","year":"2013","journal-title":"Oncoimmunology"},{"key":"B177","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12964-024-01624-8","article-title":"Emerging roles of lactate in acute and chronic inflammation","volume":"22","author":"Fang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13786","article-title":"The dysfunction of CD8(+) T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis","volume":"172","author":"Huang","year":"2024","journal-title":"Immunology"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1855106\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:38:06Z","timestamp":1784007486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1855106\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":179,"alternative-id":["10.3389\/fimmu.2026.1855106"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1855106","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"article-number":"1855106"}}