{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:15:22Z","timestamp":1783577722983,"version":"3.55.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>RNA-binding motif protein 47 (RBM47) is an evolutionarily conserved multifunctional RNA-binding protein. It mediates post-transcriptional regulation through C-to-U RNA editing, alternative splicing, and messenger RNA (mRNA) stability control. Preclinical evidence indicates that RBM47 exhibits context-dependent, dual effects in human disease. In breast cancer (BC), colorectal cancer (CRC), renal cell carcinoma (RCC), papillary thyroid carcinoma (PTC), and non-small cell lung cancer (NSCLC), experimental studies suggest that RBM47 exerts tumor-suppressive activity through the inhibition of the Wnt\/\u03b2-catenin, phosphoinositide 3-kinase (PI3K)-AKT, and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways. Conversely, in glioma and pancreatic cancer (PC), cell and animal models indicate that RBM47 exerts oncogenic activity by promoting M2 macrophage polarization and immune evasion. Furthermore, aberrant RBM47 expression has been implicated in postoperative cognitive dysfunction (POCD), inflammatory bowel disease (IBD), and antiviral innate immune regulation in preclinical models. This review summarizes the molecular characteristics and pathological mechanisms of RBM47, discusses the preclinical rationale for its potential utility as a biomarker and therapeutic node, and critically analyzes current research limitations, conflicting evidence, and translational bottlenecks. All biomarker and therapeutic applications discussed remain at the preclinical or retrospective-correlative stage; no RBM47-targeted intervention has entered clinical trials.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1863629","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:34:38Z","timestamp":1783575278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["RNA-binding protein RBM47 in health and disease: molecular mechanisms, preclinical evidence, and translational challenges"],"prefix":"10.3389","volume":"17","author":[{"given":"Shihua","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center, Sichuan Provincial Women's and Children's Hospital \/ The Affiliated Women's and Children's Hospital of Chengdu Medical College","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyong","family":"Luo","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center, Sichuan Provincial Women's and Children's Hospital \/ The Affiliated Women's and Children's Hospital of Chengdu Medical College","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, West China Hospital Sichuan University Jintang Hospital. Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04256-5","article-title":"Rna binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer","volume":"476","author":"Shivalingappa","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"B2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41420-023-01623-7","article-title":"Rbm47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1","volume":"9","author":"Su","year":"2023","journal-title":"Cell Death Discov"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02734","article-title":"Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer","volume":"3","author":"Vanharanta","year":"2014","journal-title":"Elife"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22920","article-title":"Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth","volume":"54","author":"Fossat","year":"2016","journal-title":"Genesis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10441-w","article-title":"Rbm47 is a critical regulator of mouse embryonic stem cell differentiation","volume":"19","author":"Shivalingappa","year":"2023","journal-title":"Stem Cell Rev Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901387","article-title":"Zebrafish RBM47 promotes lysosome-dependent degradation of MAVS to inhibit IFN induction","volume":"205","author":"Lu","year":"2020","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1038\/s42003-025-09170-w","article-title":"Microglial RUNX1\/RBM47 ablation inhibits neuronal ferroptosis via regulating the cGAS-STING-MEF2C pathway in mice with postoperative cognitive dysfunction","volume":"8","author":"Wang","year":"2025","journal-title":"Commun Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41419-022-04728-6","article-title":"Rbm47\/SNHG5\/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s43556-025-00382-4","article-title":"Down-regulation of RBM47 due to diminished activation by forkhead box A1 (FOXA1) and silencing by CpG methylation is associated with epithelial-mesenchymal transition and metastasis of colorectal cancer","volume":"6","author":"Rokavec","year":"2025","journal-title":"Mol BioMed"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155417","article-title":"Dioscin decreases M2 polarization via inhibiting a positive feedback loop between RBM47 and NF-\u03baB in glioma","volume":"128","author":"Bai","year":"2024","journal-title":"Phytomedicine"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1038\/s41598-017-04234-2","article-title":"Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression","volume":"7","author":"Rokavec","year":"2017","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23474","article-title":"Saponin from Platycodi radix inactivates PI3K\/AKT signaling pathway to hinder colorectal cancer cell proliferation, invasion, and migration through miR-181c\/d-5p\/RBM47","volume":"62","author":"Liu","year":"2023","journal-title":"Mol Carcinog"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1186\/s12967-024-05970-6","article-title":"Rbm47 promotes cell proliferation and immune evasion by upregulating PDIA6: a novel mechanism of pancreatic cancer progression","volume":"22","author":"Ma","year":"2024","journal-title":"J Transl Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24039","article-title":"rbm47, a novel RNA binding protein, regulates zebrafish head development","volume":"242","author":"Guan","year":"2013","journal-title":"Dev Dyn"},{"key":"B17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.devcel.2017.11.021","article-title":"Long-range signaling activation and local inhibition separate the mesoderm and endoderm lineages","volume":"44","author":"van Boxtel","year":"2018","journal-title":"Dev Cell"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24466","article-title":"Anatomical and histological characteristics of the hepatobiliary system in adult Sox17 heterozygote mice","volume":"303","author":"Pattarapanawan","year":"2020","journal-title":"Anat Rec (Hoboken)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.08.005","article-title":"PDGFRA is not essential for the derivation and maintenance of mouse extraembryonic endoderm stem cell lines","volume":"9","author":"Lin","year":"2017","journal-title":"Stem Cell Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2020.100127","article-title":"Fast in vitro procedure to identify extraembryonic differentiation defect of mouse embryonic stem cells","volume":"1","author":"Ngondo","year":"2020","journal-title":"STAR Protoc"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-017-0125-0","article-title":"Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression","volume":"18","author":"Smith","year":"2017","journal-title":"BMC Cell Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12663","article-title":"Modeling early stages of endoderm development in epiblast stem cell aggregates with supply of extracellular matrices","volume":"62","author":"Inamori","year":"2020","journal-title":"Dev Growth Differ"},{"key":"B23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.devcel.2020.09.030","article-title":"Live visualization of ERK activity in the mouse blastocyst reveals lineage-specific signaling dynamics","volume":"55","author":"Simon","year":"2020","journal-title":"Dev Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1732-z","article-title":"Dynamic lineage priming is driven via direct enhancer regulation by ERK","volume":"575","author":"Hamilton","year":"2019","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.02.025","article-title":"Comparison of RNA editing activity of APOBEC1-A1CF and APOBEC1-RBM47 complexes reconstituted in HEK293T cells","volume":"431","author":"Wolfe","year":"2019","journal-title":"J Mol Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1261\/rna.068395.118","article-title":"Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver","volume":"25","author":"Blanc","year":"2019","journal-title":"RNA"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0892-5","article-title":"RBM47-regulated alternative splicing of TJP1 promotes actin stress fiber assembly during epithelial-to-mesenchymal transition","volume":"38","author":"Kim","year":"2019","journal-title":"Oncogene"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00019-16","article-title":"Determination of a comprehensive alternative splicing regulatory network and combinatorial regulation by key factors during the epithelial-to-mesenchymal transition","volume":"36","author":"Yang","year":"2016","journal-title":"Mol Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0041-z","article-title":"Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells","volume":"16","author":"Wei","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052205","article-title":"RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity","volume":"22","author":"Wang","year":"2021","journal-title":"EMBO Rep"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.02.011","article-title":"The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt\/\u03b2-catenin signaling","volume":"34","author":"Shen","year":"2020","journal-title":"Surg Oncol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.35","article-title":"RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma","volume":"35","author":"Sakurai","year":"2016","journal-title":"Oncogene"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16301","article-title":"Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition","volume":"289","author":"Roy","year":"2022","journal-title":"FEBS J"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s12104-025-10248-z","article-title":"1H, 13C and 15N backbone resonance assignment of the RNA binding motif 39 (RBM39) tandem RNA recognition motifs (RRM1-2)","volume":"19","author":"Malard","year":"2025","journal-title":"Biomol NMR Assign"},{"key":"B35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41589-019-0411-6","article-title":"Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex","volume":"16","author":"Bussiere","year":"2020","journal-title":"Nat Chem Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab075","article-title":"Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45","volume":"49","author":"Chen","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107640","article-title":"Structural basis for RNA recognition by the C-terminal RRM domain of human RBM45","volume":"300","author":"Chen","year":"2024","journal-title":"J Biol Chem"},{"key":"B38","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1107\/S2053230X16006129","article-title":"RRM domain of human RBM7: purification, crystallization and structure determination","volume":"72","author":"Sofos","year":"2016","journal-title":"Acta Crystallogr F Struct Biol Commun"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx418","article-title":"Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition","volume":"45","author":"Krepl","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6c01856","article-title":"RBM45 preferential binding to m6A: simulations suggest synergy of RRM3 and other domains","volume":"130","author":"Park","year":"2026","journal-title":"J Phys Chem B"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.101404","article-title":"RBM39 enhances cholangiocarcinoma growth through EZH2-mediated WNT7B\/\u03b2-catenin pathway","volume":"19","author":"Liu","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2025-1945","article-title":"Pseudomonas putida KT2440-induced RBM47 regulates non-small cell lung cancer stem cell properties and T cell-mediated antitumor activity","volume":"17","author":"Zheng","year":"2025","journal-title":"J Thorac Dis"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000184","article-title":"Aggressive variants of papillary thyroid carcinoma: hobnail, tall cell, columnar, and solid","volume":"25","author":"Nath","year":"2018","journal-title":"Adv Anat Pathol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.120277","article-title":"Tumor-derived lactate drives Malignant progression of refractory papillary thyroid carcinoma via the H3K18la-STAT1-LDHA axis","volume":"21","author":"Zhou","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2020.01.43","article-title":"MicroRNA-643 promotes proliferation and inhibits apoptosis of papillary thyroid carcinoma by down-regulating the cytochrome P450 family member 11B1","volume":"9","author":"Yin","year":"2020","journal-title":"Transl Cancer Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010139","article-title":"Identification of R-Spondin gene signature predictive of metastatic progression in BRAFV600E-positive papillary thyroid cancer","volume":"12","author":"da Silva","year":"2022","journal-title":"Cells"},{"key":"B47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12022-017-9502-7","article-title":"Hobnail variant of papillary thyroid carcinoma: a literature review","volume":"28","author":"Ambrosi","year":"2017","journal-title":"Endocr Pathol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"29167","DOI":"10.1038\/s41598-024-81017-6","article-title":"FBP1 over-expression suppresses HIF-1\u03b1 in papillary thyroid cancer","volume":"14","author":"Li","year":"2024","journal-title":"Sci Rep"},{"key":"B49","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/s13256-023-04265-6","article-title":"Metastatic papillary thyroid carcinoma in pleural effusion: a case report and review of the literature","volume":"17","author":"Abutalib","year":"2023","journal-title":"J Med Case Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02641-6","article-title":"HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer","volume":"42","author":"Liu","year":"2023","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41419-025-08138-2","article-title":"ZC3H15 regulates the ubiquitination of PTEN via recruitment of TRIM56 and promotes Malignant progression of non-small cell lung cancer","volume":"17","author":"Wu","year":"2026","journal-title":"Cell Death Dis"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098212","article-title":"The long run towards personalized therapy in non-small-cell lung cancer: current state and future directions","volume":"24","author":"Genova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15188","article-title":"TRIM47 overexpression is a poor prognostic factor and contributes to carcinogenesis in non-small cell lung carcinoma","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11417","article-title":"Increased expression of the RNA-binding motif protein 47 predicts poor prognosis in non-small-cell lung cancer","volume":"19","author":"Li","year":"2020","journal-title":"Oncol Lett"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155600","article-title":"Natural products and derivatives for breast cancer treatment: from drug discovery to molecular mechanism","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70733","article-title":"Targeted therapies for each subtype of breast cancer","volume":"7","author":"Liu","year":"2026","journal-title":"MedComm (2020)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-025-03202-2","article-title":"Androgen receptor interacts with c-Myc to regulate macrophage-osteoclast axis and drive bone metastasis in triple negative breast cancer","volume":"133","author":"Liu","year":"2025","journal-title":"Br J Cancer"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000247","article-title":"Molecular pathology of colorectal cancer","volume":"27","author":"Harada","year":"2020","journal-title":"Adv Anat Pathol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-022-00886-0","article-title":"To \u03b2 or not to \u03b2: lack of correlation between APC mutation and \u03b2-catenin nuclear localization in colorectal cancer","volume":"54","author":"Bala","year":"2023","journal-title":"J\u00a0Gastrointest Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116827","article-title":"Unlocking the potential of flavonoids: natural solutions in the fight against colon cancer","volume":"176","author":"Hasibuan","year":"2024","journal-title":"BioMed Pharmacother"},{"key":"B62","doi-asserted-by":"publisher","first-page":"26685","DOI":"10.1038\/s41598-025-05151-5","article-title":"RBM47 functions as an antioncogene by regulating expression and alternative splicing of cell proliferation and apoptosis associated genes in colorectal cancer cells","volume":"15","author":"Liu","year":"2025","journal-title":"Sci Rep"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.161118","article-title":"RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways","volume":"8","author":"Soleymanjahi","year":"2023","journal-title":"JCI Insight"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189165","article-title":"Decoding PTEN regulation in clear cell renal cell carcinoma: pathway for biomarker discovery and therapeutic insights","volume":"1879","author":"Alves","year":"2024","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1681503","article-title":"The role of the nervous system in the occurrence, development, and immune response of renal cell carcinoma","volume":"16","author":"Sun","year":"2025","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-03198-8","article-title":"PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC","volume":"43","author":"Ma","year":"2024","journal-title":"Oncogene"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.102666","article-title":"IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway","volume":"20","author":"Liu","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000004600","article-title":"Insights into the mechanisms of drug resistance in renal cell carcinoma: from multi-omics perspective","volume":"112","author":"Li","year":"2026","journal-title":"Int J Surg"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143324","article-title":"Advances in the in vivo quantitative and qualitative imaging characterization of gliomas","volume":"14","author":"Alongi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.32604\/or.2023.043391","article-title":"GRIK1 promotes glioblastoma Malignancy and is a novel prognostic factor of poor prognosis","volume":"32","author":"Hou","year":"2024","journal-title":"Oncol Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00401-005-0991-y","article-title":"Epidemiology and etiology of gliomas","volume":"109","author":"Ohgaki","year":"2005","journal-title":"Acta Neuropathol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2023.0368","article-title":"RNA-binding motif protein RBM47 promotes invasiveness of glioblastoma through activation of epithelial-to-mesenchymal transition program","volume":"27","author":"Xing","year":"2023","journal-title":"Genet Test Mol Biomarkers"},{"key":"B73","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/s41598-024-84719-z","article-title":"RBM47 is a novel immunotherapeutic target and prognostic biomarker in gliomas","volume":"15","author":"Wei","year":"2025","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s43556-023-00148-w","article-title":"Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell Malignancies through RNA stability modification","volume":"4","author":"Wang","year":"2023","journal-title":"Mol BioMed"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"B76","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","article-title":"Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors","volume":"18","author":"Klein","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10829","article-title":"Upconversion-mediated optogenetics for the treatment of surgery-induced postoperative neurocognitive dysfunction","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"key":"B78","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12974-024-03216-2","article-title":"Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model","volume":"21","author":"Li","year":"2024","journal-title":"J Neuroinflamm"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00812-1","article-title":"Neuroinflammation after surgery: from mechanisms to therapeutic targets","volume":"21","author":"Yang","year":"2020","journal-title":"Nat Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-16-0124","article-title":"Colorectal cancer and dysplasia in inflammatory bowel disease: a review of disease epidemiology, pathophysiology, and management","volume":"9","author":"Dulai","year":"2016","journal-title":"Cancer Prev Res (Phila)"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.08.016","article-title":"Cytapheresis (CAP) with leukocyte removal filter\/bead column as one therapeutic option for inflammatory bowel disease","volume":"56","author":"Sawada","year":"2017","journal-title":"Transfus Apher Sci"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189160","article-title":"Utilization of AhR and GPR35 receptor ligands as superfoods in cancer prevention for individuals with IBD","volume":"26","author":"Pozniak","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01188-2","article-title":"Colon-targeted S100A8\/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models","volume":"45","author":"Cho","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117995","article-title":"Anchang Yuyang Decoction inhibits experimental colitis-related carcinogenesis by regulating PPAR signaling pathway and affecting metabolic homeostasis of host and microbiota","volume":"326","author":"Wei","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41418-023-01233-x","article-title":"LUBAC is required for RIG-I sensing of RNA viruses","volume":"31","author":"Teague","year":"2024","journal-title":"Cell Death Differ"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2408117121","article-title":"Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication","volume":"121","author":"Yang","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.970750","article-title":"Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination","volume":"13","author":"Tanaka","year":"2022","journal-title":"Front Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00208-25","article-title":"E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production","volume":"16","author":"Li","year":"2025","journal-title":"mBio"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02028-24","article-title":"Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway","volume":"15","author":"Zhang","year":"2024","journal-title":"mBio"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863629\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:34:39Z","timestamp":1783575279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863629\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":89,"alternative-id":["10.3389\/fimmu.2026.1863629"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1863629","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"article-number":"1863629"}}