{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:52:08Z","timestamp":1789595528010,"version":"build-2803163510"},"reference-count":162,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Therapeutic resistance remains a major barrier to durable cancer control and cannot be fully explained by tumor-intrinsic genetic and epigenetic alterations alone. Increasing evidence indicates that resistance emerges within a dynamic tumor microenvironment in which immune cells actively instruct tumor cell behavior through ligand\u2013receptor (LR) signaling. These immune\u2013tumor communication axes link inflammatory cues, checkpoint-associated signals, chemokine networks, and metabolite-derived messages to adaptive tumor phenotypes. In particular, these axes may contribute to metabolic reprogramming across glucose, lipid, amino acid, and redox pathways, thereby supporting tumor-cell proliferation, therapeutic stress tolerance, and immune evasion. Lactate-centered signaling, macrophage-derived cytokine and chemokine axes, and checkpoint-associated pathways such as PD-L1-related signaling have emerged as major regulators of this process. These LR-mediated circuits are increasingly associated with tumor metabolic remodeling, immune suppression, phenotypic plasticity, and reduced responsiveness to chemotherapy and immune checkpoint blockade. Recent advances in single-cell transcriptomics, spatial omics, multiplex imaging, metabolomics, and computational modeling are accelerating the mapping of these communication networks\n                    <jats:italic>in situ<\/jats:italic>\n                    and revealing clinically relevant resistance niches. In this review, we synthesize current evidence on how immune\u2013tumor cell LR axes drive metabolic adaptation and therapeutic resistance across cancers, discuss the technologies enabling their dissection, and highlight their translational potential as biomarkers and therapeutic targets. Understanding these communication systems may provide new opportunities to disrupt resistant tumor ecosystems and improve the durability of cancer therapy.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1864068","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:28:51Z","timestamp":1781584131000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune\u2013tumor cell ligand\u2013receptor axes driving metabolic reprogramming and therapeutic resistance in cancer"],"prefix":"10.3389","volume":"17","author":[{"given":"Hailin","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology, The Affiliated Cancer Hospital Of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Breast Disease Center, The First Affiliated Hospital of Nanchang University, The First Clinical Medical College of Nanchang University, Jiangxi Medical College","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wu","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, Second Clinical Medical College of Nanchang University, Jiangxi Medical College","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Cancer Hospital Of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Breast Disease Center, The First Affiliated Hospital of Nanchang University, The First Clinical Medical College of Nanchang University, Jiangxi Medical College","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01059-1","article-title":"Understanding and overcoming multidrug resistance in cancer","volume":"22","author":"Ge","year":"2025","journal-title":"Nat Rev Clin Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s41065-025-00564-8","article-title":"Cancer cell plasticity and therapeutic resistance: mechanisms, crosstalk, and translational perspectives","volume":"162","author":"Ghorbian","year":"2025","journal-title":"Hereditas"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.657293","article-title":"Immunometabolism at the nexus of cancer therapeutic efficacy and resistance","volume":"12","author":"Traba","year":"2021","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188866","article-title":"Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy","volume":"1878","author":"Ye","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.102055","article-title":"Non-genetic heterogeneity and immune subtyping in breast cancer: implications for immunotherapy and targeted therapeutics","volume":"47","author":"Hassan","year":"2024","journal-title":"Transl Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-25-0999","article-title":"Epigenetic heritability of cell plasticity drives cancer drug resistance through a one-to-many genotype-to-phenotype paradigm","volume":"85","author":"Oliveira","year":"2025","journal-title":"Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0573-8","article-title":"Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer","volume":"121","author":"Leonetti","year":"2019","journal-title":"Br J Cancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09580-0","article-title":"Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA","volume":"647","author":"Williams","year":"2025","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.cd-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg3840","article-title":"The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets","volume":"16","author":"Sleeboom","year":"2024","journal-title":"Sci Transl Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003746","article-title":"A ligand-receptor interactome of the bone tumor microenvironment in multiple myeloma bone pain","volume":"166","author":"Barakat","year":"2025","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-20-2352","article-title":"Pan-cancer analysis of ligand-receptor cross-talk in the tumor microenvironment","volume":"81","author":"Ghoshdastider","year":"2021","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6136","DOI":"10.1038\/s41467-025-61439-0","article-title":"Suppression of multiple mouse models of refractory Malignancies by reprogramming IL-18 ligand-receptor interaction","volume":"16","author":"Fan","year":"2025","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45825","article-title":"Multiplexed non-invasive tumor imaging of glucose metabolism and receptor-ligand engagement using dark quencher FRET acceptor","volume":"10","author":"Rudkouskaya","year":"2020","journal-title":"Theranostics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101222","article-title":"A redox-responsive nanovaccine combined with A2A receptor antagonist for cancer immunotherapy","volume":"10","author":"Yan","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/08977194.2019.1703702","article-title":"Epidermal growth factor receptor ligands: targets for optimizing treatment of metastatic colorectal cancer","volume":"37","author":"Foroughi","year":"2019","journal-title":"Growth Factors"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091408","article-title":"Sigma receptor (\u03c3R) ligands with antiproliferative and anticancer activity","volume":"22","author":"Georgiadis","year":"2017","journal-title":"Molecules"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.08.022","article-title":"Potential applications for sigma receptor ligands in cancer diagnosis and therapy","volume":"1848","author":"van Waarde","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2503259122","article-title":"Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse","volume":"122","author":"Hoffmann","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00976","article-title":"CXCR3 ligands in cancer and autoimmunity, chemoattraction of effector T cells, and beyond","volume":"11","author":"Karin","year":"2020","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmed.2013.10.006","article-title":"Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer","volume":"20","author":"Vyas","year":"2014","journal-title":"Trends Mol Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/08830180802262765","article-title":"G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer","volume":"27","author":"Fraser","year":"2008","journal-title":"Int Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2023.2243029","article-title":"Molecular dissection of anti-colon cancer activity of NARI-29: special focus on H(2)O(2) modulated NF-\u03baB and death receptor signaling","volume":"57","author":"Np","year":"2023","journal-title":"Free Radic Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2025.112583","article-title":"Androgen receptor plays critical role in regulating cervical cancer cell migration","volume":"606","author":"Bose","year":"2025","journal-title":"Mol Cell Endocrinol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060762","article-title":"Sigma-1 receptor modulation by ligands coordinates cancer cell energy metabolism","volume":"12","author":"Oflaz","year":"2022","journal-title":"Biomolecules"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x10666150728122034","article-title":"Peroxisome proliferator-activated receptor-\u03b3 and its ligands in the treatment of tumors in the nervous system","volume":"11","author":"Shen","year":"2016","journal-title":"Curr Stem Cell Res Ther"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-18-1487","article-title":"The effects of cholesterol-derived oncometabolites on nuclear receptor function in cancer","volume":"78","author":"Silvente-Poirot","year":"2018","journal-title":"Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aau9048","article-title":"GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump","volume":"12","author":"Schneditz","year":"2019","journal-title":"Sci Signal"},{"key":"B29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.51620\/0869-2084-2022-67-2-76-80","article-title":"Soluble forms of PD-1\/PD-L immune checkpoint receptor and ligand in blood serum of breast cancer patients: association with clinical pathologic factors and molecular type of the tumor","volume":"67","author":"Gershtein","year":"2022","journal-title":"Klin Lab Diagn"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211039590","article-title":"Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer","volume":"104","author":"Gonda","year":"2021","journal-title":"Sci Prog"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218412","article-title":"CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.immuni.2024.03.020","article-title":"Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages","volume":"57","author":"Mandula","year":"2024","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102616","article-title":"Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling","volume":"298","author":"Pennarubia","year":"2022","journal-title":"J Biol Chem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-024-01828-x","article-title":"Notch signaling pathway in cancer: from mechanistic insights to targeted therapies","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.11.009","article-title":"Targeting myeloid cells for cancer immunotherapy: Siglec-7\/9\/10\/15 and their ligands","volume":"10","author":"Boelaars","year":"2024","journal-title":"Trends Cancer"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02454-w","article-title":"The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9","volume":"39","author":"Krishnamoorthy","year":"2025","journal-title":"Leukemia"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0956-8","article-title":"Natural killer group 2D receptor and its ligands in cancer immune escape","volume":"18","author":"Duan","year":"2019","journal-title":"Mol Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/s41467-025-56134-z","article-title":"Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23339","article-title":"A potential signaling axis between RON kinase receptor and hypoxia-inducible factor-1 alpha in pancreatic cancer","volume":"60","author":"Kato","year":"2021","journal-title":"Mol Carcinog"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02259.x","article-title":"Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia","volume":"103","author":"Lin","year":"2012","journal-title":"Cancer Sci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106590","article-title":"Discovery of estrogen receptor \u03b1 targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment","volume":"137","author":"Xie","year":"2023","journal-title":"Bioorg Chem"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12135","article-title":"Inhibition of IL-6-JAK\/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1\/NKG2D ligand levels","volume":"12","author":"Xu","year":"2018","journal-title":"Mol Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra119.009091","article-title":"Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP\/TAZ protein signaling","volume":"294","author":"Gopal","year":"2019","journal-title":"J Biol Chem"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030369","article-title":"Nexus between PI3K\/AKT and estrogen receptor signaling in breast cancer","volume":"13","author":"Khatpe","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/cas.14230","article-title":"Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K\/Akt\/mTOR in breast cancer","volume":"111","author":"Li","year":"2020","journal-title":"Cancer Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17047","article-title":"The Sigma-2 receptor\/TMEM97 agonist PB28 suppresses cell proliferation and invasion by regulating the PI3K-AKT-mTOR signalling pathway in renal cancer","volume":"25","author":"Zhan","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12918-015-0201-z","article-title":"Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis","volume":"9","author":"Bender","year":"2015","journal-title":"BMC Syst Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/157489207779561426","article-title":"Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy","volume":"2","author":"Veeravagu","year":"2007","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12573","article-title":"\u03ba opioid receptor ligands regulate angiogenesis in development and in tumours","volume":"172","author":"Yamamizu","year":"2015","journal-title":"Br J Pharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00783","article-title":"Controlled epidermal growth factor receptor ligand display on cancer suicide enzymes via unnatural amino acid engineering for enhanced intracellular delivery in breast cancer cells","volume":"30","author":"Lieser","year":"2019","journal-title":"Bioconjug Chem"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10495","article-title":"Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer","volume":"100","author":"Steketee","year":"2002","journal-title":"Int J Cancer"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217984","article-title":"Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress","volume":"633","author":"Sabarwal","year":"2025","journal-title":"Cancer Lett"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.3783","article-title":"Aryl hydrocarbon receptor suppresses the prostate cancer LNCaP cell growth and invasion by promoting DNA damage response under oxidative stress","volume":"36","author":"Yu","year":"2017","journal-title":"DNA Cell Biol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-18-3842","article-title":"Retinoic acid-related orphan receptor C regulates proliferation, glycolysis, and chemoresistance via the PD-L1\/ITGB6\/STAT3 signaling axis in bladder cancer","volume":"79","author":"Cao","year":"2019","journal-title":"Cancer Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s12032-019-1299-4","article-title":"Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis","volume":"36","author":"Giatromanolaki","year":"2019","journal-title":"Med Oncol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1410-1","article-title":"Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion","volume":"572","author":"Paczulla","year":"2019","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/cells13060480","article-title":"Functional selectivity of cannabinoid type 1 G protein-coupled receptor agonists in transactivating glycosylated receptors on cancer cells to induce epithelial-mesenchymal transition metastatic phenotype","volume":"13","author":"Bunsick","year":"2024","journal-title":"Cells"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2048984","article-title":"C-X-C motif chemokine ligand 12 (CXCL12)\/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway","volume":"13","author":"Guo","year":"2022","journal-title":"Bioengineered"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.85","article-title":"SCUBE3 is an endogenous TGF-\u03b2 receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer","volume":"30","author":"Wu","year":"2011","journal-title":"Oncogene"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1530\/erc-12-0405","article-title":"AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation","volume":"20","author":"Lee","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00380-3","article-title":"Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer","volume":"3","author":"Cheng","year":"2022","journal-title":"Nat Cancer"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/s2666-1683(22)01964-4","article-title":"Androgen receptor-mediated transcriptional repression targets cell plasticity in prostate cancer","volume":"16","author":"Erdmann","year":"2022","journal-title":"Mol Oncol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"101871","DOI":"10.1016\/j.ctrv.2019.05.001","article-title":"Androgen receptor plasticity and its implications for prostate cancer therapy","volume":"81","author":"Snow","year":"2019","journal-title":"Cancer Treat Rev"},{"key":"B64","doi-asserted-by":"publisher","first-page":"5511","DOI":"10.1038\/s41467-025-60649-w","article-title":"Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma","volume":"16","author":"Sun","year":"2025","journal-title":"Nat Commun"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0406-2","article-title":"Lactate modulation of immune responses in inflammatory versus tumour microenvironments","volume":"21","author":"Certo","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216837","article-title":"The emerging role of lactate in tumor microenvironment and its clinical relevance","volume":"590","author":"Chen","year":"2024","journal-title":"Cancer Lett"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43093-1_7","article-title":"The immune consequences of lactate in the tumor microenvironment","volume":"1259","author":"Harmon","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103627","article-title":"Lactate in the tumour microenvironment: From immune modulation to therapy","volume":"73","author":"Wang","year":"2021","journal-title":"EBioMedicine"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4161\/cc.21384","article-title":"Metabolic reprogramming of cancer-associated fibroblasts by TGF-\u03b2 drives tumor growth: connecting TGF-\u03b2 signaling with \"Warburg-like\" cancer metabolism and L-lactate production","volume":"11","author":"Guido","year":"2012","journal-title":"Cell Cycle"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s109001","article-title":"Toll-like receptor 3-induced immune response by poly(d,l-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy","volume":"11","author":"Han","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1186\/s12885-023-11631-6","article-title":"Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4","volume":"23","author":"Lund\u00f8","year":"2023","journal-title":"BMC Cancer"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2320951","DOI":"10.21203\/rs.3.rs-3389565\/v1","article-title":"Lactate\/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer","volume":"13","author":"Su","year":"2024","journal-title":"Oncoimmunology"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003126","article-title":"Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity","volume":"23","author":"Pan","year":"2025","journal-title":"PloS Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41590-024-02068-5","article-title":"The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer","volume":"26","author":"He","year":"2025","journal-title":"Nat Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1113\/jp270463","article-title":"Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB\/c mice","volume":"593","author":"Aveseh","year":"2015","journal-title":"J Physiol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1038\/s41467-021-23244-3","article-title":"PLGA-particle vaccine carrying TLR3\/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy","volume":"12","author":"Koerner","year":"2021","journal-title":"Nat Commun"},{"key":"B77","doi-asserted-by":"publisher","first-page":"C1502","DOI":"10.1152\/ajpcell.00346.2023","article-title":"Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological processes","volume":"325","author":"Mohammad Nezhady","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11010-016-2873-0","article-title":"TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production","volume":"425","author":"Park","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.ccell.2023.05.015","article-title":"MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma","volume":"41","author":"Qian","year":"2023","journal-title":"Cancer Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952980","article-title":"Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function","volume":"13","author":"Zeng","year":"2022","journal-title":"Front Pharmacol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.semcancer.2014.02.010","article-title":"Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance","volume":"28","author":"Mincheva-Nilsson","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006581","article-title":"Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment","volume":"11","author":"Xu","year":"2023","journal-title":"J Immunother Cancer"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31855","article-title":"Group-2 innate lymphoid cells promote HCC progression through CXCL2-neutrophil-induced immunosuppression","volume":"74","author":"Xu","year":"2021","journal-title":"Hepatology"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01088-w","article-title":"CB11, a novel purine-based PPAR\u0263 ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells","volume":"123","author":"Kim","year":"2020","journal-title":"Br J Cancer"},{"key":"B85","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13046-019-1216-x","article-title":"Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib","volume":"38","author":"Zheng","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1111\/cas.70157","article-title":"Androgen receptor-controlled microRNA-124-3p.2 suppresses prostate cancer progression via CCL2 inhibition","volume":"116","author":"Aoyama","year":"2025","journal-title":"Cancer Sci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13115","article-title":"Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting","volume":"54","author":"Xu","year":"2021","journal-title":"Cell Prolif"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11778","article-title":"CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells","volume":"46","author":"Qian","year":"2022","journal-title":"Cell Biol Int"},{"key":"B89","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12943-025-02471-y","article-title":"Integrated multi-omics identifies a CD54(+) iCAF-ITGAL(+) macrophage niche driving immunosuppression via CXCL8-PDL1 axis in cervical cancer","volume":"24","author":"Chen","year":"2025","journal-title":"Mol Cancer"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.009","article-title":"CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis","volume":"21","author":"Zhang","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.02.005","article-title":"Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates anti-PD-1 therapy efficacy in hepatocellular carcinoma","volume":"164","author":"Zhou","year":"2023","journal-title":"Gastroenterology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.lungcan.2017.01.003","article-title":"The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation","volume":"106","author":"Iriki","year":"2017","journal-title":"Lung Cancer"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114289","article-title":"Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer","volume":"182","author":"Dong","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155296","article-title":"ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion","volume":"7","author":"Gnosa","year":"2022","journal-title":"JCI Insight"},{"key":"B95","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ajpath.2024.12.007","article-title":"Chemokine (C-C motif) ligand 2\/CCR2\/extracellular signal-regulated kinase signal induced through cancer cell-macrophage interaction contributes to hepatocellular carcinoma progression","volume":"195","author":"Ishihara","year":"2025","journal-title":"Am J Pathol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416028","article-title":"Macrophage-colony-stimulating factor receptor enhances prostate cancer cell growth and aggressiveness in vitro and in vivo and increases osteopontin expression","volume":"23","author":"Mougel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.70011","article-title":"The macrophage galactose-type C-type lectin 1 receptor plays a major role in mediating colitis-associated colorectal cancer Malignancy","volume":"103","author":"Nieto-Ya\u00f1ez","year":"2025","journal-title":"Immunol Cell Biol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2007160117","article-title":"Estrogen receptor \u03b2 regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3","volume":"117","author":"Chaurasiya","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105498","article-title":"Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation","volume":"196","author":"Kollara","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3979","article-title":"P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway","volume":"34","author":"Xia","year":"2015","journal-title":"Oncol Rep"},{"key":"B101","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13058-025-02072-z","article-title":"MSN\/STAT3 drives cancer stemness and chemoresistance via IL-6\/LPAR1 ligand receptor complex in triple-negative breast cancer","volume":"27","author":"Lee","year":"2025","journal-title":"Breast Cancer Res"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332901","article-title":"Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between CCL2+ fibroblasts and STAT3-activated macrophages","volume":"74","author":"Lee","year":"2025","journal-title":"Gut"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.09.010","article-title":"CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3\/NF-\u03baB\/SDF-1\u03b1 axis to enhance efficacy against pancreatic cancer","volume":"31","author":"Sun","year":"2023","journal-title":"Mol Ther"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-15-2510","article-title":"Breast tumor kinase (Brk\/PTK6) is induced by HIF, glucocorticoid receptor, and PELP1-mediated stress signaling in triple-negative breast cancer","volume":"76","author":"Regan Anderson","year":"2016","journal-title":"Cancer Res"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0443","article-title":"Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms","volume":"22","author":"Hardy","year":"2008","journal-title":"Mol Endocrinol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666161202145509","article-title":"Control of inflammatory bowel disease and colorectal cancer by synthetic vitamin D receptor ligands","volume":"24","author":"Takada","year":"2017","journal-title":"Curr Med Chem"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.188","article-title":"Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells","volume":"36","author":"Feng","year":"2017","journal-title":"Oncogene"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31921","article-title":"Lenvatinib targets FGF receptor 4 to enhance antitumor immune response of anti-programmed cell death-1 in HCC","volume":"74","author":"Yi","year":"2021","journal-title":"Hepatology"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01786-6","article-title":"Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8(+) T cell exclusion","volume":"40","author":"Fang","year":"2021","journal-title":"J Exp Clin Cancer Res CR"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4647906","article-title":"Targeting nuclear receptor coactivator SRC-1 prevents colorectal cancer immune escape by reducing transcription and protein stability of PD-L1","volume":"11","author":"Hong","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B111","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12929-025-01181-3","article-title":"PD-L1 regulates c-MET phosphorylation and contributes to MET-dependent resistance to osimertinib in EGFR-mutant NSCLC","volume":"32","author":"Hsu","year":"2025","journal-title":"J BioMed Sci"},{"key":"B112","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1186\/s12967-024-05472-5","article-title":"Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer","volume":"22","author":"Hu","year":"2024","journal-title":"J Transl Med"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.cmet.2022.08.002","article-title":"Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I\u03baB\u03b1","volume":"34","author":"Guo","year":"2022","journal-title":"Cell Metab"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1189953","article-title":"Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion","volume":"14","author":"Lin","year":"2023","journal-title":"Front Immunol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s13046-019-1407-5","article-title":"Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer","volume":"38","author":"Kim","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/cac2.12117","article-title":"The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells","volume":"41","author":"Liu","year":"2021","journal-title":"Cancer Commun (Lond)"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01300","article-title":"Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors","volume":"8","author":"Palsson-McDermott","year":"2017","journal-title":"Front Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101009","article-title":"Tumour cell-expressed PD-L1 reprograms lipid metabolism via EGFR\/ITGB4\/SREBP1c signalling in liver cancer","volume":"6","author":"Zhao","year":"2024","journal-title":"JHEP Rep Innovation Hepatol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s12885-023-10947-7","article-title":"PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia","volume":"23","author":"Soltani","year":"2023","journal-title":"BMC Cancer"},{"key":"B120","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1038\/s41467-024-49199-9","article-title":"Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2\/IR\/NPM1-driven PD-L1 expression","volume":"15","author":"Jang","year":"2024","journal-title":"Nat Commun"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0252-x","article-title":"Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin \u03b24\/SNAI1\/SIRT3 signaling pathway","volume":"37","author":"Wang","year":"2018","journal-title":"Oncogene"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305215","article-title":"A PD-L1 antibody-conjugated PAMAM dendrimer nanosystem for simultaneously inhibiting glycolysis and promoting immune response in fighting breast cancer","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202310163","article-title":"Metabolism\/immunity dual-regulation thermogels potentiating immunotherapy of glioblastoma through lactate-excretion inhibition and PD-1\/PD-L1 blockade","volume":"11","author":"Li","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103660","article-title":"Chemotherapy and programmed cell death protein 1\/programmed death-ligand 1 inhibitor combinations for tyrosine kinase inhibitor-resistant, epidermal growth factor receptor-mutated non-small-cell lung cancer: a meta-analysis","volume":"9","author":"Piotrowska","year":"2024","journal-title":"ESMO Open"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-12-1780","article-title":"Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer","volume":"18","author":"Stevenson","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B126","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41419-024-07123-5","article-title":"Tumor-associated macrophages\/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R\/STAT3\/HMGB1 signaling","volume":"15","author":"Yang","year":"2024","journal-title":"Cell Death Dis"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277285","article-title":"Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells","volume":"18","author":"Jang","year":"2023","journal-title":"PloS One"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30164-1","article-title":"Small molecules, big impact: 20 years of targeted therapy in oncology","volume":"395","author":"Bedard","year":"2020","journal-title":"Lancet (London England)"},{"key":"B129","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccr.2009.11.022","article-title":"Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC","volume":"17","author":"Turke","year":"2010","journal-title":"Cancer Cell"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2330","article-title":"Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer","volume":"44","author":"Zhang","year":"2012","journal-title":"Nat Genet"},{"key":"B132","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/s41467-018-08074-0","article-title":"AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells","volume":"10","author":"Taniguchi","year":"2019","journal-title":"Nat Commun"},{"key":"B133","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41419-019-1601-6","article-title":"AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells","volume":"10","author":"Kim","year":"2019","journal-title":"Cell Death Dis"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605968","article-title":"CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy","volume":"103","author":"Singh","year":"2010","journal-title":"Br J Cancer"},{"key":"B135","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12885-016-2340-z","article-title":"Enhancement of the CXCL12\/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists","volume":"16","author":"Morimoto","year":"2016","journal-title":"BMC Cancer"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155709","article-title":"TGF-beta signaling in cancer radiotherapy","volume":"148","author":"Wang","year":"2021","journal-title":"Cytokine"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-12-3981","article-title":"CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer","volume":"73","author":"Xu","year":"2013","journal-title":"Cancer Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/neuonc\/now136","article-title":"CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone","volume":"19","author":"Goffart","year":"2017","journal-title":"Neuro-Oncology"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-12-0546","article-title":"Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-\u03b2","volume":"72","author":"Hardee","year":"2012","journal-title":"Cancer Res"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.cir-20-0111","article-title":"Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the radioresistance of pancreatic cancer","volume":"8","author":"Yang","year":"2020","journal-title":"Cancer Immunol Res"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216807","article-title":"LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer","volume":"593","author":"Lin","year":"2024","journal-title":"Cancer Lett"},{"key":"B143","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13046-024-03073-0","article-title":"ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages","volume":"43","author":"Hua","year":"2024","journal-title":"J Exp Clin Cancer Res CR"},{"key":"B144","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40164-024-00550-2","article-title":"M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis","volume":"13","author":"Chen","year":"2024","journal-title":"Exp Hematol Oncol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.051","article-title":"Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy","volume":"349","author":"Quick","year":"2022","journal-title":"J Control Release"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249622","article-title":"Novel liver X receptor ligand GAC0001E5 disrupts glutamine metabolism and induces oxidative stress in pancreatic cancer cells","volume":"21","author":"Srivastava","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13989","article-title":"Hypoxia-inducible factor-1\u03b1 and nuclear factor-\u03baB play important roles in regulating programmed cell death ligand 1 expression by epidermal growth factor receptor mutants in non-small-cell lung cancer cells","volume":"110","author":"Guo","year":"2019","journal-title":"Cancer Sci"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3892\/or.2010.1090","article-title":"NF-\u03baB participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck","volume":"25","author":"Liu","year":"2011","journal-title":"Oncol Rep"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj3301","article-title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival","volume":"10","author":"Haley","year":"2024","journal-title":"Sci Adv"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.760971","article-title":"IL-6\/STAT3 is a promising therapeutic target for hepatocellular carcinoma","volume":"11","author":"Xu","year":"2021","journal-title":"Front Oncol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.taap.2018.12.013","article-title":"M2 macrophage-derived IL6 mediates resistance of breast cancer cells to hedgehog inhibition","volume":"364","author":"Xu","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1216-5","article-title":"The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment","volume":"39","author":"Brown","year":"2020","journal-title":"Oncogene"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1038\/s41467-022-29366-6","article-title":"Single-cell and spatial analysis reveal interaction of FAP(+) fibroblasts and SPP1(+) macrophages in colorectal cancer","volume":"13","author":"Qi","year":"2022","journal-title":"Nat Commun"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333617","article-title":"CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases","volume":"74","author":"Li","year":"2025","journal-title":"Gut"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215834","article-title":"Single cell RNA-seq reveals the CCL5\/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancer","volume":"545","author":"Chen","year":"2022","journal-title":"Cancer Lett"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c00002","article-title":"Glucocorticoid receptor-targeted nanoliposome for STAT3 inhibition-led myeloid-derived suppressor cell modulation and efficient colon cancer treatment","volume":"8","author":"Bhattacharyya","year":"2025","journal-title":"ACS Appl Bio Mater"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0059","article-title":"Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation","volume":"21","author":"Al-Dhaheri","year":"2007","journal-title":"Mol Endocrinol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.487","article-title":"Ligand-independent epidermal growth factor receptor overexpression correlates with poor prognosis in colorectal cancer","volume":"50","author":"Yun","year":"2018","journal-title":"Cancer Res Treat"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2015.04.008","article-title":"Perspectives on epidermal growth factor receptor regulation in triple-negative breast cancer: Ligand-mediated mechanisms of receptor regulation and potential for clinical targeting","volume":"127","author":"Williams","year":"2015","journal-title":"Adv Cancer Res"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2346","article-title":"Clinical pharmacology profile of AMG 119, the first chimeric antigen receptor T (CAR-T) cell therapy targeting delta-like ligand 3 (DLL3), in patients with relapsed\/refractory small cell lung cancer (SCLC)","volume":"64","author":"Zhou","year":"2024","journal-title":"J Clin Pharmacol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000026367","article-title":"Precise medicine of programmed cell death-1\/programmed cell death 1 ligand 1 inhibitor immunotherapy combined radiotherapy for inoperable advanced lung cancer: A protocol for systematic review and meta-analysis","volume":"100","author":"Liu","year":"2021","journal-title":"Med (Baltimore)"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-094859","article-title":"Low-dose radiation and stereotactic body radiotherapy with PD-1 inhibitor sintilimab and chemotherapy for first-line treatment of locally advanced or metastatic squamous lung cancer: protocol for a randomised phase II trial (IHC002 study)","volume":"15","author":"Zhang","year":"2025","journal-title":"BMJ Open"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864068\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:28:54Z","timestamp":1781584134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864068\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":162,"alternative-id":["10.3389\/fimmu.2026.1864068"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1864068","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"article-number":"1864068"}}