{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:24:09Z","timestamp":1787059449104,"version":"build-2736575974"},"reference-count":214,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome characterized by persistent oxidative stress and maladaptive immune responses, rather than a single disease entity. Oxidative stress not only damages lung tissue but also reprograms immune cells through both classical epigenetic mechanisms (DNA methylation, histone modifications) and epitranscriptomic regulation (m\n                    <jats:sup>6<\/jats:sup>\n                    A RNA methylation), shaping disease endotypes and treatment resistance. This review presents an integrated framework in which redox signals dynamically reshape the epigenetic and epitranscriptomic landscape, thereby locking immune cells into pathogenic states. Metabolic intermediates (S-adenosylmethionine, \u03b1-ketoglutarate, succinate, NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) serve as critical nodes that connect immunometabolism to both classical epigenetic enzymes and the m\n                    <jats:sup>6<\/jats:sup>\n                    A machinery, thereby linking redox status to RNA fate. Using NETosis as a paradigm, we illustrate how oxidative\u2013epigenetic\u2013metabolic loops sustain neutrophilic inflammation and resolution failure. Finally, we outline a treatable traits framework that integrates these mechanistic insights into precision combination therapies. This conceptual roadmap aims to shift COPD management from symptom control toward durable, mechanism-driven disease modification.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1865051","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:26:07Z","timestamp":1787055967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative stress-driven epigenetic reprogramming of immune cells in COPD: from epitranscriptomic and metabolic crosstalk to treatable traits"],"prefix":"10.3389","volume":"17","author":[{"given":"Chun Feng","family":"Pan","sequence":"first","affiliation":[{"name":"Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wan","sequence":"additional","affiliation":[{"name":"Zhuhai Hospital of Integrated Traditional Chinese 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, Guangdong, China"]},{"name":"Zhuhai Hospital, Faculty of Chinese Medicine, Macau University of Science and Technology","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-080919-112707","article-title":"Advances in chronic obstructive pulmonary disease","volume":"72","author":"Ferrera","year":"2021","journal-title":"Annu Rev Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1733726","article-title":"The gut-lung axis in COPD: immunomodulatory roles of gut microbiota and novel therapeutic 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