{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:17Z","timestamp":1783318517824,"version":"3.54.6"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>POEMS syndrome is a rare and chronic paraneoplastic syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. The pathophysiology of this disease is not well understood, but current research focuses on the increase in VEGF and the highly restrictive nature of \u03bb light chains produced by monoclonal plasma cells. Recently, studies have looked deeper into the possibility of these \u03bb light chains being a major factor in onset and progression of this disease focusing on molecular mimicry and links to viral infections. This mini review will summarize current literature on POEMS syndrome as well as hypothesize and analyze the role of the \u03bb light chain in the pathophysiology of the disease.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1865997","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:38:00Z","timestamp":1783316280000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lambda restricted light chain as pathogenic cause of POEMS syndrome: a review of the hypothesis"],"prefix":"10.3389","volume":"17","author":[{"given":"Rebecca","family":"Troutman","sequence":"first","affiliation":[{"name":"Wood College of Osteopathic Medicine, Marian University","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wagner","sequence":"additional","affiliation":[{"name":"Wood College of Osteopathic Medicine, Marian 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