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By analyzing HCC data, we identified an epithelial subtype marked by proliferative capacity, invasiveness, and metabolic reprogramming, particularly in sugar and lipid metabolism. This subtype contributes to immune microenvironment complexity through interactions with Lipid-Associated tumor associated macrophage cells (LA_TAMs) that are linked to disease progression. A prognostic model (Tumor Epithelial Feature Signature, TEFS) revealed UAP1L1 as a computationally predicted key modulator of the cell cycle and extracellular matrix remodeling. Functional validation confirmed its clinical relevance and oncogenic role. 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