{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:05:26Z","timestamp":1790355926929,"version":"4.1.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Postpartum alopecia (PPA) is a common physiological hair loss in women, characterized by complex pathogenesis involving abrupt postpartum hormonal withdrawal, disrupted hair follicle cycling, local microenvironmental inflammation, and oxidative stress. Umbilical cord blood-derived extracellular vesicles (UCB-EVs)\u2014nanosized, lipid-bilayer-enclosed particles enriched with microRNAs, growth factors, and proteins\u2014have shown considerable promise in regenerative medicine owing to their low immunogenicity, high biocompatibility, and tissue-repair capacity. This review systematically summarizes the current state of research on UCB-EVs in the context of PPA, focusing on their proposed molecular mechanisms in hair follicle regeneration, hair-cycle modulation, antiinflammatory effects, and antioxidative stress responses. Importantly, the available evidence remains largely preclinical, derived from\n                    <jats:italic>in vitro<\/jats:italic>\n                    and animal-model studies; direct clinical evidence for UCBEVs in PPA is still lacking. UCB-EVs should therefore be regarded as a promising investigational strategy, and their clinical translation will require rigorous validation of standardization, safety, and efficacy.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1872590","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:16:18Z","timestamp":1790352978000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Translating umbilical cord blood extracellular vesicles into a novel therapy for postpartum alopecia: a mechanistic and preclinical review"],"prefix":"10.3389","volume":"17","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Wenzhou People\u2019s Hospital","place":["Wenzhou, China"]},{"name":"Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"The Third Affiliated Hospital of Shanghai 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Third Affiliated Hospital of Shanghai University","place":["Wenzhou, China"]},{"name":"The Wenzhou People\u2019s Hospital Affiliated of Hangzhou Medical College","place":["Wenzhou, China"]},{"name":"Department of General Practice, Wenzhou People\u2019s Hospital","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"The Third Affiliated Hospital of Shanghai University","place":["Wenzhou, China"]},{"name":"The Wenzhou People\u2019s Hospital Affiliated of Hangzhou Medical College","place":["Wenzhou, China"]},{"name":"Department of General Practice, Wenzhou People\u2019s Hospital","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Wenzhou Third Clinical 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