{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:47:46Z","timestamp":1785822466639,"version":"3.56.0"},"reference-count":151,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Wound healing after malignant tumor surgery is a critical determinant of patient recovery, and the dynamic changes in the postoperative immune system may alter tolerance to food allergens, thereby influencing the healing process. This review aims to systematically explore the alterations in immune tolerance following malignancy surgery, investigate the effects of potential food allergen exposure on wound healing, and analyze associated clinical risks. By integrating recent findings from immunology, nutrition, and surgery, we propose that postoperative allergen exposure may impede normal wound healing through mechanisms such as activating inflammatory responses, delaying angiogenesis, and disrupting collagen deposition. 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