{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:46:27Z","timestamp":1782301587158,"version":"3.54.5"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postpartum depression (PPD) is a common complication with adverse maternal and child outcomes. Immune\u2212inflammatory dysregulation has been implicated in its pathogenesis, but evidence from twin pregnancies is limited. This study aimed to investigate associations between routine prenatal inflammatory biomarkers and PPD symptoms in women with twin deliveries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 846 women with twin pregnancies delivered between May 2022 and May 2024 at a tertiary hospital. PPD symptoms were screened within 4 weeks postpartum using the Edinburgh Postnatal Depression Scale. Blood samples at admission provided complete blood counts, from which neutrophil, lymphocyte, monocyte, platelet counts, and derived ratios (NLR, LMR, PLR, SII, SIRI, PIV) were calculated. Multivariable logistic regression was used to assess associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 846 participants, 145 (17.14%) had PPD symptoms. Women with PPD symptoms had significantly higher neutrophil, lymphocyte, and monocyte counts (all P&amp;lt;0.05). After full adjustment, higher neutrophil count (OR\u00a0=\u00a01.46, 95% CI: 1.01\u20132.12, P\u00a0=\u00a00.047), higher LMR (OR\u00a0=\u00a01.36, 95% CI: 1.01\u20131.83, P\u00a0=\u00a00.041), and lower PLR (OR\u00a0=\u00a00.98, 95% CI: 0.96\u20130.99, P\u00a0=\u00a00.029) were independently associated with PPD symptoms. Lymphocyte count showed a borderline protective effect (OR\u00a0=\u00a00.33, 95% CI: 0.11\u20131.02, P\u00a0=\u00a00.055). Quartile analyses revealed significant dose-response relationships for neutrophils (P for trend &amp;lt;0.001), lymphocytes (P\u00a0=\u00a00.03), monocytes (P\u00a0=\u00a00.015), and SIRI (P\u00a0=\u00a00.023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher neutrophil count, higher LMR, and lower PLR are independently associated with PPD symptoms in twin pregnancies, supporting immune inflammatory involvement in PPD pathophysiology. Future studies should integrate psychosocial and hormonal factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1874901","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:48:29Z","timestamp":1782298109000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Higher neutrophil count, higher lymphocyte-to-monocyte ratio, and lower platelet-to-lymphocyte ratio are independently associated with postpartum depression symptoms in twin pregnancies"],"prefix":"10.3389","volume":"17","author":[{"given":"Hui","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of 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