{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:07:38Z","timestamp":1784700458836,"version":"3.55.0"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>OTUD1 is a deubiquitinase of the OTU family that participates in immune signaling, redox balance, and cell death through modulating substrate ubiquitination. Under physiological conditions, OTUD1 primarily exerts negative regulatory effects, restricting excessive activation of NF-\u03baB inflammatory signaling and type I interferon responses, thereby maintaining immune and oxidative homeostasis. Under pathological conditions, its functional effects undergo tissue-dependent reprogramming: it is downregulated in most epithelial tumors and suppresses malignant progression, whereas it is upregulated in certain tumors and cardiovascular or metabolic diseases and promotes pathological remodeling. It exerts protective regulation in the nervous system and mucosal inflammation, yet drives hypertrophy and fibrosis in the cardiovascular system. Preclinical studies indicate that OTUD1 expression levels correlate with tumor stage, prognosis, and therapeutic sensitivity, suggesting potential as a biomarker for diagnostic subtyping and prognostic assessment. However, marked tissue functional heterogeneity, the discovery of non-enzymatic scaffold functions, and the lack of highly selective targeting probes constitute central bottlenecks for clinical translation. This review systematically summarizes the molecular characteristics, physiological functions, disease regulatory networks, and current clinical translational status of OTUD1, with the aim of clarifying the molecular basis of its functional duality and providing a theoretical foundation for optimizing precision diagnostic and therapeutic strategies targeting OTUD1.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1877213","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:56:42Z","timestamp":1784699802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of OTUD1-mediated deubiquitination in disease pathogenesis: from molecular mechanisms to clinical translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Qingsong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiJuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center, Sichuan Provincial Women\u2019s and Children\u2019s Hospital\/The Affiliated Women\u2019s and Children\u2019s Hospital of Chengdu Medical College","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyong","family":"Luo","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center, Sichuan Provincial Women\u2019s and Children\u2019s Hospital\/The Affiliated Women\u2019s and Children\u2019s Hospital of Chengdu Medical College","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, West China Hospital Sichuan University Jintang Hospital, Jintang First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3892\/mmr.2025.13571","article-title":"METTL3-mediated m6A methylation and its impact on OTUD1 expression in chronic obstructive pulmonary disease","volume":"32","author":"Gao","year":"2025","journal-title":"Mol Med Rep"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020350","article-title":"Pleiotropic roles of a KEAP1-associated deubiquitinase, OTUD1","volume":"12","author":"Oikawa","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167018","article-title":"OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes","volume":"1870","author":"Wang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s41419-022-05145-5","article-title":"OTUD1 deubiquitinase regulates NF-\u03baB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways","volume":"13","author":"Oikawa","year":"2022","journal-title":"Cell Death Dis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83340","article-title":"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes","volume":"13","author":"Wang","year":"2023","journal-title":"Theranostics"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.046","article-title":"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis","volume":"154","author":"Mevissen","year":"2013","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.07.019","article-title":"Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders","volume":"94","author":"Lu","year":"2018","journal-title":"J Autoimmun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1038\/s41467-017-02029-7","article-title":"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256135","article-title":"Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3","volume":"24","author":"Huang","year":"2023","journal-title":"EMBO Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01192-6","article-title":"OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.95707","article-title":"METTL3-mediated m6A modification of OTUD1 aggravates press overload induced myocardial hypertrophy by deubiquitinating PGAM5","volume":"20","author":"Huang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-025-03647-y","article-title":"The deubiquitinase OTUD1 orchestrates cisplatin chemosensitivity of non-small cell lung cancer through destabilizing RAD23B\/XPC","volume":"44","author":"Wu","year":"2025","journal-title":"Oncogene"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00810-9","article-title":"The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-\u03baB signaling","volume":"19","author":"Wu","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/s41467-024-45698-x","article-title":"Aggresome formation promotes ASK1\/JNK signaling activation and stemness maintenance in ovarian cancer","volume":"15","author":"Chen","year":"2024","journal-title":"Nat Commun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/1751-2980.70017","article-title":"Regulatory role of protein ubiquitination in the pathogenesis and progression of ulcerative colitis","volume":"26","author":"Zhu","year":"2025","journal-title":"J Dig Dis"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155263","article-title":"Arteannuin B, a sesquiterpene lactone from Artemisia annua, attenuates inflammatory response by inhibiting the ubiquitin-conjugating enzyme UBE2D3-mediated NF-\u03baB activation","volume":"124","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"B17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1585","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116418","article-title":"The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-\u03baB signaling","volume":"227","author":"Ming","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2300239","DOI":"10.1183\/13993003.00239-2023","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"61","author":"Agust\u00ed","year":"2023","journal-title":"Eur Respir J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jaci.2016.05.011","article-title":"Inflammatory mechanisms in patients with chronic obstructive pulmonary disease","volume":"138","author":"Barnes","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S398289","article-title":"Mettl3 mediated m6A methylation involved in epithelial-mesenchymal transition by targeting SOCS3\/STAT3\/SNAI1 in cigarette smoking-induced COPD","volume":"18","author":"Zhang","year":"2023","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3892\/mmr.2022.12735","article-title":"lncRNA GAS5 promotes pyroptosis in COPD by functioning as a ceRNA to regulate the miR-223-3p\/NLRP3 axis","volume":"26","author":"Mo","year":"2022","journal-title":"Mol Med Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155220","article-title":"Cigarette smoke and extracellular Hsp70 induce secretion of ATP and differential activation of NLRP3 inflammasome in monocytic and bronchial epithelial cells","volume":"135","author":"Rumora","year":"2020","journal-title":"Cytokine"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1686175","article-title":"Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications","volume":"16","author":"Ni","year":"2025","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2933","article-title":"Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling","volume":"46","author":"Rice","year":"2014","journal-title":"Nat Genet"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease - a systematic review and meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1790","article-title":"Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling","volume":"14","author":"Qian","year":"2024","journal-title":"Clin Transl Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6886752","article-title":"Chlorpromazine and Promethazine (C+P) reduce brain injury after ischemic stroke through the PKC-\u03b4\/NOX\/MnSOD pathway","volume":"2022","author":"Guo","year":"2022","journal-title":"Mediators Inflammation"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01383","article-title":"Drug delivery strategies for neuroprotective therapy in ischemic stroke: application of nanotechnology","volume":"21","author":"Jiang","year":"2025","journal-title":"Neural Regener Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091384","article-title":"The alterations in mitochondrial dynamics following cerebral ischemia\/reperfusion injury","volume":"10","author":"Vongsfak","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104261","article-title":"The beneficial roles of metformin on the brain with cerebral ischaemia\/reperfusion injury","volume":"146","author":"Leech","year":"2019","journal-title":"Pharmacol Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00433","article-title":"Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: potential application of natural compounds","volume":"11","author":"Chen","year":"2020","journal-title":"Front Physiol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157468","article-title":"Allicin alleviates cerebral ischemia\/reperfusion injury by inhibiting neuronal mitochondrial oxidative stress via OTUD1\/NRF2 axis","volume":"148","author":"Jiang","year":"2025","journal-title":"Phytomedicine"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103287","article-title":"The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia\/reperfusion injury","volume":"75","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx7695","article-title":"Athlete-derived extracellular vesicles protect against spinal cord injury via inhibition of neuronal ferroptosis","volume":"11","author":"Wang","year":"2025","journal-title":"Sci Adv"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05164-1","article-title":"Exosomal miR-494 from bone marrow mesenchymal stem cells attenuates ferroptosis and enhances spinal cord injury repair by modulating the SIRT1\/HO-1 pathway","volume":"62","author":"Shi","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14150","article-title":"Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1557133","article-title":"Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review","volume":"16","author":"She","year":"2025","journal-title":"Front Pharmacol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.10.270","article-title":"Apoptotic extracellular vesicles derived from UC-MSCs promote spinal cord injury repair by inhibiting ferroptosis via OTUD1","volume":"242","author":"Li","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134646","article-title":"NRF2 knockdown resensitizes preclinically 5-fluorouracil-resistant pancreatic cancer cells by suppressing HO-1 and ABCG2 expression","volume":"21","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1363","article-title":"Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers","volume":"80","author":"Mukhopadhyay","year":"2020","journal-title":"Cancer Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.08.006","article-title":"Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells","volume":"174","author":"Grattarola","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/iub.70094","article-title":"OTUD1 relieves coxsackievirus-induced ferroptosis and inflammation in myocardial cells by stabilizing NRF2 and inhibiting NF-\u03baB signaling","volume":"78","author":"Chen","year":"2026","journal-title":"IUBMB Life"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2026.2658796","article-title":"Fluoxetine alleviates vascular cognitive impairment by activating the Nrf2\/ARE pathway via Sp1-mediated OTUD1 transcription","volume":"60","author":"Wan","year":"2026","journal-title":"Free Radic Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114039","article-title":"Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells","volume":"157","author":"Bae","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B48","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13046-022-02270-z","article-title":"Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway","volume":"41","author":"Zhang","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2511733123","article-title":"Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug","volume":"123","author":"Antonucci","year":"2026","journal-title":"Proc Natl Acad Sci USA"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.74985","article-title":"Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis","volume":"19","author":"Lv","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v15.i3.375","article-title":"Role of targeting ferroptosis as a component of combination therapy in combating drug resistance in colorectal cancer","volume":"15","author":"Xie","year":"2024","journal-title":"World J Clin Oncol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41420-025-02652-0","article-title":"Development of a bispecific CDH17-GUCY2C ADC bearing the ferroptosis inducer RSL3 for the treatment of colorectal cancer","volume":"11","author":"Zhang","year":"2025","journal-title":"Cell Death Discov"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051162","article-title":"The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity","volume":"22","author":"Song","year":"2021","journal-title":"EMBO Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"37189","DOI":"10.1038\/s41598-025-14086-w","article-title":"Targeting FBXL5 to induce ferroptosis and reverse oxaliplatin resistance in iron-rich colorectal cancer","volume":"15","author":"Wang","year":"2025","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121186","article-title":"Yangjing Zhongyu decoction ameliorates polycystic ovary syndrome via multi-organ ferroptosis inhibition: A mechanistic study","volume":"361","author":"Lu","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s12672-025-03147-1","article-title":"Identification of a novel ferroptosis-induced immunogenic cell death related signature based on a machine learning framework in colorectal cancer","volume":"16","author":"Zhu","year":"2025","journal-title":"Discov Oncol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s10495-026-02294-2","article-title":"The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-\u03b2 signaling","volume":"31","author":"Han","year":"2026","journal-title":"Apoptosis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002874","article-title":"OTUD1 activates caspase-independent and caspase-dependent apoptosis by promoting AIF nuclear translocation and MCL1 degradation","volume":"8","author":"Luo","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02641-6","article-title":"HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer","volume":"42","author":"Liu","year":"2023","journal-title":"Oncogene"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1924958","article-title":"LncRNA SENCR promotes cell proliferation and progression in non-small-cell lung cancer cells via sponging miR-1-3p","volume":"20","author":"Cheng","year":"2021","journal-title":"Cell Cycle"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098212","article-title":"The long run towards personalized therapy in non-small-cell lung cancer: Current state and future directions","volume":"24","author":"Genova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s41420-025-02564-z","article-title":"The Nrf2-HMOX1 pathway as a therapeutic target for reversing cisplatin resistance in non-small cell lung cancer via inhibiting ferroptosis","volume":"11","author":"Zuo","year":"2025","journal-title":"Cell Death Discov"},{"key":"B64","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41420-022-01119-w","article-title":"Deubiquitylase OTUD1 confers Erlotinib sensitivity in non-small cell lung cancer through inhibition of nuclear translocation of YAP1","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Death Discov"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14320","article-title":"The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4","volume":"13","author":"Ma","year":"2022","journal-title":"Thorac Cancer"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-023-00793-x","article-title":"VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma","volume":"46","author":"Zhang","year":"2023","journal-title":"Cell Oncol (Dordr)"},{"key":"B67","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s12935-025-03822-x","article-title":"OTUD3 inhibits breast cancer cell metastasis by regulating TGF-\u03b2 pathway through deubiquitinating SMAD7","volume":"25","author":"Geng","year":"2025","journal-title":"Cancer Cell Int"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-022-01519-x","article-title":"Clinical significance of HER2-low expression in early breast cancer: a nationwide study from the Korean Breast Cancer Society","volume":"24","author":"Won","year":"2022","journal-title":"Breast Cancer Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2024.103830","article-title":"Unveiling the future of breast cancer therapy: Cutting-edge antibody-drug conjugate strategies and clinical outcomes","volume":"78","author":"Sun","year":"2024","journal-title":"Breast"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2021.0358","article-title":"Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women","volume":"19","author":"Fu","year":"2021","journal-title":"Cancer Biol Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab151","article-title":"Association of genetic testing results with mortality among women with breast cancer or ovarian cancer","volume":"114","author":"Kurian","year":"2022","journal-title":"J Natl Cancer Inst"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adf1947","article-title":"The lncRNA LETS1 promotes TGF-\u03b2-induced EMT and cancer cell migration by transcriptionally activating a T\u03b2R1-stabilizing mechanism","volume":"16","author":"Fan","year":"2023","journal-title":"Sci Signal"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217942","article-title":"OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma","volume":"632","author":"Xu","year":"2025","journal-title":"Cancer Lett"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-026-01723-8","article-title":"DR5\/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma","author":"Tao","year":"2026","journal-title":"Cell Death Differ"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.107981","article-title":"Identification of the LCOR-PLCL1 pathway that restrains lipid accumulation and tumor progression in clear cell renal cell carcinoma","volume":"21","author":"Li","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.68980","article-title":"OTUD1 stabilizes PTEN to inhibit the PI3K\/AKT and TNF-alpha\/NF-kappaB signaling pathways and sensitize ccRCC to TKIs","volume":"18","author":"Liu","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/s41419-023-06165-5","article-title":"Fallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis","volume":"14","author":"Wisztorski","year":"2023","journal-title":"Cell Death Dis"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0500","article-title":"Synthetic lethality in ovarian cancer","volume":"20","author":"Chandrasekaran","year":"2021","journal-title":"Mol Cancer Ther"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1779912","article-title":"STAT1 and IL-7 as potential diagnostic biomarkers for distinguishing high-grade from low-grade serous ovarian cancer: a multi-cohort analysis","volume":"17","author":"Wu","year":"2026","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41419-022-04670-7","article-title":"HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer","volume":"13","author":"Ma","year":"2022","journal-title":"Cell Death Dis"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003820","article-title":"Multiple myeloma cells depend on the DDI2\/NRF1-mediated proteasome stress response for survival","volume":"6","author":"Chen","year":"2022","journal-title":"Blood Adv"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2024.100964","article-title":"Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors","volume":"50","author":"Zhou","year":"2024","journal-title":"Neoplasia"},{"key":"B83","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12964-024-01699-3","article-title":"Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy","volume":"22","author":"Wang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27073001","article-title":"Oxidative stress in multiple myeloma: Pathogenic mechanisms, biomarkers, and redox-targeted therapeutic strategies","volume":"27","author":"Bilski","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B85","doi-asserted-by":"publisher","first-page":"6820","DOI":"10.1038\/s41467-022-34654-2","article-title":"The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma","volume":"13","author":"Vdovin","year":"2022","journal-title":"Nat Commun"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ Res"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6668","DOI":"10.1038\/s41467-025-61901-z","article-title":"Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPK\u03b12 and inducing mitochondrial dysfunction","volume":"16","author":"Han","year":"2025","journal-title":"Nat Commun"},{"key":"B88","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01567-x","article-title":"OTUD1 deficiency attenuates myocardial ischemia\/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation","volume":"46","author":"Luo","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01610-0","article-title":"Mitochondrial fission inhibition protects against hypertension induced by angiotensin II","volume":"47","author":"Preston","year":"2024","journal-title":"Hypertens Res"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07620","article-title":"Vascular ADAM17 as a novel therapeutic target in mediating cardiovascular hypertrophy and perivascular fibrosis induced by angiotensin II","volume":"68","author":"Takayanagi","year":"2016","journal-title":"Hypertension"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7177","article-title":"Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-\u03b21","volume":"16","author":"Shang","year":"2017","journal-title":"Mol Med Rep"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.104382","article-title":"OTUD1 regulates cytokine expression and related pathways in goose fatty liver by promoting deubiquitination of its target proteins","volume":"103","author":"Zhou","year":"2024","journal-title":"Poult Sci"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20230119","article-title":"Development of an OTUD1 ubiquitin variant inhibitor","volume":"480","author":"Liu","year":"2023","journal-title":"Biochem J"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12781","article-title":"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation","volume":"72","author":"Woo","year":"2022","journal-title":"J Pineal Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1877213\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:56:43Z","timestamp":1784699803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1877213\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":95,"alternative-id":["10.3389\/fimmu.2026.1877213"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1877213","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1877213"}}