{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:47:01Z","timestamp":1782798421306,"version":"3.54.5"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Globally, 15-30% of patients with chronic hepatitis C develop compensated advanced chronic liver disease (cACLD). cACLD may further advance to decompensated ACLD (dACLD), which is associated with higher liver-related mortality, even after successful antiviral treatment. This progression is accelerated by HIV coinfection, yet its underlying molecular mechanisms remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, we characterized the plasma lipidomic profiles of 58 HIV\/HCV-coinfected patients using untargeted liquid chromatography-mass spectrometry. Multivariate (OPLS-DA) and univariate (GLM) statistical models were employed to identify lipid species associated with disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a signature of 28 lipids\u2014predominantly phosphatidylcholines, phosphatidylethanolamines, and triglycerides\u2014 that were significantly depleted in patients with dACLD (17.2% of the cohort). This systemic lipid depletion showed relevant correlations with the pro-inflammatory chemokine IP-10 and soluble immune checkpoint proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings indicate that dACLD in HIV\/HCV-coinfection is defined by a profound collapse in plasma lipids. This metabolic failure correlates with markers of inflammation and immune activation, suggesting that lipid dysregulation plays a critical role in the pathogenesis of liver decompensation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1878207","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:40:20Z","timestamp":1782798020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipidomics of HIV\/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation"],"prefix":"10.3389","volume":"17","author":[{"given":"Raquel","family":"Behar-Lagares","sequence":"first","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad, Centro Nacional de Microbiolog\u00eda (CNM), Instituto de Salud Carlos III (ISCIII)","place":["Majadahonda, Madrid, 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