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Flavonoids have garnered increasing scientific interest due to their pleiotropic biological activities; however, there is still a lack of summary on the mechanism of flavonoids in key pathological processes of asthma. This review summarizes the evidence on how flavonoids modulate key asthma pathologies, covering airway inflammation, T cell subset imbalance, airway remodeling, and smooth muscle contractility. However, clinical translation is severely constrained by poor solubility, rapid metabolism, and low oral bioavailability. Flavonoids exhibit multi-target therapeutic potential for asthma, but well-designed, large-scale clinical trials are necessary to validate these preclinical observations.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1880181","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:50:26Z","timestamp":1785397826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids as potential anti-asthmatic agents"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhuofen","family":"Deng","sequence":"first","affiliation":[{"name":"Central Laboratory of YunFu People\u2019s Hospital, YunFu Key Laboratory of Brain Diseases Research","place":["Guangdong Yunfu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyi","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, YunFu People\u2019s Hospital","place":["Guangdong Yunfu, 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