{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:28:55Z","timestamp":1787128135477,"version":"build-2736575974"},"reference-count":205,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008326","name":"Ball State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Insects are the most diverse group of animals in nature, occupying nearly every ecological niche and playing central roles as pollinators, pests, and disease vectors. Despite this vast diversity, insects rely on a set of conserved yet evolutionarily adaptable immune pathways to defend against pathogens. Early studies in insect immunity have laid the foundation for human immunology, and recent advances in genomic and transgenic technologies have renewed interest in understanding how immune responses vary across insect orders. Insects are highly diverse in their immune systems; each species has unique immune responses that help fight infections from specific pathogens. Nevertheless, they share multiple aspects of recognition, regulation, and effector mechanisms. This review focuses on current knowledge of the immune systems of major insect lineages to highlight both shared signaling pathways, immune cells, and humoral factors, as well as lineage-specific responses that reflect distinct ecological pressures that have shaped the host-microbe interactions. Comparing different insect species and orders not only provides insights into the evolutionary divergences and convergences of immune system features but also offers complementary knowledge among species within the same order, helping fill existing gaps. Understanding these evolutionary patterns not only deepens our understanding of insect immunity but also informs the development of transgenic strategies to disrupt pathogen transmission in key vector species.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1884037","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:44:43Z","timestamp":1786607083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insect immune systems: same same but different but still same"],"prefix":"10.3389","volume":"17","author":[{"given":"Victor","family":"Cardoso-Jaime","sequence":"first","affiliation":[{"name":"Colegio de Ciencias y Humanidades, Academia de Nutrici\u00f3n y Salud, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico","place":["Plantel Casa Libertad, Mexico City, Mexico"]},{"name":"Biochemistry Department, Center for Research and Advanced Studies","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal","family":"Maya-Maldonado","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Center for Research and Advanced Studies","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Biology, Ball State University","place":["Muncie, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay V.","family":"Tikhe","sequence":"additional","affiliation":[{"name":"Department of Biology, Ball State University","place":["Muncie, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.11536548","article-title":"Insect diversity in the fossil record","volume":"261","author":"Labandeira","year":"1993","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185x.2007.00018.x","article-title":"Why are there so many insect species? 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